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UniProtKB - P43300 (EGR3_MOUSE)
Protein
Early growth response protein 3
Gene
Egr3
Organism
Mus musculus (Mouse)
Status
Functioni
Probable transcription factor involved in muscle spindle development.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 275 – 299 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 305 – 327 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- cell migration involved in sprouting angiogenesis Source: MGI
- cellular response to fibroblast growth factor stimulus Source: MGI
- cellular response to vascular endothelial growth factor stimulus Source: MGI
- endothelial cell chemotaxis Source: MGI
- negative regulation of apoptotic process Source: MGI
- neuromuscular synaptic transmission Source: MGI
- peripheral nervous system development Source: MGI
- positive regulation of endothelial cell proliferation Source: MGI
- positive regulation of T cell differentiation in thymus Source: MGI
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of gamma-delta T cell differentiation Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Early growth response protein 3Short name: EGR-3 |
Gene namesi | Name:Egr3 Synonyms:Egr-3 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1306780, Egr3 |
VEuPathDBi | HostDB:ENSMUSG00000033730 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleoplasm Source: Reactome
Other locations
- synapse Source: GOC
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047126 | 1 – 387 | Early growth response protein 3Add BLAST | 387 |
Proteomic databases
PaxDbi | P43300 |
PRIDEi | P43300 |
ProteomicsDBi | 277733 |
PTM databases
PhosphoSitePlusi | P43300 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000033730, Expressed in vibrissa unit and 94 other tissues |
ExpressionAtlasi | P43300, baseline and differential |
Genevisiblei | P43300, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000037042 |
Miscellaneous databases
RNActi | P43300, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 241 – 283 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 348 – 387 | DisorderedSequence analysisAdd BLAST | 40 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 265 – 283 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 369 – 387 | Polar residuesSequence analysisAdd BLAST | 19 |
Sequence similaritiesi
Belongs to the EGR C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 275 – 299 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 305 – 327 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 333 – 355 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160355 |
HOGENOMi | CLU_043235_0_0_1 |
InParanoidi | P43300 |
OMAi | GEVEPMY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P43300 |
TreeFami | TF318980 |
Family and domain databases
InterProi | View protein in InterPro IPR021849, EGR_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF11928, DUF3446, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P43300-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYNQMA
60 70 80 90 100
TENVMDIGLT NEKPNPELSY SSSFQPAPGN KTVTYLGKFA FDSPSNWCQD
110 120 130 140 150
NIISLMSAGI LGVPPASGAL STQTSTASMV QPPQGDVEAM YPALPPYSNC
160 170 180 190 200
GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP
210 220 230 240 250
NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP
260 270 280 290 300
LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT
310 320 330 340 350
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR
360 370 380
HAKIHLKQKE KKSEKGGAPS ASSAPTVSLA PVVTTCA
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ3ZB14 | Q3ZB14_MOUSE | Early growth response protein 3 | Egr3 | 349 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 324 – 325 | IR → TH (PubMed:1906159).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132128 mRNA Translation: AAD28261.1 S40835 mRNA Translation: AAB19318.1 |
CCDSi | CCDS27246.1 |
PIRi | B43819 |
RefSeqi | NP_061251.1, NM_018781.3 |
Genome annotation databases
Ensembli | ENSMUST00000225200; ENSMUSP00000153491; ENSMUSG00000033730 |
GeneIDi | 13655 |
KEGGi | mmu:13655 |
UCSCi | uc007unb.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF132128 mRNA Translation: AAD28261.1 S40835 mRNA Translation: AAB19318.1 |
CCDSi | CCDS27246.1 |
PIRi | B43819 |
RefSeqi | NP_061251.1, NM_018781.3 |
3D structure databases
AlphaFoldDBi | P43300 |
SMRi | P43300 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000037042 |
PTM databases
PhosphoSitePlusi | P43300 |
Proteomic databases
PaxDbi | P43300 |
PRIDEi | P43300 |
ProteomicsDBi | 277733 |
Protocols and materials databases
Antibodypediai | 22692, 238 antibodies from 28 providers |
DNASUi | 13655 |
Genome annotation databases
Ensembli | ENSMUST00000225200; ENSMUSP00000153491; ENSMUSG00000033730 |
GeneIDi | 13655 |
KEGGi | mmu:13655 |
UCSCi | uc007unb.2, mouse |
Organism-specific databases
CTDi | 1960 |
MGIi | MGI:1306780, Egr3 |
VEuPathDBi | HostDB:ENSMUSG00000033730 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000160355 |
HOGENOMi | CLU_043235_0_0_1 |
InParanoidi | P43300 |
OMAi | GEVEPMY |
OrthoDBi | 1318335at2759 |
PhylomeDBi | P43300 |
TreeFami | TF318980 |
Miscellaneous databases
BioGRID-ORCSi | 13655, 0 hits in 72 CRISPR screens |
PROi | PR:P43300 |
RNActi | P43300, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033730, Expressed in vibrissa unit and 94 other tissues |
ExpressionAtlasi | P43300, baseline and differential |
Genevisiblei | P43300, MM |
Family and domain databases
InterProi | View protein in InterPro IPR021849, EGR_N IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF11928, DUF3446, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 3 hits |
SUPFAMi | SSF57667, SSF57667, 2 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 3 hits PS50157, ZINC_FINGER_C2H2_2, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | EGR3_MOUSE | |
Accessioni | P43300Primary (citable) accession number: P43300 Secondary accession number(s): Q9R276 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | May 9, 2003 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families