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Protein

Matrin-3

Gene

MATR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728). May bind to specific miRNA hairpins (PubMed:28431233).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri801 – 832Matrin-typePROSITE-ProRule annotationAdd BLAST32

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • identical protein binding Source: IntAct
  • miRNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • structural molecule activity Source: ProtInc
  • zinc ion binding Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processImmunity, Innate immunity
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Matrin-3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MATR3
Synonyms:KIAA0723
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000015479.17
HostDB:ENSG00000280987.3

Human Gene Nomenclature Database

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HGNCi
HGNC:6912 MATR3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
164015 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43243

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amyotrophic lateral sclerosis 21 (ALS21)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodegenerative disorder affecting upper and lower motor neurons, resulting in muscle weakness and respiratory failure. Some patients may develop myopathic features or dementia.
See also OMIM:606070
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07406772A → T in ALS21; unknown pathological significance. 1 Publication1
Natural variantiVAR_06342185S → C in ALS21; results in increased interaction with TARDBP. 2 PublicationsCorresponds to variant dbSNP:rs121434591EnsemblClinVar.1
Natural variantiVAR_071078115F → C in ALS21. 1 PublicationCorresponds to variant dbSNP:rs587777300EnsemblClinVar.1
Natural variantiVAR_078513147R → W in ALS21; unknown pathological significance. 1 Publication1
Natural variantiVAR_071079154P → S in ALS21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777302EnsemblClinVar.1
Natural variantiVAR_071080622T → A in ALS21. 1 PublicationCorresponds to variant dbSNP:rs587777301EnsemblClinVar.1

Keywords - Diseasei

Amyotrophic lateral sclerosis, Disease mutation, Neurodegeneration

Organism-specific databases

DisGeNET

More...
DisGeNETi
9782

MalaCards human disease database

More...
MalaCardsi
MATR3
MIMi606070 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000015479
ENSG00000280987

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
803 Amyotrophic lateral sclerosis
600 Vocal cord and pharyngeal distal myopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30655

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
MATR3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12643409

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources1 Publication
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000816222 – 847Matrin-3Add BLAST846

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei3N6-acetyllysine; alternateCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki3Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei4PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei14PhosphoserineCombined sources1
Modified residuei22PhosphoserineCombined sources1
Modified residuei41PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei126PhosphoserineCombined sources1
Cross-linki132Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki146Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei150PhosphothreonineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei158PhosphotyrosineCombined sources1
Modified residuei164PhosphoserineCombined sources1
Modified residuei188PhosphoserineCombined sources1
Modified residuei195PhosphoserineCombined sources1
Modified residuei202PhosphotyrosineCombined sources1
Modified residuei206PhosphoserineCombined sources1
Modified residuei208PhosphoserineCombined sources1
Modified residuei211PhosphoserineCombined sources1
Modified residuei219PhosphotyrosineCombined sources1
Modified residuei234PhosphoserineCombined sources1
Cross-linki245Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei264PhosphoserineCombined sources1
Cross-linki269Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei275PhosphoserineCombined sources1
Cross-linki478Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki487Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki491Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei509PhosphoserineCombined sources1
Modified residuei511PhosphoserineCombined sources1
Cross-linki515Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei522N6-acetyllysine; alternateCombined sources1
Cross-linki522Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei533PhosphoserineCombined sources1
Cross-linki554Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki555Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei571N6-acetyllysineCombined sources1
Modified residuei596PhosphoserineCombined sources1
Modified residuei598PhosphoserineCombined sources1
Modified residuei604PhosphoserineCombined sources1
Modified residuei606PhosphoserineCombined sources1
Cross-linki617Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki630Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei654PhosphoserineCombined sources1
Modified residuei671PhosphoserineCombined sources1
Modified residuei673PhosphoserineCombined sources1
Modified residuei674PhosphoserineCombined sources1
Modified residuei679PhosphothreonineCombined sources1
Modified residuei689PhosphoserineCombined sources1
Cross-linki719Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki736Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei741PhosphothreonineCombined sources1
Modified residuei747PhosphoserineCombined sources1
Modified residuei759PhosphoserineBy similarity1
Modified residuei766PhosphoserineCombined sources1
Cross-linki770Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei836N6-acetyllysine; alternateCombined sources1
Cross-linki836Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P43243

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P43243

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43243

PeptideAtlas

More...
PeptideAtlasi
P43243

PRoteomics IDEntifications database

More...
PRIDEi
P43243

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55599
55600 [P43243-2]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P43243-1 [P43243-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43243

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43243

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P43243

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P43243

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000015479 Expressed in 96 organ(s), highest expression level in frontal cortex

CleanEx database of gene expression profiles

More...
CleanExi
HS_MATR3

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P43243 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43243 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB033552
HPA036564
HPA036565

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Part of a complex consisting of SFPQ, NONO and MATR3. Interacts with AGO1 and AGO2. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Interacts with TARDBP. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA (PubMed:28712728).5 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
115126, 272 interactors

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
P43243

Protein interaction database and analysis system

More...
IntActi
P43243, 154 interactors

Molecular INTeraction database

More...
MINTi
P43243

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000354346

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P43243

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43243

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini398 – 473RRM 1PROSITE-ProRule annotationAdd BLAST76
Domaini496 – 571RRM 2PROSITE-ProRule annotationAdd BLAST76

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi710 – 718Nuclear localization signalSequence analysis9

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri801 – 832Matrin-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IGPC Eukaryota
ENOG410XSPB LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153322

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000015369

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG057347

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43243

KEGG Orthology (KO)

More...
KOi
K13213

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0QCV

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43243

TreeFam database of animal gene trees

More...
TreeFami
TF333921

Family and domain databases

Conserved Domains Database

More...
CDDi
cd12714 RRM1_MATR3, 1 hit
cd12715 RRM2_MATR3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR034928 MATR3_RRM1
IPR034930 MATR3_RRM2
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00360 RRM, 2 hits
SM00451 ZnF_U1, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54928 SSF54928, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50102 RRM, 2 hits
PS50171 ZF_MATRIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 21 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43243-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKSFQQSSL SRDSQGHGRD LSAAGIGLLA AATQSLSMPA SLGRMNQGTA
60 70 80 90 100
RLASLMNLGM SSSLNQQGAH SALSSASTSS HNLQSIFNIG SRGPLPLSSQ
110 120 130 140 150
HRGDADQASN ILASFGLSAR DLDELSRYPE DKITPENLPQ ILLQLKRRRT
160 170 180 190 200
EEGPTLSYGR DGRSATREPP YRVPRDDWEE KRHFRRDSFD DRGPSLNPVL
210 220 230 240 250
DYDHGSRSQE SGYYDRMDYE DDRLRDGERC RDDSFFGETS HNYHKFDSEY
260 270 280 290 300
ERMGRGPGPL QERSLFEKKR GAPPSSNIED FHGLLPKGYP HLCSICDLPV
310 320 330 340 350
HSNKEWSQHI NGASHSRRCQ LLLEIYPEWN PDNDTGHTMG DPFMLQQSTN
360 370 380 390 400
PAPGILGPPP PSFHLGGPAV GPRGNLGAGN GNLQGPRHMQ KGRVETSRVV
410 420 430 440 450
HIMDFQRGKN LRYQLLQLVE PFGVISNHLI LNKINEAFIE MATTEDAQAA
460 470 480 490 500
VDYYTTTPAL VFGKPVRVHL SQKYKRIKKP EGKPDQKFDQ KQELGRVIHL
510 520 530 540 550
SNLPHSGYSD SAVLKLAEPY GKIKNYILMR MKSQAFIEME TREDAMAMVD
560 570 580 590 600
HCLKKALWFQ GRCVKVDLSE KYKKLVLRIP NRGIDLLKKD KSRKRSYSPD
610 620 630 640 650
GKESPSDKKS KTDGSQKTES STEGKEQEEK SGEDGEKDTK DDQTEQEPNM
660 670 680 690 700
LLESEDELLV DEEEAAALLE SGSSVGDETD LANLGDVASD GKKEPSDKAV
710 720 730 740 750
KKDGSASAAA KKKLKKVDKI EELDQENEAA LENGIKNEEN TEPGAESSEN
760 770 780 790 800
ADDPNKDTSE NADGQSDENK DDYTIPDEYR IGPYQPNVPV GIDYVIPKTG
810 820 830 840
FYCKLCSLFY TNEEVAKNTH CSSLPHYQKL KKFLNKLAEE RRQKKET
Length:847
Mass (Da):94,623
Last modified:January 24, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i530AA49214BC1611
GO
Isoform 2 (identifier: P43243-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-304: MSKSFQQSSL...ICDLPVHSNK → MLGAQWRRNQPSRAAE

Note: No experimental confirmation available.
Show »
Length:559
Mass (Da):62,576
Checksum:i7E7772B22A7AF741
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 21 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q68E03Q68E03_HUMAN
Matrin-3
MATR3 DKFZp686L22104
283Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B3KM87B3KM87_HUMAN
cDNA FLJ10526 fis, clone NT2RP20009...
MATR3
509Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A8MXP9A8MXP9_HUMAN
Matrin-3
MATR3
895Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0R4J2E8A0A0R4J2E8_HUMAN
Matrin-3
MATR3
847Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6REM6D6REM6_HUMAN
Matrin-3
MATR3
794Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y8T4H0Y8T4_HUMAN
Matrin-3
MATR3
334Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6R991D6R991_HUMAN
Matrin-3
MATR3
433Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBK5D6RBK5_HUMAN
Matrin-3
MATR3
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RBI2D6RBI2_HUMAN
Matrin-3
MATR3
109Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RE02D6RE02_HUMAN
Matrin-3
MATR3
124Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF17217 differs from that shown. Reason: Frameshift at several positions.Curated
The sequence BAA34443 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti257P → S in AAF17217 (PubMed:10931946).Curated1
Sequence conflicti274P → S in AAF17217 (PubMed:10931946).Curated1
Sequence conflicti572Y → C in AAF17217 (PubMed:10931946).Curated1
Sequence conflicti572Y → C in M63483 (PubMed:2033075).Curated1
Sequence conflicti691G → P in M63483 (PubMed:2033075).Curated1
Sequence conflicti703D → H in M63483 (PubMed:2033075).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07406772A → T in ALS21; unknown pathological significance. 1 Publication1
Natural variantiVAR_06342185S → C in ALS21; results in increased interaction with TARDBP. 2 PublicationsCorresponds to variant dbSNP:rs121434591EnsemblClinVar.1
Natural variantiVAR_07406889I → V1 PublicationCorresponds to variant dbSNP:rs528548235Ensembl.1
Natural variantiVAR_071078115F → C in ALS21. 1 PublicationCorresponds to variant dbSNP:rs587777300EnsemblClinVar.1
Natural variantiVAR_078513147R → W in ALS21; unknown pathological significance. 1 Publication1
Natural variantiVAR_071079154P → S in ALS21; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs587777302EnsemblClinVar.1
Natural variantiVAR_071080622T → A in ALS21. 1 PublicationCorresponds to variant dbSNP:rs587777301EnsemblClinVar.1
Natural variantiVAR_074069664E → A1 PublicationCorresponds to variant dbSNP:rs139589527EnsemblClinVar.1
Natural variantiVAR_074070787N → S1 PublicationCorresponds to variant dbSNP:rs148402819EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0426241 – 304MSKSF…VHSNK → MLGAQWRRNQPSRAAE in isoform 2. 1 PublicationAdd BLAST304

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB018266 mRNA Translation: BAA34443.2 Different initiation.
AF117236 mRNA Translation: AAF17217.1 Frameshift.
AK316420 mRNA Translation: BAH14791.1
AC011404 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62114.1
CH471062 Genomic DNA Translation: EAW62115.1
CH471062 Genomic DNA Translation: EAW62116.1
CH471062 Genomic DNA Translation: EAW62117.1
BC015031 mRNA Translation: AAH15031.1
M63483 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4210.1 [P43243-1]
CCDS54908.1 [P43243-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001181883.1, NM_001194954.1 [P43243-1]
NP_001181884.1, NM_001194955.1 [P43243-1]
NP_001181885.1, NM_001194956.1 [P43243-2]
NP_001269207.1, NM_001282278.1
NP_061322.2, NM_018834.5 [P43243-1]
NP_954659.1, NM_199189.2 [P43243-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.268939
Hs.595110

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000394805; ENSP00000378284; ENSG00000015479 [P43243-1]
ENST00000503811; ENSP00000423587; ENSG00000015479 [P43243-2]
ENST00000618441; ENSP00000482895; ENSG00000015479 [P43243-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
9782

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:9782

UCSC genome browser

More...
UCSCi
uc003ldx.4 human [P43243-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB018266 mRNA Translation: BAA34443.2 Different initiation.
AF117236 mRNA Translation: AAF17217.1 Frameshift.
AK316420 mRNA Translation: BAH14791.1
AC011404 Genomic DNA No translation available.
CH471062 Genomic DNA Translation: EAW62114.1
CH471062 Genomic DNA Translation: EAW62115.1
CH471062 Genomic DNA Translation: EAW62116.1
CH471062 Genomic DNA Translation: EAW62117.1
BC015031 mRNA Translation: AAH15031.1
M63483 mRNA No translation available.
CCDSiCCDS4210.1 [P43243-1]
CCDS54908.1 [P43243-2]
RefSeqiNP_001181883.1, NM_001194954.1 [P43243-1]
NP_001181884.1, NM_001194955.1 [P43243-1]
NP_001181885.1, NM_001194956.1 [P43243-2]
NP_001269207.1, NM_001282278.1
NP_061322.2, NM_018834.5 [P43243-1]
NP_954659.1, NM_199189.2 [P43243-1]
UniGeneiHs.268939
Hs.595110

3D structure databases

ProteinModelPortaliP43243
SMRiP43243
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115126, 272 interactors
CORUMiP43243
IntActiP43243, 154 interactors
MINTiP43243
STRINGi9606.ENSP00000354346

PTM databases

iPTMnetiP43243
PhosphoSitePlusiP43243
SwissPalmiP43243

Polymorphism and mutation databases

BioMutaiMATR3
DMDMi12643409

Proteomic databases

EPDiP43243
MaxQBiP43243
PaxDbiP43243
PeptideAtlasiP43243
PRIDEiP43243
ProteomicsDBi55599
55600 [P43243-2]
TopDownProteomicsiP43243-1 [P43243-1]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
9782
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394805; ENSP00000378284; ENSG00000015479 [P43243-1]
ENST00000503811; ENSP00000423587; ENSG00000015479 [P43243-2]
ENST00000618441; ENSP00000482895; ENSG00000015479 [P43243-1]
GeneIDi9782
KEGGihsa:9782
UCSCiuc003ldx.4 human [P43243-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9782
DisGeNETi9782
EuPathDBiHostDB:ENSG00000015479.17
HostDB:ENSG00000280987.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
MATR3
HGNCiHGNC:6912 MATR3
HPAiCAB033552
HPA036564
HPA036565
MalaCardsiMATR3
MIMi164015 gene
606070 phenotype
neXtProtiNX_P43243
OpenTargetsiENSG00000015479
ENSG00000280987
Orphaneti803 Amyotrophic lateral sclerosis
600 Vocal cord and pharyngeal distal myopathy
PharmGKBiPA30655

Human Unidentified Gene-Encoded large proteins database

More...
HUGEi
Search...

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IGPC Eukaryota
ENOG410XSPB LUCA
GeneTreeiENSGT00940000153322
HOGENOMiHOG000015369
HOVERGENiHBG057347
InParanoidiP43243
KOiK13213
OrthoDBiEOG091G0QCV
PhylomeDBiP43243
TreeFamiTF333921

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MATR3 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
MATR3

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
9782
PMAP-CutDBiP43243

Protein Ontology

More...
PROi
PR:P43243

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000015479 Expressed in 96 organ(s), highest expression level in frontal cortex
CleanExiHS_MATR3
ExpressionAtlasiP43243 baseline and differential
GenevisibleiP43243 HS

Family and domain databases

CDDicd12714 RRM1_MATR3, 1 hit
cd12715 RRM2_MATR3, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034928 MATR3_RRM1
IPR034930 MATR3_RRM2
IPR000690 Matrin/U1-C_Znf_C2H2
IPR003604 Matrin/U1-like-C_Znf_C2H2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SM00451 ZnF_U1, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits
PS50171 ZF_MATRIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMATR3_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43243
Secondary accession number(s): B7ZAV5
, D3DQC3, Q9UHW0, Q9UQ27
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 24, 2001
Last modified: December 5, 2018
This is version 202 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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