Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gastric inhibitory polypeptide receptor

Gene

Gipr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • gastric inhibitory peptide receptor activity Source: RGD
  • peptide hormone binding Source: RGD

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-420092 Glucagon-type ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Gastric inhibitory polypeptide receptor
Short name:
GIP-R
Alternative name(s):
Glucose-dependent insulinotropic polypeptide receptor
Gene namesi
Name:Gipr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2689 Gipr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 135ExtracellularSequence analysisAdd BLAST117
Transmembranei136 – 158Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini159 – 166CytoplasmicSequence analysis8
Transmembranei167 – 186Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini187 – 214ExtracellularSequence analysisAdd BLAST28
Transmembranei215 – 239Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini240 – 251CytoplasmicSequence analysisAdd BLAST12
Transmembranei252 – 275Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini276 – 290ExtracellularSequence analysisAdd BLAST15
Transmembranei291 – 316Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini317 – 338CytoplasmicSequence analysisAdd BLAST22
Transmembranei339 – 359Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini360 – 374ExtracellularSequence analysisAdd BLAST15
Transmembranei375 – 395Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini396 – 455CytoplasmicSequence analysisAdd BLAST60

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5001
GuidetoPHARMACOLOGYi248

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001282719 – 455Gastric inhibitory polypeptide receptorAdd BLAST437

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi43 ↔ 67By similarity
Disulfide bondi58 ↔ 100By similarity
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi81 ↔ 115By similarity

Post-translational modificationi

N-glycosylation is required for cell surface expression and lengthens receptor half-life by preventing degradation in the ER.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43219
PRIDEiP43219

PTM databases

PhosphoSitePlusiP43219

Expressioni

Tissue specificityi

Present in the pancreas as well as the gut, adipose tissue, heart, pituitary, and inner layers of the adrenal cortex, whereas it is not found in kidney, spleen, or liver. It is also expressed in several brain regions, including the cerebral cortex, hippocampus, and olfactory bulb.

Gene expression databases

BgeeiENSRNOG00000015860 Expressed in 8 organ(s), highest expression level in brain
GenevisibleiP43219 RN

Interactioni

Subunit structurei

May form homodimers and heterodimers with GLP1R.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021456

Chemistry databases

BindingDBiP43219

Structurei

3D structure databases

ProteinModelPortaliP43219
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiP43219
KOiK04580
OMAiSFDMYVC
OrthoDBiEOG091G0NF8
PhylomeDBiP43219
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR001749 GPCR_2_GIP_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01129 GIPRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43219-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPLRLLLLLL WLWGLSLQRA ETDSEGQTTG ELYQRWERYG WECQNTLEAT
60 70 80 90 100
EPPSGLACNG SFDMYACWNY TAANTTARVS CPWYLPWYRQ VAAGFVFRQC
110 120 130 140 150
GSDGQWGSWR DHTQCENPEK NGAFQDQKLI LERLQVVYTV GYSLSLATLL
160 170 180 190 200
LALLILSLFR RLHCTRNYIH MNLFTSFMLR AGAILTRDQL LPPLGPYTGN
210 220 230 240 250
QTPTLWNQAL AACRTAQILT QYCVGANYTW LLVEGVYLHH LLVVVRRSEK
260 270 280 290 300
GHFRCYLLLG WGAPALFVIP WVIVRYLYEN TQCWERNEVK AIWWIIRTPI
310 320 330 340 350
LITILINFLI FIRILGILVS KLRTRQMRCP DYRLRLARST LTLMPLLGVH
360 370 380 390 400
EVVFAPVTEE QAEGSLRFAK LAFEIFLSSF QGFLVSVLYC FINKEVQSEI
410 420 430 440 450
RRLRLSLQEQ CPRPHLGQAP RAVPLSSAPQ EAAIRNALPS GMLHVPGDEV

LESYC
Length:455
Mass (Da):52,257
Last modified:November 1, 1995 - v1
Checksum:i5454B0638ABF9A06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19660 mRNA Translation: AAC37637.1
PIRiI53273
RefSeqiNP_036846.1, NM_012714.1
XP_017444289.1, XM_017588800.1
UniGeneiRn.9676

Genome annotation databases

EnsembliENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860
GeneIDi25024
KEGGirno:25024
UCSCiRGD:2689 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19660 mRNA Translation: AAC37637.1
PIRiI53273
RefSeqiNP_036846.1, NM_012714.1
XP_017444289.1, XM_017588800.1
UniGeneiRn.9676

3D structure databases

ProteinModelPortaliP43219
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000021456

Chemistry databases

BindingDBiP43219
ChEMBLiCHEMBL5001
GuidetoPHARMACOLOGYi248

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP43219

Proteomic databases

PaxDbiP43219
PRIDEiP43219

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021456; ENSRNOP00000021456; ENSRNOG00000015860
GeneIDi25024
KEGGirno:25024
UCSCiRGD:2689 rat

Organism-specific databases

CTDi2696
RGDi2689 Gipr

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00760000118800
HOGENOMiHOG000008250
HOVERGENiHBG008318
InParanoidiP43219
KOiK04580
OMAiSFDMYVC
OrthoDBiEOG091G0NF8
PhylomeDBiP43219
TreeFamiTF315710

Enzyme and pathway databases

ReactomeiR-RNO-420092 Glucagon-type ligand receptors

Miscellaneous databases

PROiPR:P43219

Gene expression databases

BgeeiENSRNOG00000015860 Expressed in 8 organ(s), highest expression level in brain
GenevisibleiP43219 RN

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR001749 GPCR_2_GIP_rcpt
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01129 GIPRECEPTOR
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGIPR_RAT
AccessioniPrimary (citable) accession number: P43219
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again