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Protein

Carbonic anhydrase 7

Gene

CA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+1 Publication

Activity regulationi

Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorBy similarity1
Metal bindingi96Zinc; catalytic1 Publication1
Metal bindingi98Zinc; catalytic1 Publication1
Metal bindingi121Zinc; catalytic1 Publication1
Active sitei130By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi4.2.1.1 2681
ReactomeiR-HSA-1475029 Reversible hydration of carbon dioxide
SABIO-RKiP43166

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 7 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VII
Carbonic anhydrase VII
Short name:
CA-VII
Gene namesi
Name:CA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000168748.13
HGNCiHGNC:1381 CA7
MIMi114770 gene
neXtProtiNX_P43166

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi766
OpenTargetsiENSG00000168748
PharmGKBiPA25996

Chemistry databases

ChEMBLiCHEMBL2326
DrugBankiDB00819 Acetazolamide
DB01144 Diclofenamide
DB08846 Ellagic Acid
DB00311 Ethoxzolamide
DB00703 Methazolamide
DB00909 Zonisamide
GuidetoPHARMACOLOGYi2749

Polymorphism and mutation databases

BioMutaiCA7
DMDMi1168744

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774311 – 264Carbonic anhydrase 7Add BLAST264

Proteomic databases

PaxDbiP43166
PeptideAtlasiP43166
PRIDEiP43166
ProteomicsDBi55595

PTM databases

iPTMnetiP43166
PhosphoSitePlusiP43166

Expressioni

Gene expression databases

BgeeiENSG00000168748 Expressed in 64 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_CA7
ExpressionAtlasiP43166 baseline and differential
GenevisibleiP43166 HS

Organism-specific databases

HPAiHPA047237

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345659

Chemistry databases

BindingDBiP43166

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP43166
SMRiP43166
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 262Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 202Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP43166
KOiK01672
OMAiLYMVKFK
OrthoDBiEOG091G0XFM
PhylomeDBiP43166
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P43166-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGHHGWGYG QDDGPSHWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE
60 70 80 90 100
LSYEACMSLS ITNNGHSVQV DFNDSDDRTV VTGGPLEGPY RLKQFHFHWG
110 120 130 140 150
KKHDVGSEHT VDGKSFPSEL HLVHWNAKKY STFGEAASAP DGLAVVGVFL
160 170 180 190 200
ETGDEHPSMN RLTDALYMVR FKGTKAQFSC FNPKCLLPAS RHYWTYPGSL
210 220 230 240 250
TTPPLSESVT WIVLREPICI SERQMGKFRS LLFTSEDDER IHMVNNFRPP
260
QPLKGRVVKA SFRA
Length:264
Mass (Da):29,658
Last modified:November 1, 1995 - v1
Checksum:i7AD559FC6E07EF96
GO
Isoform 2 (identifier: P43166-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:208
Mass (Da):23,452
Checksum:iAF3D016A27182D18
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W0L0F8W0L0_HUMAN
Carbonic anhydrase 7
CA7
44Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442541 – 56Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76423
, M76420, M76421, M76422 Genomic DNA Translation: AAA51923.1
AY075019 mRNA Translation: AAL78167.1
AY075020 mRNA Translation: AAL78168.1
AC004638 Genomic DNA Translation: AAC23785.1
AC044802 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83047.1
BC033865 mRNA Translation: AAH33865.1
CCDSiCCDS10821.1 [P43166-1]
CCDS42173.1 [P43166-2]
PIRiA55272 CRHU7
RefSeqiNP_001014435.1, NM_001014435.1 [P43166-2]
NP_005173.1, NM_005182.2 [P43166-1]
XP_005256193.1, XM_005256136.3 [P43166-2]
XP_011521614.1, XM_011523312.1 [P43166-2]
UniGeneiHs.37014

Genome annotation databases

EnsembliENST00000338437; ENSP00000345659; ENSG00000168748 [P43166-1]
ENST00000394069; ENSP00000377632; ENSG00000168748 [P43166-2]
GeneIDi766
KEGGihsa:766
UCSCiuc002eqi.4 human [P43166-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76423
, M76420, M76421, M76422 Genomic DNA Translation: AAA51923.1
AY075019 mRNA Translation: AAL78167.1
AY075020 mRNA Translation: AAL78168.1
AC004638 Genomic DNA Translation: AAC23785.1
AC044802 Genomic DNA No translation available.
CH471092 Genomic DNA Translation: EAW83047.1
BC033865 mRNA Translation: AAH33865.1
CCDSiCCDS10821.1 [P43166-1]
CCDS42173.1 [P43166-2]
PIRiA55272 CRHU7
RefSeqiNP_001014435.1, NM_001014435.1 [P43166-2]
NP_005173.1, NM_005182.2 [P43166-1]
XP_005256193.1, XM_005256136.3 [P43166-2]
XP_011521614.1, XM_011523312.1 [P43166-2]
UniGeneiHs.37014

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MDZX-ray2.32A5-262[»]
3ML5X-ray2.05A1-264[»]
6G4TX-ray1.91A1-264[»]
ProteinModelPortaliP43166
SMRiP43166
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345659

Chemistry databases

BindingDBiP43166
ChEMBLiCHEMBL2326
DrugBankiDB00819 Acetazolamide
DB01144 Diclofenamide
DB08846 Ellagic Acid
DB00311 Ethoxzolamide
DB00703 Methazolamide
DB00909 Zonisamide
GuidetoPHARMACOLOGYi2749

PTM databases

iPTMnetiP43166
PhosphoSitePlusiP43166

Polymorphism and mutation databases

BioMutaiCA7
DMDMi1168744

Proteomic databases

PaxDbiP43166
PeptideAtlasiP43166
PRIDEiP43166
ProteomicsDBi55595

Protocols and materials databases

DNASUi766
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338437; ENSP00000345659; ENSG00000168748 [P43166-1]
ENST00000394069; ENSP00000377632; ENSG00000168748 [P43166-2]
GeneIDi766
KEGGihsa:766
UCSCiuc002eqi.4 human [P43166-1]

Organism-specific databases

CTDi766
DisGeNETi766
EuPathDBiHostDB:ENSG00000168748.13
GeneCardsiCA7
HGNCiHGNC:1381 CA7
HPAiHPA047237
MIMi114770 gene
neXtProtiNX_P43166
OpenTargetsiENSG00000168748
PharmGKBiPA25996
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP43166
KOiK01672
OMAiLYMVKFK
OrthoDBiEOG091G0XFM
PhylomeDBiP43166
TreeFamiTF316425

Enzyme and pathway databases

BRENDAi4.2.1.1 2681
ReactomeiR-HSA-1475029 Reversible hydration of carbon dioxide
SABIO-RKiP43166

Miscellaneous databases

GeneWikiiCarbonic_anhydrase_7
GenomeRNAii766
PROiPR:P43166
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168748 Expressed in 64 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_CA7
ExpressionAtlasiP43166 baseline and differential
GenevisibleiP43166 HS

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAH7_HUMAN
AccessioniPrimary (citable) accession number: P43166
Secondary accession number(s): Q541F0, Q86YU0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 12, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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