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Protein

Netrin receptor DCC

Gene

DCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.2 Publications

Miscellaneous

Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and hematogenous metastatic tumor dissemination.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • netrin receptor activity Source: InterPro
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, Receptor
Biological processApoptosis

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-373752 Netrin-1 signaling
R-HSA-376172 DSCAM interactions
R-HSA-418885 DCC mediated attractive signaling
R-HSA-418886 Netrin mediated repulsion signals
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P43146

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Netrin receptor DCC
Alternative name(s):
Colorectal cancer suppressor
Immunoglobulin superfamily DCC subclass member 1
Tumor suppressor protein DCC
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DCC
Synonyms:IGDCC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 18

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187323.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2701 DCC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
120470 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43146

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini26 – 1097ExtracellularSequence analysisAdd BLAST1072
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1098 – 1122HelicalSequence analysisAdd BLAST25
Topological domaini1123 – 1447CytoplasmicSequence analysisAdd BLAST325

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Mirror movements 1 (MRMV1)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Some MRMV1 patients have agenesis of the corpus callosum.
See also OMIM:157600
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_079145275 – 1447Missing in MRMV1. 1 PublicationAdd BLAST1173
Natural variantiVAR_079146597R → P in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057519056Ensembl.1
Natural variantiVAR_079147743M → L in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199651452EnsemblClinVar.1
Natural variantiVAR_079148754V → M in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs775565634EnsemblClinVar.1
Natural variantiVAR_079149793V → G in MRMV1. 1 PublicationCorresponds to variant dbSNP:rs1057519054Ensembl.1
Natural variantiVAR_079150805G → E in MRMV1. 1 PublicationCorresponds to variant dbSNP:rs1057519055Ensembl.1
Natural variantiVAR_079151893A → T in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057519057Ensembl.1
Natural variantiVAR_0791521217M → V in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1039528164Ensembl.1
Natural variantiVAR_0791531250A → T in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748112308EnsemblClinVar.1
Gaze palsy, familial horizontal, with progressive scoliosis, 2 (HGPPS2)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive neurologic disorder characterized by global developmental delay, delayed walking, intellectual disability, horizontal gaze palsy, and childhood-onset progressive scoliosis.
See also OMIM:617542
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_079287691Q → K in HGPPS2; unknown pathological significance. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi1432L → S: Abolishes interaction with MYO10. 1 Publication1
Mutagenesisi1435 – 1436LM → SS: Abolishes interaction with MYO10. 1 Publication2
Mutagenesisi1439L → S: Abolishes interaction with MYO10. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation, Tumor suppressor

Organism-specific databases

DisGeNET

More...
DisGeNETi
1630

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
DCC

MalaCards human disease database

More...
MalaCardsi
DCC
MIMi157600 phenotype
617542 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000187323

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
238722 Familial congenital mirror movements
478 Kallmann syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27170

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DCC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434474

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001474426 – 1447Netrin receptor DCCAdd BLAST1422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi61 ↔ 117PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi94N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 212PROSITE-ProRule annotation
Disulfide bondi261 ↔ 310PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi352 ↔ 400PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi628N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi702N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1178Phosphoserine; by MAPK1By similarity1
Modified residuei1187Phosphothreonine; by MAPK1By similarity1
Modified residuei1267Phosphoserine; by MAPK1By similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P43146

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P43146

MaxQB - The MaxQuant DataBase

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MaxQBi
P43146

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P43146

PeptideAtlas

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PeptideAtlasi
P43146

PRoteomics IDEntifications database

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PRIDEi
P43146

ProteomicsDB human proteome resource

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ProteomicsDBi
55591

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P43146

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P43146

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P43146

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187323 Expressed in 92 organ(s), highest expression level in forebrain

CleanEx database of gene expression profiles

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CleanExi
HS_DCC

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P43146 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P43146 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055376
HPA069552

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with DSCAM. Interacts with PTK2/FAK1 and MAPK1. Interacts with NTN1 (By similarity). Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity).By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107998, 41 interactors

Database of interacting proteins

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DIPi
DIP-38423N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P43146

Protein interaction database and analysis system

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IntActi
P43146, 44 interactors

Molecular INTeraction database

More...
MINTi
P43146

STRING: functional protein association networks

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STRINGi
9606.ENSP00000389140

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ED7NMR-A419-524[»]
2ED8NMR-A528-620[»]
2ED9NMR-A602-718[»]
2EDBNMR-A716-818[»]
2EDDNMR-A833-942[»]
2EDENMR-A944-1044[»]
3AU4X-ray1.90B1390-1447[»]
4URTX-ray3.10B844-1043[»]
5X83X-ray3.00A/C721-815[»]
B/D844-1043[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P43146

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P43146

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P43146

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 135Ig-like C2-type 1Add BLAST110
Domaini139 – 229Ig-like C2-type 2Add BLAST91
Domaini234 – 326Ig-like C2-type 3Add BLAST93
Domaini331 – 416Ig-like C2-type 4Add BLAST86
Domaini431 – 524Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini530 – 620Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini625 – 718Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini728 – 821Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini846 – 942Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST97
Domaini947 – 1044Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1432 – 1439Interaction with MYO101 Publication8

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4221 Eukaryota
ENOG410Z913 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158867

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000230686

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005455

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P43146

KEGG Orthology (KO)

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KOi
K06765

Identification of Orthologs from Complete Genome Data

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OMAi
KMMIPMD

Database of Orthologous Groups

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OrthoDBi
217780at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P43146

TreeFam database of animal gene trees

More...
TreeFami
TF321506

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033012 DCC
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR010560 Neogenin_C

The PANTHER Classification System

More...
PANTHERi
PTHR44146:SF3 PTHR44146:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF06583 Neogenin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

P43146-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENSLRCVWV PKLAFVLFGA SLFSAHLQVT GFQIKAFTAL RFLSEPSDAV
60 70 80 90 100
TMRGGNVLLD CSAESDRGVP VIKWKKDGIH LALGMDERKQ QLSNGSLLIQ
110 120 130 140 150
NILHSRHHKP DEGLYQCEAS LGDSGSIISR TAKVAVAGPL RFLSQTESVT
160 170 180 190 200
AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL TPIPGDSRVV VLPSGALQIS
210 220 230 240 250
RLQPGDIGIY RCSARNPASS RTGNEAEVRI LSDPGLHRQL YFLQRPSNVV
260 270 280 290 300
AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV
310 320 330 340 350
TDDDSGMYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF
360 370 380 390 400
ECTVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC
410 420 430 440 450
VAENEAGNAQ TSAQLIVPKP AIPSSSVLPS APRDVVPVLV SSRFVRLSWR
460 470 480 490 500
PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF
510 520 530 540 550
RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLQAVSTS PTSILITWEP
560 570 580 590 600
PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYSLRFLA
610 620 630 640 650
YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT
710 720 730 740 750
VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSVPDL STPMLPPVGV
860 870 880 890 900
QAVALTHDAV RVSWADNSVP KNQKTSEVRL YTVRWRTSFS ASAKYKSEDT
910 920 930 940 950
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD
960 970 980 990 1000
LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI
1010 1020 1030 1040 1050
SGDRLTHQIM DLNLDTMYYF RIQARNSKGV GPLSDPILFR TLKVEHPDKM
1060 1070 1080 1090 1100
ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV
1110 1120 1130 1140 1150
IIVVTVGVIT VLVVVIVAVI CTRRSSAQQR KKRATHSAGK RKGSQKDLRP
1160 1170 1180 1190 1200
PDLWIHHEEM EMKNIEKPSG TDPAGRDSPI QSCQDLTPVS HSQSETQLGS
1210 1220 1230 1240 1250
KSTSHSGQDT EEAGSSMSTL ERSLAARRAP RAKLMIPMDA QSNNPAVVSA
1260 1270 1280 1290 1300
IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRSQS
1310 1320 1330 1340 1350
VSEGPTTQQP PMLPPSQPEH SSSEEAPSRT IPTACVRPTH PLRSFANPLL
1360 1370 1380 1390 1400
PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP
1410 1420 1430 1440
TAPEVSEESH KPTEDSANVY EQDDLSEQMA SLEGLMKQLN AITGSAF
Length:1,447
Mass (Da):158,457
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC17EA0E93DE8768
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EQM8E7EQM8_HUMAN
Netrin receptor DCC
DCC
1,424Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QS93J3QS93_HUMAN
Netrin receptor DCC
DCC
1,076Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y2Q5H0Y2Q5_HUMAN
Netrin receptor DCC
DCC
772Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRM6J3QRM6_HUMAN
Netrin receptor DCC
DCC
208Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QQJ6J3QQJ6_HUMAN
Netrin receptor DCC
DCC
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLT8J3QLT8_HUMAN
Netrin receptor DCC
DCC
181Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLB0J3QLB0_HUMAN
Netrin receptor DCC
DCC
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRL3J3QRL3_HUMAN
Netrin receptor DCC
DCC
74Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QKL2J3QKL2_HUMAN
Netrin receptor DCC
DCC
88Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA52175 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA52177 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA52179 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA52180 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti951L → F in CAA53735 (PubMed:7926722).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06025723F → L2 PublicationsCorresponds to variant dbSNP:rs9951523Ensembl.1
Natural variantiVAR_003909168M → T in a esophageal carcinoma. 1 PublicationCorresponds to variant dbSNP:rs121912967EnsemblClinVar.1
Natural variantiVAR_003910201R → G1 PublicationCorresponds to variant dbSNP:rs2229080Ensembl.1
Natural variantiVAR_079145275 – 1447Missing in MRMV1. 1 PublicationAdd BLAST1173
Natural variantiVAR_079146597R → P in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057519056Ensembl.1
Natural variantiVAR_060258679L → R. Corresponds to variant dbSNP:rs2271042Ensembl.1
Natural variantiVAR_079287691Q → K in HGPPS2; unknown pathological significance. 1 Publication1
Natural variantiVAR_079147743M → L in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs199651452EnsemblClinVar.1
Natural variantiVAR_079148754V → M in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs775565634EnsemblClinVar.1
Natural variantiVAR_056043759I → M. Corresponds to variant dbSNP:rs2278339Ensembl.1
Natural variantiVAR_079149793V → G in MRMV1. 1 PublicationCorresponds to variant dbSNP:rs1057519054Ensembl.1
Natural variantiVAR_079150805G → E in MRMV1. 1 PublicationCorresponds to variant dbSNP:rs1057519055Ensembl.1
Natural variantiVAR_079151893A → T in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1057519057Ensembl.1
Natural variantiVAR_0244951017M → V. Corresponds to variant dbSNP:rs984274Ensembl.1
Natural variantiVAR_0355111039F → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0602591191H → L. Corresponds to variant dbSNP:rs2270950Ensembl.1
Natural variantiVAR_0791521217M → V in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs1039528164Ensembl.1
Natural variantiVAR_0791531250A → T in MRMV1; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs748112308EnsemblClinVar.1
Natural variantiVAR_0039111375P → H in a colorectal carcinoma. 1 PublicationCorresponds to variant dbSNP:rs387906555EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X76132 mRNA Translation: CAA53735.1
AC011155 Genomic DNA No translation available.
AC016383 Genomic DNA No translation available.
AC019239 Genomic DNA No translation available.
AC021486 Genomic DNA No translation available.
AC027248 Genomic DNA No translation available.
AC078999 Genomic DNA No translation available.
AC090660 Genomic DNA No translation available.
AC100777 Genomic DNA No translation available.
AC103949 Genomic DNA No translation available.
AC110591 Genomic DNA No translation available.
AC116002 Genomic DNA No translation available.
M32292 mRNA Translation: AAA35751.1
M32286 Genomic DNA Translation: AAA52174.1
M32288 Genomic DNA Translation: AAA52175.1 Sequence problems.
M32290 Genomic DNA Translation: AAA52176.1
M63696 Genomic DNA Translation: AAA52177.1 Different initiation.
M63700 Genomic DNA Translation: AAA52178.1
M63702 Genomic DNA Translation: AAA52179.1 Different initiation.
M63718 Genomic DNA Translation: AAA52180.1 Different initiation.
M63698 Genomic DNA Translation: AAA52181.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11952.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A54100

NCBI Reference Sequences

More...
RefSeqi
NP_005206.2, NM_005215.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.162025

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000442544; ENSP00000389140; ENSG00000187323

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1630

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1630

UCSC genome browser

More...
UCSCi
uc002lfe.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76132 mRNA Translation: CAA53735.1
AC011155 Genomic DNA No translation available.
AC016383 Genomic DNA No translation available.
AC019239 Genomic DNA No translation available.
AC021486 Genomic DNA No translation available.
AC027248 Genomic DNA No translation available.
AC078999 Genomic DNA No translation available.
AC090660 Genomic DNA No translation available.
AC100777 Genomic DNA No translation available.
AC103949 Genomic DNA No translation available.
AC110591 Genomic DNA No translation available.
AC116002 Genomic DNA No translation available.
M32292 mRNA Translation: AAA35751.1
M32286 Genomic DNA Translation: AAA52174.1
M32288 Genomic DNA Translation: AAA52175.1 Sequence problems.
M32290 Genomic DNA Translation: AAA52176.1
M63696 Genomic DNA Translation: AAA52177.1 Different initiation.
M63700 Genomic DNA Translation: AAA52178.1
M63702 Genomic DNA Translation: AAA52179.1 Different initiation.
M63718 Genomic DNA Translation: AAA52180.1 Different initiation.
M63698 Genomic DNA Translation: AAA52181.1
CCDSiCCDS11952.1
PIRiA54100
RefSeqiNP_005206.2, NM_005215.3
UniGeneiHs.162025

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ED7NMR-A419-524[»]
2ED8NMR-A528-620[»]
2ED9NMR-A602-718[»]
2EDBNMR-A716-818[»]
2EDDNMR-A833-942[»]
2EDENMR-A944-1044[»]
3AU4X-ray1.90B1390-1447[»]
4URTX-ray3.10B844-1043[»]
5X83X-ray3.00A/C721-815[»]
B/D844-1043[»]
ProteinModelPortaliP43146
SMRiP43146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107998, 41 interactors
DIPiDIP-38423N
ELMiP43146
IntActiP43146, 44 interactors
MINTiP43146
STRINGi9606.ENSP00000389140

PTM databases

iPTMnetiP43146
PhosphoSitePlusiP43146
SwissPalmiP43146

Polymorphism and mutation databases

BioMutaiDCC
DMDMi296434474

Proteomic databases

EPDiP43146
jPOSTiP43146
MaxQBiP43146
PaxDbiP43146
PeptideAtlasiP43146
PRIDEiP43146
ProteomicsDBi55591

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1630
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442544; ENSP00000389140; ENSG00000187323
GeneIDi1630
KEGGihsa:1630
UCSCiuc002lfe.3 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1630
DisGeNETi1630
EuPathDBiHostDB:ENSG00000187323.11

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DCC
GeneReviewsiDCC

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0039754
HGNCiHGNC:2701 DCC
HPAiHPA055376
HPA069552
MalaCardsiDCC
MIMi120470 gene
157600 phenotype
617542 phenotype
neXtProtiNX_P43146
OpenTargetsiENSG00000187323
Orphaneti238722 Familial congenital mirror movements
478 Kallmann syndrome
PharmGKBiPA27170

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG4221 Eukaryota
ENOG410Z913 LUCA
GeneTreeiENSGT00940000158867
HOGENOMiHOG000230686
HOVERGENiHBG005455
InParanoidiP43146
KOiK06765
OMAiKMMIPMD
OrthoDBi217780at2759
PhylomeDBiP43146
TreeFamiTF321506

Enzyme and pathway databases

ReactomeiR-HSA-373752 Netrin-1 signaling
R-HSA-376172 DSCAM interactions
R-HSA-418885 DCC mediated attractive signaling
R-HSA-418886 Netrin mediated repulsion signals
R-HSA-418889 Caspase activation via Dependence Receptors in the absence of ligand
R-HSA-418890 Role of second messengers in netrin-1 signaling
R-HSA-428542 Regulation of commissural axon pathfinding by SLIT and ROBO
SIGNORiP43146

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DCC human
EvolutionaryTraceiP43146

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Deleted_in_Colorectal_Cancer

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1630

Protein Ontology

More...
PROi
PR:P43146

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000187323 Expressed in 92 organ(s), highest expression level in forebrain
CleanExiHS_DCC
ExpressionAtlasiP43146 baseline and differential
GenevisibleiP43146 HS

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR033012 DCC
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR010560 Neogenin_C
PANTHERiPTHR44146:SF3 PTHR44146:SF3, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF06583 Neogenin_C, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDCC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43146
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 18, 2010
Last modified: January 16, 2019
This is version 186 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
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