GLP1R

Functionⁱ

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).By similarity7 Publications

Activity regulationⁱ

GO - Molecular functionⁱ

glucagon-like peptide 1 receptor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 28514449
glucagon receptor activity Source: InterPro
G protein-coupled peptide receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
peptide hormone binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transmembrane signaling receptor activity
Source: ProtInc
Traceable author statementⁱ
- 8405712

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of adenylate cyclase activity
Source: ProtInc
Traceable author statementⁱ
- 8405712
adenylate cyclase-activating G protein-coupled receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 28514449
cAMP-mediated signaling
Source: UniProtKB
Inferred from direct assayⁱ
- 7589461
cell surface receptor signaling pathway Source: InterPro
G protein-coupled receptor signaling pathway Source: Reactome
learning or memory Source: Ensembl
positive regulation of blood pressure
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cytosolic calcium ion concentration
Source: UniProtKB
Inferred from direct assayⁱ
- 7589461
regulation of heart contraction Source: Ensembl
regulation of insulin secretion Source: Reactome
response to psychosocial stress Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-418555 G alpha (s) signalling events R-HSA-420092 Glucagon-type ligand receptors
SIGNORⁱ	P43220

Protein family/group databases

TCDBⁱ

9.A.14.4.6 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glucagon-like peptide 1 receptor Short name: GLP-1 receptor Short name: GLP-1-R Short name: GLP-1R
Gene namesⁱ	Name:GLP1R
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000112164.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4324 GLP1R
MIMⁱ	138032 gene
neXtProtⁱ	NX_P43220

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 139	Extracellular1 PublicationAdd BLAST	116
Transmembraneⁱ	140 – 164	Helical; Name=11 PublicationAdd BLAST	25
Topological domainⁱ	165 – 175	Cytoplasmic1 PublicationAdd BLAST	11
Transmembraneⁱ	176 – 201	Helical; Name=21 PublicationAdd BLAST	26
Topological domainⁱ	202 – 227	Extracellular1 PublicationAdd BLAST	26
Transmembraneⁱ	228 – 251	Helical; Name=31 PublicationAdd BLAST	24
Topological domainⁱ	252 – 265	Cytoplasmic1 PublicationAdd BLAST	14
Transmembraneⁱ	266 – 290	Helical; Name=41 PublicationAdd BLAST	25
Topological domainⁱ	291 – 305	Extracellular1 PublicationAdd BLAST	15
Transmembraneⁱ	306 – 328	Helical; Name=51 PublicationAdd BLAST	23
Topological domainⁱ	329 – 348	Cytoplasmic1 PublicationAdd BLAST	20
Transmembraneⁱ	349 – 370	Helical; Name=61 PublicationAdd BLAST	22
Topological domainⁱ	371 – 383	Extracellular1 PublicationAdd BLAST	13
Transmembraneⁱ	384 – 404	Helical; Name=71 PublicationAdd BLAST	21
Topological domainⁱ	405 – 463	Cytoplasmic1 PublicationAdd BLAST	59

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	32	L → A: No effect on stimulation of cAMP accumulation and on GLP-1 binding. 1 Publication	1
Mutagenesisⁱ	69	Y → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication	1
Mutagenesisⁱ	88	Y → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication	1
Mutagenesisⁱ	89	L → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication	1
Mutagenesisⁱ	90	P → A: Strongly decreased stimulation of cAMP accumulation in response to GLP-1. 1 Publication	1
Mutagenesisⁱ	121	R → A: Strongly decreased stimulation of cAMP accumulation in response to GLP-1. 1 Publication	1
Mutagenesisⁱ	127	E → A: No effect on stimulation of cAMP accumulation in response to GLP-1. 1 Publication	1
Mutagenesisⁱ	128	E → A: Slightly decreases stimulation of cAMP accumulation in response to GLP-1. 1 Publication	1
Mutagenesisⁱ	128	E → Q: No effect on stimulation of cAMP accumulation in response to GLP-1. 1 Publication	1
Mutagenesisⁱ	176	R → Q: Decreases sensitivity to GLP-1. 1 Publication	1
Mutagenesisⁱ	317	I → C: Causes the formation of an artifactual disulfide bond that abolishes signaling in response to GLP-1 binding; when associated with C-361. 1 Publication	1
Mutagenesisⁱ	352	S → A: Abolishes inhibition by negative allosteric modulators. 1 Publication	1
Mutagenesisⁱ	355	T → A: Abolishes inhibition by the negative allosteric modulators NNC0640 and PF-06372222, but does not abolish inhibition by MK-0893. 1 Publication	1
Mutagenesisⁱ	361	G → C: Causes the formation of an artifactual disulfide bond that abolishes signaling in response to GLP-1 binding; when associated with C-317. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2740
Open Targets More...OpenTargetsⁱ	ENSG00000112164
PharmGKBⁱ	PA28725

Chemistry databases

ChEMBLⁱ	CHEMBL1784
Drug and drug target database More...DrugBankⁱ	DB09043 Albiglutide DB09045 Dulaglutide DB01276 Exenatide DB00040 Glucagon recombinant DB05162 GSK716155 DB06655 Liraglutide
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	249

Polymorphism and mutation databases

BioMutaⁱ	GLP1R
DMDMⁱ	311033387

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000012835	24 – 463	Glucagon-like peptide 1 receptorAdd BLAST		440

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	46 ↔ 71	Combined sources3 Publications
Disulfide bondⁱ	62 ↔ 104	Combined sources3 Publications
Glycosylationⁱ	63	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	82	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	85 ↔ 126	Combined sources3 Publications
Glycosylationⁱ	115	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	226 ↔ 296	Combined sources4 Publications
Modified residueⁱ	341	ADP-ribosylcysteine1 Publication	1
Modified residueⁱ	348	ADP-ribosylarginine1 Publication	1

Post-translational modificationⁱ

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.1 Publication

Keywords - PTMⁱ

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P43220
PeptideAtlas More...PeptideAtlasⁱ	P43220
PRIDEⁱ	P43220
ProteomicsDBⁱ	55596

PTM databases

iPTMnetⁱ	P43220
PhosphoSitePlusⁱ	P43220

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000112164 Expressed in 165 organ(s), highest expression level in myocardium
CleanExⁱ	HS_GLP1R
Genevisibleⁱ	P43220 HS

Interactionⁱ

Subunit structureⁱ

May form homodimers and heterodimers with GIPR.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	121	Interaction with the endogenous ligand GLP-11 Publication		1
Siteⁱ	128	Interaction with the endogenous ligand GLP-11 Publication		1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
KRTAP10-7	P60409	3	EBI-7466542,EBI-10172290
KRTAP10-8	P60410	3	EBI-7466542,EBI-10171774
KRTAP10-9	P60411	3	EBI-7466542,EBI-10172052
NOTCH2NLA	Q7Z3S9	5	EBI-7466542,EBI-945833

Protein-protein interaction databases

BioGridⁱ	109002, 106 interactors
Database of interacting proteins More...DIPⁱ	DIP-29980N
IntActⁱ	P43220, 9 interactors
Molecular INTeraction database More...MINTⁱ	P43220
STRINGⁱ	9606.ENSP00000362353

Chemistry databases

BindingDBⁱ

P43220

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	32 – 52	Combined sources	21
Beta strandⁱ	57 – 59	Combined sources	3
Beta strandⁱ	68 – 71	Combined sources	4
Beta strandⁱ	79 – 84	Combined sources	6
Helixⁱ	92 – 94	Combined sources	3
Beta strandⁱ	99 – 104	Combined sources	6
Beta strandⁱ	108 – 110	Combined sources	3
Beta strandⁱ	116 – 119	Combined sources	4
Helixⁱ	124 – 126	Combined sources	3
Helixⁱ	137 – 142	Combined sources	6
Helixⁱ	170 – 172	Combined sources	3
Helixⁱ	175 – 199	Combined sources	25
Helixⁱ	206 – 210	Combined sources	5
Turnⁱ	220 – 222	Combined sources	3
Helixⁱ	224 – 256	Combined sources	33
Helixⁱ	263 – 273	Combined sources	11
Helixⁱ	275 – 291	Combined sources	17
Turnⁱ	295 – 298	Combined sources	4
Turnⁱ	304 – 306	Combined sources	3
Helixⁱ	307 – 336	Combined sources	30
Helixⁱ	345 – 366	Combined sources	22
Turnⁱ	367 – 369	Combined sources	3
Turnⁱ	370 – 372	Combined sources	3
Helixⁱ	373 – 375	Combined sources	3
Helixⁱ	381 – 384	Combined sources	4
Helixⁱ	387 – 402	Combined sources	16
Turnⁱ	403 – 405	Combined sources	3
Helixⁱ	407 – 421	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P43220
SMRⁱ	P43220
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P43220

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	352 – 355	Important for allosteric inhibitor binding1 Publication		4

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 2 family.Curated

Keywords - Domainⁱ

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4564 Eukaryota ENOG410XRS2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000161009
HOGENOMⁱ	HOG000008250
HOVERGENⁱ	HBG008318
InParanoidⁱ	P43220
KEGG Orthology (KO) More...KOⁱ	K04581
OMAⁱ	CQRFLTE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0NF8
PhylomeDBⁱ	P43220
TreeFamⁱ	TF315710

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd15268 7tmB1_GLP1R, 1 hit
Gene3Dⁱ	4.10.1240.10, 1 hit
InterProⁱ	View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR003290 GPCR_2_GLP1/glucagon_rcpt IPR003292 GPCR_2_GLP1_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS
PANTHERⁱ	PTHR12011:SF245 PTHR12011:SF245, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit
PRINTSⁱ	PR01353 GLUCAGNFAMLY PR01355 GLUCAGNLIKER PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00008 HormR, 1 hit
SUPFAMⁱ	SSF111418 SSF111418, 1 hit
PROSITEⁱ	View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P43220-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL 
        60         70         80         90        100
TEDPPPATDL FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV 
       110        120        130        140        150
YRFCTAEGLW LQKDNSSLPW RDLSECEESK RGERSSPEEQ LLFLYIIYTV 
       160        170        180        190        200
GYALSFSALV IASAILLGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA 
       210        220        230        240        250
LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN YYWLLVEGVY 
       260        270        280        290        300
LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN 
       310        320        330        340        350
SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA 
       360        370        380        390        400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI 
       410        420        430        440        450
LYCFVNNEVQ LEFRKSWERW RLEHLHIQRD SSMKPLKCPT SSLSSGATAG 
       460 
SSMYTATCQA SCS

Length:463

Mass (Da):53,026

Last modified:November 2, 2010 - v2

Checksum:ⁱEE7C0EAE29931F5D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	12	L → V in AAA03614 (PubMed:8405712).Curated	1
Sequence conflictⁱ	12	L → V no nucleotide entry (PubMed:7517895).Curated	1
Sequence conflictⁱ	12	L → V in AAB64013 (PubMed:9213353).Curated	1
Sequence conflictⁱ	136 – 137	SP → WG in AAA03614 (PubMed:8405712).Curated	2
Sequence conflictⁱ	137	P → R no nucleotide entry (PubMed:7517895).Curated	1
Sequence conflictⁱ	151	G → A in AAA03614 (PubMed:8405712).Curated	1
Sequence conflictⁱ	221	Q → L in AAA63787 (PubMed:7843404).Curated	1
Sequence conflictⁱ	289	Y → I in AAA03614 (PubMed:8405712).Curated	1
Sequence conflictⁱ	316	A → G in AAA62471 (PubMed:8404634).Curated	1
Sequence conflictⁱ	316	A → G in AAC50050 (PubMed:8404634).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_018924	7	P → L1 PublicationCorresponds to variant dbSNP:rs10305420Ensembl.	1
Natural variantⁱVAR_018925	20	R → K1 PublicationCorresponds to variant dbSNP:rs10305421Ensembl.	1
Natural variantⁱVAR_018926	44	R → H1 PublicationCorresponds to variant dbSNP:rs2295006Ensembl.	1
Natural variantⁱVAR_018927	131	R → Q1 PublicationCorresponds to variant dbSNP:rs3765467Ensembl.	1
Natural variantⁱVAR_018928	168	G → S1 PublicationCorresponds to variant dbSNP:rs6923761Ensembl.	1
Natural variantⁱVAR_015098	260	L → F6 PublicationsCorresponds to variant dbSNP:rs1042044Ensembl.	1
Natural variantⁱVAR_018929	316	A → T1 PublicationCorresponds to variant dbSNP:rs10305492Ensembl.	1
Natural variantⁱVAR_018930	333	S → C1 PublicationCorresponds to variant dbSNP:rs10305493Ensembl.	1
Natural variantⁱVAR_018931	421	R → Q1 PublicationCorresponds to variant dbSNP:rs10305510Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U01104 mRNA Translation: AAA03614.1 U01157 mRNA Translation: AAA62471.1 U01156 mRNA Translation: AAC50050.1 L23503 mRNA Translation: AAA17021.1 U10037 mRNA Translation: AAA63787.1 AB065685 Genomic DNA Translation: BAC05908.1 AY439112 Genomic DNA Translation: AAR05444.1 AL035690 Genomic DNA No translation available. BC112126 mRNA Translation: AAI12127.1 BC113493 mRNA Translation: AAI13494.1 U66062 Genomic DNA Translation: AAB64013.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4839.1
PIRⁱ	I84494 S71624
NCBI Reference Sequences More...RefSeqⁱ	NP_002053.3, NM_002062.4
UniGeneⁱ	Hs.351883 Hs.389103

Genome annotation databases

Ensemblⁱ	ENST00000373256; ENSP00000362353; ENSG00000112164
GeneIDⁱ	2740
KEGGⁱ	hsa:2740
UCSC genome browser More...UCSCⁱ	uc003ooj.5 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43220	Glucagon-like peptide 1 receptor		RAT		463	UniRef90_P43220
Glp1r protein		MOUSE		464
glucagon-like peptide 1 receptor		MESAU		464
Glucagon like peptide 1 receptor		CHLSB		464
GLP1R isoform 1		PONAB		463
+37

Protein	Similar proteins		Species	Score	Length	Source
P43220	Glucagon-like peptide 1 receptor		RAT		463	UniRef50_P43220
Glucagon-like peptide 1 receptor		MOUSE		463
Glucagon like peptide 1 receptor		CHLSB		464
glucagon-like peptide 1 receptor		MESAU		464
glucagon-like peptide 1 receptor		DELLE		463
+137

Cross-referencesⁱ

Web resourcesⁱ

NIEHS-SNPs

Wikipedia

Glucagon-like peptide 1 entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U01104 mRNA Translation: AAA03614.1 U01157 mRNA Translation: AAA62471.1 U01156 mRNA Translation: AAC50050.1 L23503 mRNA Translation: AAA17021.1 U10037 mRNA Translation: AAA63787.1 AB065685 Genomic DNA Translation: BAC05908.1 AY439112 Genomic DNA Translation: AAR05444.1 AL035690 Genomic DNA No translation available. BC112126 mRNA Translation: AAI12127.1 BC113493 mRNA Translation: AAI13494.1 U66062 Genomic DNA Translation: AAB64013.1
CCDSⁱ	CCDS4839.1
PIRⁱ	I84494 S71624
RefSeqⁱ	NP_002053.3, NM_002062.4
UniGeneⁱ	Hs.351883 Hs.389103

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3C59	X-ray	2.30	A	24-145	[»]
	3C5T	X-ray	2.10	A	24-145	[»]
	3IOL	X-ray	2.10	A	24-145	[»]
	4ZGM	X-ray	1.80	A	24-145	[»]
	5E94	X-ray	2.00	G/H	24-145	[»]
	5NX2	X-ray	3.70	A	24-432	[»]
	5OTT	X-ray	1.92	A	24-139	[»]
	5OTU	X-ray	1.80	A/C	24-139	[»]
	5OTV	X-ray	2.00	A/C	24-139	[»]
	5OTW	X-ray	2.10	A/C	24-139	[»]
	5OTX	X-ray	2.00	A/C	24-139	[»]
	5VEW	X-ray	2.70	A/B	128-257	[»]
				A/B	261-431	[»]
	5VEX	X-ray	3.00	A/B	128-257	[»]
				A/B	261-431	[»]
	6B3J	electron microscopy	3.30	R	24-463	[»]
	6GB1	X-ray	2.73	A	21-145	[»]
ProteinModelPortalⁱ	P43220
SMRⁱ	P43220
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109002, 106 interactors
DIPⁱ	DIP-29980N
IntActⁱ	P43220, 9 interactors
MINTⁱ	P43220
STRINGⁱ	9606.ENSP00000362353

Chemistry databases

BindingDBⁱ	P43220
ChEMBLⁱ	CHEMBL1784
DrugBankⁱ	DB09043 Albiglutide DB09045 Dulaglutide DB01276 Exenatide DB00040 Glucagon recombinant DB05162 GSK716155 DB06655 Liraglutide
GuidetoPHARMACOLOGYⁱ	249

Protein family/group databases

TCDBⁱ	9.A.14.4.6 the g-protein-coupled receptor (gpcr) family
GPCRDBⁱ	Search...

PTM databases

iPTMnetⁱ	P43220
PhosphoSitePlusⁱ	P43220

Polymorphism and mutation databases

BioMutaⁱ	GLP1R
DMDMⁱ	311033387

Proteomic databases

PaxDbⁱ	P43220
PeptideAtlasⁱ	P43220
PRIDEⁱ	P43220
ProteomicsDBⁱ	55596

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2740
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000373256; ENSP00000362353; ENSG00000112164
GeneIDⁱ	2740
KEGGⁱ	hsa:2740
UCSCⁱ	uc003ooj.5 human

Organism-specific databases

CTDⁱ	2740
DisGeNETⁱ	2740
EuPathDBⁱ	HostDB:ENSG00000112164.5
GeneCardsⁱ	GLP1R
H-InvDBⁱ	HIX0095000 HIX0200932
HGNCⁱ	HGNC:4324 GLP1R
MIMⁱ	138032 gene
neXtProtⁱ	NX_P43220
OpenTargetsⁱ	ENSG00000112164
PharmGKBⁱ	PA28725
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4564 Eukaryota ENOG410XRS2 LUCA
GeneTreeⁱ	ENSGT00940000161009
HOGENOMⁱ	HOG000008250
HOVERGENⁱ	HBG008318
InParanoidⁱ	P43220
KOⁱ	K04581
OMAⁱ	CQRFLTE
OrthoDBⁱ	EOG091G0NF8
PhylomeDBⁱ	P43220
TreeFamⁱ	TF315710

Enzyme and pathway databases

Reactomeⁱ	R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion R-HSA-418555 G alpha (s) signalling events R-HSA-420092 Glucagon-type ligand receptors
SIGNORⁱ	P43220

Miscellaneous databases

EvolutionaryTraceⁱ	P43220
GeneWikiⁱ	Glucagon-like_peptide_1_receptor
GenomeRNAiⁱ	2740
Protein Ontology More...PROⁱ	PR:P43220
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000112164 Expressed in 165 organ(s), highest expression level in myocardium
CleanExⁱ	HS_GLP1R
Genevisibleⁱ	P43220 HS

Family and domain databases

CDDⁱ	cd15268 7tmB1_GLP1R, 1 hit
Gene3Dⁱ	4.10.1240.10, 1 hit
InterProⁱ	View protein in InterPro IPR017981 GPCR_2-like IPR036445 GPCR_2_extracell_dom_sf IPR001879 GPCR_2_extracellular_dom IPR003290 GPCR_2_GLP1/glucagon_rcpt IPR003292 GPCR_2_GLP1_rcpt IPR000832 GPCR_2_secretin-like IPR017983 GPCR_2_secretin-like_CS
PANTHERⁱ	PTHR12011:SF245 PTHR12011:SF245, 1 hit
Pfamⁱ	View protein in Pfam PF00002 7tm_2, 1 hit PF02793 HRM, 1 hit
PRINTSⁱ	PR01353 GLUCAGNFAMLY PR01355 GLUCAGNLIKER PR00249 GPCRSECRETIN
SMARTⁱ	View protein in SMART SM00008 HormR, 1 hit
SUPFAMⁱ	SSF111418 SSF111418, 1 hit
PROSITEⁱ	View protein in PROSITE PS00649 G_PROTEIN_RECEP_F2_1, 1 hit PS00650 G_PROTEIN_RECEP_F2_2, 1 hit PS50227 G_PROTEIN_RECEP_F2_3, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GLP1R_HUMAN
Accessionⁱ	P43220Primary (citable) accession number: P43220 Secondary accession number(s): Q2M229, Q99669
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	November 2, 2010
	Last modified:	December 5, 2018
	This is version 179 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniRef

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Supporting data

UniProtKB - P43220 (GLP1R_HUMAN)

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Glucagon-like peptide 1 receptor

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ