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Entry version 197 (07 Apr 2021)
Sequence version 2 (23 Jan 2002)
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Protein

E3 ubiquitin-protein ligase COP1

Gene

COP1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

E3 ubiquitin-protein ligase that acts as a repressor of photomorphogenesis and as an activator of etiolation in darkness. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Represses photomorphogenesis in darkness by mediating ubiquitination and subsequent proteasomal degradation of light-induced transcription factors such as HY5, HYH and LAF1. Down-regulates MYB21, probably via ubiquitination process. Light stimuli abrogate the repression of photomorphogenesis, possibly due to its localization to the cytoplasm. Could play a role in switching between skotomorphogenetic and photomorphogenetic pathways. Mediates the ubiquitination-dependent degradation of HY5 in the darkness during seedling development (e.g. hypocotyl growth) (PubMed:26474641). Represses CIP7 in darkness (PubMed:9668129).4 Publications

Miscellaneous

Plants lacking COP1 are not viable.
Although plants lack TRIB proteins, a human TRIB1 peptide binds to a highly conserved surface on the top face of the beta propeller, indicating a general mode for recognition of peptide motifs by COP1.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.1 Publication
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei422Human TRIB1 COP1-binding motif1 Publication1
Binding sitei441Human TRIB1 COP1-binding motif1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri52 – 90RING-typePROSITE-ProRule annotationAdd BLAST39

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processPhytochrome signaling pathway, Ubl conjugation pathway
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
E3 ubiquitin-protein ligase COP11 Publication (EC:2.3.2.271 Publication)
Alternative name(s):
Constitutive photomorphogenesis protein 11 Publication
RING-type E3 ubiquitin transferase COP11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:COP11 Publication
Ordered Locus Names:At2g32950Imported
ORF Names:T21L14.11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT2G32950

The Arabidopsis Information Resource

More...
TAIRi
locus:2059359, AT2G32950

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

The double mutant shw1 cop1 displays an enhanced photomorphogenic growth in the darkness as well as abnormal accumulation of HY5.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi52C → S: Abolishes LAF1 ubiquitination and degradation; when associated with S-55. 1 Publication1
Mutagenesisi55C → S: Abolishes LAF1 ubiquitination and degradation; when associated with S-52. 1 Publication1
Mutagenesisi294 – 296RKK → SKT: Abolishes localization to the nucleus. 1 Publication3
Mutagenesisi312 – 314KRR → TRS: Abolishes localization to the nucleus. 1 Publication3
Mutagenesisi422K → E: 5-fold increase in interaction with HY5, weak interaction with BBX24/STO and BBX25/STH, and at low light intensity shorter hypocotyl. 1 Publication1
Mutagenesisi465R → E: No interaction with BBX24/STO and BBX25/STH, and at low light intensity shorter hypocotyl. 1 Publication1
Mutagenesisi467W → A: No interaction with HY5, BBX24/STO and BBX25/STH and at low light intensity shorter hypocotyl. 1 Publication1
Mutagenesisi523 – 584Missing in COP1-8; no interaction with SPA1 and lethal. Add BLAST62
Mutagenesisi524G → E in COP1-9; no interaction with HY5, SPA1, BBX25/STH or BBX24/STO and lethal. 1
Mutagenesisi550K → E: No interaction with HY5, BBX24/STO and BBX25/STH and at low light intensity shorter hypocotyl. 1 Publication1
Mutagenesisi592E → R: Better interaction with HY5, BBX24/STO and BBX25/STH and slightly longer hypocotyls. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000558811 – 675E3 ubiquitin-protein ligase COP1Add BLAST675

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Autoubiquitinated.4 Publications

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43254

PRoteomics IDEntifications database

More...
PRIDEi
P43254

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
220616

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43254

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P43254, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43254, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with HY5, HYH, BBX24/STO, BBX25/STH, CIP8, COP10, SPA1, SPA2, SPA3, SPA4 and UVR8 and phosphorylated PHYA. Light induces dissociation of the SPA1/COP1 complex.

Interacts with HRT/RPP8 and triggers it to the 26s proteasome. Binds to CRY2; this competitive interaction prevents triggering to proteasome of other binding proteins (PubMed:20624951). Binds to SHW1 in the nucleus (PubMed:26474641). Bonds to CIP7 (PubMed:9668129).

Interacts with CSU2 (PubMed:26714275). Binds to CIP1 (PubMed:7753789).

16 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
3204, 59 interactors

Database of interacting proteins

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DIPi
DIP-32850N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P43254

Protein interaction database and analysis system

More...
IntActi
P43254, 30 interactors

Molecular INTeraction database

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MINTi
P43254

STRING: functional protein association networks

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STRINGi
3702.AT2G32950.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1675
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P43254

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati369 – 408WD 1Sequence analysisAdd BLAST40
Repeati418 – 458WD 2Sequence analysisAdd BLAST41
Repeati461 – 501WD 3Sequence analysisAdd BLAST41
Repeati503 – 543WD 4Sequence analysisAdd BLAST41
Repeati547 – 585WD 5Sequence analysisAdd BLAST39
Repeati588 – 627WD 6Sequence analysisAdd BLAST40
Repeati642 – 674WD 7Sequence analysisAdd BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni67 – 177CLS (cytoplasmic localization signal)Add BLAST111
Regioni120 – 177SNLS (subnuclear localization signal)Add BLAST58
Regioni593 – 595Binding of human TRIB1 COP1-binding-motif1 Publication3

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili134 – 201Sequence analysisAdd BLAST68

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi294 – 317Bipartite nuclear localization signalAdd BLAST24
Motifi522 – 536DWD box 1Add BLAST15
Motifi563 – 578DWD box 2Add BLAST16

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The coiled-coil domain (134-201) is necessary for SPA1, SPA3 or SPA4 binding. The DWD box is required for interaction with DDB1A.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri52 – 90RING-typePROSITE-ProRule annotationAdd BLAST39

Keywords - Domaini

Coiled coil, Repeat, WD repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0297, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_006994_2_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P43254

Identification of Orthologs from Complete Genome Data

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OMAi
RMHAHFD

Database of Orthologous Groups

More...
OrthoDBi
857220at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P43254

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.130.10.10, 1 hit
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042755, COP1
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS

The PANTHER Classification System

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PANTHERi
PTHR44080, PTHR44080, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00400, WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00184, RING, 1 hit
SM00320, WD40, 7 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50978, SSF50978, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 2 hits
PS50294, WD_REPEATS_REGION, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P43254-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEISTDPVV PAVKPDPRTS SVGEGANRHE NDDGGSGGSE IGAPDLDKDL
60 70 80 90 100
LCPICMQIIK DAFLTACGHS FCYMCIITHL RNKSDCPCCS QHLTNNQLYP
110 120 130 140 150
NFLLDKLLKK TSARHVSKTA SPLDQFREAL QRGCDVSIKE VDNLLTLLAE
160 170 180 190 200
RKRKMEQEEA ERNMQILLDF LHCLRKQKVD ELNEVQTDLQ YIKEDINAVE
210 220 230 240 250
RHRIDLYRAR DRYSVKLRML GDDPSTRNAW PHEKNQIGFN SNSLSIRGGN
260 270 280 290 300
FVGNYQNKKV EGKAQGSSHG LPKKDALSGS DSQSLNQSTV SMARKKRIHA
310 320 330 340 350
QFNDLQECYL QKRRQLADQP NSKQENDKSV VRREGYSNGL ADFQSVLTTF
360 370 380 390 400
TRYSRLRVIA EIRHGDIFHS ANIVSSIEFD RDDELFATAG VSRCIKVFDF
410 420 430 440 450
SSVVNEPADM QCPIVEMSTR SKLSCLSWNK HEKNHIASSD YEGIVTVWDV
460 470 480 490 500
TTRQSLMEYE EHEKRAWSVD FSRTEPSMLV SGSDDCKVKV WCTRQEASVI
510 520 530 540 550
NIDMKANICC VKYNPGSSNY IAVGSADHHI HYYDLRNISQ PLHVFSGHKK
560 570 580 590 600
AVSYVKFLSN NELASASTDS TLRLWDVKDN LPVRTFRGHT NEKNFVGLTV
610 620 630 640 650
NSEYLACGSE TNEVYVYHKE ITRPVTSHRF GSPDMDDAEE EAGSYFISAV
660 670
CWKSDSPTML TANSQGTIKV LVLAA
Length:675
Mass (Da):76,188
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6D9A1B702EAE8F0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1P8B2S1A0A1P8B2S1_ARATH
Transducin/WD40 repeat-like superfa...
COP1 ATCOP1, DEETIOLATED MUTANT 340, DET340, EMB168, EMBRYO DEFECTIVE 168
562Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti292M → I in AAA32772 (PubMed:1423630).Curated1
Sequence conflicti361E → Q in CAA04168 (PubMed:9744100).Curated1
Sequence conflicti381R → P in CAA04168 (PubMed:9744100).Curated1
Sequence conflicti403V → F in AAA32772 (PubMed:1423630).Curated1
Sequence conflicti456L → R in AAA32772 (PubMed:1423630).Curated1
Sequence conflicti515P → R in CAA04169 (PubMed:9744100).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L24437 mRNA Translation: AAA32772.1
AC003033 Genomic DNA Translation: AAB91983.1
CP002685 Genomic DNA Translation: AEC08766.1
BT025337 mRNA Translation: ABF57293.1
AJ000535 Genomic DNA Translation: CAA04168.1
AJ000536 Genomic DNA Translation: CAA04169.1

Protein sequence database of the Protein Information Resource

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PIRi
T01112

NCBI Reference Sequences

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RefSeqi
NP_180854.1, NM_128855.4

Genome annotation databases

Ensembl plant genome annotation project

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EnsemblPlantsi
AT2G32950.1; AT2G32950.1; AT2G32950

Database of genes from NCBI RefSeq genomes

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GeneIDi
817857

Gramene; a comparative resource for plants

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Gramenei
AT2G32950.1; AT2G32950.1; AT2G32950

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
ath:AT2G32950

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24437 mRNA Translation: AAA32772.1
AC003033 Genomic DNA Translation: AAB91983.1
CP002685 Genomic DNA Translation: AEC08766.1
BT025337 mRNA Translation: ABF57293.1
AJ000535 Genomic DNA Translation: CAA04168.1
AJ000536 Genomic DNA Translation: CAA04169.1
PIRiT01112
RefSeqiNP_180854.1, NM_128855.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5IGOX-ray1.60A/B/C/D349-675[»]
5KWNX-ray1.42A349-675[»]
6QTOX-ray1.27A349-675[»]
6QTQX-ray1.30A349-675[»]
6QTRX-ray1.37A349-675[»]
6QTSX-ray1.11A349-675[»]
6QTTX-ray1.51A349-675[»]
6QTUX-ray1.30A349-675[»]
6QTVX-ray1.31A349-675[»]
6QTWX-ray1.39A349-675[»]
6QTXX-ray1.95A349-675[»]
SMRiP43254
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi3204, 59 interactors
DIPiDIP-32850N
ELMiP43254
IntActiP43254, 30 interactors
MINTiP43254
STRINGi3702.AT2G32950.1

PTM databases

iPTMnetiP43254

Proteomic databases

PaxDbiP43254
PRIDEiP43254
ProteomicsDBi220616

Genome annotation databases

EnsemblPlantsiAT2G32950.1; AT2G32950.1; AT2G32950
GeneIDi817857
GrameneiAT2G32950.1; AT2G32950.1; AT2G32950
KEGGiath:AT2G32950

Organism-specific databases

AraportiAT2G32950
TAIRilocus:2059359, AT2G32950

Phylogenomic databases

eggNOGiKOG0297, Eukaryota
HOGENOMiCLU_006994_2_1_1
InParanoidiP43254
OMAiRMHAHFD
OrthoDBi857220at2759
PhylomeDBiP43254

Enzyme and pathway databases

UniPathwayiUPA00143

Miscellaneous databases

Protein Ontology

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PROi
PR:P43254

Gene expression databases

ExpressionAtlasiP43254, baseline and differential
GenevisibleiP43254, AT

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR042755, COP1
IPR015943, WD40/YVTN_repeat-like_dom_sf
IPR001680, WD40_repeat
IPR019775, WD40_repeat_CS
IPR017986, WD40_repeat_dom
IPR036322, WD40_repeat_dom_sf
IPR001841, Znf_RING
IPR013083, Znf_RING/FYVE/PHD
IPR017907, Znf_RING_CS
PANTHERiPTHR44080, PTHR44080, 1 hit
PfamiView protein in Pfam
PF00400, WD40, 2 hits
SMARTiView protein in SMART
SM00184, RING, 1 hit
SM00320, WD40, 7 hits
SUPFAMiSSF50978, SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS00678, WD_REPEATS_1, 1 hit
PS50082, WD_REPEATS_2, 2 hits
PS50294, WD_REPEATS_REGION, 1 hit
PS00518, ZF_RING_1, 1 hit
PS50089, ZF_RING_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCOP1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43254
Secondary accession number(s): O23974
, O23975, O48770, Q1JPL6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2002
Last modified: April 7, 2021
This is version 197 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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