UniProtKB - P43268 (ETV4_HUMAN)
ETS translocation variant 4
ETV4
Functioni
Transcriptional activator (PubMed:19307308, PubMed:31552090).
May play a role in keratinocyte differentiation (PubMed:31552090).
2 Publications(Microbial infection) Binds to the enhancer of the adenovirus E1A gene and acts as a transcriptional activator; the core-binding sequence is 5'-[AC]GGA[AT]GT-3'.
1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 341 – 421 | ETSPROSITE-ProRule annotationAdd BLAST | 81 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: GO_Central
- positive regulation of keratinocyte differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P43268 |
Reactomei | R-HSA-5687128, MAPK6/MAPK4 signaling |
SignaLinki | P43268 |
SIGNORi | P43268 |
Names & Taxonomyi
Protein namesi | Recommended name: ETS translocation variant 4Alternative name(s): Adenovirus E1A enhancer-binding protein E1A-F Polyomavirus enhancer activator 3 homolog Short name: Protein PEA3 |
Gene namesi | Name:ETV4 Synonyms:E1AF, PEA3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3493, ETV4 |
MIMi | 600711, gene |
neXtProti | NX_P43268 |
VEuPathDBi | HostDB:ENSG00000175832 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- chromatin Source: NTNU_SB
- chromosome Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 96 | K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-226 and R-260. 1 Publication | 1 | |
Mutagenesisi | 98 | E → A: Loss of polysumoylation and ubiquitination; when associated with A-228; A-262; A-324 and A-443. 1 Publication | 1 | |
Mutagenesisi | 101 | S → A: Loss of sumoylation at K-96. 1 Publication | 1 | |
Mutagenesisi | 101 | S → E: Normal sumoylation at K-96. 1 Publication | 1 | |
Mutagenesisi | 102 | P → A: Loss of sumoylation at K-96. 1 Publication | 1 | |
Mutagenesisi | 226 | K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-96 and R-260. 1 Publication | 1 | |
Mutagenesisi | 228 | E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-262; A-324 and A-443. 1 Publication | 1 | |
Mutagenesisi | 260 | K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-96 and R-226. 1 Publication | 1 | |
Mutagenesisi | 262 | E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-324 and A-443. 1 Publication | 1 | |
Mutagenesisi | 324 | E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-262 and A-443. 1 Publication | 1 | |
Mutagenesisi | 443 | E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-262 and A-324. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2118 |
MalaCardsi | ETV4 |
OpenTargetsi | ENSG00000175832 |
Orphaneti | 319, Skeletal Ewing sarcoma |
PharmGKBi | PA27907 |
Miscellaneous databases
Pharosi | P43268, Tbio |
Genetic variation databases
BioMutai | ETV4 |
DMDMi | 62512145 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000204116 | 1 – 484 | ETS translocation variant 4Add BLAST | 484 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 6 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 96 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | ||
Modified residuei | 101 | Phosphoserine1 Publication | 1 | |
Cross-linki | 139 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 140 | PhosphoserineCombined sources | 1 | |
Modified residuei | 149 | PhosphoserineCombined sources | 1 | |
Modified residuei | 214 | PhosphoserineBy similarity | 1 | |
Cross-linki | 226 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | ||
Cross-linki | 260 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) | ||
Cross-linki | 322 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P43268 |
jPOSTi | P43268 |
MassIVEi | P43268 |
MaxQBi | P43268 |
PaxDbi | P43268 |
PeptideAtlasi | P43268 |
PRIDEi | P43268 |
ProteomicsDBi | 55606 [P43268-1] 6696 |
PTM databases
iPTMneti | P43268 |
PhosphoSitePlusi | P43268 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000175832, Expressed in cingulate cortex and 171 other tissues |
ExpressionAtlasi | P43268, baseline and differential |
Genevisiblei | P43268, HS |
Organism-specific databases
HPAi | ENSG00000175832, Low tissue specificity |
Interactioni
Binary interactionsi
P43268
With | #Exp. | IntAct |
---|---|---|
NFE2L2 [Q16236] | 6 | EBI-6447147,EBI-2007911 |
tax [P14079] from Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A). | 3 | EBI-6447147,EBI-9675698 |
Isoform 3 [P43268-3]
With | #Exp. | IntAct |
---|---|---|
MEOX2 [Q6FHY5] | 3 | EBI-12130722,EBI-16439278 |
SMAD4 [Q13485] | 3 | EBI-12130722,EBI-347263 |
Protein-protein interaction databases
BioGRIDi | 108419, 20 interactors |
DIPi | DIP-748N |
IntActi | P43268, 9 interactors |
MINTi | P43268 |
STRINGi | 9606.ENSP00000321835 |
Miscellaneous databases
RNActi | P43268, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P43268 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 90 – 115 | DisorderedSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000158142 |
HOGENOMi | CLU_030025_1_0_1 |
InParanoidi | P43268 |
OMAi | PLDVCHS |
OrthoDBi | 536648at2759 |
PhylomeDBi | P43268 |
TreeFami | TF316214 |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR006715, ETS_PEA3_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF04621, ETS_PEA3_N, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS
60 70 80 90 100
EDLFQDLSHF QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ
110 120 130 140 150
SPRTDPALSC SRKPPLPYHH GEQCLYSSAY DPPRQIAIKS PAPGALGQSP
160 170 180 190 200
LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE HSSVFQQPLD ICHSFTSQGG
210 220 230 240 250
GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP AVDQGGVNGH
260 270 280 290 300
RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE
310 320 330 340 350
KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL
360 370 380 390 400
LDDPTNAHFI AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR
410 420 430 440 450
YYYEKGIMQK VAGERYVYKF VCEPEALFSL AFPDNQRPAL KAEFDRPVSE
460 470 480
EDTVPLSHLD ESPAYLPELA GPAQPFGPKG GYSY
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7Z5F4 | B7Z5F4_HUMAN | ETS translocation variant 4 | ETV4 | 430 | Annotation score: | ||
K7EMW0 | K7EMW0_HUMAN | ETS translocation variant 4 | ETV4 | 28 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 24 – 27 | GNGS → EMSD in BAA02234 (PubMed:8441666).Curated | 4 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_069110 | 195 | F → I1 PublicationCorresponds to variant dbSNP:rs150119757EnsemblClinVar. | 1 | |
Natural variantiVAR_048950 | 437 | R → C. Corresponds to variant dbSNP:rs34260468Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055314 | 1 – 277 | Missing in isoform 3. 1 PublicationAdd BLAST | 277 | |
Alternative sequenceiVSP_046036 | 1 – 39 | Missing in isoform 2. 1 PublicationAdd BLAST | 39 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18018 mRNA Translation: AAA95991.1 Different initiation. AF095890 , AF095887, AF095888, AF095889 Genomic DNA Translation: AAD09186.1 AK290429 mRNA Translation: BAF83118.1 AK299019 mRNA Translation: BAH12929.1 AK315961 mRNA Translation: BAH14332.1 AC068675 Genomic DNA No translation available. BC007242 mRNA No translation available. BC016623 mRNA Translation: AAH16623.1 D12765 mRNA Translation: BAA02234.1 |
CCDSi | CCDS11465.1 [P43268-1] CCDS58553.1 [P43268-2] CCDS59292.1 [P43268-3] |
PIRi | S35534 |
RefSeqi | NP_001073143.1, NM_001079675.2 [P43268-1] NP_001248366.1, NM_001261437.1 [P43268-2] NP_001248367.1, NM_001261438.1 [P43268-2] NP_001248368.1, NM_001261439.1 [P43268-3] NP_001977.1, NM_001986.2 [P43268-1] |
Genome annotation databases
Ensembli | ENST00000319349; ENSP00000321835; ENSG00000175832 ENST00000393664; ENSP00000377273; ENSG00000175832 ENST00000538265; ENSP00000443846; ENSG00000175832 [P43268-2] ENST00000545954; ENSP00000440023; ENSG00000175832 [P43268-2] ENST00000586826; ENSP00000468636; ENSG00000175832 [P43268-3] ENST00000591713; ENSP00000465718; ENSG00000175832 |
GeneIDi | 2118 |
KEGGi | hsa:2118 |
MANE-Selecti | ENST00000319349.10; ENSP00000321835.4; NM_001079675.5; NP_001073143.1 |
UCSCi | uc002idv.5, human [P43268-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18018 mRNA Translation: AAA95991.1 Different initiation. AF095890 , AF095887, AF095888, AF095889 Genomic DNA Translation: AAD09186.1 AK290429 mRNA Translation: BAF83118.1 AK299019 mRNA Translation: BAH12929.1 AK315961 mRNA Translation: BAH14332.1 AC068675 Genomic DNA No translation available. BC007242 mRNA No translation available. BC016623 mRNA Translation: AAH16623.1 D12765 mRNA Translation: BAA02234.1 |
CCDSi | CCDS11465.1 [P43268-1] CCDS58553.1 [P43268-2] CCDS59292.1 [P43268-3] |
PIRi | S35534 |
RefSeqi | NP_001073143.1, NM_001079675.2 [P43268-1] NP_001248366.1, NM_001261437.1 [P43268-2] NP_001248367.1, NM_001261438.1 [P43268-2] NP_001248368.1, NM_001261439.1 [P43268-3] NP_001977.1, NM_001986.2 [P43268-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4CO8 | X-ray | 1.05 | A | 338-470 | [»] | |
4UUV | X-ray | 2.80 | A/D/G/J/M/P/S/V | 338-435 | [»] | |
5ILU | X-ray | 1.10 | A | 340-436 | [»] | |
SMRi | P43268 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108419, 20 interactors |
DIPi | DIP-748N |
IntActi | P43268, 9 interactors |
MINTi | P43268 |
STRINGi | 9606.ENSP00000321835 |
PTM databases
iPTMneti | P43268 |
PhosphoSitePlusi | P43268 |
Genetic variation databases
BioMutai | ETV4 |
DMDMi | 62512145 |
Proteomic databases
EPDi | P43268 |
jPOSTi | P43268 |
MassIVEi | P43268 |
MaxQBi | P43268 |
PaxDbi | P43268 |
PeptideAtlasi | P43268 |
PRIDEi | P43268 |
ProteomicsDBi | 55606 [P43268-1] 6696 |
Protocols and materials databases
Antibodypediai | 890, 307 antibodies from 37 providers |
DNASUi | 2118 |
Genome annotation databases
Ensembli | ENST00000319349; ENSP00000321835; ENSG00000175832 ENST00000393664; ENSP00000377273; ENSG00000175832 ENST00000538265; ENSP00000443846; ENSG00000175832 [P43268-2] ENST00000545954; ENSP00000440023; ENSG00000175832 [P43268-2] ENST00000586826; ENSP00000468636; ENSG00000175832 [P43268-3] ENST00000591713; ENSP00000465718; ENSG00000175832 |
GeneIDi | 2118 |
KEGGi | hsa:2118 |
MANE-Selecti | ENST00000319349.10; ENSP00000321835.4; NM_001079675.5; NP_001073143.1 |
UCSCi | uc002idv.5, human [P43268-1] |
Organism-specific databases
CTDi | 2118 |
DisGeNETi | 2118 |
GeneCardsi | ETV4 |
HGNCi | HGNC:3493, ETV4 |
HPAi | ENSG00000175832, Low tissue specificity |
MalaCardsi | ETV4 |
MIMi | 600711, gene |
neXtProti | NX_P43268 |
OpenTargetsi | ENSG00000175832 |
Orphaneti | 319, Skeletal Ewing sarcoma |
PharmGKBi | PA27907 |
VEuPathDBi | HostDB:ENSG00000175832 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3806, Eukaryota |
GeneTreei | ENSGT00940000158142 |
HOGENOMi | CLU_030025_1_0_1 |
InParanoidi | P43268 |
OMAi | PLDVCHS |
OrthoDBi | 536648at2759 |
PhylomeDBi | P43268 |
TreeFami | TF316214 |
Enzyme and pathway databases
PathwayCommonsi | P43268 |
Reactomei | R-HSA-5687128, MAPK6/MAPK4 signaling |
SignaLinki | P43268 |
SIGNORi | P43268 |
Miscellaneous databases
BioGRID-ORCSi | 2118, 12 hits in 1079 CRISPR screens |
ChiTaRSi | ETV4, human |
GeneWikii | ETV4 |
GenomeRNAii | 2118 |
Pharosi | P43268, Tbio |
PROi | PR:P43268 |
RNActi | P43268, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000175832, Expressed in cingulate cortex and 171 other tissues |
ExpressionAtlasi | P43268, baseline and differential |
Genevisiblei | P43268, HS |
Family and domain databases
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR000418, Ets_dom IPR006715, ETS_PEA3_N IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF00178, Ets, 1 hit PF04621, ETS_PEA3_N, 1 hit |
PRINTSi | PR00454, ETSDOMAIN |
SMARTi | View protein in SMART SM00413, ETS, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00345, ETS_DOMAIN_1, 1 hit PS00346, ETS_DOMAIN_2, 1 hit PS50061, ETS_DOMAIN_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ETV4_HUMAN | |
Accessioni | P43268Primary (citable) accession number: P43268 Secondary accession number(s): A8K314 Q96AW9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | April 12, 2005 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families