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Protein

Neuronal acetylcholine receptor subunit alpha-6

Gene

Chrna6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-6
Gene namesi
Name:Chrna6
Synonyms:Acra6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69281 Chrna6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 240ExtracellularSequence analysisAdd BLAST210
Transmembranei241 – 265HelicalSequence analysisAdd BLAST25
Transmembranei272 – 290HelicalSequence analysisAdd BLAST19
Transmembranei306 – 327HelicalSequence analysisAdd BLAST22
Topological domaini328 – 464CytoplasmicSequence analysisAdd BLAST137
Transmembranei465 – 484HelicalSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL4747

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30By similarityAdd BLAST30
ChainiPRO_000000036331 – 493Neuronal acetylcholine receptor subunit alpha-6Add BLAST463

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi54N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi158 ↔ 172By similarity
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi222 ↔ 223Associated with receptor activationBy similarity
Modified residuei401PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP43143
PRIDEiP43143

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Interacts with LYPD6.By similarity

Protein-protein interaction databases

ComplexPortaliCPX-203 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
CPX-211 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4
STRINGi10116.ENSRNOP00000016452

Chemistry databases

BindingDBiP43143

Structurei

3D structure databases

ProteinModelPortaliP43143
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3644 Eukaryota
ENOG410XP43 LUCA
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP43143
KOiK04808
PhylomeDBiP43143

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P43143-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLNGWGRGDL RSGLCLWICG FLAFFKGSRG CVSEEQLFHT LFAHYNRFIR
60 70 80 90 100
PVENVSDPVT VHFELAITQL ANVDEVNQIM ETNLWLRHVW KDYRLCWDPT
110 120 130 140 150
EYDGIETLRV PADNIWKPDI VLYNNAVGDF QVEGKTKALL KYDGVITWTP
160 170 180 190 200
PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT YDKAEIDLLI IGSKVDMNDF
210 220 230 240 250
WENSEWEIVD ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP MFYTINLIIP
260 270 280 290 300
CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVI
310 320 330 340 350
PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPATHTMPKW VKTMFLQVFP
360 370 380 390 400
SILMMRRPLD KTKEMDGVKD PKTHTKRPAK VKFTHRKEPK LLKECRHCHK
410 420 430 440 450
SSEIAPGKRL SQQPAQWVTE NSEHPPDVED VIDSVQFIAE NMKSHNETKE
460 470 480 490
VEDDWKYMAM VVDRVFLWVF IIVCVFGTVG LFLQPLLGNT GAS
Length:493
Mass (Da):56,947
Last modified:November 1, 1995 - v1
Checksum:iA829FAF8FFB060FE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V7L7G3V7L7_RAT
Neuronal acetylcholine receptor sub...
Chrna6 rCG_43054
493Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08227 mRNA Translation: AAA41674.1
RefSeqiNP_476532.1, NM_057184.1
UniGeneiRn.9696

Genome annotation databases

GeneIDi81721
KEGGirno:81721
UCSCiRGD:69281 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08227 mRNA Translation: AAA41674.1
RefSeqiNP_476532.1, NM_057184.1
UniGeneiRn.9696

3D structure databases

ProteinModelPortaliP43143
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-203 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta2-beta3
CPX-211 Neuronal nicotinic acetylcholine receptor complex, alpha3-alpha6-beta4
STRINGi10116.ENSRNOP00000016452

Chemistry databases

BindingDBiP43143
ChEMBLiCHEMBL4747

Proteomic databases

PaxDbiP43143
PRIDEiP43143

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81721
KEGGirno:81721
UCSCiRGD:69281 rat

Organism-specific databases

CTDi8973
RGDi69281 Chrna6

Phylogenomic databases

eggNOGiKOG3644 Eukaryota
ENOG410XP43 LUCA
HOGENOMiHOG000006756
HOVERGENiHBG003756
InParanoidiP43143
KOiK04808
PhylomeDBiP43143

Miscellaneous databases

PROiPR:P43143

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
IPR002394 Nicotinic_acetylcholine_rcpt
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00254 NICOTINICR
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACHA6_RAT
AccessioniPrimary (citable) accession number: P43143
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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