MCAM

Functionⁱ

Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.2 Publications

GO - Biological processⁱ

anatomical structure morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 8378324
angiogenesis
Source: MGI
Inferred from direct assayⁱ
- 23878390
cell adhesion
Source: ProtInc
Traceable author statementⁱ
- 8378324
glomerular filtration
Source: UniProtKB
Inferred from expression patternⁱ
- 20354148
positive regulation of cell migration Source: Ensembl
vascular wound healing
Source: UniProtKB
Inferred from expression patternⁱ
- 20354148

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell surface glycoprotein MUC18 Alternative name(s): Cell surface glycoprotein P1H12 Melanoma cell adhesion molecule Melanoma-associated antigen A32 Melanoma-associated antigen MUC18 S-endo 1 endothelial-associated antigen CD_antigen: CD146
Gene namesⁱ	Name:MCAM Synonyms:MUC18
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 11

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000076706.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6934 MCAM
MIMⁱ	155735 gene
neXtProtⁱ	NX_P43121

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 559	ExtracellularSequence analysisAdd BLAST	536
Transmembraneⁱ	560 – 583	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	584 – 646	CytoplasmicSequence analysisAdd BLAST	63

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4162
Open Targets More...OpenTargetsⁱ	ENSG00000076706
PharmGKBⁱ	PA30678

Chemistry databases

ChEMBLⁱ	CHEMBL3712863
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2988

Polymorphism and mutation databases

BioMutaⁱ	MCAM
DMDMⁱ	85681878

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	1 PublicationAdd BLAST		23
ChainⁱPRO_0000014891	24 – 646	Cell surface glycoprotein MUC18Add BLAST		623

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	48 ↔ 116	Curated
Glycosylationⁱ	56	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	161 ↔ 223	Curated
Disulfide bondⁱ	272 ↔ 320	Curated
Disulfide bondⁱ	365 ↔ 407	Curated
Glycosylationⁱ	418	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	449	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	452 ↔ 499	Curated
Glycosylationⁱ	467	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	508	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	518	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	527	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	544	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	606	PhosphoserineBy similarity	1
Modified residueⁱ	614	PhosphoserineCombined sources	1
Modified residueⁱ	628	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P43121
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P43121
PaxDbⁱ	P43121
PeptideAtlas More...PeptideAtlasⁱ	P43121
PRIDEⁱ	P43121
ProteomicsDBⁱ	55589 55590 [P43121-2]

PTM databases

GlyConnectⁱ	1104
iPTMnetⁱ	P43121
PhosphoSitePlusⁱ	P43121
SwissPalmⁱ	P43121

Expressionⁱ

Tissue specificityⁱ

Detected in endothelial cells in vascular tissue throughout the body. May appear at the surface of neural crest cells during their embryonic migration. Appears to be limited to vascular smooth muscle in normal adult tissues. Associated with tumor progression and the development of metastasis in human malignant melanoma. Expressed most strongly on metastatic lesions and advanced primary tumors and is only rarely detected in benign melanocytic nevi and thin primary melanomas with a low probability of metastasis.

Gene expression databases

Bgeeⁱ	ENSG00000076706 Expressed in 231 organ(s), highest expression level in popliteal artery
CleanExⁱ	HS_MCAM
ExpressionAtlasⁱ	P43121 baseline and differential
Genevisibleⁱ	P43121 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002147 HPA008848

HPAⁱ

CAB002147
HPA008848

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	110332, 15 interactors
Database of interacting proteins More...DIPⁱ	DIP-52791N
IntActⁱ	P43121, 8 interactors
Molecular INTeraction database More...MINTⁱ	P43121
STRINGⁱ	9606.ENSP00000264036

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P43121
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	24 – 129	Ig-like V-type 1Add BLAST	106
Domainⁱ	139 – 242	Ig-like V-type 2Add BLAST	104
Domainⁱ	244 – 330	Ig-like C2-type 1Add BLAST	87
Domainⁱ	335 – 424	Ig-like C2-type 2Add BLAST	90
Domainⁱ	430 – 510	Ig-like C2-type 3Add BLAST	81

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IEC2 Eukaryota ENOG4110RPG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063457
HOGENOMⁱ	HOG000015427
HOVERGENⁱ	HBG002808
InParanoidⁱ	P43121
KEGG Orthology (KO) More...KOⁱ	K06534
OMAⁱ	GDQGEKY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G072E
PhylomeDBⁱ	P43121
TreeFamⁱ	TF330534

Family and domain databases

Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR013162 CD80_C2-set IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR013151 Immunoglobulin
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08205 C2-set_2, 1 hit PF00047 ig, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 5 hits SM00408 IGc2, 3 hits
SUPFAMⁱ	SSF48726 SSF48726, 5 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 5 hits

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P43121-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLPRLVCAF LLAACCCCPR VAGVPGEAEQ PAPELVEVEV GSTALLKCGL 
        60         70         80         90        100
SQSQGNLSHV DWFSVHKEKR TLIFRVRQGQ GQSEPGEYEQ RLSLQDRGAT 
       110        120        130        140        150
LALTQVTPQD ERIFLCQGKR PRSQEYRIQL RVYKAPEEPN IQVNPLGIPV 
       160        170        180        190        200
NSKEPEEVAT CVGRNGYPIP QVIWYKNGRP LKEEKNRVHI QSSQTVESSG 
       210        220        230        240        250
LYTLQSILKA QLVKEDKDAQ FYCELNYRLP SGNHMKESRE VTVPVFYPTE 
       260        270        280        290        300
KVWLEVEPVG MLKEGDRVEI RCLADGNPPP HFSISKQNPS TREAEEETTN 
       310        320        330        340        350
DNGVLVLEPA RKEHSGRYEC QGLDLDTMIS LLSEPQELLV NYVSDVRVSP 
       360        370        380        390        400
AAPERQEGSS LTLTCEAESS QDLEFQWLRE ETGQVLERGP VLQLHDLKRE 
       410        420        430        440        450
AGGGYRCVAS VPSIPGLNRT QLVNVAIFGP PWMAFKERKV WVKENMVLNL 
       460        470        480        490        500
SCEASGHPRP TISWNVNGTA SEQDQDPQRV LSTLNVLVTP ELLETGVECT 
       510        520        530        540        550
ASNDLGKNTS ILFLELVNLT TLTPDSNTTT GLSTSTASPH TRANSTSTER 
       560        570        580        590        600
KLPEPESRGV VIVAVIVCIL VLAVLGAVLY FLYKKGKLPC RRSGKQEITL 
       610        620        630        640 
PPSRKSELVV EVKSDKLPEE MGLLQGSSGD KRAPGDQGEK YIDLRH

Length:646

Mass (Da):71,607

Last modified:January 10, 2006 - v2

Checksum:ⁱE46CB8AC7BA0738E

GO

Isoform 2 (identifier: P43121-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-187: MGLPRLVCAF...GRPLKEEKNR → MVYIVRQFLL...SLPPLPPCPG
549-646: ERKLPEPESR...QGEKYIDLRH → GKPGLAREQGCARASFLPCPSPESPVQKGE

« Hide

        10         20         30         40         50
MVYIVRQFLL YNVSGSVYLD QLIVLLTAKF SILRIAGSRV HHSPFSGHLD 
        60         70         80         90        100
GCSFLSLQHS LHTSLDMSRH ENVFLGLTLS SKSAGLKGFQ LAFVPGLLQG 
       110        120        130        140        150
TGGYLDGPLP TPVDNPRVGL EVGLRLSLPP LPPCPGVHIQ SSQTVESSGL 
       160        170        180        190        200
YTLQSILKAQ LVKEDKDAQF YCELNYRLPS GNHMKESREV TVPVFYPTEK 
       210        220        230        240        250
VWLEVEPVGM LKEGDRVEIR CLADGNPPPH FSISKQNPST REAEEETTND 
       260        270        280        290        300
NGVLVLEPAR KEHSGRYECQ GLDLDTMISL LSEPQELLVN YVSDVRVSPA 
       310        320        330        340        350
APERQEGSSL TLTCEAESSQ DLEFQWLREE TGQVLERGPV LQLHDLKREA 
       360        370        380        390        400
GGGYRCVASV PSIPGLNRTQ LVNVAIFGPP WMAFKERKVW VKENMVLNLS 
       410        420        430        440        450
CEASGHPRPT ISWNVNGTAS EQDQDPQRVL STLNVLVTPE LLETGVECTA 
       460        470        480        490        500
SNDLGKNTSI LFLELVNLTT LTPDSNTTTG LSTSTASPHT RANSTSTGKP 
       510        520 
GLAREQGCAR ASFLPCPSPE SPVQKGE

Note: No experimental confirmation available.

Show »

Length:527

Mass (Da):57,605

Checksum:ⁱ68F5C36C5FFD36D6

GO

Sequence cautionⁱ

The sequence BAD93162 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	322 – 324	GLD → AWN (PubMed:2602381).Curated	3
Sequence conflictⁱ	322 – 324	GLD → AWN (PubMed:8378324).Curated	3
Sequence conflictⁱ	383	G → D (PubMed:2602381).Curated	1
Sequence conflictⁱ	383	G → D (PubMed:8378324).Curated	1
Sequence conflictⁱ	383	G → D (PubMed:11709656).Curated	1
Sequence conflictⁱ	424 – 425	NV → KL (PubMed:2602381).Curated	2
Sequence conflictⁱ	424 – 425	NV → KL (PubMed:8378324).Curated	2
Sequence conflictⁱ	606	S → T (PubMed:2602381).Curated	1
Sequence conflictⁱ	606	S → T (PubMed:8378324).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_049915	89	E → G1 PublicationCorresponds to variant dbSNP:rs34587557Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_016938	1 – 187	MGLPR…EEKNR → MVYIVRQFLLYNVSGSVYLD QLIVLLTAKFSILRIAGSRV HHSPFSGHLDGCSFLSLQHS LHTSLDMSRHENVFLGLTLS SKSAGLKGFQLAFVPGLLQG TGGYLDGPLPTPVDNPRVGL EVGLRLSLPPLPPCPG in isoform 2. 1 PublicationAdd BLAST		187
Alternative sequenceⁱVSP_016939	549 – 646	ERKLP…IDLRH → GKPGLAREQGCARASFLPCP SPESPVQKGE in isoform 2. 1 PublicationAdd BLAST		98

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29277 mRNA Translation: AAA20824.1 M28882 mRNA Translation: AAA20922.1 X68264 X68271 Genomic DNA Translation: CAA48332.1 AF089868 mRNA Translation: AAD17799.1 AK126303 mRNA Translation: BAC86520.1 AB209925 mRNA Translation: BAD93162.1 Different initiation. BC056418 mRNA Translation: AAH56418.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS31690.1 [P43121-1]
PIRⁱ	I38049
NCBI Reference Sequences More...RefSeqⁱ	NP_006491.2, NM_006500.2 [P43121-1]
UniGeneⁱ	Hs.599039

Genome annotation databases

Ensemblⁱ	ENST00000264036; ENSP00000264036; ENSG00000076706 [P43121-1]
GeneIDⁱ	4162
KEGGⁱ	hsa:4162
UCSC genome browser More...UCSCⁱ	uc001pwf.4 human [P43121-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43121	Melanoma cell adhesion molecule, isoform CRA_a		HUMAN		646	UniRef100_P43121

Protein	Similar proteins		Species	Score	Length	Source
P43121	Melanoma cell adhesion molecule, isoform CRA_a		HUMAN		646	UniRef90_P43121
Uncharacterized protein		MANLE		650
Uncharacterized protein		MACFA		649
Uncharacterized protein		AOTNA		647
Uncharacterized protein		RHIRO		647
+34
P43121-2	Uncharacterized protein		RHIBE		457	UniRef90_P43121-2

Protein	Similar proteins		Species	Score	Length	Source
P43121	Melanoma cell adhesion molecule, isoform CRA_a		HUMAN		646	UniRef50_P43121
Uncharacterized protein		MANLE		650
Uncharacterized protein		MACFA		649
Uncharacterized protein		AOTNA		647
Uncharacterized protein		RHIRO		647
+72
P43121-2	Uncharacterized protein		RHIBE		457	UniRef50_P43121-2
Melanoma cell adhesion molecule		RABIT		580
Uncharacterized protein		CERAT		461
Brain cDNA, clone: QflA-11258, similar to human melanoma cell adhesion molecule (MCAM)		MACFA		476
Uncharacterized protein		PAPAN		461
+10

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M29277 mRNA Translation: AAA20824.1 M28882 mRNA Translation: AAA20922.1 X68264 X68271 Genomic DNA Translation: CAA48332.1 AF089868 mRNA Translation: AAD17799.1 AK126303 mRNA Translation: BAC86520.1 AB209925 mRNA Translation: BAD93162.1 Different initiation. BC056418 mRNA Translation: AAH56418.1
CCDSⁱ	CCDS31690.1 [P43121-1]
PIRⁱ	I38049
RefSeqⁱ	NP_006491.2, NM_006500.2 [P43121-1]
UniGeneⁱ	Hs.599039

3D structure databases

ProteinModelPortalⁱ	P43121
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110332, 15 interactors
DIPⁱ	DIP-52791N
IntActⁱ	P43121, 8 interactors
MINTⁱ	P43121
STRINGⁱ	9606.ENSP00000264036

Chemistry databases

ChEMBLⁱ	CHEMBL3712863
GuidetoPHARMACOLOGYⁱ	2988

PTM databases

GlyConnectⁱ	1104
iPTMnetⁱ	P43121
PhosphoSitePlusⁱ	P43121
SwissPalmⁱ	P43121

Polymorphism and mutation databases

BioMutaⁱ	MCAM
DMDMⁱ	85681878

Proteomic databases

EPDⁱ	P43121
MaxQBⁱ	P43121
PaxDbⁱ	P43121
PeptideAtlasⁱ	P43121
PRIDEⁱ	P43121
ProteomicsDBⁱ	55589 55590 [P43121-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	4162
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000264036; ENSP00000264036; ENSG00000076706 [P43121-1]
GeneIDⁱ	4162
KEGGⁱ	hsa:4162
UCSCⁱ	uc001pwf.4 human [P43121-1]

Organism-specific databases

CTDⁱ	4162
DisGeNETⁱ	4162
EuPathDBⁱ	HostDB:ENSG00000076706.14
GeneCardsⁱ	MCAM
HGNCⁱ	HGNC:6934 MCAM
HPAⁱ	CAB002147 HPA008848
MIMⁱ	155735 gene
neXtProtⁱ	NX_P43121
OpenTargetsⁱ	ENSG00000076706
PharmGKBⁱ	PA30678
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IEC2 Eukaryota ENOG4110RPG LUCA
GeneTreeⁱ	ENSGT00530000063457
HOGENOMⁱ	HOG000015427
HOVERGENⁱ	HBG002808
InParanoidⁱ	P43121
KOⁱ	K06534
OMAⁱ	GDQGEKY
OrthoDBⁱ	EOG091G072E
PhylomeDBⁱ	P43121
TreeFamⁱ	TF330534

Miscellaneous databases

ChiTaRSⁱ	MCAM human
GeneWikiⁱ	CD146
GenomeRNAiⁱ	4162
Protein Ontology More...PROⁱ	PR:P43121
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000076706 Expressed in 231 organ(s), highest expression level in popliteal artery
CleanExⁱ	HS_MCAM
ExpressionAtlasⁱ	P43121 baseline and differential
Genevisibleⁱ	P43121 HS

Family and domain databases

Gene3Dⁱ	2.60.40.10, 5 hits
InterProⁱ	View protein in InterPro IPR013162 CD80_C2-set IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR013151 Immunoglobulin
Pfamⁱ	View protein in Pfam PF08205 C2-set_2, 1 hit PF00047 ig, 1 hit PF07686 V-set, 1 hit
SMARTⁱ	View protein in SMART SM00409 IG, 5 hits SM00408 IGc2, 3 hits
SUPFAMⁱ	SSF48726 SSF48726, 5 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	MUC18_HUMAN
Accessionⁱ	P43121Primary (citable) accession number: P43121 Secondary accession number(s): O95812 , Q59E86, Q6PHR3, Q6ZTR2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	January 10, 2006
	Last modified:	October 10, 2018
	This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
Human chromosome 11
Human chromosome 11: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P43121 (MUC18_HUMAN)

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Cell surface glycoprotein MUC18

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Extracellular region or secreted

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ