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Protein

Prostacyclin receptor

Gene

Ptgir

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908 Prostanoid ligand receptors
R-RNO-392851 Prostacyclin signalling through prostacyclin receptor
R-RNO-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Prostacyclin receptor
Alternative name(s):
Prostaglandin I2 receptor
Short name:
PGI receptor
Short name:
PGI2 receptor
Prostanoid IP receptor
Gene namesi
Name:Ptgir
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi1310890 Ptgir

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 67Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini68 – 80CytoplasmicSequence analysisAdd BLAST13
Transmembranei81 – 105Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini106 – 123ExtracellularSequence analysisAdd BLAST18
Transmembranei124 – 144Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini145 – 163CytoplasmicSequence analysisAdd BLAST19
Transmembranei164 – 187Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini188 – 215ExtracellularSequence analysisAdd BLAST28
Transmembranei216 – 237Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini238 – 264CytoplasmicSequence analysisAdd BLAST27
Transmembranei265 – 289Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini290 – 302ExtracellularSequence analysisAdd BLAST13
Transmembranei303 – 323Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini324 – 416CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3322
GuidetoPHARMACOLOGYi345

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700771 – 413Prostacyclin receptorAdd BLAST413
PropeptideiPRO_0000240006414 – 416Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 194PROSITE-ProRule annotation
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi121 ↔ 199PROSITE-ProRule annotation
Lipidationi336S-palmitoyl cysteineBy similarity1
Lipidationi339S-palmitoyl cysteineBy similarity1
Modified residuei366PhosphoserineCombined sources1
Modified residuei413Cysteine methyl esterBy similarity1
Lipidationi413S-farnesyl cysteineBy similarity1

Post-translational modificationi

Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Phosphoprotein, Prenylation

Proteomic databases

PaxDbiP43253
PRIDEiP43253

PTM databases

iPTMnetiP43253
PhosphoSitePlusiP43253

Expressioni

Gene expression databases

BgeeiENSRNOG00000016756

Interactioni

Subunit structurei

Interacts (non-isoprenylated C-terminus) with PDZK1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022461

Chemistry databases

BindingDBiP43253

Structurei

3D structure databases

ProteinModelPortaliP43253
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiP43253
KOiK04263
OMAiCFLSPAV
OrthoDBiEOG091G0F07
PhylomeDBiP43253

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR000370 Prostglndn_IP_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF7 PTHR11866:SF7, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00856 PRSTNOIDIPR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43253-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVASGGRPDG PPSITPESPL IVGGREWQGM AGSCWNITYV QDSVGPATST
60 70 80 90 100
LMFVAGVVGN GLALGILGAR RRSHPSAFAV LVTGLAVTDL LGTCFLSPAV
110 120 130 140 150
FVAYARNSSL LGLAHGGTML CDTFAFAMTF FGLASTLILF AMAVERCLAL
160 170 180 190 200
SHPYLYAQLD GPRCARLALP AIYAFCCLFC SLPLLGLGEH QQYCPGSWCF
210 220 230 240 250
IRMRSPQPGG CAFSLAYASL MALLVTSIFF CNGSVTLSLC HMYRQQRRHH
260 270 280 290 300
GSFVPTSRAR EDEVYHLILL ALMTGIMAVC SLPLTIRGFT QAIAPDSREM
310 320 330 340 350
GDLHAFRFNA FNPILDPWVF ILFRKAVFQR LKFWLCCLCA RSVHGDLQTP
360 370 380 390 400
LSRPVSGRRD TLAPDSLQAK EGNWVPLSTW GTGQVAPLTA VPLSGGDGCS
410
VGMPSKTEAV VACSLC
Length:416
Mass (Da):44,662
Last modified:November 1, 1995 - v1
Checksum:i03171B5ED21C4171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28966 mRNA Translation: BAA06091.1
PIRiS52078
RefSeqiNP_001071112.1, NM_001077644.1
UniGeneiRn.225777

Genome annotation databases

EnsembliENSRNOT00000022461; ENSRNOP00000022461; ENSRNOG00000016756
GeneIDi292661
KEGGirno:292661
UCSCiRGD:1310890 rat

Similar proteinsi

Entry informationi

Entry nameiPI2R_RAT
AccessioniPrimary (citable) accession number: P43253
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

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