Protein SOX-15

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells."
    Maruyama M., Ichisaka T., Nakagawa M., Yamanaka S.
    J. Biol. Chem. 280:24371-24379(2005) [PubMed] [Europe PMC] [Abstract]
• DNA binding Source: MGIInferred from direct assayⁱ
  • Ref.2

    "Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family."
    Beranger F., Mejean C., Moniot B., Berta P., Vandromme M.
    J. Biol. Chem. 275:16103-16109(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGIInferred from direct assayⁱ
  • "Deciphering the Sox-Oct partner code by quantitative cooperativity measurements."
    Ng C.K., Li N.X., Chee S., Prabhakar S., Kolatkar P.R., Jauch R.
    Nucleic Acids Res. 40:4933-4941(2012) [PubMed] [Europe PMC] [Abstract]
• protein heterodimerization activity Source: MGIInferred from direct assayⁱ
  • "Deciphering the Sox-Oct partner code by quantitative cooperativity measurements."
    Ng C.K., Li N.X., Chee S., Prabhakar S., Kolatkar P.R., Jauch R.
    Nucleic Acids Res. 40:4933-4941(2012) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cell differentiation Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta."
    Yamada K., Kanda H., Tanaka S., Takamatsu N., Shiba T., Ito M.
    Differentiation 74:212-221(2006) [PubMed] [Europe PMC] [Abstract]
• central nervous system development Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• myoblast development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Sox15 is required for skeletal muscle regeneration."
    Lee H.J., Goring W., Ochs M., Muhlfeld C., Steding G., Paprotta I., Engel W., Adham I.M.
    Mol. Cell. Biol. 24:8428-8436(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of striated muscle tissue development Source: MGIInferred from direct assayⁱ
  • Ref.2

    "Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family."
    Beranger F., Mejean C., Moniot B., Berta P., Vandromme M.
    J. Biol. Chem. 275:16103-16109(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • Ref.2

    "Muscle differentiation is antagonized by SOX15, a new member of the SOX protein family."
    Beranger F., Mejean C., Moniot B., Berta P., Vandromme M.
    J. Biol. Chem. 275:16103-16109(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• neuron differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of G0 to G1 transition Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells."
    Meeson A.P., Shi X., Alexander M.S., Williams R.S., Allen R.E., Jiang N., Adham I.M., Goetsch S.C., Hammer R.E., Garry D.J.
    EMBO J. 26:1902-1912(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myoblast proliferation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells."
    Meeson A.P., Shi X., Alexander M.S., Williams R.S., Allen R.E., Jiang N., Adham I.M., Goetsch S.C., Hammer R.E., Garry D.J.
    EMBO J. 26:1902-1912(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of satellite cell activation involved in skeletal muscle regeneration Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Sox15 and Fhl3 transcriptionally coactivate Foxk1 and regulate myogenic progenitor cells."
    Meeson A.P., Shi X., Alexander M.S., Williams R.S., Allen R.E., Jiang N., Adham I.M., Goetsch S.C., Hammer R.E., Garry D.J.
    EMBO J. 26:1902-1912(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Sox15 enhances trophoblast giant cell differentiation induced by Hand1 in mouse placenta."
    Yamada K., Kanda H., Tanaka S., Takamatsu N., Shiba T., Ito M.
    Differentiation 74:212-221(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal muscle tissue regeneration Source: MGIInferred from mutant phenotypeⁱ
  • "Sox15 is required for skeletal muscle regeneration."
    Lee H.J., Goring W., Ochs M., Muhlfeld C., Steding G., Paprotta I., Engel W., Adham I.M.
    Mol. Cell. Biol. 24:8428-8436(2004) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein heterodimerization activity Source: MGIInferred from direct assayⁱ
  • "Deciphering the Sox-Oct partner code by quantitative cooperativity measurements."
    Ng C.K., Li N.X., Chee S., Prabhakar S., Kolatkar P.R., Jauch R.
    Nucleic Acids Res. 40:4933-4941(2012) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MALTSSSQAE TWSLHPRAST ASLPLGPQEQ EAGGSPGASG GLPLEKVKRP 
        60         70         80         90        100
MNAFMVWSSV QRRQMAQQNP KMHNSEISKR LGAQWKLLGD EEKRPFVEEA 
       110        120        130        140        150
KRLRARHLRD YPDYKYRPRR KSKNSSTGSV PFSQEGGGLA CGGSHWGPGY 
       160        170        180        190        200
TTTQGSRGFG YQPPNYSTAY LPGSYTSSHC RPEAPLPCTF PQSDPRLQGE 
       210        220        230 
LRPSFSPYLS PDSSTPYNTS LAGAPMPVTH L                     

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot