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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

PTGER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-391908 Prostanoid ligand receptors
R-HSA-418555 G alpha (s) signalling events
SIGNORiP43116

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:PTGER2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000125384.6
HGNCiHGNC:9594 PTGER2
MIMi176804 gene
neXtProtiNX_P43116

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 65CytoplasmicSequence analysisAdd BLAST18
Transmembranei66 – 91Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini92 – 111ExtracellularSequence analysisAdd BLAST20
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 151CytoplasmicSequence analysisAdd BLAST19
Transmembranei152 – 176Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini177 – 198ExtracellularSequence analysisAdd BLAST22
Transmembranei199 – 223Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini224 – 262CytoplasmicSequence analysisAdd BLAST39
Transmembranei263 – 286Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini287 – 299ExtracellularSequence analysisAdd BLAST13
Transmembranei300 – 323Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini324 – 358CytoplasmicSequence analysisAdd BLAST35

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5732
MalaCardsiPTGER2
OpenTargetsiENSG00000125384
PharmGKBiPA287

Chemistry databases

ChEMBLiCHEMBL1881
DrugBankiDB00770 Alprostadil
DB00917 Dinoprostone
DB00929 Misoprostol
GuidetoPHARMACOLOGYi341

Polymorphism and mutation databases

BioMutaiPTGER2
DMDMi38258920

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700541 – 358Prostaglandin E2 receptor EP2 subtypeAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi96N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43116
PeptideAtlasiP43116
PRIDEiP43116
ProteomicsDBi55587

PTM databases

iPTMnetiP43116
PhosphoSitePlusiP43116

Expressioni

Tissue specificityi

Placenta and lung.

Gene expression databases

BgeeiENSG00000125384
CleanExiHS_PTGER2
ExpressionAtlasiP43116 baseline and differential
GenevisibleiP43116 HS

Interactioni

Protein-protein interaction databases

BioGridi111704, 2 interactors
IntActiP43116, 4 interactors
STRINGi9606.ENSP00000245457

Chemistry databases

BindingDBiP43116

Structurei

3D structure databases

ProteinModelPortaliP43116
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000119188
HOGENOMiHOG000115475
HOVERGENiHBG003074
InParanoidiP43116
KOiK04259
OMAiTWCFIRH
OrthoDBiEOG091G0F07
PhylomeDBiP43116
TreeFamiTF324982

Family and domain databases

CDDicd15139 7tmA_PGE2_EP2, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR008365 Prostanoid_rcpt
IPR001923 Prostglndn_EP2_rcpt
PANTHERiPTHR11866 PTHR11866, 1 hit
PTHR11866:SF8 PTHR11866:SF8, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01788 PROSTANOIDR
PR00581 PRSTNOIDEP2R
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW
60 70 80 90 100
RGDVGCSAGR RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV
110 120 130 140 150
ALAPESRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGH PYFYQRRVSR
160 170 180 190 200
SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ YCPGTWCFIR HGRTAYLQLY
210 220 230 240 250
ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS GRGGPGARRR
260 270 280 290 300
GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA
310 320 330 340 350
LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS

DASKQADL
Length:358
Mass (Da):39,761
Last modified:November 7, 2003 - v2
Checksum:iB3B0E2AA3CF2E363
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150R → A in AAA61681 (PubMed:8078484).Curated1
Sequence conflicti150R → A in AAD44177 (PubMed:10521663).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19487 mRNA Translation: AAA61681.1
X83868 mRNA Translation: CAA58749.1
AF134202, AF134201 Genomic DNA Translation: AAD44177.1
AY275471 mRNA Translation: AAP32303.1
DQ398948 Genomic DNA Translation: ABD48958.1
CH471078 Genomic DNA Translation: EAW65652.1
CH471078 Genomic DNA Translation: EAW65654.1
BC093927 mRNA Translation: AAH93927.1
BC093929 mRNA Translation: AAH93929.1
CCDSiCCDS9708.1
PIRiI38920
S51312
RefSeqiNP_000947.2, NM_000956.3
UniGeneiHs.2090

Genome annotation databases

EnsembliENST00000245457; ENSP00000245457; ENSG00000125384
GeneIDi5732
KEGGihsa:5732
UCSCiuc001wzr.4 human

Similar proteinsi

Entry informationi

Entry nameiPE2R2_HUMAN
AccessioniPrimary (citable) accession number: P43116
Secondary accession number(s): D3DSC0, Q52LG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 7, 2003
Last modified: June 20, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

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