UniProtKB - P43234 (CATO_HUMAN)
Protein
Cathepsin O
Gene
CTSO
Organism
Homo sapiens (Human)
Status
Functioni
Proteolytic enzyme possibly involved in normal cellular protein degradation and turnover.
Catalytic activityi
- The recombinant human enzyme hydrolyzes synthetic endopeptidase substrates including Z-Phe-Arg-NHMec and Z-Arg-Arg-NHMec. EC:3.4.22.42
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 132 | By similarity | 1 | |
Active sitei | 269 | By similarity | 1 | |
Active sitei | 289 | By similarity | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: GO_Central
GO - Biological processi
- proteolysis Source: ProtInc
- proteolysis involved in cellular protein catabolic process Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Enzyme and pathway databases
PathwayCommonsi | P43234 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation |
Protein family/group databases
MEROPSi | C01.035 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:CTSO Synonyms:CTSO1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000256043.2 |
HGNCi | HGNC:2542, CTSO |
MIMi | 600550, gene |
neXtProti | NX_P43234 |
Subcellular locationi
Lysosome
Extracellular region or secreted
- extracellular space Source: GO_Central
Lysosome
- lysosome Source: GO_Central
Keywords - Cellular componenti
LysosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1519 |
OpenTargetsi | ENSG00000256043 |
PharmGKBi | PA27040 |
Miscellaneous databases
Pharosi | P43234, Tbio |
Polymorphism and mutation databases
BioMutai | CTSO |
DMDMi | 1168795 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
PropeptideiPRO_0000026321 | 24 – 107 | Activation peptideAdd BLAST | 84 | |
ChainiPRO_0000026322 | 108 – 321 | Cathepsin OAdd BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 62 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 105 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 129 ↔ 170 | By similarity | ||
Disulfide bondi | 163 ↔ 204 | By similarity | ||
Disulfide bondi | 262 ↔ 310 | By similarity |
Keywords - PTMi
Disulfide bond, Glycoprotein, ZymogenProteomic databases
EPDi | P43234 |
jPOSTi | P43234 |
MassIVEi | P43234 |
PaxDbi | P43234 |
PeptideAtlasi | P43234 |
PRIDEi | P43234 |
ProteomicsDBi | 55597 |
PTM databases
GlyGeni | P43234, 2 sites |
iPTMneti | P43234 |
PhosphoSitePlusi | P43234 |
Expressioni
Tissue specificityi
Expressed in all tissues examined. High levels seen in the ovary, kidney and placenta while low levels seen in thymus and skeletal muscle.
Gene expression databases
Bgeei | ENSG00000256043, Expressed in caput epididymis and 227 other tissues |
Genevisiblei | P43234, HS |
Organism-specific databases
HPAi | ENSG00000256043, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107899, 7 interactors |
IntActi | P43234, 4 interactors |
STRINGi | 9606.ENSP00000414904 |
Miscellaneous databases
RNActi | P43234, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the peptidase C1 family.PROSITE-ProRule annotation
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG1542, Eukaryota |
GeneTreei | ENSGT00940000159253 |
HOGENOMi | CLU_012184_1_3_1 |
InParanoidi | P43234 |
OMAi | FTPTWPR |
OrthoDBi | 1275401at2759 |
PhylomeDBi | P43234 |
TreeFami | TF331594 |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like |
Pfami | View protein in Pfam PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P43234-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDVRALPWLP WLLWLLCRGG GDADSRAPFT PTWPRSRERE AAAFRESLNR
60 70 80 90 100
HRYLNSLFPS ENSTAFYGIN QFSYLFPEEF KAIYLRSKPS KFPRYSAEVH
110 120 130 140 150
MSIPNVSLPL RFDWRDKQVV TQVRNQQMCG GCWAFSVVGA VESAYAIKGK
160 170 180 190 200
PLEDLSVQQV IDCSYNNYGC NGGSTLNALN WLNKMQVKLV KDSEYPFKAQ
210 220 230 240 250
NGLCHYFSGS HSGFSIKGYS AYDFSDQEDE MAKALLTFGP LVVIVDAVSW
260 270 280 290 300
QDYLGGIIQH HCSSGEANHA VLITGFDKTG STPYWIVRNS WGSSWGVDGY
310 320
AHVKMGSNVC GIADSVSSIF V
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77383 mRNA Translation: CAA54562.1 BC049206 mRNA Translation: AAH49206.1 |
CCDSi | CCDS3794.1 |
PIRi | A55090 |
RefSeqi | NP_001325.1, NM_001334.2 |
Genome annotation databases
Ensembli | ENST00000433477; ENSP00000414904; ENSG00000256043 ENST00000573499; ENSP00000460395; ENSG00000263238 |
GeneIDi | 1519 |
KEGGi | hsa:1519 |
UCSCi | uc003ipg.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X77383 mRNA Translation: CAA54562.1 BC049206 mRNA Translation: AAH49206.1 |
CCDSi | CCDS3794.1 |
PIRi | A55090 |
RefSeqi | NP_001325.1, NM_001334.2 |
3D structure databases
SMRi | P43234 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107899, 7 interactors |
IntActi | P43234, 4 interactors |
STRINGi | 9606.ENSP00000414904 |
Protein family/group databases
MEROPSi | C01.035 |
PTM databases
GlyGeni | P43234, 2 sites |
iPTMneti | P43234 |
PhosphoSitePlusi | P43234 |
Polymorphism and mutation databases
BioMutai | CTSO |
DMDMi | 1168795 |
Proteomic databases
EPDi | P43234 |
jPOSTi | P43234 |
MassIVEi | P43234 |
PaxDbi | P43234 |
PeptideAtlasi | P43234 |
PRIDEi | P43234 |
ProteomicsDBi | 55597 |
Protocols and materials databases
Antibodypediai | 48148, 132 antibodies |
DNASUi | 1519 |
Genome annotation databases
Ensembli | ENST00000433477; ENSP00000414904; ENSG00000256043 ENST00000573499; ENSP00000460395; ENSG00000263238 |
GeneIDi | 1519 |
KEGGi | hsa:1519 |
UCSCi | uc003ipg.4, human |
Organism-specific databases
CTDi | 1519 |
DisGeNETi | 1519 |
EuPathDBi | HostDB:ENSG00000256043.2 |
GeneCardsi | CTSO |
HGNCi | HGNC:2542, CTSO |
HPAi | ENSG00000256043, Low tissue specificity |
MIMi | 600550, gene |
neXtProti | NX_P43234 |
OpenTargetsi | ENSG00000256043 |
PharmGKBi | PA27040 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1542, Eukaryota |
GeneTreei | ENSGT00940000159253 |
HOGENOMi | CLU_012184_1_3_1 |
InParanoidi | P43234 |
OMAi | FTPTWPR |
OrthoDBi | 1275401at2759 |
PhylomeDBi | P43234 |
TreeFami | TF331594 |
Enzyme and pathway databases
PathwayCommonsi | P43234 |
Reactomei | R-HSA-2132295, MHC class II antigen presentation |
Miscellaneous databases
BioGRID-ORCSi | 1519, 3 hits in 844 CRISPR screens |
ChiTaRSi | CTSO, human |
GeneWikii | Cathepsin_O |
GenomeRNAii | 1519 |
Pharosi | P43234, Tbio |
PROi | PR:P43234 |
RNActi | P43234, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000256043, Expressed in caput epididymis and 227 other tissues |
Genevisiblei | P43234, HS |
Family and domain databases
CDDi | cd02248, Peptidase_C1A, 1 hit |
InterProi | View protein in InterPro IPR038765, Papain-like_cys_pep_sf IPR000169, Pept_cys_AS IPR025660, Pept_his_AS IPR000668, Peptidase_C1A_C IPR039417, Peptidase_C1A_papain-like |
Pfami | View protein in Pfam PF00112, Peptidase_C1, 1 hit |
PRINTSi | PR00705, PAPAIN |
SMARTi | View protein in SMART SM00645, Pept_C1, 1 hit |
SUPFAMi | SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS00139, THIOL_PROTEASE_CYS, 1 hit PS00639, THIOL_PROTEASE_HIS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CATO_HUMAN | |
Accessioni | P43234Primary (citable) accession number: P43234 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Peptidase families
Classification of peptidase families and list of entries