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UniProtKB - P43295 (RD19B_ARATH)
Protein
Probable cysteine protease RD19B
Gene
RD19B
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Functioni
Probable thiol protease.
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 156 | PROSITE-ProRule annotation | 1 | |
Active sitei | 299 | PROSITE-ProRule annotation | 1 | |
Active sitei | 326 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- proteolysis involved in cellular protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Protein family/group databases
MEROPSi | C01.A04 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable cysteine protease RD19BCurated (EC:3.4.22.-)Alternative name(s): RD19-like protein 11 Publication Thiol protease A14941 Publication |
Gene namesi | Name:RD19BCurated Synonyms:RDL11 Publication Ordered Locus Names:At2g21430 ORF Names:F3K23.19 |
Organismi | Arabidopsis thaliana (Mouse-ear cress) |
Taxonomic identifieri | 3702 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliopsida › eudicotyledons › Gunneridae › Pentapetalae › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis |
Proteomesi |
|
Organism-specific databases
Araporti | AT2G21430 |
TAIRi | locus:2050145, AT2G21430 |
Subcellular locationi
Vacuole
- Lytic vacuole 1 Publication
Note: Predominantly vacuolar. From the Golgi apparatus, probably transported to the lytic vacuole (LV) in clathrin-coated vesicles (CCVs) via the prevacuolar compartment (PVC).1 Publication
Extracellular region or secreted
- extracellular space Source: GO_Central
Lysosome
- lysosome Source: GO_Central
Vacuole
- lysosome Source: GO_Central
- lytic vacuole Source: UniProtKB
Keywords - Cellular componenti
VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 24 | Sequence analysisAdd BLAST | 24 | |
PropeptideiPRO_0000026453 | 25 – 131 | Activation peptideCuratedAdd BLAST | 107 | |
ChainiPRO_0000026454 | 132 – 361 | Probable cysteine protease RD19BAdd BLAST | 230 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 153 ↔ 203 | By similarity | ||
Disulfide bondi | 187 ↔ 237 | By similarity | ||
Glycosylationi | 250 | N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation | 1 | |
Disulfide bondi | 293 ↔ 347 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
PaxDbi | P43295 |
ProteomicsDBi | 225924 |
Expressioni
Inductioni
By wilting and abscisic acid (ABA) (PubMed:8018874). Induced by drought stress (PubMed:12102506).2 Publications
Gene expression databases
ExpressionAtlasi | P43295, baseline and differential |
Genevisiblei | P43295, AT |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1542, Eukaryota |
HOGENOMi | CLU_012184_1_3_1 |
InParanoidi | P43295 |
OMAi | HEKSYED |
OrthoDBi | 1264766at2759 |
PhylomeDBi | P43295 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P43295-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDYHLRVLFS VSLIFVFVSV SVCGDEDVLI RQVVDETEPK VLSSEDHFTL
60 70 80 90 100
FKKKFGKVYG SIEEHYYRFS VFKANLLRAM RHQKMDPSAR HGVTQFSDLT
110 120 130 140 150
RSEFRRKHLG VKGGFKLPKD ANQAPILPTQ NLPEEFDWRD RGAVTPVKNQ
160 170 180 190 200
GSCGSCWSFS TTGALEGAHF LATGKLVSLS EQQLVDCDHE CDPEEEGSCD
210 220 230 240 250
SGCNGGLMNS AFEYTLKTGG LMREKDYPYT GTDGGSCKLD RSKIVASVSN
260 270 280 290 300
FSVVSINEDQ IAANLIKNGP LAVAINAAYM QTYIGGVSCP YICSRRLNHG
310 320 330 340 350
VLLVGYGSAG FSQARLKEKP YWIIKNSWGE SWGENGFYKI CKGRNICGVD
360
SLVSTVAATT S
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 49 | T → A in CAA52403 (PubMed:8018874).Curated | 1 | |
Sequence conflicti | 206 | G → R in BAD43619 (Ref. 3) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006841 Genomic DNA Translation: AAD23687.1 CP002685 Genomic DNA Translation: AEC07177.1 AK175856 mRNA Translation: BAD43619.1 BT029231 mRNA Translation: ABJ98563.1 X74359 mRNA Translation: CAA52403.1 |
PIRi | B84601 |
RefSeqi | NP_565512.1, NM_127715.4 |
Genome annotation databases
EnsemblPlantsi | AT2G21430.1; AT2G21430.1; AT2G21430 |
GeneIDi | 816682 |
Gramenei | AT2G21430.1; AT2G21430.1; AT2G21430 |
KEGGi | ath:AT2G21430 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC006841 Genomic DNA Translation: AAD23687.1 CP002685 Genomic DNA Translation: AEC07177.1 AK175856 mRNA Translation: BAD43619.1 BT029231 mRNA Translation: ABJ98563.1 X74359 mRNA Translation: CAA52403.1 |
PIRi | B84601 |
RefSeqi | NP_565512.1, NM_127715.4 |
3D structure databases
SMRi | P43295 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 3702.AT2G21430.1 |
Protein family/group databases
MEROPSi | C01.A04 |
Proteomic databases
PaxDbi | P43295 |
ProteomicsDBi | 225924 |
Genome annotation databases
EnsemblPlantsi | AT2G21430.1; AT2G21430.1; AT2G21430 |
GeneIDi | 816682 |
Gramenei | AT2G21430.1; AT2G21430.1; AT2G21430 |
KEGGi | ath:AT2G21430 |
Organism-specific databases
Araporti | AT2G21430 |
TAIRi | locus:2050145, AT2G21430 |
Phylogenomic databases
eggNOGi | KOG1542, Eukaryota |
HOGENOMi | CLU_012184_1_3_1 |
InParanoidi | P43295 |
OMAi | HEKSYED |
OrthoDBi | 1264766at2759 |
PhylomeDBi | P43295 |
Miscellaneous databases
PROi | PR:P43295 |
Gene expression databases
ExpressionAtlasi | P43295, baseline and differential |
Genevisiblei | P43295, AT |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR025661, Pept_asp_AS IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like IPR013201, Prot_inhib_I29 |
Pfami | View protein in Pfam PF08246, Inhibitor_I29, 1 hit PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00848, Inhibitor_I29, 1 hit SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00640, THIOL_PROTEASE_ASN, 1 hit PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RD19B_ARATH | |
Accessioni | P43295Primary (citable) accession number: P43295 Secondary accession number(s): Q058I7, Q680L1, Q9SJT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | December 8, 2000 | |
Last modified: | February 23, 2022 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Arabidopsis thaliana
Arabidopsis thaliana: entries and gene names - SIMILARITY comments
Index of protein domains and families