COUP transcription factor 2

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Plasticity and expanding complexity of the hepatic transcription factor network during liver development."
    Kyrmizi I., Hatzis P., Katrakili N., Tronche F., Gonzalez F.J., Talianidis I.
    Genes Dev 20:2293-2305(2006) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGI
• nuclear receptor activity Source: UniProtKB
• protein homodimerization activity Source: MGI
• retinoic acid binding Source: UniProtKB
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • "A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells."
    Ben-Shushan E., Sharir H., Pikarsky E., Bergman Y.
    Mol Cell Biol 15:1034-1048(1995) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• anatomical structure development Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• anterior/posterior pattern specification Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "COUP-TFII is essential for radial and anteroposterior patterning of the stomach."
    Takamoto N., You L.R., Moses K., Chiang C., Zimmer W.E., Schwartz R.J., DeMayo F.J., Tsai M.J., Tsai S.Y.
    Development 132:2179-2189(2005) [PubMed] [Europe PMC] [Abstract]
• blood vessel morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity."
    You L.R., Lin F.J., Lee C.T., DeMayo F.J., Tsai M.J., Tsai S.Y.
    Nature 435:98-104(2005) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• female gonad development Source: UniProtKB
• fertilization Source: MGIInferred from mutant phenotypeⁱ
  • "Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency."
    Petit F.G., Jamin S.P., Kurihara I., Behringer R.R., DeMayo F.J., Tsai M.J., Tsai S.Y.
    Proc Natl Acad Sci U S A 104:6293-6298(2007) [PubMed] [Europe PMC] [Abstract]
• forebrain development Source: MGIInferred from direct assayⁱ
  • "The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain."
    Tripodi M., Filosa A., Armentano M., Studer M.
    Development 131:6119-6129(2004) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency."
    Petit F.G., Jamin S.P., Kurihara I., Behringer R.R., DeMayo F.J., Tsai M.J., Tsai S.Y.
    Proc Natl Acad Sci U S A 104:6293-6298(2007) [PubMed] [Europe PMC] [Abstract]
• limb development Source: MGIInferred from mutant phenotypeⁱ
  • "The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development."
    Lee C.T., Li L., Takamoto N., Martin J.F., Demayo F.J., Tsai M.J., Tsai S.Y.
    Mol Cell Biol 24:10835-10843(2004) [PubMed] [Europe PMC] [Abstract]
• lymphatic endothelial cell fate commitment Source: MGI
• lymph vessel development Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction."
    Yamazaki T., Yoshimatsu Y., Morishita Y., Miyazono K., Watabe T.
    Genes Cells 14:425-434(2009) [PubMed] [Europe PMC] [Abstract]
• maternal placenta development Source: MGIInferred from mutant phenotypeⁱ
  • "Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency."
    Petit F.G., Jamin S.P., Kurihara I., Behringer R.R., DeMayo F.J., Tsai M.J., Tsai S.Y.
    Proc Natl Acad Sci U S A 104:6293-6298(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
• negative regulation of endothelial cell migration Source: MGI
• negative regulation of endothelial cell proliferation Source: MGI
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells."
    Ben-Shushan E., Sharir H., Pikarsky E., Bergman Y.
    Mol Cell Biol 15:1034-1048(1995) [PubMed] [Europe PMC] [Abstract]
• neuron migration Source: MGIInferred from direct assayⁱ
  • "The COUP-TF nuclear receptors regulate cell migration in the mammalian basal forebrain."
    Tripodi M., Filosa A., Armentano M., Studer M.
    Development 131:6119-6129(2004) [PubMed] [Europe PMC] [Abstract]
• placenta blood vessel development Source: MGIInferred from mutant phenotypeⁱ
  • "Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency."
    Petit F.G., Jamin S.P., Kurihara I., Behringer R.R., DeMayo F.J., Tsai M.J., Tsai S.Y.
    Proc Natl Acad Sci U S A 104:6293-6298(2007) [PubMed] [Europe PMC] [Abstract]
• positive regulation of systemic arterial blood pressure Source: MGI
• positive regulation of transcription, DNA-templated Source: UniProtKB
• positive regulation of transcription by RNA polymerase II Source: MGI
• radial pattern formation Source: MGIInferred from mutant phenotypeⁱ
  • "COUP-TFII is essential for radial and anteroposterior patterning of the stomach."
    Takamoto N., You L.R., Moses K., Chiang C., Zimmer W.E., Schwartz R.J., DeMayo F.J., Tsai M.J., Tsai S.Y.
    Development 132:2179-2189(2005) [PubMed] [Europe PMC] [Abstract]
• regulation of transcription, DNA-templated Source: MGI
• regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • "Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors."
    Nishiyama A., Xin L., Sharov A.A., Thomas M., Mowrer G., Meyers E., Piao Y., Mehta S., Yee S., Nakatake Y., Stagg C., Sharova L., Correa-Cerro L.S., Bassey U., Hoang H., Kim E., Tapnio R., Qian Y.

    , Dudekula D., Zalzman M., Li M., Falco G., Yang H.T., Lee S.L., Monti M., Stanghellini I., Islam M.N., Nagaraja R., Goldberg I., Wang W., Longo D.L., Schlessinger D., Ko M.S.
    Cell Stem Cell 5:420-433(2009) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: Ensembl
• skeletal muscle tissue development Source: MGIInferred from mutant phenotypeⁱ
  • "The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development."
    Lee C.T., Li L., Takamoto N., Martin J.F., Demayo F.J., Tsai M.J., Tsai S.Y.
    Mol Cell Biol 24:10835-10843(2004) [PubMed] [Europe PMC] [Abstract]
  • "Mouse lacking COUP-TFII as an animal model of Bochdalek-type congenital diaphragmatic hernia."
    You L.R., Takamoto N., Yu C.T., Tanaka T., Kodama T., Demayo F.J., Tsai S.Y., Tsai M.J.
    Proc Natl Acad Sci U S A 102:16351-16356(2005) [PubMed] [Europe PMC] [Abstract]
• trophoblast giant cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Deletion of the orphan nuclear receptor COUP-TFII in uterus leads to placental deficiency."
    Petit F.G., Jamin S.P., Kurihara I., Behringer R.R., DeMayo F.J., Tsai M.J., Tsai S.Y.
    Proc Natl Acad Sci U S A 104:6293-6298(2007) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• protein homodimerization activity Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS 
        60         70         80         90        100
TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK 
       110        120        130        140        150
SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ 
       160        170        180        190        200
RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC 
       210        220        230        240        250
MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS 
       260        270        280        290        300
ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 
       310        320        330        340        350
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR 
       360        370        380        390        400
SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML 
       410 
LSGSSFNWPY MAIQ                                        

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families