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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

PTGER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • prostaglandin E receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-391908 Prostanoid ligand receptors
R-HSA-418555 G alpha (s) signalling events

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P43116

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P43116

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PTGER2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000125384.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:9594 PTGER2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
176804 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43116

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 65CytoplasmicSequence analysisAdd BLAST18
Transmembranei66 – 91Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini92 – 111ExtracellularSequence analysisAdd BLAST20
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 151CytoplasmicSequence analysisAdd BLAST19
Transmembranei152 – 176Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini177 – 198ExtracellularSequence analysisAdd BLAST22
Transmembranei199 – 223Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini224 – 262CytoplasmicSequence analysisAdd BLAST39
Transmembranei263 – 286Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini287 – 299ExtracellularSequence analysisAdd BLAST13
Transmembranei300 – 323Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini324 – 358CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
5732

MalaCards human disease database

More...
MalaCardsi
PTGER2

Open Targets

More...
OpenTargetsi
ENSG00000125384

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA287

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1881

Drug and drug target database

More...
DrugBanki
DB00770 Alprostadil
DB00917 Dinoprostone
DB00929 Misoprostol

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
341

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
PTGER2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
38258920

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700541 – 358Prostaglandin E2 receptor EP2 subtypeAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43116

PeptideAtlas

More...
PeptideAtlasi
P43116

PRoteomics IDEntifications database

More...
PRIDEi
P43116

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55587

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43116

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43116

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Placenta and lung.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125384 Expressed in 137 organ(s), highest expression level in leukocyte

CleanEx database of gene expression profiles

More...
CleanExi
HS_PTGER2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P43116 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43116 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111704, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P43116, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000245457

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P43116

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P43116

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154331

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000115475

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG003074

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43116

KEGG Orthology (KO)

More...
KOi
K04259

Identification of Orthologs from Complete Genome Data

More...
OMAi
GRPYFYE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0F07

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43116

TreeFam database of animal gene trees

More...
TreeFami
TF324982

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15139 7tmA_PGE2_EP2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001923 Prostglndn_EP2_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR11866 PTHR11866, 1 hit
PTHR11866:SF8 PTHR11866:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR01788 PROSTANOIDR
PR00581 PRSTNOIDEP2R

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P43116-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW
60 70 80 90 100
RGDVGCSAGR RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV
110 120 130 140 150
ALAPESRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGH PYFYQRRVSR
160 170 180 190 200
SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ YCPGTWCFIR HGRTAYLQLY
210 220 230 240 250
ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS GRGGPGARRR
260 270 280 290 300
GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA
310 320 330 340 350
LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS

DASKQADL
Length:358
Mass (Da):39,761
Last modified:November 7, 2003 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB3B0E2AA3CF2E363
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V2Y6G3V2Y6_HUMAN
Prostaglandin E2 receptor EP2 subty...
PTGER2
103Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti150R → A in AAA61681 (PubMed:8078484).Curated1
Sequence conflicti150R → A in AAD44177 (PubMed:10521663).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U19487 mRNA Translation: AAA61681.1
X83868 mRNA Translation: CAA58749.1
AF134202, AF134201 Genomic DNA Translation: AAD44177.1
AY275471 mRNA Translation: AAP32303.1
DQ398948 Genomic DNA Translation: ABD48958.1
CH471078 Genomic DNA Translation: EAW65652.1
CH471078 Genomic DNA Translation: EAW65654.1
BC093927 mRNA Translation: AAH93927.1
BC093929 mRNA Translation: AAH93929.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS9708.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I38920
S51312

NCBI Reference Sequences

More...
RefSeqi
NP_000947.2, NM_000956.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2090

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000245457; ENSP00000245457; ENSG00000125384

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5732

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5732

UCSC genome browser

More...
UCSCi
uc001wzr.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19487 mRNA Translation: AAA61681.1
X83868 mRNA Translation: CAA58749.1
AF134202, AF134201 Genomic DNA Translation: AAD44177.1
AY275471 mRNA Translation: AAP32303.1
DQ398948 Genomic DNA Translation: ABD48958.1
CH471078 Genomic DNA Translation: EAW65652.1
CH471078 Genomic DNA Translation: EAW65654.1
BC093927 mRNA Translation: AAH93927.1
BC093929 mRNA Translation: AAH93929.1
CCDSiCCDS9708.1
PIRiI38920
S51312
RefSeqiNP_000947.2, NM_000956.3
UniGeneiHs.2090

3D structure databases

ProteinModelPortaliP43116
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111704, 2 interactors
IntActiP43116, 4 interactors
STRINGi9606.ENSP00000245457

Chemistry databases

BindingDBiP43116
ChEMBLiCHEMBL1881
DrugBankiDB00770 Alprostadil
DB00917 Dinoprostone
DB00929 Misoprostol
GuidetoPHARMACOLOGYi341

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP43116
PhosphoSitePlusiP43116

Polymorphism and mutation databases

BioMutaiPTGER2
DMDMi38258920

Proteomic databases

PaxDbiP43116
PeptideAtlasiP43116
PRIDEiP43116
ProteomicsDBi55587

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5732
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245457; ENSP00000245457; ENSG00000125384
GeneIDi5732
KEGGihsa:5732
UCSCiuc001wzr.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5732
DisGeNETi5732
EuPathDBiHostDB:ENSG00000125384.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PTGER2
HGNCiHGNC:9594 PTGER2
MalaCardsiPTGER2
MIMi176804 gene
neXtProtiNX_P43116
OpenTargetsiENSG00000125384
PharmGKBiPA287

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000154331
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiP43116
KOiK04259
OMAiGRPYFYE
OrthoDBiEOG091G0F07
PhylomeDBiP43116
TreeFamiTF324982

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-418555 G alpha (s) signalling events
SABIO-RKiP43116
SIGNORiP43116

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Prostaglandin_E2_receptor

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5732

Protein Ontology

More...
PROi
PR:P43116

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125384 Expressed in 137 organ(s), highest expression level in leukocyte
CleanExiHS_PTGER2
ExpressionAtlasiP43116 baseline and differential
GenevisibleiP43116 HS

Family and domain databases

CDDicd15139 7tmA_PGE2_EP2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001923 Prostglndn_EP2_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF8 PTHR11866:SF8, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01788 PROSTANOIDR
PR00581 PRSTNOIDEP2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPE2R2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43116
Secondary accession number(s): D3DSC0, Q52LG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 7, 2003
Last modified: December 5, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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