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Protein

Prostacyclin receptor

Gene

PTGIR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • cell-cell signaling Source: ProtInc
  • G-protein coupled receptor signaling pathway Source: Reactome
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
  • negative regulation of smooth muscle cell proliferation Source: BHF-UCL
  • response to lipopolysaccharide Source: Ensembl

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-392851 Prostacyclin signalling through prostacyclin receptor
R-HSA-418555 G alpha (s) signalling events
SIGNORiP43119

Names & Taxonomyi

Protein namesi
Recommended name:
Prostacyclin receptor
Alternative name(s):
Prostaglandin I2 receptor
Short name:
PGI receptor
Short name:
PGI2 receptor
Prostanoid IP receptor
Gene namesi
Name:PTGIR
Synonyms:PRIPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000160013.8
HGNCiHGNC:9602 PTGIR
MIMi600022 gene
neXtProtiNX_P43119

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 38Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini39 – 51CytoplasmicSequence analysisAdd BLAST13
Transmembranei52 – 76Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 134CytoplasmicSequence analysisAdd BLAST19
Transmembranei135 – 158Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini159 – 181ExtracellularSequence analysisAdd BLAST23
Transmembranei182 – 208Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini209 – 235CytoplasmicSequence analysisAdd BLAST27
Transmembranei236 – 260Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini261 – 274ExtracellularSequence analysisAdd BLAST14
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 386CytoplasmicSequence analysisAdd BLAST91

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi308C → S: Reduced palmitoylation, coupling to G protein unaffected. Abolished palmitoylation and coupling to G protein; when associated with S-311. 1 Publication1
Mutagenesisi309C → S: No effect on palmitoylation level. 1 Publication1
Mutagenesisi311C → S: Reduced palmitoylation, coupling to G protein unaffected. Abolished palmitoylation and coupling to G protein; when associated with S-308. 1 Publication1
Mutagenesisi383C → S: Abolishes isoprenylation. 1 Publication1

Organism-specific databases

DisGeNETi5739
OpenTargetsiENSG00000160013
PharmGKBiPA291

Chemistry databases

ChEMBLiCHEMBL1995
DrugBankiDB05229 Beraprost
DB01160 Dinoprost Tromethamine
DB01240 Epoprostenol
DB01088 Iloprost
DB11362 Selexipag
DB00374 Treprostinil
GuidetoPHARMACOLOGYi345

Polymorphism and mutation databases

BioMutaiPTGIR
DMDMi1172500

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700751 – 383Prostacyclin receptorAdd BLAST383
PropeptideiPRO_0000240004384 – 386Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 165PROSITE-ProRule annotation1 Publication
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi92 ↔ 170PROSITE-ProRule annotation1 Publication
Lipidationi308S-palmitoyl cysteine1 Publication1
Lipidationi311S-palmitoyl cysteine1 Publication1
Modified residuei383Cysteine methyl esterCurated1
Lipidationi383S-farnesyl cysteine1 Publication1

Post-translational modificationi

Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.1 Publication
Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei309Not S-palmitoylated1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiP43119
PeptideAtlasiP43119
PRIDEiP43119
ProteomicsDBi55588

PTM databases

iPTMnetiP43119
PhosphoSitePlusiP43119
SwissPalmiP43119

Expressioni

Gene expression databases

BgeeiENSG00000160013
CleanExiHS_PTGIR
ExpressionAtlasiP43119 baseline and differential
GenevisibleiP43119 HS

Interactioni

Subunit structurei

Interacts (non-isoprenylated C-terminus) with PDZK1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111711, 74 interactors
STRINGi9606.ENSP00000291294

Chemistry databases

BindingDBiP43119

Structurei

3D structure databases

ProteinModelPortaliP43119
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiP43119
KOiK04263
OMAiCFLSPAV
OrthoDBiEOG091G0F07
PhylomeDBiP43119
TreeFamiTF324982

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR000370 Prostglndn_IP_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF7 PTHR11866:SF7, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01788 PROSTANOIDR
PR00856 PRSTNOIDIPR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA
60 70 80 90 100
VLVTGLAATD LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT
110 120 130 140 150
FFGLASMLIL FAMAVERCLA LSHPYLYAQL DGPRCARLAL PAIYAFCVLF
160 170 180 190 200
CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG GAAFSLAYAG LVALLVAAIF
210 220 230 240 250
LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL LALMTVVMAV
260 270 280 290 300
CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF
310 320 330 340 350
QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS
360 370 380
AWGEGQVEPL PPTQQSSGSA VGTSSKAEAS VACSLC
Length:386
Mass (Da):40,956
Last modified:November 1, 1995 - v1
Checksum:i2B6B0CDBACED1608
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02426025V → M. Corresponds to variant dbSNP:rs2229127Ensembl.1
Natural variantiVAR_061226319S → W. Corresponds to variant dbSNP:rs28590598Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29016 mRNA Translation: AAA36448.1
D25418 mRNA Translation: BAA05008.1
D29634 mRNA Translation: BAA06110.1
D38127 Genomic DNA Translation: BAA07325.1
AY242134 mRNA Translation: AAO92301.1
BC075814 mRNA Translation: AAH75814.1
CCDSiCCDS12686.1
PIRiA57066
RefSeqiNP_000951.1, NM_000960.3
UniGeneiHs.458324

Genome annotation databases

EnsembliENST00000291294; ENSP00000291294; ENSG00000160013
GeneIDi5739
KEGGihsa:5739
UCSCiuc002pex.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPI2R_HUMAN
AccessioniPrimary (citable) accession number: P43119
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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