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Protein

Extracellular small neutral protease

Gene

snpA

Organism
Streptomyces sp. (strain C5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Milk hydrolyzing.

Catalytic activityi

Hydrolyzes proteins with a preference for Tyr or Phe in the P1' position. Has no action on amino-acid p-nitroanilides.

Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity
  • Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

pH dependencei

Optimum pH is 7.0.

Temperature dependencei

Optimum temperature is 55 degrees Celsius.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi159CalciumBy similarity1
Metal bindingi161CalciumBy similarity1
Metal bindingi166Zinc; catalyticBy similarity1
Active sitei167By similarity1
Metal bindingi170Zinc; catalyticBy similarity1
Metal bindingi176Zinc; catalyticBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandCalcium, Metal-binding, Zinc

Protein family/group databases

MEROPSiM07.001

Names & Taxonomyi

Protein namesi
Recommended name:
Extracellular small neutral protease (EC:3.4.24.77)
Alternative name(s):
Snapalysin
Gene namesi
Name:snpA
OrganismiStreptomyces sp. (strain C5)
Taxonomic identifieri45212 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
PropeptideiPRO_000002865029 – 811 PublicationAdd BLAST53
ChainiPRO_000002865182 – 229Extracellular small neutral proteaseAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi182 ↔ 195By similarity

Keywords - PTMi

Disulfide bond, Zymogen

Interactioni

Subunit structurei

Monomer.

Structurei

3D structure databases

ProteinModelPortaliP43163
SMRiP43163
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M7 family.Curated

Keywords - Domaini

Signal

Family and domain databases

Gene3Di3.40.390.10, 1 hit
InterProiView protein in InterPro
IPR024079 MetalloPept_cat_dom_sf
IPR000013 Peptidase_M7
PfamiView protein in Pfam
PF02031 Peptidase_M7, 1 hit
PIRSFiPIRSF016573 Peptidase_M7, 1 hit
PRINTSiPR00787 NEUTRALPTASE
ProDomiView protein in ProDom or Entries sharing at least one domain
PD016028 Peptidase_M7, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43163-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRMPLSVLTA AGLSLATLGL GTAGPASATP TAEGAPVVAY DGSPSAGSPA
60 70 80 90 100
DAKAEAAANR AFFEAVLRSV AEKRAANPKS TAAVTVVYNA SGAPSFATQI
110 120 130 140 150
ARGTQIWNSS VSNVRLQAGS SGVDFTYREG NDPRGSYAST DGHGRGYIFL
160 170 180 190 200
DYRQNQTYDS TRVTAHETGH VLGLPDHYSG PCSELMSGGG PGPSCTNAYP
210 220
NSAERSRVNQ LWANGFAAAM DKALEKSAR
Length:229
Mass (Da):23,607
Last modified:November 1, 1995 - v1
Checksum:i60B1CA358C297749
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86606 Genomic DNA No translation available.

Similar proteinsi

Entry informationi

Entry nameiSNPA_STRS5
AccessioniPrimary (citable) accession number: P43163
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 22, 2017
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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