Egr3

Functionⁱ

Probable transcription factor involved in muscle spindle development.

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	275 – 299	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	305 – 327	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	333 – 355	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

metal ion binding Source: UniProtKB-KW
sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 23332764
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell migration involved in sprouting angiogenesis Source: MGI
cellular response to fibroblast growth factor stimulus Source: MGI
cellular response to vascular endothelial growth factor stimulus Source: MGI
endothelial cell chemotaxis Source: MGI
negative regulation of apoptotic process Source: MGI
neuromuscular synaptic transmission
Source: MGI
Inferred from mutant phenotypeⁱ
- 11978828
peripheral nervous system development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15582775
positive regulation of endothelial cell proliferation Source: MGI
positive regulation of T cell differentiation in thymus
Source: MGI
Inferred from mutant phenotypeⁱ
- 21737317
positive regulation of transcription by RNA polymerase II
Source: NTNU_SB
Inferred from direct assayⁱ
- 14560009
regulation of gamma-delta T cell differentiation
Source: MGI
Inferred from direct assayⁱ
- 21737317

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Early growth response protein 3 Short name: EGR-3
Gene namesⁱ	Name:Egr3 Synonyms:Egr-3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 14

Organism-specific databases

MGIⁱ	MGI:1306780 Egr3

Keywords - Cellular componentⁱ

Nucleus

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047126	1 – 387	Early growth response protein 3Add BLAST		387

Proteomic databases

PaxDbⁱ	P43300
PRIDEⁱ	P43300

PTM databases

PhosphoSitePlusⁱ	P43300

PhosphoSitePlusⁱ

P43300

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000033730 Expressed in 52 organ(s), highest expression level in vibrissa unit
CleanExⁱ	MM_EGR3
ExpressionAtlasⁱ	P43300 baseline and differential
Genevisibleⁱ	P43300 MM

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000037042

STRINGⁱ

10090.ENSMUSP00000037042

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P43300
SMRⁱ	P43300
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the EGR C2H2-type zinc-finger protein family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	275 – 299	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	305 – 327	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	333 – 355	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23

Keywords - Domainⁱ

Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074455
HOGENOMⁱ	HOG000036856
HOVERGENⁱ	HBG003909
InParanoidⁱ	P43300
KEGG Orthology (KO) More...KOⁱ	K12497
OMAⁱ	SGWCSDN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08QI
PhylomeDBⁱ	P43300
TreeFamⁱ	TF318980

Family and domain databases

InterProⁱ	View protein in InterPro IPR021849 EGR IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF11928 DUF3446, 1 hit PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P43300-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTGKLAEKLP VTMSSLLNQL PDNLYPEEIP SALNLFSGSS DSVAHYNQMA 
        60         70         80         90        100
TENVMDIGLT NEKPNPELSY SSSFQPAPGN KTVTYLGKFA FDSPSNWCQD 
       110        120        130        140        150
NIISLMSAGI LGVPPASGAL STQTSTASMV QPPQGDVEAM YPALPPYSNC 
       160        170        180        190        200
GDLYSEPVSF HDPQGNPGLA YSPQDYQSAK PALDSNLFPM IPDYNLYHHP 
       210        220        230        240        250
NDMGSIPEHK PFQGMDPIRV NPPPITPLET IKAFKDKQIH PGFGSLPQPP 
       260        270        280        290        300
LTLKPIRPRK YPNRPSKTPL HERPHACPAE GCDRRFSRSD ELTRHLRIHT 
       310        320        330        340        350
GHKPFQCRIC MRSFSRSDHL TTHIRTHTGE KPFACEFCGR KFARSDERKR 
       360        370        380 
HAKIHLKQKE KKSEKGGAPS ASSAPTVSLA PVVTTCA

Length:387

Mass (Da):42,635

Last modified:May 9, 2003 - v2

Checksum:ⁱD6EE31B8D4F26949

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Q3ZB14	Q3ZB14_MOUSE		Early growth response protein 3 Early growth response protein 3 (Egr3 protein)	Egr3	349	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	324 – 325	IR → TH (PubMed:1906159).Curated		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132128 mRNA Translation: AAD28261.1 S40835 mRNA Translation: AAB19318.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27246.1
PIRⁱ	B43819
NCBI Reference Sequences More...RefSeqⁱ	NP_061251.1, NM_018781.3
UniGeneⁱ	Mm.103737 Mm.440893

Genome annotation databases

Ensemblⁱ	ENSMUST00000225200; ENSMUSP00000153491; ENSMUSG00000033730
GeneIDⁱ	13655
KEGGⁱ	mmu:13655
UCSC genome browser More...UCSCⁱ	uc007unb.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43300	Egr3 protein (Fragment)		MOUSE		386	UniRef100_P43300

Protein	Similar proteins		Species	Score	Length	Source
P43300	Early growth response protein 3		HUMAN		387	UniRef90_Q06889
Early growth response protein 3		RAT		387
EGR3 isoform 1		PANTR		387
Early growth response protein 3 isoform 1		CALJA		387
Early growth response 3		SAIBB		387
+103

Protein	Similar proteins		Species	Score	Length	Source
P43300	Early growth response protein 3		HUMAN		387	UniRef50_Q06889
Early growth response protein 3		RAT		387
EGR3 isoform 1		PANTR		387
Early growth response protein 3 isoform 1		CALJA		387
Early growth response 3		SAIBB		387
+237

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF132128 mRNA Translation: AAD28261.1 S40835 mRNA Translation: AAB19318.1
CCDSⁱ	CCDS27246.1
PIRⁱ	B43819
RefSeqⁱ	NP_061251.1, NM_018781.3
UniGeneⁱ	Mm.103737 Mm.440893

3D structure databases

ProteinModelPortalⁱ	P43300
SMRⁱ	P43300
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000037042

STRINGⁱ

10090.ENSMUSP00000037042

PTM databases

PhosphoSitePlusⁱ	P43300

PhosphoSitePlusⁱ

P43300

Proteomic databases

PaxDbⁱ	P43300
PRIDEⁱ	P43300

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000225200; ENSMUSP00000153491; ENSMUSG00000033730
GeneIDⁱ	13655
KEGGⁱ	mmu:13655
UCSCⁱ	uc007unb.2 mouse

Organism-specific databases

CTDⁱ	1960
MGIⁱ	MGI:1306780 Egr3

Phylogenomic databases

eggNOGⁱ	KOG1721 Eukaryota COG5048 LUCA
GeneTreeⁱ	ENSGT00550000074455
HOGENOMⁱ	HOG000036856
HOVERGENⁱ	HBG003909
InParanoidⁱ	P43300
KOⁱ	K12497
OMAⁱ	SGWCSDN
OrthoDBⁱ	EOG091G08QI
PhylomeDBⁱ	P43300
TreeFamⁱ	TF318980

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P43300
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000033730 Expressed in 52 organ(s), highest expression level in vibrissa unit
CleanExⁱ	MM_EGR3
ExpressionAtlasⁱ	P43300 baseline and differential
Genevisibleⁱ	P43300 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR021849 EGR IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF11928 DUF3446, 1 hit PF00096 zf-C2H2, 3 hits
SMARTⁱ	View protein in SMART SM00355 ZnF_C2H2, 3 hits
SUPFAMⁱ	SSF57667 SSF57667, 2 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 3 hits PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EGR3_MOUSE
Accessionⁱ	P43300Primary (citable) accession number: P43300 Secondary accession number(s): Q9R276
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	May 9, 2003
	Last modified:	October 10, 2018
	This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P43300 (EGR3_MOUSE)

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Early growth response protein 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ