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UniProtKB - P43261 (EAE_ECO57)

Entry version 152 (02 Jun 2021)
Sequence version 2 (29 Aug 2001)
Previous versions | rss
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Protein

Intimin

Gene

eae

Organism
Escherichia coli O157:H7
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Necessary for the production of attaching and effacing lesions on tissue culture cells.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cell adhesion Source: InterPro
  • pathogenesis Source: CACAO
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processVirulence

Protein family/group databases

Transport Classification Database

More...TCDBi		1.B.54.1.1, the intimin/invasin (int/inv) or autotransporter-3 (at-3) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intimin
Alternative name(s):
Attaching and effacing protein
Short name:
Eae protein
Gamma-intimin
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:eae
Synonyms:eaeA
Ordered Locus Names:Z5110, ECs4559
ORF Names:L0025
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli O157:H7
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83334 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000558 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000002519 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei20 – 39HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell outer membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Miscellaneous databases

Pathogen-Host Interaction database

More...PHI-basei		PHI:7913

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002118281 – 934IntiminAdd BLAST934

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		155864.EDL933_4947

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1934
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		P43261

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P43261

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P43261

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 112LysMPROSITE-ProRule annotationAdd BLAST50
Domaini560 – 653Big-1 1PROSITE-ProRule annotationAdd BLAST94
Domaini660 – 753Big-1 2PROSITE-ProRule annotationAdd BLAST94
Domaini787 – 834BIG2Sequence analysisAdd BLAST48

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intimin/invasin family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG5492, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000210_1_1_6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.40.160.160, 1 hit
2.60.40.10, 2 hits
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003344, Big_1_dom
IPR003343, Big_2
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR024519, IAT_beta
IPR038177, IAT_beta_sf
IPR013783, Ig-like_fold
IPR003535, Intimin/invasin_bac
IPR013117, Intimin_C
IPR008964, Invasin/intimin_cell_adhesion
IPR018392, LysM_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02369, Big_1, 2 hits
PF02368, Big_2, 1 hit
PF11924, IAT_beta, 1 hit
PF07979, Intimin_C, 1 hit
PF01476, LysM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01369, INTIMIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00634, BID_1, 2 hits
SM00635, BID_2, 1 hit
SM00257, LysM, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49373, SSF49373, 3 hits
SSF56436, SSF56436, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51127, BIG1, 2 hits
PS51782, LYSM, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P43261-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MITHGCYTRT RHKHKLKKTL IMLSAGLGLF FYVNQNSFAN GENYFKLGSD 
        60         70         80         90        100
SKLLTHDSYQ NRLFYTLKTG ETVADLSKSQ DINLSTIWSL NKHLYSSESE 
       110        120        130        140        150
MMKAAPGQQI ILPLKKLPFE YSALPLLGSA PLVAAGGVAG HTNKLTKMSP 
       160        170        180        190        200
DVTKSNMTDD KALNYAAQQA ASLGSQLQSR SLNGDYAKDT ALGIAGNQAS 
       210        220        230        240        250
SQLQAWLQHY GTAEVNLQSG NNFDGSSLDF LLPFYDSEKM LAFGQVGARY 
       260        270        280        290        300
IDSRFTANLG AGQRFFLPAN MLGYNVFIDQ DFSGDNTRLG IGGEYWRDYF 
       310        320        330        340        350
KSSVNGYFRM SGWHESYNKK DYDERPANGF DIRFNGYLPS YPALGAKLIY 
       360        370        380        390        400
EQYYGDNVAL FNSDKLQSNP GAATVGVNYT PIPLVTMGID YRHGTGNEND 
       410        420        430        440        450
LLYSMQFRYQ FDKSWSQQIE PQYVNELRTL SGSRYDLVQR NNNIILEYKK 
       460        470        480        490        500
QDILSLNIPH DINGTEHSTQ KIQLIVKSKY GLDRIVWDDS ALRSQGGQIQ 
       510        520        530        540        550
HSGSQSAQDY QAILPAYVQG GSNIYKVTAR AYDRNGNSSN NVQLTITVLS 
       560        570        580        590        600
NGQVVDQVGV TDFTADKTSA KADNADTITY TATVKKNGVA QANVPVSFNI 
       610        620        630        640        650
VSGTATLGAN SAKTDANGKA TVTLKSSTPG QVVVSAKTAE MTSALNASAV 
       660        670        680        690        700
IFFDQTKASI TEIKADKTTA VANGKDAIKY TVKVMKNGQP VNNQSVTFST 
       710        720        730        740        750
NFGMFNGKSQ TQATTGNDGR ATITLTSSSA GKATVSATVS DGAEVKATEV 
       760        770        780        790        800
TFFDELKIDN KVDIIGNNVR GELPNIWLQY GQFKLKASGG DGTYSWYSEN 
       810        820        830        840        850
TSIATVDASG KVTLNGKGSV VIKATSGDKQ TVSYTIKAPS YMIKVDKQAY 
       860        870        880        890        900
YADAMSICKN LLPSTQTVLS DIYDSWGAAN KYSHYSSMNS ITAWIKQTSS 
       910        920        930 
EQRSGVSSTY NLITQNPLPG VNVNTPNVYA VCVE
Length:934
Mass (Da):101,836
Last modified:August 29, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBE73686D7F79D3C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti221N → D in CAA77642 (PubMed:1552854).Curated1
Sequence conflicti311 – 312SG → RR in CAA77642 (PubMed:1552854).Curated2
Sequence conflicti318N → H in CAA77642 (PubMed:1552854).Curated1
Sequence conflicti642T → S in CAA77642 (PubMed:1552854).Curated1
Sequence conflicti769V → VK (PubMed:1577255).Curated1
Sequence conflicti771 – 772GE → SM (PubMed:1577255).Curated2
Sequence conflicti903R → S in AAA21468 (PubMed:8005211).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z11541 Genomic DNA Translation: CAA77642.1
X60439 Genomic DNA Translation: CAA42967.1
AF071034 Genomic DNA Translation: AAC31504.1
AF081182 Genomic DNA Translation: AAD05498.1
AF081183 Genomic DNA Translation: AAD05499.1
AE005174 Genomic DNA Translation: AAG58823.1
BA000007 Genomic DNA Translation: BAB37982.1
U32312 Genomic DNA Translation: AAB00111.1
L08095 Genomic DNA Translation: AAA21468.1

Protein sequence database of the Protein Information Resource

More...PIRi		C86045
G91198
I41193

NCBI Reference Sequences

More...RefSeqi		NP_312586.1, NC_002695.1
WP_000627885.1, NZ_SWKA01000005.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAG58823; AAG58823; Z5110
BAB37982; BAB37982; ECs_4559

Database of genes from NCBI RefSeq genomes

More...GeneIDi		915471

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ece:Z5110
ecs:ECs4559

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|386585.9.peg.4776

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11541 Genomic DNA Translation: CAA77642.1
X60439 Genomic DNA Translation: CAA42967.1
AF071034 Genomic DNA Translation: AAC31504.1
AF081182 Genomic DNA Translation: AAD05498.1
AF081183 Genomic DNA Translation: AAD05499.1
AE005174 Genomic DNA Translation: AAG58823.1
BA000007 Genomic DNA Translation: BAB37982.1
U32312 Genomic DNA Translation: AAB00111.1
L08095 Genomic DNA Translation: AAA21468.1
PIRiC86045
G91198
I41193
RefSeqiNP_312586.1, NC_002695.1
WP_000627885.1, NZ_SWKA01000005.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ZQKX-ray2.80A/B747-934[»]
2ZWKX-ray3.10A/C/E752-934[»]
3NCWX-ray2.80A/B/C/D747-934[»]
3NCXX-ray2.60A/B747-934[»]
4E1SX-ray1.86A208-449[»]
5G26X-ray2.42A208-449[»]
BMRBiP43261
SMRiP43261
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi155864.EDL933_4947

Protein family/group databases

TCDBi1.B.54.1.1, the intimin/invasin (int/inv) or autotransporter-3 (at-3) family

Genome annotation databases

EnsemblBacteriaiAAG58823; AAG58823; Z5110
BAB37982; BAB37982; ECs_4559
GeneIDi915471
KEGGiece:Z5110
ecs:ECs4559
PATRICifig|386585.9.peg.4776

Phylogenomic databases

eggNOGiCOG5492, Bacteria
HOGENOMiCLU_000210_1_1_6

Miscellaneous databases

EvolutionaryTraceiP43261
PHI-baseiPHI:7913

Family and domain databases

Gene3Di2.40.160.160, 1 hit
2.60.40.10, 2 hits
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR003344, Big_1_dom
IPR003343, Big_2
IPR016186, C-type_lectin-like/link_sf
IPR016187, CTDL_fold
IPR024519, IAT_beta
IPR038177, IAT_beta_sf
IPR013783, Ig-like_fold
IPR003535, Intimin/invasin_bac
IPR013117, Intimin_C
IPR008964, Invasin/intimin_cell_adhesion
IPR018392, LysM_dom
PfamiView protein in Pfam
PF02369, Big_1, 2 hits
PF02368, Big_2, 1 hit
PF11924, IAT_beta, 1 hit
PF07979, Intimin_C, 1 hit
PF01476, LysM, 1 hit
PRINTSiPR01369, INTIMIN
SMARTiView protein in SMART
SM00634, BID_1, 2 hits
SM00635, BID_2, 1 hit
SM00257, LysM, 1 hit
SUPFAMiSSF49373, SSF49373, 3 hits
SSF56436, SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS51127, BIG1, 2 hits
PS51782, LYSM, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEAE_ECO57
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43261
Secondary accession number(s): O85627, Q47168
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: August 29, 2001
Last modified: June 2, 2021
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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