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Entry version 162 (12 Aug 2020)
Sequence version 3 (27 Apr 2001)
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Protein

ATP-dependent RNA helicase HrpA

Gene

hrpA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Not yet known.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi100 – 107ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • helicase activity Source: EcoliWiki
  • nucleic acid binding Source: InterPro
  • RNA helicase activity Source: EcoCyc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHelicase, Hydrolase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:G6732-MONOMER
ECOL316407:JW5905-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-dependent RNA helicase HrpA (EC:3.6.4.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:hrpA
Ordered Locus Names:b1413, JW5905
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000551781 – 1300ATP-dependent RNA helicase HrpAAdd BLAST1300

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P43329

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43329

PRoteomics IDEntifications database

More...
PRIDEi
P43329

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4261507, 128 interactors

Database of interacting proteins

More...
DIPi
DIP-9937N

Protein interaction database and analysis system

More...
IntActi
P43329, 26 interactors

STRING: functional protein association networks

More...
STRINGi
511145.b1413

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43329

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini87 – 250Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST164
Domaini274 – 444Helicase C-terminalPROSITE-ProRule annotationAdd BLAST171

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi197 – 200DEAH box4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG1643, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_001832_3_3_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43329

KEGG Orthology (KO)

More...
KOi
K03578

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43329

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR011545, DEAD/DEAH_box_helicase_dom
IPR011709, DUF1605
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR024590, HrpA_C
IPR027417, P-loop_NTPase
IPR010222, RNA_helicase_HrpA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00270, DEAD, 1 hit
PF11898, DUF3418, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF07717, OB_NTP_bind, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 1 hit
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01967, DEAH_box_HrpA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P43329-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEQQKLTFT ALQQRLDSLM LRDRLRFSRR LHGVKKVKNP DAQQAIFQEM
60 70 80 90 100
AKEIDQAAGK VLLREAARPE ITYPDNLPVS QKKQDILEAI RDHQVVIVAG
110 120 130 140 150
ETGSGKTTQL PKICMELGRG IKGLIGHTQP RRLAARTVAN RIAEELKTEP
160 170 180 190 200
GGCIGYKVRF SDHVSDNTMV KLMTDGILLA EIQQDRLLMQ YDTIIIDEAH
210 220 230 240 250
ERSLNIDFLL GYLKELLPRR PDLKIIITSA TIDPERFSRH FNNAPIIEVS
260 270 280 290 300
GRTYPVEVRY RPIVEEADDT ERDQLQAIFD AVDELSQESH GDILIFMSGE
310 320 330 340 350
REIRDTADAL NKLNLRHTEI LPLYARLSNS EQNRVFQSHS GRRIVLATNV
360 370 380 390 400
AETSLTVPGI KYVIDPGTAR ISRYSYRTKV QRLPIEPISQ ASANQRKGRC
410 420 430 440 450
GRVSEGICIR LYSEDDFLSR PEFTDPEILR TNLASVILQM TALGLGDIAA
460 470 480 490 500
FPFVEAPDKR NIQDGVRLLE ELGAITTDEQ ASAYKLTPLG RQLSQLPVDP
510 520 530 540 550
RLARMVLEAQ KHGCVREAMI ITSALSIQDP RERPMDKQQA SDEKHRRFHD
560 570 580 590 600
KESDFLAFVN LWNYLGEQQK ALSSNAFRRL CRTDYLNYLR VREWQDIYTQ
610 620 630 640 650
LRQVVKELGI PVNSEPAEYR EIHIALLTGL LSHIGMKDAD KQEYTGARNA
660 670 680 690 700
RFSIFPGSGL FKKPPKWVMV AELVETSRLW GRIAARIDPE WVEPVAQHLI
710 720 730 740 750
KRTYSEPHWE RAQGAVMATE KVTVYGLPIV AARKVNYSQI DPALCRELFI
760 770 780 790 800
RHALVEGDWQ TRHAFFRENL KLRAEVEELE HKSRRRDILV DDETLFEFYD
810 820 830 840 850
QRISHDVISA RHFDSWWKKV SRETPDLLNF EKSMLIKEGA EKISKLDYPN
860 870 880 890 900
FWHQGNLKLR LSYQFEPGAD ADGVTVHIPL PLLNQVEESG FEWQIPGLRR
910 920 930 940 950
ELVIALIKSL PKPVRRNFVP APNYAEAFLG RVKPLELPLL DSLERELRRM
960 970 980 990 1000
TGVTVDREDW HWDQVPDHLK ITFRVVDDKN KKLKEGRSLQ DLKDALKGKV
1010 1020 1030 1040 1050
QETLSAVADD GIEQSGLHIW SFGQLPESYE QKRGNYKVKA WPALVDERDS
1060 1070 1080 1090 1100
VAIKLFDNPL EQKQAMWNGL RRLLLLNIPS PIKYLHEKLP NKAKLGLYFN
1110 1120 1130 1140 1150
PYGKVLELID DCISCGVDKL IDANGGPVWT EEGFAALHEK VRAELNDTVV
1160 1170 1180 1190 1200
DIAKQVEQIL TAVFNINKRL KGRVDMTMAL GLSDIKAQMG GLVYRGFVTG
1210 1220 1230 1240 1250
NGFKRLGDTL RYLQAIEKRL EKLAVDPHRD RAQMLKVENV QQAWQQWINK
1260 1270 1280 1290 1300
LPPARREDED VKEIRWMIEE LRVSYFAQQL GTPYPISDKR ILQAMEQISG
Length:1,300
Mass (Da):149,028
Last modified:April 27, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA26601266D771638
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA07685 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAA15029 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti152G → V in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti202R → H in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti301Missing in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti304R → P in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti681 – 694GRIAA…EWVEP → AHCCVSTRNGGA (PubMed:7899078).CuratedAdd BLAST14
Sequence conflicti705S → T in BAA07685 (PubMed:7899078).Curated1
Sequence conflicti712 – 713AQ → E in BAA07685 (PubMed:7899078).Curated2
Sequence conflicti869A → P in BAA07685 (PubMed:7899078).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D42105 Genomic DNA Translation: BAA07685.1 Different initiation.
U00096 Genomic DNA Translation: AAC74495.2
AP009048 Genomic DNA Translation: BAA15029.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
H64892

NCBI Reference Sequences

More...
RefSeqi
NP_415931.4, NC_000913.3
WP_000139543.1, NZ_SSZK01000021.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74495; AAC74495; b1413
BAA15029; BAA15029; BAA15029

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948444

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW5905
eco:b1413

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.858

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42105 Genomic DNA Translation: BAA07685.1 Different initiation.
U00096 Genomic DNA Translation: AAC74495.2
AP009048 Genomic DNA Translation: BAA15029.1 Different initiation.
PIRiH64892
RefSeqiNP_415931.4, NC_000913.3
WP_000139543.1, NZ_SSZK01000021.1

3D structure databases

SMRiP43329
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4261507, 128 interactors
DIPiDIP-9937N
IntActiP43329, 26 interactors
STRINGi511145.b1413

Proteomic databases

jPOSTiP43329
PaxDbiP43329
PRIDEiP43329

Genome annotation databases

EnsemblBacteriaiAAC74495; AAC74495; b1413
BAA15029; BAA15029; BAA15029
GeneIDi948444
KEGGiecj:JW5905
eco:b1413
PATRICifig|1411691.4.peg.858

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2772

Phylogenomic databases

eggNOGiCOG1643, Bacteria
HOGENOMiCLU_001832_3_3_6
InParanoidiP43329
KOiK03578
PhylomeDBiP43329

Enzyme and pathway databases

BioCyciEcoCyc:G6732-MONOMER
ECOL316407:JW5905-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P43329

Family and domain databases

InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR011545, DEAD/DEAH_box_helicase_dom
IPR011709, DUF1605
IPR007502, Helicase-assoc_dom
IPR014001, Helicase_ATP-bd
IPR001650, Helicase_C
IPR024590, HrpA_C
IPR027417, P-loop_NTPase
IPR010222, RNA_helicase_HrpA
PfamiView protein in Pfam
PF00270, DEAD, 1 hit
PF11898, DUF3418, 1 hit
PF04408, HA2, 1 hit
PF00271, Helicase_C, 1 hit
PF07717, OB_NTP_bind, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 1 hit
SM00487, DEXDc, 1 hit
SM00847, HA2, 1 hit
SM00490, HELICc, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR01967, DEAH_box_HrpA, 1 hit
PROSITEiView protein in PROSITE
PS51192, HELICASE_ATP_BIND_1, 1 hit
PS51194, HELICASE_CTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHRPA_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43329
Secondary accession number(s): P76861, P76863, P77479
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 27, 2001
Last modified: August 12, 2020
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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