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Protein

Translocon-associated protein subunit beta

Gene

SSR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

GO - Biological processi

  • cotranslational protein targeting to membrane Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit beta
Short name:
TRAP-beta
Alternative name(s):
Signal sequence receptor subunit beta
Short name:
SSR-beta
Gene namesi
Name:SSR2
Synonyms:TRAPB
ORF Names:HSD25
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163479.13
HGNCiHGNC:11324 SSR2
MIMi600867 gene
neXtProtiNX_P43308

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 149LumenalSequence analysisAdd BLAST132
Transmembranei150 – 169HelicalSequence analysisAdd BLAST20
Topological domaini170 – 183CytoplasmicSequence analysisAdd BLAST14

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6746
OpenTargetsiENSG00000163479
PharmGKBiPA36148

Polymorphism and mutation databases

BioMutaiSSR2
DMDMi1174451

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17By similarityAdd BLAST17
ChainiPRO_000003329018 – 183Translocon-associated protein subunit betaAdd BLAST166

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi88N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi104N-linked (GlcNAc...) asparagine2 Publications1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP43308
PaxDbiP43308
PeptideAtlasiP43308
PRIDEiP43308
ProteomicsDBi55611
TopDownProteomicsiP43308

PTM databases

iPTMnetiP43308
PhosphoSitePlusiP43308

Expressioni

Gene expression databases

BgeeiENSG00000163479
CleanExiHS_SSR2
ExpressionAtlasiP43308 baseline and differential
GenevisibleiP43308 HS

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with TMEM173/STING.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TMEM173Q86WV64EBI-2822012,EBI-2800345

Protein-protein interaction databases

BioGridi112624, 38 interactors
DIPiDIP-60652N
IntActiP43308, 3 interactors
STRINGi9606.ENSP00000295702

Structurei

3D structure databases

ProteinModelPortaliP43308
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-beta family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3317 Eukaryota
ENOG4111KGI LUCA
GeneTreeiENSGT00390000005125
HOVERGENiHBG000858
InParanoidiP43308
KOiK13250
OMAiDNGFHPE
OrthoDBiEOG091G0V9U
PhylomeDBiP43308
TreeFamiTF314461

Family and domain databases

InterProiView protein in InterPro
IPR008856 TRAP_beta
PIRSFiPIRSF016400 TRAP_beta, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43308-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLLSFVVLA LFAVTQAEEG ARLLASKSLL NRYAVEGRDL TLQYNIYNVG
60 70 80 90 100
SSAALDVELS DDSFPPEDFG IVSGMLNVKW DRIAPASNVS HTVVLRPLKA
110 120 130 140 150
GYFNFTSATI TYLAQEDGPV VIGSTSAPGQ GGILAQREFD RRFSPHFLDW
160 170 180
AAFGVMTLPS IGIPLLLWYS SKRKYDTPKT KKN
Length:183
Mass (Da):20,135
Last modified:November 1, 1995 - v1
Checksum:i575715449B8586D8
GO

Sequence cautioni

The sequence CAH72631 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAH72632 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti46I → T in BAD96320 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X74104 mRNA Translation: CAA52207.1
D37991 mRNA Translation: BAA07206.1
AY251536 mRNA Translation: AAP20059.1
CR456973 mRNA Translation: CAG33254.1
AK222600 mRNA Translation: BAD96320.1
AK313821 mRNA Translation: BAG36556.1
AL355388 Genomic DNA Translation: CAH72631.1 Sequence problems.
AL355388 Genomic DNA Translation: CAH72632.1 Sequence problems.
CH471121 Genomic DNA Translation: EAW53010.1
CH471121 Genomic DNA Translation: EAW53011.1
BC000341 mRNA Translation: AAH00341.2
CCDSiCCDS1126.1
PIRiS41063
RefSeqiNP_003136.1, NM_003145.3
UniGeneiHs.74564

Genome annotation databases

EnsembliENST00000295702; ENSP00000295702; ENSG00000163479
ENST00000480567; ENSP00000434306; ENSG00000163479
GeneIDi6746
KEGGihsa:6746
UCSCiuc001fmx.4 human

Similar proteinsi

Entry informationi

Entry nameiSSRB_HUMAN
AccessioniPrimary (citable) accession number: P43308
Secondary accession number(s): B2R9K9
, D3DVA7, Q53HI0, Q5VY95, Q5VY96, Q6IB31, Q9BWE4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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