UniProtKB - P43135 (COT2_MOUSE)
COUP transcription factor 2
Nr2f2
Functioni
Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 76 – 151 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 76 | |
Zinc fingeri | 79 – 99 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 115 – 139 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- nuclear receptor activity Source: UniProtKB
- protein homodimerization activity Source: MGI
- retinoic acid binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific DNA binding Source: MGI
- zinc ion binding Source: InterPro
GO - Biological processi
- anatomical structure development Source: GO_Central
- anterior/posterior pattern specification Source: MGI
- blood vessel morphogenesis Source: MGI
- cell differentiation Source: GO_Central
- female gonad development Source: UniProtKB
- fertilization Source: MGI
- forebrain development Source: MGI
- in utero embryonic development Source: MGI
- limb development Source: MGI
- lymphatic endothelial cell fate commitment Source: MGI
- lymph vessel development Source: BHF-UCL
- maternal placenta development Source: MGI
- negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
- negative regulation of endothelial cell migration Source: MGI
- negative regulation of endothelial cell proliferation Source: MGI
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- neuron migration Source: MGI
- placenta blood vessel development Source: MGI
- positive regulation of systemic arterial blood pressure Source: MGI
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- radial pattern formation Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: MGI
- response to estradiol Source: Ensembl
- skeletal muscle tissue development Source: MGI
- trophoblast giant cell differentiation Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: COUP transcription factor 2Short name: COUP-TF2 Alternative name(s): Apolipoprotein AI regulatory protein 1 Short name: ARP-1 COUP transcription factor II Short name: COUP-TF II Nuclear receptor subfamily 2 group F member 2 |
Gene namesi | Name:Nr2f2 Synonyms:Aporp1, Arp-1, Arp1, Tfcoup2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1352452, Nr2f2 |
VEuPathDBi | HostDB:ENSMUSG00000030551 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
Keywords - Cellular componenti
NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 363 – 367 | LLLRL → RSLRF: Abolishes interaction with ZFPM2. 1 Publication | 5 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053607 | 1 – 414 | COUP transcription factor 2Add BLAST | 414 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 51 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | P43135 |
PeptideAtlasi | P43135 |
PRIDEi | P43135 |
ProteomicsDBi | 283355 |
PTM databases
iPTMneti | P43135 |
PhosphoSitePlusi | P43135 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030551, Expressed in uterus and 398 other tissues |
Genevisiblei | P43135, MM |
Interactioni
Subunit structurei
Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6.
Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A (By similarity).
Interacts with ZFPM2.
By similarity1 PublicationGO - Molecular functioni
- protein homodimerization activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 198166, 1 interactor |
IntActi | P43135, 2 interactors |
MINTi | P43135 |
STRINGi | 10090.ENSMUSP00000032768 |
Miscellaneous databases
RNActi | P43135, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 177 – 403 | NR LBDPROSITE-ProRule annotationAdd BLAST | 227 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 72 | DisorderedSequence analysisAdd BLAST | 72 | |
Regioni | 117 – 414 | Interaction with ZFPM21 PublicationAdd BLAST | 298 | |
Regioni | 337 – 414 | Important for dimerizationAdd BLAST | 78 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 26 – 41 | Pro residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 43 – 57 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 79 – 99 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 115 – 139 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 25 |
Keywords - Domaini
Zinc-fingerPhylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000157540 |
InParanoidi | P43135 |
OMAi | FATVNWA |
OrthoDBi | 666130at2759 |
PhylomeDBi | P43135 |
TreeFami | TF352097 |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS
60 70 80 90 100
TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK
110 120 130 140 150
SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ
160 170 180 190 200
RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC
210 220 230 240 250
MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS
260 270 280 290 300
ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE
310 320 330 340 350
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR
360 370 380 390 400
SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML
410
LSGSSFNWPY MAIQ
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YYP4 | D3YYP4_MOUSE | COUP transcription factor 2 | Nr2f2 | 281 | Annotation score: | ||
A0A140LJF1 | A0A140LJF1_MOUSE | COUP transcription factor 2 | Nr2f2 | 170 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 36 | A → P in CAA54096 (PubMed:7947324).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76653 mRNA Translation: CAA54096.1 U07635 mRNA Translation: AAA19854.1 BC042484 mRNA Translation: AAH42484.1 |
CCDSi | CCDS21359.1 |
RefSeqi | NP_033827.2, NM_009697.3 |
Genome annotation databases
Ensembli | ENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551 |
GeneIDi | 11819 |
KEGGi | mmu:11819 |
UCSCi | uc009hni.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76653 mRNA Translation: CAA54096.1 U07635 mRNA Translation: AAA19854.1 BC042484 mRNA Translation: AAH42484.1 |
CCDSi | CCDS21359.1 |
RefSeqi | NP_033827.2, NM_009697.3 |
3D structure databases
SMRi | P43135 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198166, 1 interactor |
IntActi | P43135, 2 interactors |
MINTi | P43135 |
STRINGi | 10090.ENSMUSP00000032768 |
PTM databases
iPTMneti | P43135 |
PhosphoSitePlusi | P43135 |
Proteomic databases
PaxDbi | P43135 |
PeptideAtlasi | P43135 |
PRIDEi | P43135 |
ProteomicsDBi | 283355 |
Protocols and materials databases
Antibodypediai | 16260, 329 antibodies from 34 providers |
DNASUi | 11819 |
Genome annotation databases
Ensembli | ENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551 |
GeneIDi | 11819 |
KEGGi | mmu:11819 |
UCSCi | uc009hni.1, mouse |
Organism-specific databases
CTDi | 7026 |
MGIi | MGI:1352452, Nr2f2 |
VEuPathDBi | HostDB:ENSMUSG00000030551 |
Phylogenomic databases
eggNOGi | KOG3575, Eukaryota |
GeneTreei | ENSGT00940000157540 |
InParanoidi | P43135 |
OMAi | FATVNWA |
OrthoDBi | 666130at2759 |
PhylomeDBi | P43135 |
TreeFami | TF352097 |
Miscellaneous databases
BioGRID-ORCSi | 11819, 5 hits in 66 CRISPR screens |
ChiTaRSi | Nr2f2, mouse |
PROi | PR:P43135 |
RNActi | P43135, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030551, Expressed in uterus and 398 other tissues |
Genevisiblei | P43135, MM |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | COT2_MOUSE | |
Accessioni | P43135Primary (citable) accession number: P43135 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | April 13, 2004 | |
Last modified: | February 23, 2022 | |
This is version 178 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families