UniProtKB - P43220 (GLP1R_HUMAN)
Protein
Glucagon-like peptide 1 receptor
Gene
GLP1R
Organism
Homo sapiens (Human)
Status
Functioni
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).By similarity7 Publications
Activity regulationi
The allosteric modulators NNC0640, PF-06372222 and MK-0893 inhibit the increase of intracellular cAMP levels in response to GLP-1.1 Publication
GO - Molecular functioni
- glucagon-like peptide 1 receptor activity Source: UniProtKB
- glucagon receptor activity Source: InterPro
- G protein-coupled peptide receptor activity Source: GO_Central
- peptide hormone binding Source: GO_Central
- transmembrane signaling receptor activity Source: ProtInc
GO - Biological processi
- activation of adenylate cyclase activity Source: ProtInc
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
- cAMP-mediated signaling Source: UniProtKB
- cell surface receptor signaling pathway Source: InterPro
- G protein-coupled receptor signaling pathway Source: Reactome
- learning or memory Source: Ensembl
- positive regulation of blood pressure Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- regulation of heart contraction Source: Ensembl
- regulation of insulin secretion Source: Reactome
- response to psychosocial stress Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-418555 G alpha (s) signalling events R-HSA-420092 Glucagon-type ligand receptors |
SIGNORi | P43220 |
Protein family/group databases
TCDBi | 9.A.14.4.6 the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Glucagon-like peptide 1 receptorShort name: GLP-1 receptor Short name: GLP-1-R Short name: GLP-1R |
Gene namesi | Name:GLP1R |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:4324 GLP1R |
MIMi | 138032 gene |
neXtProti | NX_P43220 |
Subcellular locationi
Plasma membrane
- Cell membrane 7 Publications; Multi-pass membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: Reactome
Other locations
- cell Source: GOC
- integral component of membrane Source: ProtInc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 139 | Extracellular1 PublicationAdd BLAST | 116 | |
Transmembranei | 140 – 164 | Helical; Name=11 PublicationAdd BLAST | 25 | |
Topological domaini | 165 – 175 | Cytoplasmic1 PublicationAdd BLAST | 11 | |
Transmembranei | 176 – 201 | Helical; Name=21 PublicationAdd BLAST | 26 | |
Topological domaini | 202 – 227 | Extracellular1 PublicationAdd BLAST | 26 | |
Transmembranei | 228 – 251 | Helical; Name=31 PublicationAdd BLAST | 24 | |
Topological domaini | 252 – 265 | Cytoplasmic1 PublicationAdd BLAST | 14 | |
Transmembranei | 266 – 290 | Helical; Name=41 PublicationAdd BLAST | 25 | |
Topological domaini | 291 – 305 | Extracellular1 PublicationAdd BLAST | 15 | |
Transmembranei | 306 – 328 | Helical; Name=51 PublicationAdd BLAST | 23 | |
Topological domaini | 329 – 348 | Cytoplasmic1 PublicationAdd BLAST | 20 | |
Transmembranei | 349 – 370 | Helical; Name=61 PublicationAdd BLAST | 22 | |
Topological domaini | 371 – 383 | Extracellular1 PublicationAdd BLAST | 13 | |
Transmembranei | 384 – 404 | Helical; Name=71 PublicationAdd BLAST | 21 | |
Topological domaini | 405 – 463 | Cytoplasmic1 PublicationAdd BLAST | 59 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 32 | L → A: No effect on stimulation of cAMP accumulation and on GLP-1 binding. 1 Publication | 1 | |
Mutagenesisi | 69 | Y → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 88 | Y → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 89 | L → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 90 | P → A: Strongly decreased stimulation of cAMP accumulation in response to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 121 | R → A: Strongly decreased stimulation of cAMP accumulation in response to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 127 | E → A: No effect on stimulation of cAMP accumulation in response to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 128 | E → A: Slightly decreases stimulation of cAMP accumulation in response to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 128 | E → Q: No effect on stimulation of cAMP accumulation in response to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 176 | R → Q: Decreases sensitivity to GLP-1. 1 Publication | 1 | |
Mutagenesisi | 317 | I → C: Causes the formation of an artifactual disulfide bond that abolishes signaling in response to GLP-1 binding; when associated with C-361. 1 Publication | 1 | |
Mutagenesisi | 352 | S → A: Abolishes inhibition by negative allosteric modulators. 1 Publication | 1 | |
Mutagenesisi | 355 | T → A: Abolishes inhibition by the negative allosteric modulators NNC0640 and PF-06372222, but does not abolish inhibition by MK-0893. 1 Publication | 1 | |
Mutagenesisi | 361 | G → C: Causes the formation of an artifactual disulfide bond that abolishes signaling in response to GLP-1 binding; when associated with C-317. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 2740 |
OpenTargetsi | ENSG00000112164 |
PharmGKBi | PA28725 |
Miscellaneous databases
Pharosi | P43220 |
Chemistry databases
ChEMBLi | CHEMBL1784 |
DrugBanki | DB09043 Albiglutide DB09045 Dulaglutide DB01276 Exenatide DB00040 Glucagon DB06655 Liraglutide DB09265 Lixisenatide DB13928 Semaglutide |
DrugCentrali | P43220 |
GuidetoPHARMACOLOGYi | 249 |
Polymorphism and mutation databases
BioMutai | GLP1R |
DMDMi | 311033387 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000012835 | 24 – 463 | Glucagon-like peptide 1 receptorAdd BLAST | 440 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 46 ↔ 71 | Combined sources3 Publications | ||
Disulfide bondi | 62 ↔ 104 | Combined sources3 Publications | ||
Glycosylationi | 63 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 82 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 85 ↔ 126 | Combined sources3 Publications | ||
Glycosylationi | 115 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 226 ↔ 296 | Combined sources4 Publications | ||
Modified residuei | 341 | ADP-ribosylcysteine1 Publication | 1 | |
Modified residuei | 348 | ADP-ribosylarginine1 Publication | 1 |
Post-translational modificationi
N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.1 Publication
Keywords - PTMi
ADP-ribosylation, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P43220 |
PeptideAtlasi | P43220 |
PRIDEi | P43220 |
ProteomicsDBi | 55596 |
PTM databases
iPTMneti | P43220 |
PhosphoSitePlusi | P43220 |
Expressioni
Gene expression databases
Bgeei | ENSG00000112164 Expressed in 165 organ(s), highest expression level in myocardium |
Genevisiblei | P43220 HS |
Interactioni
Subunit structurei
May form homodimers and heterodimers with GIPR.
2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 121 | Interaction with the endogenous ligand GLP-11 Publication | 1 | |
Sitei | 128 | Interaction with the endogenous ligand GLP-11 Publication | 1 |
Binary interactionsi
Protein-protein interaction databases
BioGridi | 109002, 254 interactors |
DIPi | DIP-29980N |
IntActi | P43220, 10 interactors |
MINTi | P43220 |
STRINGi | 9606.ENSP00000362353 |
Chemistry databases
BindingDBi | P43220 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P43220 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P43220 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 352 – 355 | Important for allosteric inhibitor binding1 Publication | 4 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 2 family.Curated
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000161009 |
HOGENOMi | HOG000008250 |
InParanoidi | P43220 |
KOi | K04581 |
OMAi | GLWLHKD |
OrthoDBi | 651627at2759 |
PhylomeDBi | P43220 |
TreeFami | TF315710 |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR003290 GPCR_2_GLP1/glucagon_rcpt IPR003292 GPCR_2_GLP1_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF25 PTHR45620:SF25, 1 hit |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR01353 GLUCAGNFAMLY PR01355 GLUCAGNLIKER PR00249 GPCRSECRETIN |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P43220-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL
60 70 80 90 100
TEDPPPATDL FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV
110 120 130 140 150
YRFCTAEGLW LQKDNSSLPW RDLSECEESK RGERSSPEEQ LLFLYIIYTV
160 170 180 190 200
GYALSFSALV IASAILLGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA
210 220 230 240 250
LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN YYWLLVEGVY
260 270 280 290 300
LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN
310 320 330 340 350
SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA
360 370 380 390 400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI
410 420 430 440 450
LYCFVNNEVQ LEFRKSWERW RLEHLHIQRD SSMKPLKCPT SSLSSGATAG
460
SSMYTATCQA SCS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | L → V in AAA03614 (PubMed:8405712).Curated | 1 | |
Sequence conflicti | 12 | L → V no nucleotide entry (PubMed:7517895).Curated | 1 | |
Sequence conflicti | 12 | L → V in AAB64013 (PubMed:9213353).Curated | 1 | |
Sequence conflicti | 136 – 137 | SP → WG in AAA03614 (PubMed:8405712).Curated | 2 | |
Sequence conflicti | 137 | P → R no nucleotide entry (PubMed:7517895).Curated | 1 | |
Sequence conflicti | 151 | G → A in AAA03614 (PubMed:8405712).Curated | 1 | |
Sequence conflicti | 221 | Q → L in AAA63787 (PubMed:7843404).Curated | 1 | |
Sequence conflicti | 289 | Y → I in AAA03614 (PubMed:8405712).Curated | 1 | |
Sequence conflicti | 316 | A → G in AAA62471 (PubMed:8404634).Curated | 1 | |
Sequence conflicti | 316 | A → G in AAC50050 (PubMed:8404634).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_018924 | 7 | P → L1 PublicationCorresponds to variant dbSNP:rs10305420Ensembl. | 1 | |
Natural variantiVAR_018925 | 20 | R → K1 PublicationCorresponds to variant dbSNP:rs10305421Ensembl. | 1 | |
Natural variantiVAR_018926 | 44 | R → H1 PublicationCorresponds to variant dbSNP:rs2295006Ensembl. | 1 | |
Natural variantiVAR_018927 | 131 | R → Q1 PublicationCorresponds to variant dbSNP:rs3765467Ensembl. | 1 | |
Natural variantiVAR_018928 | 168 | G → S1 PublicationCorresponds to variant dbSNP:rs6923761Ensembl. | 1 | |
Natural variantiVAR_015098 | 260 | L → F6 PublicationsCorresponds to variant dbSNP:rs1042044Ensembl. | 1 | |
Natural variantiVAR_018929 | 316 | A → T1 PublicationCorresponds to variant dbSNP:rs10305492Ensembl. | 1 | |
Natural variantiVAR_018930 | 333 | S → C1 PublicationCorresponds to variant dbSNP:rs10305493Ensembl. | 1 | |
Natural variantiVAR_018931 | 421 | R → Q1 PublicationCorresponds to variant dbSNP:rs10305510Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U01104 mRNA Translation: AAA03614.1 U01157 mRNA Translation: AAA62471.1 U01156 mRNA Translation: AAC50050.1 L23503 mRNA Translation: AAA17021.1 U10037 mRNA Translation: AAA63787.1 AB065685 Genomic DNA Translation: BAC05908.1 AY439112 Genomic DNA Translation: AAR05444.1 AL035690 Genomic DNA No translation available. BC112126 mRNA Translation: AAI12127.1 BC113493 mRNA Translation: AAI13494.1 U66062 Genomic DNA Translation: AAB64013.1 |
CCDSi | CCDS4839.1 |
PIRi | I84494 S71624 |
RefSeqi | NP_002053.3, NM_002062.4 |
Genome annotation databases
Ensembli | ENST00000373256; ENSP00000362353; ENSG00000112164 |
GeneIDi | 2740 |
KEGGi | hsa:2740 |
UCSCi | uc003ooj.5 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Wikipedia Glucagon-like peptide 1 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U01104 mRNA Translation: AAA03614.1 U01157 mRNA Translation: AAA62471.1 U01156 mRNA Translation: AAC50050.1 L23503 mRNA Translation: AAA17021.1 U10037 mRNA Translation: AAA63787.1 AB065685 Genomic DNA Translation: BAC05908.1 AY439112 Genomic DNA Translation: AAR05444.1 AL035690 Genomic DNA No translation available. BC112126 mRNA Translation: AAI12127.1 BC113493 mRNA Translation: AAI13494.1 U66062 Genomic DNA Translation: AAB64013.1 |
CCDSi | CCDS4839.1 |
PIRi | I84494 S71624 |
RefSeqi | NP_002053.3, NM_002062.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3C59 | X-ray | 2.30 | A | 24-145 | [»] | |
3C5T | X-ray | 2.10 | A | 24-145 | [»] | |
3IOL | X-ray | 2.10 | A | 24-145 | [»] | |
4ZGM | X-ray | 1.80 | A | 24-145 | [»] | |
5E94 | X-ray | 2.00 | G/H | 24-145 | [»] | |
5NX2 | X-ray | 3.70 | A | 24-432 | [»] | |
5OTT | X-ray | 1.92 | A | 24-139 | [»] | |
5OTU | X-ray | 1.80 | A/C | 24-139 | [»] | |
5OTV | X-ray | 2.00 | A/C | 24-139 | [»] | |
5OTW | X-ray | 2.10 | A/C | 24-139 | [»] | |
5OTX | X-ray | 2.00 | A/C | 24-139 | [»] | |
5VEW | X-ray | 2.70 | A/B | 128-257 | [»] | |
A/B | 261-431 | [»] | ||||
5VEX | X-ray | 3.00 | A/B | 128-257 | [»] | |
A/B | 261-431 | [»] | ||||
6B3J | electron microscopy | 3.30 | R | 24-463 | [»] | |
6GB1 | X-ray | 2.73 | A | 21-145 | [»] | |
SMRi | P43220 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 109002, 254 interactors |
DIPi | DIP-29980N |
IntActi | P43220, 10 interactors |
MINTi | P43220 |
STRINGi | 9606.ENSP00000362353 |
Chemistry databases
BindingDBi | P43220 |
ChEMBLi | CHEMBL1784 |
DrugBanki | DB09043 Albiglutide DB09045 Dulaglutide DB01276 Exenatide DB00040 Glucagon DB06655 Liraglutide DB09265 Lixisenatide DB13928 Semaglutide |
DrugCentrali | P43220 |
GuidetoPHARMACOLOGYi | 249 |
Protein family/group databases
TCDBi | 9.A.14.4.6 the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
iPTMneti | P43220 |
PhosphoSitePlusi | P43220 |
Polymorphism and mutation databases
BioMutai | GLP1R |
DMDMi | 311033387 |
Proteomic databases
PaxDbi | P43220 |
PeptideAtlasi | P43220 |
PRIDEi | P43220 |
ProteomicsDBi | 55596 |
Protocols and materials databases
ABCDi | P43220 |
DNASUi | 2740 |
Genome annotation databases
Ensembli | ENST00000373256; ENSP00000362353; ENSG00000112164 |
GeneIDi | 2740 |
KEGGi | hsa:2740 |
UCSCi | uc003ooj.5 human |
Organism-specific databases
CTDi | 2740 |
DisGeNETi | 2740 |
GeneCardsi | GLP1R |
HGNCi | HGNC:4324 GLP1R |
MIMi | 138032 gene |
neXtProti | NX_P43220 |
OpenTargetsi | ENSG00000112164 |
PharmGKBi | PA28725 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4564 Eukaryota ENOG410XRS2 LUCA |
GeneTreei | ENSGT00940000161009 |
HOGENOMi | HOG000008250 |
InParanoidi | P43220 |
KOi | K04581 |
OMAi | GLWLHKD |
OrthoDBi | 651627at2759 |
PhylomeDBi | P43220 |
TreeFami | TF315710 |
Enzyme and pathway databases
Reactomei | R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-418555 G alpha (s) signalling events R-HSA-420092 Glucagon-type ligand receptors |
SIGNORi | P43220 |
Miscellaneous databases
EvolutionaryTracei | P43220 |
GeneWikii | Glucagon-like_peptide_1_receptor |
GenomeRNAii | 2740 |
Pharosi | P43220 |
PROi | PR:P43220 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112164 Expressed in 165 organ(s), highest expression level in myocardium |
Genevisiblei | P43220 HS |
Family and domain databases
Gene3Di | 4.10.1240.10, 1 hit |
InterProi | View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR003290 GPCR_2_GLP1/glucagon_rcpt IPR003292 GPCR_2_GLP1_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS |
PANTHERi | PTHR45620:SF25 PTHR45620:SF25, 1 hit |
Pfami | View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit |
PRINTSi | PR01353 GLUCAGNFAMLY PR01355 GLUCAGNLIKER PR00249 GPCRSECRETIN |
SMARTi | View protein in SMART SM00008 HormR, 1 hit |
SUPFAMi | SSF111418 SSF111418, 1 hit |
PROSITEi | View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLP1R_HUMAN | |
Accessioni | P43220Primary (citable) accession number: P43220 Secondary accession number(s): Q2M229, Q99669 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 2, 2010 | |
Last modified: | November 13, 2019 | |
This is version 188 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references