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Protein

ETS translocation variant 4

Gene

ETV4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi341 – 421ETSPROSITE-ProRule annotationAdd BLAST81

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-5687128 MAPK6/MAPK4 signaling

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...
SignaLinki
P43268

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P43268

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ETS translocation variant 4
Alternative name(s):
Adenovirus E1A enhancer-binding protein
E1A-F
Polyomavirus enhancer activator 3 homolog
Short name:
Protein PEA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ETV4
Synonyms:E1AF, PEA3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000175832.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:3493 ETV4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600711 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43268

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi96K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-226 and R-260. 1 Publication1
Mutagenesisi98E → A: Loss of polysumoylation and ubiquitination; when associated with A-228; A-262; A-324 and A-443. 1 Publication1
Mutagenesisi101S → A: Loss of sumoylation at K-96. 1 Publication1
Mutagenesisi101S → E: Normal sumoylation at K-96. 1 Publication1
Mutagenesisi102P → A: Loss of sumoylation at K-96. 1 Publication1
Mutagenesisi226K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-96 and R-260. 1 Publication1
Mutagenesisi228E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-262; A-324 and A-443. 1 Publication1
Mutagenesisi260K → R: Altered sumoylation pattern. Loss of sumoylation, ubiquitination and transcriptional activator function; when associated with R-96 and R-226. 1 Publication1
Mutagenesisi262E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-324 and A-443. 1 Publication1
Mutagenesisi324E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-262 and A-443. 1 Publication1
Mutagenesisi443E → A: Loss of polysumoylation and ubiquitination; when associated with A-98; A-228; A-262 and A-324. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
2118

MalaCards human disease database

More...
MalaCardsi
ETV4

Open Targets

More...
OpenTargetsi
ENSG00000175832

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
319 Ewing sarcoma

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27907

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ETV4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
62512145

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002041161 – 484ETS translocation variant 4Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki6Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki96Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei101Phosphoserine1 Publication1
Cross-linki139Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei140PhosphoserineCombined sources1
Modified residuei149PhosphoserineCombined sources1
Modified residuei214PhosphoserineBy similarity1
Cross-linki226Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)
Cross-linki322Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Sumoylated; enhanced upon ERK/MAP kinase pathway activation, it positively regulates the transcriptional activator capacity. Sumoylation at Lys-96 probably requires phosphorylation at Ser-101. Transiently polysumoylated and desumoylated by SENP1. Sumoylation is a prerequisite to polyubiquitination which in turn increases proteasomal-mediated degradation. Probably polyubiquitinated by RNF4 and deubiquitinated by USP2.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P43268

MaxQB - The MaxQuant DataBase

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MaxQBi
P43268

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P43268

PeptideAtlas

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PeptideAtlasi
P43268

PRoteomics IDEntifications database

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PRIDEi
P43268

ProteomicsDB human proteome resource

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ProteomicsDBi
55606

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43268

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43268

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000175832 Expressed in 149 organ(s), highest expression level in dorsal plus ventral thalamus

CleanEx database of gene expression profiles

More...
CleanExi
HS_ETV4

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P43268 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P43268 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA005768

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
taxP140793EBI-6447147,EBI-9675698From Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A).

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
108419, 13 interactors

Database of interacting proteins

More...
DIPi
DIP-748N

Protein interaction database and analysis system

More...
IntActi
P43268, 6 interactors

Molecular INTeraction database

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MINTi
P43268

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000321835

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1484
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P43268

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P43268

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi49 – 75Asp/Glu-rich (acidic)Add BLAST27
Compositional biasi148 – 244Gln-richAdd BLAST97

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ETS family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3806 Eukaryota
ENOG410Z0ZF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158142

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230986

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000231

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P43268

KEGG Orthology (KO)

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KOi
K15592

Identification of Orthologs from Complete Genome Data

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OMAi
DGYLDQQ

Database of Orthologous Groups

More...
OrthoDBi
EOG091G04YU

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43268

TreeFam database of animal gene trees

More...
TreeFami
TF316214

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000418 Ets_dom
IPR006715 ETS_PEA3_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00178 Ets, 1 hit
PF04621 ETS_PEA3_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00454 ETSDOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00413 ETS, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46785 SSF46785, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43268-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERRMKAGYL DQQVPYTFSS KSPGNGSLRE ALIGPLGKLM DPGSLPPLDS
60 70 80 90 100
EDLFQDLSHF QETWLAEAQV PDSDEQFVPD FHSENLAFHS PTTRIKKEPQ
110 120 130 140 150
SPRTDPALSC SRKPPLPYHH GEQCLYSSAY DPPRQIAIKS PAPGALGQSP
160 170 180 190 200
LQPFPRAEQR NFLRSSGTSQ PHPGHGYLGE HSSVFQQPLD ICHSFTSQGG
210 220 230 240 250
GREPLPAPYQ HQLSEPCPPY PQQSFKQEYH DPLYEQAGQP AVDQGGVNGH
260 270 280 290 300
RYPGAGVVIK QEQTDFAYDS DVTGCASMYL HTEGFSGPSP GDGAMGYGYE
310 320 330 340 350
KPLRPFPDDV CVVPEKFEGD IKQEGVGAFR EGPPYQRRGA LQLWQFLVAL
360 370 380 390 400
LDDPTNAHFI AWTGRGMEFK LIEPEEVARL WGIQKNRPAM NYDKLSRSLR
410 420 430 440 450
YYYEKGIMQK VAGERYVYKF VCEPEALFSL AFPDNQRPAL KAEFDRPVSE
460 470 480
EDTVPLSHLD ESPAYLPELA GPAQPFGPKG GYSY
Length:484
Mass (Da):53,938
Last modified:April 12, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA9864F3C690A8C1
GO
Isoform 2 (identifier: P43268-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):49,659
Checksum:i391745C2ADC1C064
GO
Isoform 3 (identifier: P43268-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-277: Missing.

Note: No experimental confirmation available.
Show »
Length:207
Mass (Da):23,422
Checksum:iF06C459C28B09DF5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B7Z5F4B7Z5F4_HUMAN
cDNA FLJ55351, highly similar to ET...
ETV4
430Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EMW0K7EMW0_HUMAN
ETS translocation variant 4
ETV4
28Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA95991 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti24 – 27GNGS → EMSD in BAA02234 (PubMed:8441666).Curated4

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_069110195F → I1 PublicationCorresponds to variant dbSNP:rs150119757Ensembl.1
Natural variantiVAR_048950437R → C. Corresponds to variant dbSNP:rs34260468Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0553141 – 277Missing in isoform 3. 1 PublicationAdd BLAST277
Alternative sequenceiVSP_0460361 – 39Missing in isoform 2. 1 PublicationAdd BLAST39

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U18018 mRNA Translation: AAA95991.1 Different initiation.
AF095890
, AF095887, AF095888, AF095889 Genomic DNA Translation: AAD09186.1
AK290429 mRNA Translation: BAF83118.1
AK299019 mRNA Translation: BAH12929.1
AK315961 mRNA Translation: BAH14332.1
AC068675 Genomic DNA No translation available.
BC007242 mRNA No translation available.
BC016623 mRNA Translation: AAH16623.1
D12765 mRNA Translation: BAA02234.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS11465.1 [P43268-1]
CCDS58553.1 [P43268-2]
CCDS59292.1 [P43268-3]

Protein sequence database of the Protein Information Resource

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PIRi
S35534

NCBI Reference Sequences

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RefSeqi
NP_001073143.1, NM_001079675.2 [P43268-1]
NP_001248366.1, NM_001261437.1 [P43268-2]
NP_001248367.1, NM_001261438.1 [P43268-2]
NP_001248368.1, NM_001261439.1 [P43268-3]
NP_001977.1, NM_001986.2 [P43268-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.434059

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000319349; ENSP00000321835; ENSG00000175832 [P43268-1]
ENST00000393664; ENSP00000377273; ENSG00000175832 [P43268-1]
ENST00000538265; ENSP00000443846; ENSG00000175832 [P43268-2]
ENST00000545954; ENSP00000440023; ENSG00000175832 [P43268-2]
ENST00000586826; ENSP00000468636; ENSG00000175832 [P43268-3]
ENST00000591713; ENSP00000465718; ENSG00000175832 [P43268-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
2118

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2118

UCSC genome browser

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UCSCi
uc002idv.5 human [P43268-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18018 mRNA Translation: AAA95991.1 Different initiation.
AF095890
, AF095887, AF095888, AF095889 Genomic DNA Translation: AAD09186.1
AK290429 mRNA Translation: BAF83118.1
AK299019 mRNA Translation: BAH12929.1
AK315961 mRNA Translation: BAH14332.1
AC068675 Genomic DNA No translation available.
BC007242 mRNA No translation available.
BC016623 mRNA Translation: AAH16623.1
D12765 mRNA Translation: BAA02234.1
CCDSiCCDS11465.1 [P43268-1]
CCDS58553.1 [P43268-2]
CCDS59292.1 [P43268-3]
PIRiS35534
RefSeqiNP_001073143.1, NM_001079675.2 [P43268-1]
NP_001248366.1, NM_001261437.1 [P43268-2]
NP_001248367.1, NM_001261438.1 [P43268-2]
NP_001248368.1, NM_001261439.1 [P43268-3]
NP_001977.1, NM_001986.2 [P43268-1]
UniGeneiHs.434059

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4CO8X-ray1.05A338-470[»]
4UUVX-ray2.80A/D/G/J/M/P/S/V338-435[»]
5ILUX-ray1.10A340-436[»]
ProteinModelPortaliP43268
SMRiP43268
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108419, 13 interactors
DIPiDIP-748N
IntActiP43268, 6 interactors
MINTiP43268
STRINGi9606.ENSP00000321835

PTM databases

iPTMnetiP43268
PhosphoSitePlusiP43268

Polymorphism and mutation databases

BioMutaiETV4
DMDMi62512145

Proteomic databases

EPDiP43268
MaxQBiP43268
PaxDbiP43268
PeptideAtlasiP43268
PRIDEiP43268
ProteomicsDBi55606

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
2118
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319349; ENSP00000321835; ENSG00000175832 [P43268-1]
ENST00000393664; ENSP00000377273; ENSG00000175832 [P43268-1]
ENST00000538265; ENSP00000443846; ENSG00000175832 [P43268-2]
ENST00000545954; ENSP00000440023; ENSG00000175832 [P43268-2]
ENST00000586826; ENSP00000468636; ENSG00000175832 [P43268-3]
ENST00000591713; ENSP00000465718; ENSG00000175832 [P43268-1]
GeneIDi2118
KEGGihsa:2118
UCSCiuc002idv.5 human [P43268-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2118
DisGeNETi2118
EuPathDBiHostDB:ENSG00000175832.12

GeneCards: human genes, protein and diseases

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GeneCardsi
ETV4
HGNCiHGNC:3493 ETV4
HPAiHPA005768
MalaCardsiETV4
MIMi600711 gene
neXtProtiNX_P43268
OpenTargetsiENSG00000175832
Orphaneti319 Ewing sarcoma
PharmGKBiPA27907

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3806 Eukaryota
ENOG410Z0ZF LUCA
GeneTreeiENSGT00940000158142
HOGENOMiHOG000230986
HOVERGENiHBG000231
InParanoidiP43268
KOiK15592
OMAiDGYLDQQ
OrthoDBiEOG091G04YU
PhylomeDBiP43268
TreeFamiTF316214

Enzyme and pathway databases

ReactomeiR-HSA-5687128 MAPK6/MAPK4 signaling
SignaLinkiP43268
SIGNORiP43268

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
ETV4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
ETV4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2118

Protein Ontology

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PROi
PR:P43268

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000175832 Expressed in 149 organ(s), highest expression level in dorsal plus ventral thalamus
CleanExiHS_ETV4
ExpressionAtlasiP43268 baseline and differential
GenevisibleiP43268 HS

Family and domain databases

Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR000418 Ets_dom
IPR006715 ETS_PEA3_N
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00178 Ets, 1 hit
PF04621 ETS_PEA3_N, 1 hit
PRINTSiPR00454 ETSDOMAIN
SMARTiView protein in SMART
SM00413 ETS, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00345 ETS_DOMAIN_1, 1 hit
PS00346 ETS_DOMAIN_2, 1 hit
PS50061 ETS_DOMAIN_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiETV4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43268
Secondary accession number(s): A8K314
, B7Z5J3, B7Z9J6, Q96AW9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 12, 2005
Last modified: December 5, 2018
This is version 162 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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