Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - P43220 (GLP1R_HUMAN)

Entry version 192 (17 Jun 2020)
Sequence version 2 (02 Nov 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Glucagon-like peptide 1 receptor

Gene

GLP1R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled receptor for glucagon-like peptide 1 (GLP-1) (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels (PubMed:8405712, PubMed:8216285, PubMed:7517895, PubMed:19861722, PubMed:26308095, PubMed:27196125, PubMed:28514449). Plays a role in regulating insulin secretion in response to GLP-1 (By similarity).By similarity7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

The allosteric modulators NNC0640, PF-06372222 and MK-0893 inhibit the increase of intracellular cAMP levels in response to GLP-1.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors

SIGNOR Signaling Network Open Resource

More...SIGNORi		P43220

Protein family/group databases

Transport Classification Database

More...TCDBi		9.A.14.4.6 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Glucagon-like peptide 1 receptor
Short name:
GLP-1 receptor
Short name:
GLP-1-R
Short name:
GLP-1R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GLP1R
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000112164.5

Human Gene Nomenclature Database

More...HGNCi		HGNC:4324 GLP1R

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		138032 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P43220

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 139Extracellular1 PublicationAdd BLAST116
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei140 – 164Helical; Name=11 PublicationAdd BLAST25
Topological domaini165 – 175Cytoplasmic1 PublicationAdd BLAST11
Transmembranei176 – 201Helical; Name=21 PublicationAdd BLAST26
Topological domaini202 – 227Extracellular1 PublicationAdd BLAST26
Transmembranei228 – 251Helical; Name=31 PublicationAdd BLAST24
Topological domaini252 – 265Cytoplasmic1 PublicationAdd BLAST14
Transmembranei266 – 290Helical; Name=41 PublicationAdd BLAST25
Topological domaini291 – 305Extracellular1 PublicationAdd BLAST15
Transmembranei306 – 328Helical; Name=51 PublicationAdd BLAST23
Topological domaini329 – 348Cytoplasmic1 PublicationAdd BLAST20
Transmembranei349 – 370Helical; Name=61 PublicationAdd BLAST22
Topological domaini371 – 383Extracellular1 PublicationAdd BLAST13
Transmembranei384 – 404Helical; Name=71 PublicationAdd BLAST21
Topological domaini405 – 463Cytoplasmic1 PublicationAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi32L → A: No effect on stimulation of cAMP accumulation and on GLP-1 binding. 1 Publication1
Mutagenesisi69Y → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication1
Mutagenesisi88Y → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication1
Mutagenesisi89L → A: Abolishes stimulation of cAMP accumulation in response to GLP-1. 1 Publication1
Mutagenesisi90P → A: Strongly decreased stimulation of cAMP accumulation in response to GLP-1. 1 Publication1
Mutagenesisi121R → A: Strongly decreased stimulation of cAMP accumulation in response to GLP-1. 1 Publication1
Mutagenesisi127E → A: No effect on stimulation of cAMP accumulation in response to GLP-1. 1 Publication1
Mutagenesisi128E → A: Slightly decreases stimulation of cAMP accumulation in response to GLP-1. 1 Publication1
Mutagenesisi128E → Q: No effect on stimulation of cAMP accumulation in response to GLP-1. 1 Publication1
Mutagenesisi176R → Q: Decreases sensitivity to GLP-1. 1 Publication1
Mutagenesisi317I → C: Causes the formation of an artifactual disulfide bond that abolishes signaling in response to GLP-1 binding; when associated with C-361. 1 Publication1
Mutagenesisi352S → A: Abolishes inhibition by negative allosteric modulators. 1 Publication1
Mutagenesisi355T → A: Abolishes inhibition by the negative allosteric modulators NNC0640 and PF-06372222, but does not abolish inhibition by MK-0893. 1 Publication1
Mutagenesisi361G → C: Causes the formation of an artifactual disulfide bond that abolishes signaling in response to GLP-1 binding; when associated with C-317. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		2740

Open Targets

More...OpenTargetsi		ENSG00000112164

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA28725

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P43220 Tclin

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL1784

Drug and drug target database

More...DrugBanki		DB09043 Albiglutide
DB09045 Dulaglutide
DB01276 Exenatide
DB00040 Glucagon
DB06655 Liraglutide
DB09265 Lixisenatide
DB13928 Semaglutide

DrugCentral

More...DrugCentrali		P43220

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		249

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		GLP1R

Domain mapping of disease mutations (DMDM)

More...DMDMi		311033387

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001283524 – 463Glucagon-like peptide 1 receptorAdd BLAST440

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi46 ↔ 71Combined sources3 Publications
Disulfide bondi62 ↔ 104Combined sources3 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi63N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi82N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi85 ↔ 126Combined sources3 Publications
Glycosylationi115N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi226 ↔ 296Combined sources4 Publications
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei341ADP-ribosylcysteine1 Publication1
Modified residuei348ADP-ribosylarginine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER.1 Publication

Keywords - PTMi

ADP-ribosylation, Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P43220

PeptideAtlas

More...PeptideAtlasi		P43220

PRoteomics IDEntifications database

More...PRIDEi		P43220

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55596

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P43220

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P43220

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112164 Expressed in myocardium and 164 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P43220 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000112164 Tissue enhanced (pancreas)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homodimers and heterodimers with GIPR.

2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei121Interaction with the endogenous ligand GLP-11 Publication1
Sitei128Interaction with the endogenous ligand GLP-11 Publication1

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109002, 254 interactors

Database of interacting proteins

More...DIPi		DIP-29980N

Protein interaction database and analysis system

More...IntActi		P43220, 11 interactors

Molecular INTeraction database

More...MINTi		P43220

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000362353

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P43220

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P43220 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1463
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P43220

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P43220

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni352 – 355Important for allosteric inhibitor binding1 Publication4

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4564 Eukaryota
ENOG410XRS2 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161009

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_002753_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P43220

KEGG Orthology (KO)

More...KOi		K04581

Identification of Orthologs from Complete Genome Data

More...OMAi		CRLVFVM

Database of Orthologous Groups

More...OrthoDBi		651627at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P43220

TreeFam database of animal gene trees

More...TreeFami		TF315710

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.1240.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003290 GPCR_2_GLP1/glucagon_rcpt
IPR003292 GPCR_2_GLP1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS

The PANTHER Classification System

More...PANTHERi		PTHR45620:SF25 PTHR45620:SF25, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01353 GLUCAGNFAMLY
PR01355 GLUCAGNLIKER
PR00249 GPCRSECRETIN

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00008 HormR, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF111418 SSF111418, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P43220-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAPGPLRL ALLLLGMVGR AGPRPQGATV SLWETVQKWR EYRRQCQRSL 
        60         70         80         90        100
TEDPPPATDL FCNRTFDEYA CWPDGEPGSF VNVSCPWYLP WASSVPQGHV 
       110        120        130        140        150
YRFCTAEGLW LQKDNSSLPW RDLSECEESK RGERSSPEEQ LLFLYIIYTV 
       160        170        180        190        200
GYALSFSALV IASAILLGFR HLHCTRNYIH LNLFASFILR ALSVFIKDAA 
       210        220        230        240        250
LKWMYSTAAQ QHQWDGLLSY QDSLSCRLVF LLMQYCVAAN YYWLLVEGVY 
       260        270        280        290        300
LYTLLAFSVL SEQWIFRLYV SIGWGVPLLF VVPWGIVKYL YEDEGCWTRN 
       310        320        330        340        350
SNMNYWLIIR LPILFAIGVN FLIFVRVICI VVSKLKANLM CKTDIKCRLA 
       360        370        380        390        400
KSTLTLIPLL GTHEVIFAFV MDEHARGTLR FIKLFTELSF TSFQGLMVAI 
       410        420        430        440        450
LYCFVNNEVQ LEFRKSWERW RLEHLHIQRD SSMKPLKCPT SSLSSGATAG 
       460 
SSMYTATCQA SCS
Length:463
Mass (Da):53,026
Last modified:November 2, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEE7C0EAE29931F5D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti12L → V in AAA03614 (PubMed:8405712).Curated1
Sequence conflicti12L → V no nucleotide entry (PubMed:7517895).Curated1
Sequence conflicti12L → V in AAB64013 (PubMed:9213353).Curated1
Sequence conflicti136 – 137SP → WG in AAA03614 (PubMed:8405712).Curated2
Sequence conflicti137P → R no nucleotide entry (PubMed:7517895).Curated1
Sequence conflicti151G → A in AAA03614 (PubMed:8405712).Curated1
Sequence conflicti221Q → L in AAA63787 (PubMed:7843404).Curated1
Sequence conflicti289Y → I in AAA03614 (PubMed:8405712).Curated1
Sequence conflicti316A → G in AAA62471 (PubMed:8404634).Curated1
Sequence conflicti316A → G in AAC50050 (PubMed:8404634).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0189247P → L1 PublicationCorresponds to variant dbSNP:rs10305420Ensembl.1
Natural variantiVAR_01892520R → K1 PublicationCorresponds to variant dbSNP:rs10305421Ensembl.1
Natural variantiVAR_01892644R → H1 PublicationCorresponds to variant dbSNP:rs2295006Ensembl.1
Natural variantiVAR_018927131R → Q1 PublicationCorresponds to variant dbSNP:rs3765467Ensembl.1
Natural variantiVAR_018928168G → S1 PublicationCorresponds to variant dbSNP:rs6923761Ensembl.1
Natural variantiVAR_015098260L → F6 PublicationsCorresponds to variant dbSNP:rs1042044Ensembl.1
Natural variantiVAR_018929316A → T1 PublicationCorresponds to variant dbSNP:rs10305492Ensembl.1
Natural variantiVAR_018930333S → C1 PublicationCorresponds to variant dbSNP:rs10305493Ensembl.1
Natural variantiVAR_018931421R → Q1 PublicationCorresponds to variant dbSNP:rs10305510Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U01104 mRNA Translation: AAA03614.1
U01157 mRNA Translation: AAA62471.1
U01156 mRNA Translation: AAC50050.1
L23503 mRNA Translation: AAA17021.1
U10037 mRNA Translation: AAA63787.1
AB065685 Genomic DNA Translation: BAC05908.1
AY439112 Genomic DNA Translation: AAR05444.1
AL035690 Genomic DNA No translation available.
BC112126 mRNA Translation: AAI12127.1
BC113493 mRNA Translation: AAI13494.1
U66062 Genomic DNA Translation: AAB64013.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4839.1

Protein sequence database of the Protein Information Resource

More...PIRi		I84494
S71624

NCBI Reference Sequences

More...RefSeqi		NP_002053.3, NM_002062.4

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000373256; ENSP00000362353; ENSG00000112164

Database of genes from NCBI RefSeq genomes

More...GeneIDi		2740

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:2740

UCSC genome browser

More...UCSCi		uc003ooj.5 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

NIEHS-SNPs
Wikipedia

Glucagon-like peptide 1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01104 mRNA Translation: AAA03614.1
U01157 mRNA Translation: AAA62471.1
U01156 mRNA Translation: AAC50050.1
L23503 mRNA Translation: AAA17021.1
U10037 mRNA Translation: AAA63787.1
AB065685 Genomic DNA Translation: BAC05908.1
AY439112 Genomic DNA Translation: AAR05444.1
AL035690 Genomic DNA No translation available.
BC112126 mRNA Translation: AAI12127.1
BC113493 mRNA Translation: AAI13494.1
U66062 Genomic DNA Translation: AAB64013.1
CCDSiCCDS4839.1
PIRiI84494
S71624
RefSeqiNP_002053.3, NM_002062.4

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3C59X-ray2.30A24-145[»]
3C5TX-ray2.10A24-145[»]
3IOLX-ray2.10A24-145[»]
4ZGMX-ray1.80A24-145[»]
5E94X-ray2.00G/H24-145[»]
5NX2X-ray3.70A24-432[»]
5OTTX-ray1.92A24-139[»]
5OTUX-ray1.80A/C24-139[»]
5OTVX-ray2.00A/C24-139[»]
5OTWX-ray2.10A/C24-139[»]
5OTXX-ray2.00A/C24-139[»]
5VEWX-ray2.70A/B128-257[»]
A/B261-431[»]
5VEXX-ray3.00A/B128-257[»]
A/B261-431[»]
6B3Jelectron microscopy3.30R24-463[»]
6GB1X-ray2.73A21-145[»]
6ORVelectron microscopy3.00RP24-463[»]
SMRiP43220
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109002, 254 interactors
DIPiDIP-29980N
IntActiP43220, 11 interactors
MINTiP43220
STRINGi9606.ENSP00000362353

Chemistry databases

BindingDBiP43220
ChEMBLiCHEMBL1784
DrugBankiDB09043 Albiglutide
DB09045 Dulaglutide
DB01276 Exenatide
DB00040 Glucagon
DB06655 Liraglutide
DB09265 Lixisenatide
DB13928 Semaglutide
DrugCentraliP43220
GuidetoPHARMACOLOGYi249

Protein family/group databases

TCDBi9.A.14.4.6 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiP43220
PhosphoSitePlusiP43220

Polymorphism and mutation databases

BioMutaiGLP1R
DMDMi311033387

Proteomic databases

PaxDbiP43220
PeptideAtlasiP43220
PRIDEiP43220
ProteomicsDBi55596

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P43220 1 sequenced antibody

Antibodypedia a portal for validated antibodies

More...Antibodypediai		15682 522 antibodies

The DNASU plasmid repository

More...DNASUi		2740

Genome annotation databases

EnsembliENST00000373256; ENSP00000362353; ENSG00000112164
GeneIDi2740
KEGGihsa:2740
UCSCiuc003ooj.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		2740
DisGeNETi2740
EuPathDBiHostDB:ENSG00000112164.5

GeneCards: human genes, protein and diseases

More...GeneCardsi		GLP1R
HGNCiHGNC:4324 GLP1R
HPAiENSG00000112164 Tissue enhanced (pancreas)
MIMi138032 gene
neXtProtiNX_P43220
OpenTargetsiENSG00000112164
PharmGKBiPA28725

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00940000161009
HOGENOMiCLU_002753_4_0_1
InParanoidiP43220
KOiK04581
OMAiCRLVFVM
OrthoDBi651627at2759
PhylomeDBiP43220
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
R-HSA-418555 G alpha (s) signalling events
R-HSA-420092 Glucagon-type ligand receptors
SIGNORiP43220

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		2740 3 hits in 787 CRISPR screens
EvolutionaryTraceiP43220

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Glucagon-like_peptide_1_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		2740
PharosiP43220 Tclin

Protein Ontology

More...PROi		PR:P43220
RNActiP43220 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112164 Expressed in myocardium and 164 other tissues
GenevisibleiP43220 HS

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR003290 GPCR_2_GLP1/glucagon_rcpt
IPR003292 GPCR_2_GLP1_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PANTHERiPTHR45620:SF25 PTHR45620:SF25, 1 hit
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01353 GLUCAGNFAMLY
PR01355 GLUCAGNLIKER
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGLP1R_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43220
Secondary accession number(s): Q2M229, Q99669
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 2, 2010
Last modified: June 17, 2020
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again