UniProtKB - P43135 (COT2_MOUSE)

BLAST

>sp|P43135|COT2_MOUSE COUP transcription factor 2 OS=Mus musculus OX=10090 GN=Nr2f2 PE=1 SV=2
MAMVVSTWRDPQDEVPGSQGSQASQAPPVPGPPPGAPHTPQTPGQGGPASTPAQTAAGGQ
GGPGGPGSDKQQQQQHIECVVCGDKSSGKHYGQFTCEGCKSFFKRSVRRNLSYTCRANRN
CPIDQHHRNQCQYCRLKKCLKVGMRREAVQRGRMPPTQPTHGQFALTNGDPLNCHSYLSG
YISLLLRAEPYPTSRFGSQCMQPNNIMGIENICELAARMLFSAVEWARNIPFFPDLQITD
QVALLRLTWSELFVLNAAQCSMPLHVAPLLAAAGLHASPMSADRVVAFMDHIRIFQEQVE
KLKALHVDSAEYSCLKAIVLFTSDACGLSDVAHVESLQEKSQCALEEYVRSQYPNQPTRF
GKLLLRLPSLRTVSSSVIEQLFFVRLVGKTPIETLIRDMLLSGSSFNWPYMAIQ

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History
Entry version 160 (07 Nov 2018)
Sequence version 2 (13 Apr 2004)
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Protein

COUP transcription factor 2

Gene

Nr2f2

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity).By similarity

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	76 – 151	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	79 – 99	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	115 – 139	NR C4-typePROSITE-ProRule annotationAdd BLAST	25

GO - Molecular functionⁱ

DNA binding
Source: MGI
Inferred from direct assayⁱ
- 16912278
DNA-binding transcription factor activity Source: MGI
nuclear receptor activity Source: UniProtKB
protein homodimerization activity Source: MGI
retinoic acid binding Source: UniProtKB
sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 7823919
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anterior/posterior pattern specification
Source: MGI
Inferred from mutant phenotypeⁱ
- 15829524
blood vessel morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 15875024
fertilization
Source: MGI
Inferred from mutant phenotypeⁱ
- 17404209
forebrain development
Source: MGI
Inferred from direct assayⁱ
- 15548577
in utero embryonic development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17404209
limb development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15546392
lymph vessel development
Source: BHF-UCL
Inferred from expression patternⁱ
- 19210544
maternal placenta development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17404209
negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
negative regulation of endothelial cell migration Source: MGI
negative regulation of endothelial cell proliferation Source: MGI
negative regulation of transcription, DNA-templated Source: MGI
negative regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 7823919
neuron migration
Source: MGI
Inferred from direct assayⁱ
- 15548577
placenta blood vessel development
Source: MGI
Inferred from mutant phenotypeⁱ
- 17404209
positive regulation of systemic arterial blood pressure Source: MGI
positive regulation of transcription, DNA-templated Source: UniProtKB
radial pattern formation
Source: MGI
Inferred from mutant phenotypeⁱ
- 15829524
regulation of transcription, DNA-templated Source: MGI
regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 19796622
regulation of transcription involved in lymphatic endothelial cell fate commitment Source: MGI
response to estradiol Source: Ensembl
skeletal muscle tissue development
Source: MGI
Inferred from mutant phenotypeⁱ
- 15546392
- 16251273
trophoblast giant cell differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 17404209

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: COUP transcription factor 2 Short name: COUP-TF2 Alternative name(s): Apolipoprotein AI regulatory protein 1 Short name: ARP-1 COUP transcription factor II Short name: COUP-TF II Nuclear receptor subfamily 2 group F member 2
Gene namesⁱ	Name:Nr2f2 Synonyms:Aporp1, Arp-1, Arp1, Tfcoup2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 7

Organism-specific databases

MGIⁱ	MGI:1352452 Nr2f2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	363 – 367	LLLRL → RSLRF: Abolishes interaction with ZFPM2. 1 Publication		5

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053607	1 – 414	COUP transcription factor 2Add BLAST		414

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	51	PhosphothreonineBy similarity		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P43135
PeptideAtlas More...PeptideAtlasⁱ	P43135
PRIDEⁱ	P43135

PTM databases

iPTMnetⁱ	P43135
PhosphoSitePlusⁱ	P43135

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000030551 Expressed in 381 organ(s), highest expression level in gonadal ridge
CleanExⁱ	MM_NR2F2
ExpressionAtlasⁱ	P43135 baseline and differential
Genevisibleⁱ	P43135 MM

Interactionⁱ

Subunit structureⁱ

Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A (By similarity). Interacts with ZFPM2.By similarity1 Publication

GO - Molecular functionⁱ

protein homodimerization activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	198166, 1 interactor
STRINGⁱ	10090.ENSMUSP00000032768

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P43135
SMRⁱ	P43135
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	177 – 403	NR LBDPROSITE-ProRule annotationAdd BLAST		227

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	117 – 414	Interaction with ZFPM21 PublicationAdd BLAST		298
Regionⁱ	337 – 414	Important for dimerizationAdd BLAST		78

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	71 – 75	Poly-Gln		5

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR2 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	79 – 99	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	115 – 139	NR C4-typePROSITE-ProRule annotationAdd BLAST		25

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118948
HOGENOMⁱ	HOG000260820
HOVERGENⁱ	HBG005606
InParanoidⁱ	P43135
KEGG Orthology (KO) More...KOⁱ	K08548
OMAⁱ	HHVIKED
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0YX6
PhylomeDBⁱ	P43135
TreeFamⁱ	TF352097

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

P43135-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS 
        60         70         80         90        100
TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK 
       110        120        130        140        150
SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ 
       160        170        180        190        200
RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC 
       210        220        230        240        250
MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS 
       260        270        280        290        300
ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 
       310        320        330        340        350
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR 
       360        370        380        390        400
SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML 
       410 
LSGSSFNWPY MAIQ

Length:414

Mass (Da):45,571

Last modified:April 13, 2004 - v2

Checksum:ⁱC24CB2E8C8A27E8C

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

D3YYP4	D3YYP4_MOUSE	COUP transcription factor 2 COUP transcription factor 2	Nr2f2	281	Annotation score:
A0A140LJF1	A0A140LJF1_MOUSE	COUP transcription factor 2 COUP transcription factor 2	Nr2f2	170	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	36	A → P in CAA54096 (PubMed:7947324).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X76653 mRNA Translation: CAA54096.1 U07635 mRNA Translation: AAA19854.1 BC042484 mRNA Translation: AAH42484.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS21359.1
NCBI Reference Sequences More...RefSeqⁱ	NP_033827.2, NM_009697.3
UniGeneⁱ	Mm.158143

Genome annotation databases

Ensemblⁱ	ENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551
GeneIDⁱ	11819
KEGGⁱ	mmu:11819
UCSC genome browser More...UCSCⁱ	uc009hni.1 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43135	COUP transcription factor 2	)	HUMAN		414	UniRef100_P24468
COUP transcription factor 2 isoform a		CALJA		414
NR2F2 isoform 2		PANTR		414
Uncharacterized protein		PROCO		414
Uncharacterized protein		Cebus capucinus imitator		414
+15

Protein	Similar proteins		Species	Score	Length	Source
P43135	COUP transcription factor 2	)	HUMAN		414	UniRef90_P24468
COUP transcription factor 2		BOVIN		414
COUP transcription factor 2		RAT		414
COUP transcription factor 2 isoform a		CALJA		414
NR2F2 isoform 2		PANTR		414
+99

Protein	Similar proteins		Species	Score	Length	Source
P43135	COUP transcription factor 2	)	HUMAN		414	UniRef50_P24468
COUP transcription factor 2		RAT		414
COUP transcription factor 2		BOVIN		414
COUP transcription factor 2		CHICK		410
Nuclear receptor subfamily 2 group F member 5		DANRE		403
+640

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X76653 mRNA Translation: CAA54096.1 U07635 mRNA Translation: AAA19854.1 BC042484 mRNA Translation: AAH42484.1
CCDSⁱ	CCDS21359.1
RefSeqⁱ	NP_033827.2, NM_009697.3
UniGeneⁱ	Mm.158143

3D structure databases

ProteinModelPortalⁱ	P43135
SMRⁱ	P43135
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	198166, 1 interactor
STRINGⁱ	10090.ENSMUSP00000032768

PTM databases

iPTMnetⁱ	P43135
PhosphoSitePlusⁱ	P43135

Proteomic databases

PaxDbⁱ	P43135
PeptideAtlasⁱ	P43135
PRIDEⁱ	P43135

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551
GeneIDⁱ	11819
KEGGⁱ	mmu:11819
UCSCⁱ	uc009hni.1 mouse

Organism-specific databases

CTDⁱ	7026
MGIⁱ	MGI:1352452 Nr2f2

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00760000118948
HOGENOMⁱ	HOG000260820
HOVERGENⁱ	HBG005606
InParanoidⁱ	P43135
KOⁱ	K08548
OMAⁱ	HHVIKED
OrthoDBⁱ	EOG091G0YX6
PhylomeDBⁱ	P43135
TreeFamⁱ	TF352097

Miscellaneous databases

ChiTaRSⁱ	Bace2 mouse
Protein Ontology More...PROⁱ	PR:P43135
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000030551 Expressed in 381 organ(s), highest expression level in gonadal ridge
CleanExⁱ	MM_NR2F2
ExpressionAtlasⁱ	P43135 baseline and differential
Genevisibleⁱ	P43135 MM

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003068 COUP_TF IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01282 COUPTNFACTOR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	COT2_MOUSE
Accessionⁱ	P43135Primary (citable) accession number: P43135
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	April 13, 2004
	Last modified:	November 7, 2018
	This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P43135 (COT2_MOUSE)

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COUP transcription factor 2

Nr2f2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ