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Protein

Early growth response protein 3

Gene

Egr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in muscle spindle development.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 3
Short name:
EGR-3
Gene namesi
Name:Egr3
Synonyms:Egr-3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 15

Organism-specific databases

RGDi2545 Egr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471271 – 387Early growth response protein 3Add BLAST387

Proteomic databases

PaxDbiP43301

PTM databases

iPTMnetiP43301
PhosphoSitePlusiP43301

Expressioni

Gene expression databases

BgeeiENSRNOG00000017828 Expressed in 9 organ(s), highest expression level in brain
ExpressionAtlasiP43301 baseline and differential
GenevisibleiP43301 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024066

Structurei

3D structure databases

ProteinModelPortaliP43301
SMRiP43301
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP43301
KOiK12497
OMAiSGWCSDN
OrthoDBiEOG091G08QI
PhylomeDBiP43301
TreeFamiTF318980

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11928 DUF3446, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P43301-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYTQMA
60 70 80 90 100
TENVMDIGLT NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD
110 120 130 140 150
NIISLMSAGI LGVPPASGAL STQTTTASMV QPPQGDVEAM YPALPPYSNC
160 170 180 190 200
GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP
210 220 230 240 250
NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP
260 270 280 290 300
LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT
310 320 330 340 350
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR
360 370 380
HAKIHLKQKE KKSEKGGAPS ASSAPTVSLA PVVTTCA
Length:387
Mass (Da):42,606
Last modified:November 1, 1995 - v1
Checksum:iA56F4A22B438323E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JTQ1A0A0G2JTQ1_RAT
Early growth response protein 3
Egr3
71Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12428 mRNA Translation: AAA20818.1
RefSeqiNP_058782.1, NM_017086.1
UniGeneiRn.44371

Genome annotation databases

EnsembliENSRNOT00000024067; ENSRNOP00000024066; ENSRNOG00000017828
GeneIDi25148
KEGGirno:25148
UCSCiRGD:2545 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12428 mRNA Translation: AAA20818.1
RefSeqiNP_058782.1, NM_017086.1
UniGeneiRn.44371

3D structure databases

ProteinModelPortaliP43301
SMRiP43301
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024066

PTM databases

iPTMnetiP43301
PhosphoSitePlusiP43301

Proteomic databases

PaxDbiP43301

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000024067; ENSRNOP00000024066; ENSRNOG00000017828
GeneIDi25148
KEGGirno:25148
UCSCiRGD:2545 rat

Organism-specific databases

CTDi1960
RGDi2545 Egr3

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP43301
KOiK12497
OMAiSGWCSDN
OrthoDBiEOG091G08QI
PhylomeDBiP43301
TreeFamiTF318980

Miscellaneous databases

PROiPR:P43301

Gene expression databases

BgeeiENSRNOG00000017828 Expressed in 9 organ(s), highest expression level in brain
ExpressionAtlasiP43301 baseline and differential
GenevisibleiP43301 RN

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11928 DUF3446, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEGR3_RAT
AccessioniPrimary (citable) accession number: P43301
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 10, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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