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Protein

Translocon-associated protein subunit alpha

Gene

SSR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins.

Miscellaneous

Seems to bind calcium.

GO - Biological processi

Keywordsi

LigandCalcium

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381038 XBP1(S) activates chaperone genes

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit alpha
Short name:
TRAP-alpha
Alternative name(s):
Signal sequence receptor subunit alpha
Short name:
SSR-alpha
Gene namesi
Name:SSR1
Synonyms:TRAPA
ORF Names:PSEC0262
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000124783.12
HGNCiHGNC:11323 SSR1
MIMi600868 gene
neXtProtiNX_P43307

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 207LumenalSequence analysisAdd BLAST189
Transmembranei208 – 228HelicalSequence analysisAdd BLAST21
Topological domaini229 – 286CytoplasmicSequence analysisAdd BLAST58

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6745
OpenTargetsiENSG00000124783
PharmGKBiPA36147

Polymorphism and mutation databases

BioMutaiSSR1
DMDMi22261821

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000003328119 – 286Translocon-associated protein subunit alphaAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi136N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi191N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei247PhosphoserineCombined sources1
Modified residuei260PhosphothreonineCombined sources1
Modified residuei268PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP43307
MaxQBiP43307
PaxDbiP43307
PeptideAtlasiP43307
PRIDEiP43307
ProteomicsDBi55609
55610 [P43307-2]
TopDownProteomicsiP43307-1 [P43307-1]
P43307-2 [P43307-2]

PTM databases

GlyConnecti1839
iPTMnetiP43307
PhosphoSitePlusiP43307

Expressioni

Gene expression databases

BgeeiENSG00000124783 Expressed in 242 organ(s), highest expression level in myometrium
ExpressionAtlasiP43307 baseline and differential
GenevisibleiP43307 HS

Organism-specific databases

HPAiHPA011276
HPA017062

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi112623, 73 interactors
IntActiP43307, 44 interactors
MINTiP43307
STRINGi9606.ENSP00000244763

Structurei

3D structure databases

ProteinModelPortaliP43307
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.

Sequence similaritiesi

Belongs to the TRAP-alpha family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1631 Eukaryota
ENOG410XNTM LUCA
GeneTreeiENSGT00400000022103
HOVERGENiHBG009736
InParanoidiP43307
KOiK13249
PhylomeDBiP43307
TreeFamiTF321074

Family and domain databases

InterProiView protein in InterPro
IPR005595 TRAP_alpha
PfamiView protein in Pfam
PF03896 TRAP_alpha, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43307-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRLLPRLLLL LLLVFPATVL FRGGPRGLLA VAQDLTEDEE TVEDSIIEDE
60 70 80 90 100
DDEAEVEEDE PTDLVEDKEE EDVSGEPEAS PSADTTILFV KGEDFPANNI
110 120 130 140 150
VKFLVGFTNK GTEDFIVESL DASFRYPQDY QFYIQNFTAL PLNTVVPPQR
160 170 180 190 200
QATFEYSFIP AEPMGGRPFG LVINLNYKDL NGNVFQDAVF NQTVTVIERE
210 220 230 240 250
DGLDGETIFM YMFLAGLGLL VIVGLHQLLE SRKRKRPIQK VEMGTSSQND
260 270 280
VDMSWIPQET LNQINKASPR RLPRKRAQKR SVGSDE
Length:286
Mass (Da):32,235
Last modified:August 13, 2002 - v3
Checksum:i2C631DC0CC3EB489
GO
Isoform 2 (identifier: P43307-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     68-94: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):29,373
Checksum:iD79F40EE756B1CB5
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JBX5C9JBX5_HUMAN
Translocon-associated protein subun...
SSR1
218Annotation score:
C9IZQ1C9IZQ1_HUMAN
Translocon-associated protein subun...
SSR1
298Annotation score:
E9PAL7E9PAL7_HUMAN
Translocon-associated protein subun...
SSR1
291Annotation score:
C9J3L8C9J3L8_HUMAN
Translocon-associated protein subun...
SSR1
265Annotation score:
C9J5W0C9J5W0_HUMAN
Translocon-associated protein subun...
SSR1
266Annotation score:
C9JY01C9JY01_HUMAN
Translocon-associated protein subun...
SSR1
103Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6R → G in BAC11701 (PubMed:16303743).Curated1
Sequence conflicti37E → A in BAD96529 (Ref. 6) Curated1
Sequence conflicti130Y → H in CAA78290 (PubMed:8050590).Curated1
Sequence conflicti190F → Y in BAF84239 (PubMed:14702039).Curated1
Sequence conflicti220L → P in BAD96529 (Ref. 6) Curated1
Sequence conflicti263Q → R in BAF84239 (PubMed:14702039).Curated1
Sequence conflicti286E → D in CAG33242 (Ref. 5) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02242728L → S2 PublicationsCorresponds to variant dbSNP:rs10004Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01362168 – 94Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12830 mRNA Translation: CAA78290.1
AF156965 mRNA Translation: AAD48778.1
BT007387 mRNA Translation: AAP36051.1
AK291550 mRNA Translation: BAF84239.1
CR456961 mRNA Translation: CAG33242.1
AK222762 mRNA Translation: BAD96482.1
AK222809 mRNA Translation: BAD96529.1
AK075562 mRNA Translation: BAC11701.1
AL139095 Genomic DNA No translation available.
BC007710 mRNA Translation: AAH07710.1
CCDSiCCDS4499.1 [P43307-1]
PIRiI38246
RefSeqiNP_001278937.1, NM_001292008.1
NP_003135.2, NM_003144.4 [P43307-1]
UniGeneiHs.114033

Genome annotation databases

EnsembliENST00000244763; ENSP00000244763; ENSG00000124783 [P43307-1]
GeneIDi6745
KEGGihsa:6745
UCSCiuc003mxf.6 human [P43307-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z12830 mRNA Translation: CAA78290.1
AF156965 mRNA Translation: AAD48778.1
BT007387 mRNA Translation: AAP36051.1
AK291550 mRNA Translation: BAF84239.1
CR456961 mRNA Translation: CAG33242.1
AK222762 mRNA Translation: BAD96482.1
AK222809 mRNA Translation: BAD96529.1
AK075562 mRNA Translation: BAC11701.1
AL139095 Genomic DNA No translation available.
BC007710 mRNA Translation: AAH07710.1
CCDSiCCDS4499.1 [P43307-1]
PIRiI38246
RefSeqiNP_001278937.1, NM_001292008.1
NP_003135.2, NM_003144.4 [P43307-1]
UniGeneiHs.114033

3D structure databases

ProteinModelPortaliP43307
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112623, 73 interactors
IntActiP43307, 44 interactors
MINTiP43307
STRINGi9606.ENSP00000244763

PTM databases

GlyConnecti1839
iPTMnetiP43307
PhosphoSitePlusiP43307

Polymorphism and mutation databases

BioMutaiSSR1
DMDMi22261821

Proteomic databases

EPDiP43307
MaxQBiP43307
PaxDbiP43307
PeptideAtlasiP43307
PRIDEiP43307
ProteomicsDBi55609
55610 [P43307-2]
TopDownProteomicsiP43307-1 [P43307-1]
P43307-2 [P43307-2]

Protocols and materials databases

DNASUi6745
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244763; ENSP00000244763; ENSG00000124783 [P43307-1]
GeneIDi6745
KEGGihsa:6745
UCSCiuc003mxf.6 human [P43307-1]

Organism-specific databases

CTDi6745
DisGeNETi6745
EuPathDBiHostDB:ENSG00000124783.12
GeneCardsiSSR1
HGNCiHGNC:11323 SSR1
HPAiHPA011276
HPA017062
MIMi600868 gene
neXtProtiNX_P43307
OpenTargetsiENSG00000124783
PharmGKBiPA36147
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1631 Eukaryota
ENOG410XNTM LUCA
GeneTreeiENSGT00400000022103
HOVERGENiHBG009736
InParanoidiP43307
KOiK13249
PhylomeDBiP43307
TreeFamiTF321074

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiSSR1 human
GeneWikiiSSR1
GenomeRNAii6745
PROiPR:P43307
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124783 Expressed in 242 organ(s), highest expression level in myometrium
ExpressionAtlasiP43307 baseline and differential
GenevisibleiP43307 HS

Family and domain databases

InterProiView protein in InterPro
IPR005595 TRAP_alpha
PfamiView protein in Pfam
PF03896 TRAP_alpha, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSSRA_HUMAN
AccessioniPrimary (citable) accession number: P43307
Secondary accession number(s): A8K685
, Q53GX2, Q53H19, Q5TAM3, Q6IB43, Q8NBH9, Q96IA2, Q9TNQ8, Q9UN49
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 13, 2002
Last modified: October 10, 2018
This is version 168 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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