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Protein

Cathepsin K

Gene

CTSK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg. EC:3.4.22.38

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei139By similarity1
Active sitei276By similarity1
Active sitei296By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • collagen binding Source: BHF-UCL
  • cysteine-type endopeptidase activity Source: BHF-UCL
  • cysteine-type peptidase activity Source: MGI
  • fibronectin binding Source: BHF-UCL
  • proteoglycan binding Source: BHF-UCL
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.22.38 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2132295 MHC class II antigen presentation
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes

SIGNOR Signaling Network Open Resource

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SIGNORi
P43235

Protein family/group databases

MEROPS protease database

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MEROPSi
I29.007

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cathepsin K (EC:3.4.22.38)
Alternative name(s):
Cathepsin O
Cathepsin O2
Cathepsin X
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTSK
Synonyms:CTSO, CTSO2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000143387.12

Human Gene Nomenclature Database

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HGNCi
HGNC:2536 CTSK

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601105 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43235

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pycnodysostosis (PKND)6 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA rare autosomal recessive bone disorder characterized by deformity of the skull, maxilla and phalanges, osteosclerosis, and fragility of bone.
See also OMIM:265800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01573879G → E in PKND. 2 PublicationsCorresponds to variant dbSNP:rs74315305EnsemblClinVar.1
Natural variantiVAR_074023122R → P in PKND. 1 Publication1
Natural variantiVAR_006725146G → R in PKND. 1 PublicationCorresponds to variant dbSNP:rs74315302EnsemblClinVar.1
Natural variantiVAR_015739277A → V in PKND. 2 PublicationsCorresponds to variant dbSNP:rs74315304EnsemblClinVar.1
Natural variantiVAR_074024283Y → C in PKND; does not affect protein level; does not detect cysteine-type endopeptidase activity. 1 Publication1
Natural variantiVAR_006726309L → P in PKND. 1 PublicationCorresponds to variant dbSNP:rs29001685EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
1513

MalaCards human disease database

More...
MalaCardsi
CTSK
MIMi265800 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000143387

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
763 Pycnodysostosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA27034

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL268

Drug and drug target database

More...
DrugBanki
DB07592 (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE
DB07593 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE
DB04244 1-[2-(3-Biphenyl)-4-Methylvaleryl)]Amino-3-(2-Pyridylsulfonyl)Amino-2-Propanone
DB03405 1-[N[(Phenylmethoxy)Carbonyl]-L-Leucyl-4-[[N/N-[(Phenylmethoxy)Carbonyl]-/Nl-Leucyl]Amino]-3-Pyrrolidinone/N
DB02869 3-amino-5-phenylpentane
DB07965 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile
DB07967 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE
DB01858 [1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate
DB03642 Benzofuran-2-Carboxylic Acid {(S)-3-Methyl-1-[3-Oxo-1-(Pyridin-2-Ylsulfonyl)Azepan-4-Ylcarbamoyl]Butyl}Amide
DB05736 MIV-701
DB04234 N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide
DB03456 N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide
DB08594 TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE
DB04523 Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2350

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
CTSK

Domain mapping of disease mutations (DMDM)

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DMDMi
1168793

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 15Sequence analysisAdd BLAST15
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002629516 – 114Activation peptideAdd BLAST99
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000026296115 – 329Cathepsin KAdd BLAST215

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi136 ↔ 177
Disulfide bondi170 ↔ 210
Disulfide bondi269 ↔ 318

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P43235

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P43235

PeptideAtlas

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PeptideAtlasi
P43235

PRoteomics IDEntifications database

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PRIDEi
P43235

ProteomicsDB human proteome resource

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ProteomicsDBi
55598

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P43235

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P43235

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Predominantly expressed in osteoclasts (bones).

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000143387 Expressed in 212 organ(s), highest expression level in visceral pleura

CleanEx database of gene expression profiles

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CleanExi
HS_CTSK
HS_CTSO

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P43235 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P43235 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA050346

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
107893, 8 interactors

Database of interacting proteins

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DIPi
DIP-39993N

Protein interaction database and analysis system

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IntActi
P43235, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000271651

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P43235

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1329
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P43235

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P43235

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P43235

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG1543 Eukaryota
COG4870 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157759

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230774

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG011513

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P43235

KEGG Orthology (KO)

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KOi
K01371

Identification of Orthologs from Complete Genome Data

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OMAi
YYDENCN

Database of Orthologous Groups

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OrthoDBi
EOG091G0AKT

Database for complete collections of gene phylogenies

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PhylomeDBi
P43235

TreeFam database of animal gene trees

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TreeFami
TF313739

Family and domain databases

Conserved Domains Database

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CDDi
cd02248 Peptidase_C1A, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR015644 Peptidase_C1A_cathepsin-K
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29

The PANTHER Classification System

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PANTHERi
PTHR12411 PTHR12411, 1 hit
PTHR12411:SF55 PTHR12411:SF55, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00705 PAPAIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF54001 SSF54001, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P43235-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWGLKVLLLP VVSFALYPEE ILDTHWELWK KTHRKQYNNK VDEISRRLIW
60 70 80 90 100
EKNLKYISIH NLEASLGVHT YELAMNHLGD MTSEEVVQKM TGLKVPLSHS
110 120 130 140 150
RSNDTLYIPE WEGRAPDSVD YRKKGYVTPV KNQGQCGSCW AFSSVGALEG
160 170 180 190 200
QLKKKTGKLL NLSPQNLVDC VSENDGCGGG YMTNAFQYVQ KNRGIDSEDA
210 220 230 240 250
YPYVGQEESC MYNPTGKAAK CRGYREIPEG NEKALKRAVA RVGPVSVAID
260 270 280 290 300
ASLTSFQFYS KGVYYDESCN SDNLNHAVLA VGYGIQKGNK HWIIKNSWGE
310 320
NWGNKGYILM ARNKNNACGI ANLASFPKM
Length:329
Mass (Da):36,966
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4677C3C89FF4CE85
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5QP40Q5QP40_HUMAN
Cathepsin K
CTSK
258Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti46R → P in AAA95998 (PubMed:8585423).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01573879G → E in PKND. 2 PublicationsCorresponds to variant dbSNP:rs74315305EnsemblClinVar.1
Natural variantiVAR_074023122R → P in PKND. 1 Publication1
Natural variantiVAR_006725146G → R in PKND. 1 PublicationCorresponds to variant dbSNP:rs74315302EnsemblClinVar.1
Natural variantiVAR_015739277A → V in PKND. 2 PublicationsCorresponds to variant dbSNP:rs74315304EnsemblClinVar.1
Natural variantiVAR_074024283Y → C in PKND; does not affect protein level; does not detect cysteine-type endopeptidase activity. 1 Publication1
Natural variantiVAR_006726309L → P in PKND. 1 PublicationCorresponds to variant dbSNP:rs29001685EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U13665 mRNA Translation: AAA65233.1
X82153 mRNA Translation: CAA57649.1
U20280 mRNA Translation: AAA95998.1
S79895 mRNA Translation: AAB35521.1
CR541675 mRNA Translation: CAG46476.1
AL355860 Genomic DNA No translation available.
AL356292 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53516.1
BC016058 mRNA Translation: AAH16058.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS969.1

Protein sequence database of the Protein Information Resource

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PIRi
JC2476

NCBI Reference Sequences

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RefSeqi
NP_000387.1, NM_000396.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.632466

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000271651; ENSP00000271651; ENSG00000143387

Database of genes from NCBI RefSeq genomes

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GeneIDi
1513

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:1513

UCSC genome browser

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UCSCi
uc001evp.3 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13665 mRNA Translation: AAA65233.1
X82153 mRNA Translation: CAA57649.1
U20280 mRNA Translation: AAA95998.1
S79895 mRNA Translation: AAB35521.1
CR541675 mRNA Translation: CAG46476.1
AL355860 Genomic DNA No translation available.
AL356292 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW53516.1
BC016058 mRNA Translation: AAH16058.1
CCDSiCCDS969.1
PIRiJC2476
RefSeqiNP_000387.1, NM_000396.3
UniGeneiHs.632466

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ATKX-ray2.20A115-329[»]
1AU0X-ray2.60A115-329[»]
1AU2X-ray2.60A115-329[»]
1AU3X-ray2.50A115-329[»]
1AU4X-ray2.30A115-329[»]
1AYUX-ray2.20A115-329[»]
1AYVX-ray2.30A115-329[»]
1AYWX-ray2.40A115-329[»]
1BGOX-ray2.30A115-329[»]
1BY8X-ray2.60A16-329[»]
1MEMX-ray1.80A115-329[»]
1NL6X-ray2.80A/B115-329[»]
1NLJX-ray2.40A/B115-329[»]
1Q6KX-ray2.10A115-329[»]
1SNKX-ray2.40A116-329[»]
1TU6X-ray1.75A/B115-329[»]
1U9VX-ray2.20A113-329[»]
1U9WX-ray2.30A113-329[»]
1U9XX-ray2.10A113-329[»]
1VSNX-ray2.00A115-329[»]
1YK7X-ray2.50A115-329[»]
1YK8X-ray2.60A115-329[»]
1YT7X-ray2.30A115-329[»]
2ATOX-ray2.00A115-329[»]
2AUXX-ray2.40A115-329[»]
2AUZX-ray2.30A115-329[»]
2BDLX-ray2.00A115-329[»]
2R6NX-ray1.95A113-329[»]
3C9EX-ray1.80A115-329[»]
3H7DX-ray2.24A/E115-329[»]
3KW9X-ray1.80A115-329[»]
3KWBX-ray2.02X/Y115-329[»]
3KWZX-ray1.49A115-329[»]
3KX1X-ray1.51A115-329[»]
3O0UX-ray1.80A115-329[»]
3O1GX-ray1.65A115-329[»]
3OVZX-ray2.02A121-329[»]
4DMXX-ray1.70A115-329[»]
4DMYX-ray1.63A/B115-329[»]
4N79X-ray2.62A115-329[»]
4N8WX-ray2.02A115-329[»]
4X6HX-ray1.00A115-329[»]
4X6IX-ray1.87A115-329[»]
4X6JX-ray1.59A115-329[»]
4YV8X-ray2.00A115-329[»]
4YVAX-ray1.80A115-329[»]
5J94X-ray2.60A107-329[»]
5JA7X-ray1.61A/B107-329[»]
5JH3X-ray1.75A107-329[»]
5TDIX-ray1.40A115-329[»]
5TUNX-ray1.62A115-329[»]
5Z5OX-ray1.92A16-329[»]
B16-88[»]
6ASHX-ray1.42A115-329[»]
7PCKX-ray3.20A/B/C/D16-329[»]
ProteinModelPortaliP43235
SMRiP43235
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107893, 8 interactors
DIPiDIP-39993N
IntActiP43235, 4 interactors
STRINGi9606.ENSP00000271651

Chemistry databases

BindingDBiP43235
ChEMBLiCHEMBL268
DrugBankiDB07592 (1R)-2-METHYL-1-(PHENYLMETHYL)PROPYL[(1S)-1-FORMYLPENTYL]CARBAMATE
DB07593 1-(PHENYLMETHYL)CYCLOPENTYL[(1S)-1-FORMYLPENTYL]CARBAMATE
DB04244 1-[2-(3-Biphenyl)-4-Methylvaleryl)]Amino-3-(2-Pyridylsulfonyl)Amino-2-Propanone
DB03405 1-[N[(Phenylmethoxy)Carbonyl]-L-Leucyl-4-[[N/N-[(Phenylmethoxy)Carbonyl]-/Nl-Leucyl]Amino]-3-Pyrrolidinone/N
DB02869 3-amino-5-phenylpentane
DB07965 6-(cyclohexylamino)-9-[2-(4-methylpiperazin-1-yl)-ethyl]-9H-purine-2-carbonitrile
DB07967 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE
DB01858 [1-(4-Fluorobenzyl)Cyclobutyl]Methyl (1s)-1-[Oxo(1h-Pyrazol-5-Ylamino)Acetyl]Pentylcarbamate
DB03642 Benzofuran-2-Carboxylic Acid {(S)-3-Methyl-1-[3-Oxo-1-(Pyridin-2-Ylsulfonyl)Azepan-4-Ylcarbamoyl]Butyl}Amide
DB05736 MIV-701
DB04234 N2-({[(4-Bromophenyl)Methyl]Oxy}Carbonyl)-N1-[(1s)-1-Formylpentyl]-L-Leucinamide
DB03456 N2-[(benzyloxy)carbonyl]-n1-[(3S)-1-cyanopyrrolidin-3-yl]-l-leucinamide
DB08594 TERT-BUTYL 2-CYANO-2-METHYLHYDRAZINECARBOXYLATE
DB04523 Tert-Butyl(1s)-1-Cyclohexyl-2-Oxoethylcarbamate
GuidetoPHARMACOLOGYi2350

Protein family/group databases

MEROPSiI29.007

PTM databases

iPTMnetiP43235
PhosphoSitePlusiP43235

Polymorphism and mutation databases

BioMutaiCTSK
DMDMi1168793

Proteomic databases

EPDiP43235
PaxDbiP43235
PeptideAtlasiP43235
PRIDEiP43235
ProteomicsDBi55598

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
1513
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000271651; ENSP00000271651; ENSG00000143387
GeneIDi1513
KEGGihsa:1513
UCSCiuc001evp.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1513
DisGeNETi1513
EuPathDBiHostDB:ENSG00000143387.12

GeneCards: human genes, protein and diseases

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GeneCardsi
CTSK
HGNCiHGNC:2536 CTSK
HPAiHPA050346
MalaCardsiCTSK
MIMi265800 phenotype
601105 gene
neXtProtiNX_P43235
OpenTargetsiENSG00000143387
Orphaneti763 Pycnodysostosis
PharmGKBiPA27034

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
GeneTreeiENSGT00940000157759
HOGENOMiHOG000230774
HOVERGENiHBG011513
InParanoidiP43235
KOiK01371
OMAiYYDENCN
OrthoDBiEOG091G0AKT
PhylomeDBiP43235
TreeFamiTF313739

Enzyme and pathway databases

BRENDAi3.4.22.38 2681
ReactomeiR-HSA-1442490 Collagen degradation
R-HSA-1474228 Degradation of the extracellular matrix
R-HSA-1592389 Activation of Matrix Metalloproteinases
R-HSA-1679131 Trafficking and processing of endosomal TLR
R-HSA-2132295 MHC class II antigen presentation
R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
SIGNORiP43235

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CTSK human
EvolutionaryTraceiP43235

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Cathepsin_K

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
1513

Protein Ontology

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PROi
PR:P43235

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000143387 Expressed in 212 organ(s), highest expression level in visceral pleura
CleanExiHS_CTSK
HS_CTSO
ExpressionAtlasiP43235 baseline and differential
GenevisibleiP43235 HS

Family and domain databases

CDDicd02248 Peptidase_C1A, 1 hit
InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR015644 Peptidase_C1A_cathepsin-K
IPR039417 Peptidase_C1A_papain-like
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PTHR12411:SF55 PTHR12411:SF55, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCATK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43235
Secondary accession number(s): Q6FHS6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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