Early growth response protein 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• metal ion binding Source: UniProtKB-KW
• sequence-specific DNA binding Source: RGDInferred from sequence orthologyⁱ
  • "DNA-binding specificities of human transcription factors."
    Jolma A., Yan J., Whitington T., Toivonen J., Nitta K.R., Rastas P., Morgunova E., Enge M., Taipale M., Wei G., Palin K., Vaquerizas J.M., Vincentelli R., Luscombe N.M., Hughes T.R., Lemaire P., Ukkonen E., Kivioja T., Taipale J.
    Cell 152:327-339(2013) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell migration involved in sprouting angiogenesis Source: RGDInferred from sequence orthologyⁱ
  • "The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis."
    Liu D., Evans I., Britton G., Zachary I.
    Oncogene 27:2989-2998(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to fibroblast growth factor stimulus Source: RGDInferred from sequence orthologyⁱ
  • "The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis."
    Liu D., Evans I., Britton G., Zachary I.
    Oncogene 27:2989-2998(2008) [PubMed] [Europe PMC] [Abstract]
• cellular response to growth factor stimulus Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to vascular endothelial growth factor stimulus Source: RGDInferred from sequence orthologyⁱ
  • "The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis."
    Liu D., Evans I., Britton G., Zachary I.
    Oncogene 27:2989-2998(2008) [PubMed] [Europe PMC] [Abstract]
• endothelial cell chemotaxis Source: RGDInferred from sequence orthologyⁱ
  • "The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis."
    Liu D., Evans I., Britton G., Zachary I.
    Oncogene 27:2989-2998(2008) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: RGDInferred from sequence orthologyⁱ
  • "The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis."
    Liu D., Evans I., Britton G., Zachary I.
    Oncogene 27:2989-2998(2008) [PubMed] [Europe PMC] [Abstract]
• neuromuscular synaptic transmission Source: RGDInferred from sequence orthologyⁱ
  • "Muscle spindle-derived neurotrophin 3 regulates synaptic connectivity between muscle sensory and motor neurons."
    Chen H.H., Tourtellotte W.G., Frank E.
    J. Neurosci. 22:3512-3519(2002) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system development Source: RGDInferred from sequence orthologyⁱ
  • "Glial cell-line derived neurotrophic factor-dependent fusimotor neuron survival during development."
    Whitehead J., Keller-Peck C., Kucera J., Tourtellotte W.G.
    Mech. Dev. 122:27-41(2005) [PubMed] [Europe PMC] [Abstract]
• positive regulation of endothelial cell proliferation Source: RGDInferred from sequence orthologyⁱ
  • "The zinc-finger transcription factor, early growth response 3, mediates VEGF-induced angiogenesis."
    Liu D., Evans I., Britton G., Zachary I.
    Oncogene 27:2989-2998(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T cell differentiation in thymus Source: RGDInferred from sequence orthologyⁱ
  • "Skint-1 identifies a common molecular mechanism for the development of interferon-gamma-secreting versus interleukin-17-secreting gammadelta T cells."
    Turchinovich G., Hayday A.C.
    Immunity 35:59-68(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: RGDInferred from sequence orthologyⁱ
  • "Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses."
    Droin N.M., Pinkoski M.J., Dejardin E., Green D.R.
    Mol. Cell. Biol. 23:7638-7647(2003) [PubMed] [Europe PMC] [Abstract]
• regulation of gamma-delta T cell differentiation Source: RGDInferred from sequence orthologyⁱ
  • "Skint-1 identifies a common molecular mechanism for the development of interferon-gamma-secreting versus interleukin-17-secreting gammadelta T cells."
    Turchinovich G., Hayday A.C.
    Immunity 35:59-68(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYTQMA 
        60         70         80         90        100
TENVMDIGLT NEKPNPELSY SGSFQPAPGN KTVTYLGKFA FDSPSNWCQD 
       110        120        130        140        150
NIISLMSAGI LGVPPASGAL STQTTTASMV QPPQGDVEAM YPALPPYSNC 
       160        170        180        190        200
GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP 
       210        220        230        240        250
NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP 
       260        270        280        290        300
LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT 
       310        320        330        340        350
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR 
       360        370        380 
HAKIHLKQKE KKSEKGGAPS ASSAPTVSLA PVVTTCA               

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families