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Protein

Prostacyclin receptor

Gene

PTGIR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-391908 Prostanoid ligand receptors
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-418555 G alpha (s) signalling events

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P43119

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P43119

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostacyclin receptor
Alternative name(s):
Prostaglandin I2 receptor
Short name:
PGI receptor
Short name:
PGI2 receptor
Prostanoid IP receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGIR
Synonyms:PRIPR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000160013.8

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9602 PTGIR

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600022 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43119

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei17 – 38Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini39 – 51CytoplasmicSequence analysisAdd BLAST13
Transmembranei52 – 76Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 134CytoplasmicSequence analysisAdd BLAST19
Transmembranei135 – 158Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini159 – 181ExtracellularSequence analysisAdd BLAST23
Transmembranei182 – 208Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini209 – 235CytoplasmicSequence analysisAdd BLAST27
Transmembranei236 – 260Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini261 – 274ExtracellularSequence analysisAdd BLAST14
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 386CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi308C → S: Reduced palmitoylation, coupling to G protein unaffected. Abolished palmitoylation and coupling to G protein; when associated with S-311. 1 Publication1
Mutagenesisi309C → S: No effect on palmitoylation level. 1 Publication1
Mutagenesisi311C → S: Reduced palmitoylation, coupling to G protein unaffected. Abolished palmitoylation and coupling to G protein; when associated with S-308. 1 Publication1
Mutagenesisi383C → S: Abolishes isoprenylation. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5739

Open Targets

More...
OpenTargetsi
ENSG00000160013

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA291

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1995

Drug and drug target database

More...
DrugBanki
DB05229 Beraprost
DB01160 Dinoprost Tromethamine
DB01240 Epoprostenol
DB01088 Iloprost
DB11362 Selexipag
DB00374 Treprostinil

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
345

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTGIR

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1172500

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700751 – 383Prostacyclin receptorAdd BLAST383
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000240004384 – 386Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi5 ↔ 165PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 170PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi308S-palmitoyl cysteine1 Publication1
Lipidationi311S-palmitoyl cysteine1 Publication1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei383Cysteine methyl esterCurated1
Lipidationi383S-farnesyl cysteine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.1 Publication
Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei309Not S-palmitoylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43119

PeptideAtlas

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PeptideAtlasi
P43119

PRoteomics IDEntifications database

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PRIDEi
P43119

ProteomicsDB human proteome resource

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ProteomicsDBi
55588

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43119

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43119

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P43119

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000160013 Expressed in 111 organ(s), highest expression level in left coronary artery

CleanEx database of gene expression profiles

More...
CleanExi
HS_PTGIR

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P43119 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43119 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (non-isoprenylated C-terminus) with PDZK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111711, 74 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000291294

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P43119

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P43119

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153529

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115475

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003074

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P43119

KEGG Orthology (KO)

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KOi
K04263

Identification of Orthologs from Complete Genome Data

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OMAi
SWCFIRM

Database of Orthologous Groups

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OrthoDBi
EOG091G0F07

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43119

TreeFam database of animal gene trees

More...
TreeFami
TF324982

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR000370 Prostglndn_IP_rcpt

The PANTHER Classification System

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PANTHERi
PTHR11866 PTHR11866, 1 hit
PTHR11866:SF7 PTHR11866:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR01788 PROSTANOIDR
PR00856 PRSTNOIDIPR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P43119-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA
60 70 80 90 100
VLVTGLAATD LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT
110 120 130 140 150
FFGLASMLIL FAMAVERCLA LSHPYLYAQL DGPRCARLAL PAIYAFCVLF
160 170 180 190 200
CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG GAAFSLAYAG LVALLVAAIF
210 220 230 240 250
LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL LALMTVVMAV
260 270 280 290 300
CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF
310 320 330 340 350
QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS
360 370 380
AWGEGQVEPL PPTQQSSGSA VGTSSKAEAS VACSLC
Length:386
Mass (Da):40,956
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2B6B0CDBACED1608
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0B4J2A7A0A0B4J2A7_HUMAN
Prostacyclin receptor
PTGIR hCG_1777582
296Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QXV5M0QXV5_HUMAN
Prostacyclin receptor
PTGIR
143Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZW0M0QZW0_HUMAN
Prostacyclin receptor
PTGIR
174Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M0QZI2M0QZI2_HUMAN
Prostacyclin receptor
PTGIR
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02426025V → M. Corresponds to variant dbSNP:rs2229127Ensembl.1
Natural variantiVAR_061226319S → W. Corresponds to variant dbSNP:rs28590598Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L29016 mRNA Translation: AAA36448.1
D25418 mRNA Translation: BAA05008.1
D29634 mRNA Translation: BAA06110.1
D38127 Genomic DNA Translation: BAA07325.1
AY242134 mRNA Translation: AAO92301.1
BC075814 mRNA Translation: AAH75814.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12686.1

Protein sequence database of the Protein Information Resource

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PIRi
A57066

NCBI Reference Sequences

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RefSeqi
NP_000951.1, NM_000960.3

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.458324

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000291294; ENSP00000291294; ENSG00000160013

Database of genes from NCBI RefSeq genomes

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GeneIDi
5739

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5739

UCSC genome browser

More...
UCSCi
uc002pex.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29016 mRNA Translation: AAA36448.1
D25418 mRNA Translation: BAA05008.1
D29634 mRNA Translation: BAA06110.1
D38127 Genomic DNA Translation: BAA07325.1
AY242134 mRNA Translation: AAO92301.1
BC075814 mRNA Translation: AAH75814.1
CCDSiCCDS12686.1
PIRiA57066
RefSeqiNP_000951.1, NM_000960.3
UniGeneiHs.458324

3D structure databases

ProteinModelPortaliP43119
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111711, 74 interactors
STRINGi9606.ENSP00000291294

Chemistry databases

BindingDBiP43119
ChEMBLiCHEMBL1995
DrugBankiDB05229 Beraprost
DB01160 Dinoprost Tromethamine
DB01240 Epoprostenol
DB01088 Iloprost
DB11362 Selexipag
DB00374 Treprostinil
GuidetoPHARMACOLOGYi345

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

iPTMnetiP43119
PhosphoSitePlusiP43119
SwissPalmiP43119

Polymorphism and mutation databases

BioMutaiPTGIR
DMDMi1172500

Proteomic databases

PaxDbiP43119
PeptideAtlasiP43119
PRIDEiP43119
ProteomicsDBi55588

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
5739
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291294; ENSP00000291294; ENSG00000160013
GeneIDi5739
KEGGihsa:5739
UCSCiuc002pex.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
5739
DisGeNETi5739
EuPathDBiHostDB:ENSG00000160013.8

GeneCards: human genes, protein and diseases

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GeneCardsi
PTGIR
HGNCiHGNC:9602 PTGIR
MIMi600022 gene
neXtProtiNX_P43119
OpenTargetsiENSG00000160013
PharmGKBiPA291

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000153529
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiP43119
KOiK04263
OMAiSWCFIRM
OrthoDBiEOG091G0F07
PhylomeDBiP43119
TreeFamiTF324982

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-418555 G alpha (s) signalling events
SABIO-RKiP43119
SIGNORiP43119

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Prostacyclin_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
5739

Protein Ontology

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PROi
PR:P43119

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000160013 Expressed in 111 organ(s), highest expression level in left coronary artery
CleanExiHS_PTGIR
ExpressionAtlasiP43119 baseline and differential
GenevisibleiP43119 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR000370 Prostglndn_IP_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF7 PTHR11866:SF7, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00856 PRSTNOIDIPR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPI2R_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43119
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: December 5, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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