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Protein

Early growth response protein 3

Gene

Egr3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Probable transcription factor involved in muscle spindle development.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Early growth response protein 3
Short name:
EGR-3
Gene namesi
Name:Egr3
Synonyms:Egr-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1306780 Egr3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471261 – 387Early growth response protein 3Add BLAST387

Proteomic databases

PaxDbiP43300
PRIDEiP43300

PTM databases

PhosphoSitePlusiP43300

Expressioni

Gene expression databases

BgeeiENSMUSG00000033730 Expressed in 52 organ(s), highest expression level in vibrissa unit
CleanExiMM_EGR3
ExpressionAtlasiP43300 baseline and differential
GenevisibleiP43300 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037042

Structurei

3D structure databases

ProteinModelPortaliP43300
SMRiP43300
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri275 – 299C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri305 – 327C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri333 – 355C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP43300
KOiK12497
OMAiSGWCSDN
OrthoDBiEOG091G08QI
PhylomeDBiP43300
TreeFamiTF318980

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11928 DUF3446, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P43300-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYNQMA
60 70 80 90 100
TENVMDIGLT NEKPNPELSY SSSFQPAPGN KTVTYLGKFA FDSPSNWCQD
110 120 130 140 150
NIISLMSAGI LGVPPASGAL STQTSTASMV QPPQGDVEAM YPALPPYSNC
160 170 180 190 200
GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP
210 220 230 240 250
NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP
260 270 280 290 300
LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT
310 320 330 340 350
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR
360 370 380
HAKIHLKQKE KKSEKGGAPS ASSAPTVSLA PVVTTCA
Length:387
Mass (Da):42,635
Last modified:May 9, 2003 - v2
Checksum:iD6EE31B8D4F26949
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3ZB14Q3ZB14_MOUSE
Early growth response protein 3
Egr3
349Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti324 – 325IR → TH (PubMed:1906159).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132128 mRNA Translation: AAD28261.1
S40835 mRNA Translation: AAB19318.1
CCDSiCCDS27246.1
PIRiB43819
RefSeqiNP_061251.1, NM_018781.3
UniGeneiMm.103737
Mm.440893

Genome annotation databases

EnsembliENSMUST00000225200; ENSMUSP00000153491; ENSMUSG00000033730
GeneIDi13655
KEGGimmu:13655
UCSCiuc007unb.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132128 mRNA Translation: AAD28261.1
S40835 mRNA Translation: AAB19318.1
CCDSiCCDS27246.1
PIRiB43819
RefSeqiNP_061251.1, NM_018781.3
UniGeneiMm.103737
Mm.440893

3D structure databases

ProteinModelPortaliP43300
SMRiP43300
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037042

PTM databases

PhosphoSitePlusiP43300

Proteomic databases

PaxDbiP43300
PRIDEiP43300

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000225200; ENSMUSP00000153491; ENSMUSG00000033730
GeneIDi13655
KEGGimmu:13655
UCSCiuc007unb.2 mouse

Organism-specific databases

CTDi1960
MGIiMGI:1306780 Egr3

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00550000074455
HOGENOMiHOG000036856
HOVERGENiHBG003909
InParanoidiP43300
KOiK12497
OMAiSGWCSDN
OrthoDBiEOG091G08QI
PhylomeDBiP43300
TreeFamiTF318980

Miscellaneous databases

PROiPR:P43300
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033730 Expressed in 52 organ(s), highest expression level in vibrissa unit
CleanExiMM_EGR3
ExpressionAtlasiP43300 baseline and differential
GenevisibleiP43300 MM

Family and domain databases

InterProiView protein in InterPro
IPR021849 EGR
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF11928 DUF3446, 1 hit
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEGR3_MOUSE
AccessioniPrimary (citable) accession number: P43300
Secondary accession number(s): Q9R276
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 9, 2003
Last modified: October 10, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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