Hematopoietically-expressed homeobox protein Hhex

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)."
    Cong R., Jiang X., Wilson C.M., Hunter M.P., Vasavada H., Bogue C.W.
    Biochem. Biophys. Res. Commun. 346:535-545(2006) [PubMed] [Europe PMC] [Abstract]
• DNA binding, bending Source: MGI
• DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • "Homeobox protein Hex induces SMemb/nonmuscle myosin heavy chain-B gene expression through the cAMP-responsive element."
    Sekiguchi K., Kurabayashi M., Oyama Y., Aihara Y., Tanaka T., Sakamoto H., Hoshino Y., Kanda T., Yokoyama T., Shimomura Y., Iijima H., Ohyama Y., Nagai R.
    Circ. Res. 88:52-58(2001) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: NTNU_SBInferred from direct assayⁱ
  • "Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)."
    Cong R., Jiang X., Wilson C.M., Hunter M.P., Vasavada H., Bogue C.W.
    Biochem. Biophys. Res. Commun. 346:535-545(2006) [PubMed] [Europe PMC] [Abstract]
• eukaryotic initiation factor 4E binding Source: MGI
• HMG box domain binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."
    Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
    Nucleic Acids Res. 34:1735-1744(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: MGI
• repressing transcription factor binding Source: MGI
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: NTNU_SBInferred from direct assayⁱ
  • "Hhex is a direct repressor of endothelial cell-specific molecule 1 (ESM-1)."
    Cong R., Jiang X., Wilson C.M., Hunter M.P., Vasavada H., Bogue C.W.
    Biochem. Biophys. Res. Commun. 346:535-545(2006) [PubMed] [Europe PMC] [Abstract]
• sequence-specific DNA binding Source: UniProtKB
• transcription factor binding Source: MGI
• transcription regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processⁱ

• animal organ morphogenesis Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas."
    Bort R., Martinez-Barbera J.P., Beddington R.S., Zaret K.S.
    Development 131:797-806(2004) [PubMed] [Europe PMC] [Abstract]
• anterior/posterior pattern specification Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal."
    Zamparini A.L., Watts T., Gardner C.E., Tomlinson S.R., Johnston G.I., Brickman J.M.
    Development 133:3709-3722(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• B cell differentiation Source: BHF-UCLInferred from mutant phenotypeⁱ
  • "Impaired B cell development and function in mice with a targeted disruption of the homeobox gene Hex."
    Bogue C.W., Zhang P.X., McGrath J., Jacobs H.C., Fuleihan R.L.
    Proc. Natl. Acad. Sci. U.S.A. 100:556-561(2003) [PubMed] [Europe PMC] [Abstract]
• cell differentiation Source: MGI
• common bile duct development Source: MGIInferred from mutant phenotypeⁱ
  • "The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis."
    Hunter M.P., Wilson C.M., Jiang X., Cong R., Vasavada H., Kaestner K.H., Bogue C.W.
    Dev. Biol. 308:355-367(2007) [PubMed] [Europe PMC] [Abstract]
• DNA conformation change Source: MGI
• embryonic heart tube development Source: MGIInferred from mutant phenotypeⁱ
  • "A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels."
    Hallaq H., Pinter E., Enciso J., McGrath J., Zeiss C., Brueckner M., Madri J., Jacobs H.C., Wilson C.M., Vasavada H., Jiang X., Bogue C.W.
    Development 131:5197-5209(2004) [PubMed] [Europe PMC] [Abstract]
• embryonic organ development Source: MGIInferred from mutant phenotypeⁱ
  • "Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development."
    Bort R., Signore M., Tremblay K., Martinez Barbera J.P., Zaret K.S.
    Dev. Biol. 290:44-56(2006) [PubMed] [Europe PMC] [Abstract]
• endoderm development Source: MGIInferred from mutant phenotypeⁱ
  • "Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development."
    Bort R., Signore M., Tremblay K., Martinez Barbera J.P., Zaret K.S.
    Dev. Biol. 290:44-56(2006) [PubMed] [Europe PMC] [Abstract]
• forebrain development Source: MGIInferred from mutant phenotypeⁱ
  • "The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation."
    Martinez Barbera J.P., Clements M., Thomas P., Rodriguez T., Meloy D., Kioussis D., Beddington R.S.
    Development 127:2433-2445(2000) [PubMed] [Europe PMC] [Abstract]
  • "Getting your head around Hex and Hesx1: forebrain formation in mouse."
    Martinez-Barbera J.P., Beddington R.S.
    Int. J. Dev. Biol. 45:327-336(2001) [PubMed] [Europe PMC] [Abstract]
  • "A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels."
    Hallaq H., Pinter E., Enciso J., McGrath J., Zeiss C., Brueckner M., Madri J., Jacobs H.C., Wilson C.M., Vasavada H., Jiang X., Bogue C.W.
    Development 131:5197-5209(2004) [PubMed] [Europe PMC] [Abstract]
• forebrain morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Correct patterning of the primitive streak requires the anterior visceral endoderm."
    Stuckey D.W., Di Gregorio A., Clements M., Rodriguez T.A.
    PLoS ONE 6:e17620-e17620(2011) [PubMed] [Europe PMC] [Abstract]
• gall bladder development Source: MGIInferred from mutant phenotypeⁱ
  • "The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis."
    Hunter M.P., Wilson C.M., Jiang X., Cong R., Vasavada H., Kaestner K.H., Bogue C.W.
    Dev. Biol. 308:355-367(2007) [PubMed] [Europe PMC] [Abstract]
• hemopoiesis Source: MGIInferred from mutant phenotypeⁱ
  • "The homeoprotein Hex is required for hemangioblast differentiation."
    Guo Y., Chan R., Ramsey H., Li W., Xie X., Shelley W.C., Martinez-Barbera J.P., Bort B., Zaret K., Yoder M., Hromas R.
    Blood 102:2428-2435(2003) [PubMed] [Europe PMC] [Abstract]
  • "The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation."
    Kubo A., Chen V., Kennedy M., Zahradka E., Daley G.Q., Keller G.
    Blood 105:4590-4597(2005) [PubMed] [Europe PMC] [Abstract]
• hepatic duct development Source: MGIInferred from mutant phenotypeⁱ
  • "The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis."
    Hunter M.P., Wilson C.M., Jiang X., Cong R., Vasavada H., Kaestner K.H., Bogue C.W.
    Dev. Biol. 308:355-367(2007) [PubMed] [Europe PMC] [Abstract]
• hepatoblast differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis."
    Hunter M.P., Wilson C.M., Jiang X., Cong R., Vasavada H., Kaestner K.H., Bogue C.W.
    Dev. Biol. 308:355-367(2007) [PubMed] [Europe PMC] [Abstract]
• hepatocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage."
    Keng V.W., Yagi H., Ikawa M., Nagano T., Myint Z., Yamada K., Tanaka T., Sato A., Muramatsu I., Okabe M., Sato M., Noguchi T.
    Biochem. Biophys. Res. Commun. 276:1155-1161(2000) [PubMed] [Europe PMC] [Abstract]
• interkinetic nuclear migration Source: MGIInferred from mutant phenotypeⁱ
  • "Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development."
    Bort R., Signore M., Tremblay K., Martinez Barbera J.P., Zaret K.S.
    Dev. Biol. 290:44-56(2006) [PubMed] [Europe PMC] [Abstract]
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • "Correct patterning of the primitive streak requires the anterior visceral endoderm."
    Stuckey D.W., Di Gregorio A., Clements M., Rodriguez T.A.
    PLoS ONE 6:e17620-e17620(2011) [PubMed] [Europe PMC] [Abstract]
• liver development Source: MGIInferred from mutant phenotypeⁱ
  • "The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation."
    Martinez Barbera J.P., Clements M., Thomas P., Rodriguez T., Meloy D., Kioussis D., Beddington R.S.
    Development 127:2433-2445(2000) [PubMed] [Europe PMC] [Abstract]
  • "Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage."
    Keng V.W., Yagi H., Ikawa M., Nagano T., Myint Z., Yamada K., Tanaka T., Sato A., Muramatsu I., Okabe M., Sato M., Noguchi T.
    Biochem. Biophys. Res. Commun. 276:1155-1161(2000) [PubMed] [Europe PMC] [Abstract]
  • "A null mutation of Hhex results in abnormal cardiac development, defective vasculogenesis and elevated Vegfa levels."
    Hallaq H., Pinter E., Enciso J., McGrath J., Zeiss C., Brueckner M., Madri J., Jacobs H.C., Wilson C.M., Vasavada H., Jiang X., Bogue C.W.
    Development 131:5197-5209(2004) [PubMed] [Europe PMC] [Abstract]
  • "Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development."
    Bort R., Signore M., Tremblay K., Martinez Barbera J.P., Zaret K.S.
    Dev. Biol. 290:44-56(2006) [PubMed] [Europe PMC] [Abstract]
• morphogenesis of an epithelium Source: MGIInferred from mutant phenotypeⁱ
  • "The homeobox gene Hhex is essential for proper hepatoblast differentiation and bile duct morphogenesis."
    Hunter M.P., Wilson C.M., Jiang X., Cong R., Vasavada H., Kaestner K.H., Bogue C.W.
    Dev. Biol. 308:355-367(2007) [PubMed] [Europe PMC] [Abstract]
• mRNA export from nucleus Source: MGI
• multicellular organism growth Source: MGIInferred from mutant phenotypeⁱ
  • "Correct patterning of the primitive streak requires the anterior visceral endoderm."
    Stuckey D.W., Di Gregorio A., Clements M., Rodriguez T.A.
    PLoS ONE 6:e17620-e17620(2011) [PubMed] [Europe PMC] [Abstract]
• myeloid leukocyte differentiation Source: MGIInferred from mutant phenotypeⁱ
  • "Homeobox gene Hex is essential for onset of mouse embryonic liver development and differentiation of the monocyte lineage."
    Keng V.W., Yagi H., Ikawa M., Nagano T., Myint Z., Yamada K., Tanaka T., Sato A., Muramatsu I., Okabe M., Sato M., Noguchi T.
    Biochem. Biophys. Res. Commun. 276:1155-1161(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of angiogenesis Source: BHF-UCLInferred from direct assayⁱ
  • "HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro."
    Nakagawa T., Abe M., Yamazaki T., Miyashita H., Niwa H., Kokubun S., Sato Y.
    Arterioscler. Thromb. Vasc. Biol. 23:231-237(2003) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function."
    Brickman J.M., Jones C.M., Clements M., Smith J.C., Beddington R.S.P.
    Development 127:2303-2315(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of transcription by RNA polymerase II Source: UniProtKBInferred from direct assayⁱ
  • Ref.6

    "Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function."
    Brickman J.M., Jones C.M., Clements M., Smith J.C., Beddington R.S.P.
    Development 127:2303-2315(2000) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCLInferred from direct assayⁱ
  • "HEX acts as a negative regulator of angiogenesis by modulating the expression of angiogenesis-related gene in endothelial cells in vitro."
    Nakagawa T., Abe M., Yamazaki T., Miyashita H., Niwa H., Kokubun S., Sato Y.
    Arterioscler. Thromb. Vasc. Biol. 23:231-237(2003) [PubMed] [Europe PMC] [Abstract]
• Notch signaling pathway Source: MGIInferred from direct assayⁱ
  • "Hepatic Notch2 deficiency leads to bile duct agenesis perinatally and secondary bile duct formation after weaning."
    Falix F.A., Weeda V.B., Labruyere W.T., Poncy A., de Waart D.R., Hakvoort T.B., Lemaigre F., Gaemers I.C., Aronson D.C., Lamers W.H.
    Dev. Biol. 396:201-213(2014) [PubMed] [Europe PMC] [Abstract]
• pancreas development Source: MGIInferred from mutant phenotypeⁱ
  • "Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development."
    Bort R., Signore M., Tremblay K., Martinez Barbera J.P., Zaret K.S.
    Dev. Biol. 290:44-56(2006) [PubMed] [Europe PMC] [Abstract]
• poly(A)+ mRNA export from nucleus Source: MGI
• positive regulation of transcription by RNA polymerase II Source: MGI
• positive regulation of Wnt signaling pathway Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.7

    "Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal."
    Zamparini A.L., Watts T., Gardner C.E., Tomlinson S.R., Johnston G.I., Brickman J.M.
    Development 133:3709-3722(2006) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• primary lung bud formation Source: MGIInferred from mutant phenotypeⁱ
  • "Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development."
    Bort R., Signore M., Tremblay K., Martinez Barbera J.P., Zaret K.S.
    Dev. Biol. 290:44-56(2006) [PubMed] [Europe PMC] [Abstract]
• primitive streak formation Source: MGIInferred from mutant phenotypeⁱ
  • "Correct patterning of the primitive streak requires the anterior visceral endoderm."
    Stuckey D.W., Di Gregorio A., Clements M., Rodriguez T.A.
    PLoS ONE 6:e17620-e17620(2011) [PubMed] [Europe PMC] [Abstract]
• protein localization to nucleus Source: MGI
• regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Hex homeobox gene-dependent tissue positioning is required for organogenesis of the ventral pancreas."
    Bort R., Martinez-Barbera J.P., Beddington R.S., Zaret K.S.
    Development 131:797-806(2004) [PubMed] [Europe PMC] [Abstract]
• regulation of leukocyte proliferation Source: MGI
• regulation of transcription by RNA polymerase II Source: MGIInferred from mutant phenotypeⁱ
  • "Correct patterning of the primitive streak requires the anterior visceral endoderm."
    Stuckey D.W., Di Gregorio A., Clements M., Rodriguez T.A.
    PLoS ONE 6:e17620-e17620(2011) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: MGIInferred from mutant phenotypeⁱ
  • "Correct patterning of the primitive streak requires the anterior visceral endoderm."
    Stuckey D.W., Di Gregorio A., Clements M., Rodriguez T.A.
    PLoS ONE 6:e17620-e17620(2011) [PubMed] [Europe PMC] [Abstract]
• thyroid gland development Source: MGIInferred from mutant phenotypeⁱ
  • "The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation."
    Martinez Barbera J.P., Clements M., Thomas P., Rodriguez T., Meloy D., Kioussis D., Beddington R.S.
    Development 127:2433-2445(2000) [PubMed] [Europe PMC] [Abstract]
  • "An integrated regulatory network controlling survival and migration in thyroid organogenesis."
    Parlato R., Rosica A., Rodriguez-Mallon A., Affuso A., Postiglione M.P., Arra C., Mansouri A., Kimura S., Di Lauro R., De Felice M.
    Dev. Biol. 276:464-475(2004) [PubMed] [Europe PMC] [Abstract]
• tissue morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Correct patterning of the primitive streak requires the anterior visceral endoderm."
    Stuckey D.W., Di Gregorio A., Clements M., Rodriguez T.A.
    PLoS ONE 6:e17620-e17620(2011) [PubMed] [Europe PMC] [Abstract]
• vasculogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "The homeoprotein Hex is required for hemangioblast differentiation."
    Guo Y., Chan R., Ramsey H., Li W., Xie X., Shelley W.C., Martinez-Barbera J.P., Bort B., Zaret K., Yoder M., Hromas R.
    Blood 102:2428-2435(2003) [PubMed] [Europe PMC] [Abstract]
  • "The homeobox gene HEX regulates proliferation and differentiation of hemangioblasts and endothelial cells during ES cell differentiation."
    Kubo A., Chen V., Kennedy M., Zahradka E., Daley G.Q., Keller G.
    Blood 105:4590-4597(2005) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway Source: UniProtKB-KW

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• eukaryotic initiation factor 4E binding Source: MGI
• HMG box domain binding Source: UniProtKBInferred from physical interactionⁱ
  • "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors."
    Wissmuller S., Kosian T., Wolf M., Finzsch M., Wegner M.
    Nucleic Acids Res. 34:1735-1744(2006) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: MGI
• repressing transcription factor binding Source: MGI
• transcription factor binding Source: MGI

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MQFPHPGPAA APAVGVPLYA PTPLLQPAHP TPFYIDDILG RGPAAPTPTP 
        60         70         80         90        100
TLPSPNSSFT SLVSSYRTPV YEPTPVHPAF SHHPAAALAA AYGPSGFGGP 
       110        120        130        140        150
LYPFPRTVND YTHALLRHDP LGKPLLWSPF LQRPLHKRKG GQVRFSNDQT 
       160        170        180        190        200
VELEKKFETQ KYLSPPERKR LAKMLQLSER QVKTWFQNRR AKWRRLKQEN 
       210        220        230        240        250
PQSNKKDALD SLDTSCEQGQ DLPSEQNKGA SLDRSQCSPS PASQEDPDSE 
       260        270 
ISEDSDQEVD IEGDKGYFNA G                                

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot