UniProtKB - P43088 (PF2R_HUMAN)
Protein
Prostaglandin F2-alpha receptor
Gene
PTGFR
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.By similarity1 Publication
GO - Molecular functioni
- prostaglandin F receptor activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- calcium-mediated signaling using intracellular calcium source Source: UniProtKB
- cellular response to prostaglandin D stimulus Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- inflammatory response Source: GO_Central
- negative regulation of apoptotic process Source: Ensembl
- parturition Source: ProtInc
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of gene expression Source: Ensembl
- response to estradiol Source: Ensembl
- response to lipopolysaccharide Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P43088 |
Reactomei | R-HSA-391908, Prostanoid ligand receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P43088 |
Chemistry databases
SwissLipidsi | SLP:000001573 |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin F2-alpha receptorShort name: PGF receptor Short name: PGF2-alpha receptor Alternative name(s): Prostanoid FP receptor |
Gene namesi | Name:PTGFR |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9600, PTGFR |
MIMi | 600563, gene |
neXtProti | NX_P43088 |
VEuPathDBi | HostDB:ENSG00000122420.9 |
Subcellular locationi
Plasma membrane
Extracellular region or secreted
- extracellular region Source: MGI
Plasma Membrane
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 32 – 54 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 55 – 69 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 70 – 90 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 91 – 109 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 110 – 131 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 132 – 152 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 153 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 176 – 198 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 199 – 224 | Helical; Name=5Sequence analysisAdd BLAST | 26 | |
Topological domaini | 225 – 250 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 251 – 267 | Helical; Name=6Sequence analysisAdd BLAST | 17 | |
Topological domaini | 268 – 285 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 286 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 308 – 359 | CytoplasmicSequence analysisAdd BLAST | 52 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 5737 |
OpenTargetsi | ENSG00000122420 |
PharmGKBi | PA290 |
Miscellaneous databases
Pharosi | P43088, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1987 |
DrugBanki | DB00905, Bimatoprost DB01160, Dinoprost tromethamine DB00654, Latanoprost DB11660, Latanoprostene bunod DB08819, Tafluprost DB00287, Travoprost |
DrugCentrali | P43088 |
GuidetoPHARMACOLOGYi | 344 |
Genetic variation databases
BioMutai | PTGFR |
DMDMi | 1172442 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070070 | 1 – 359 | Prostaglandin F2-alpha receptorAdd BLAST | 359 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 19 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 108 ↔ 186 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P43088 |
PeptideAtlasi | P43088 |
PRIDEi | P43088 |
ProteomicsDBi | 55578 [P43088-1] 55579 [P43088-2] |
PTM databases
GlyGeni | P43088, 2 sites |
iPTMneti | P43088 |
PhosphoSitePlusi | P43088 |
Expressioni
Tissue specificityi
Eye.1 Publication
Gene expression databases
Bgeei | ENSG00000122420, Expressed in calcaneal tendon and 156 other tissues |
ExpressionAtlasi | P43088, baseline and differential |
Genevisiblei | P43088, HS |
Organism-specific databases
HPAi | ENSG00000122420, Low tissue specificity |
Interactioni
Subunit structurei
Isoform 1 can form heterodimers with isoform 5 (and probably other isoforms).
1 PublicationProtein-protein interaction databases
BioGRIDi | 111709, 14 interactors |
IntActi | P43088, 9 interactors |
STRINGi | 9606.ENSP00000359793 |
Chemistry databases
BindingDBi | P43088 |
Miscellaneous databases
RNActi | P43088, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214583 |
HOGENOMi | CLU_045991_3_0_1 |
InParanoidi | P43088 |
OMAi | CFYKTEH |
OrthoDBi | 972015at2759 |
PhylomeDBi | P43088 |
TreeFami | TF324982 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000141, PglndnF_rcpt IPR008365, Prostanoid_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit PTHR11866:SF4, PTHR11866:SF4, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01788, PROSTANOIDR PR00855, PRSTNOIDFPR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
s (7+)i Sequence
Sequence statusi: Complete.
This entry describes 7 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 7 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P43088-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSMNNSKQLV SPAAALLSNT TCQTENRLSV FFSVIFMTVG ILSNSLAIAI
60 70 80 90 100
LMKAYQRFRQ KSKASFLLLA SGLVITDFFG HLINGAIAVF VYASDKEWIR
110 120 130 140 150
FDQSNVLCSI FGICMVFSGL CPLLLGSVMA IERCIGVTKP IFHSTKITSK
160 170 180 190 200
HVKMMLSGVC LFAVFIALLP ILGHRDYKIQ ASRTWCFYNT EDIKDWEDRF
210 220 230 240 250
YLLLFSFLGL LALGVSLLCN AITGITLLRV KFKSQQHRQG RSHHLEMVIQ
260 270 280 290 300
LLAIMCVSCI CWSPFLVTMA NIGINGNHSL ETCETTLFAL RMATWNQILD
310 320 330 340 350
PWVYILLRKA VLKNLYKLAS QCCGVHVISL HIWELSSIKN SLKVAAISES
PVAEKSAST
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketF2Z2Z6 | F2Z2Z6_HUMAN | Prostaglandin F2-alpha receptor | PTGFR | 297 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042025 | 267 – 359 | VTMAN…KSAST → GYRIILNGKEKYKVYEEQSD FLHRLQWPTLE in isoform 2. 1 PublicationAdd BLAST | 93 | |
Alternative sequenceiVSP_053588 | 267 – 291 | VTMAN…LFALR → GYRIILNGKEKYKVYEEQSD FLHRK in isoform 4. CuratedAdd BLAST | 25 | |
Alternative sequenceiVSP_053589 | 267 – 275 | VTMANIGIN → KIEGKIKVT in isoform 3. Curated | 9 | |
Alternative sequenceiVSP_053590 | 267 – 274 | VTMANIGI → THWGKEIP in isoform 7. Curated | 8 | |
Alternative sequenceiVSP_053591 | 267 | V → R in isoform 6. Curated | 1 | |
Alternative sequenceiVSP_053592 | 268 – 359 | Missing in isoform 6. CuratedAdd BLAST | 92 | |
Alternative sequenceiVSP_053593 | 268 – 296 | TMANI…MATWN → KETHLQMRLWTWDFRVNALE DYCEGLTVF in isoform 5. CuratedAdd BLAST | 29 | |
Alternative sequenceiVSP_053594 | 275 – 359 | Missing in isoform 7. CuratedAdd BLAST | 85 | |
Alternative sequenceiVSP_053595 | 276 – 359 | Missing in isoform 3. CuratedAdd BLAST | 84 | |
Alternative sequenceiVSP_053596 | 292 – 359 | Missing in isoform 4. CuratedAdd BLAST | 68 | |
Alternative sequenceiVSP_053597 | 297 – 359 | Missing in isoform 5. CuratedAdd BLAST | 63 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L24470 mRNA Translation: AAA17684.1 AF004021 mRNA Translation: AAB63152.1 AY337000 mRNA Translation: AAQ76788.1 AY485530 mRNA Translation: AAR84381.1 AK292845 mRNA Translation: BAF85534.1 AC096531 Genomic DNA No translation available. AL158841 Genomic DNA No translation available. AL136324 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06351.1 BC112965 mRNA Translation: AAI12966.1 AB041713 Genomic DNA Translation: BAA94756.1 |
CCDSi | CCDS30759.1 [P43088-2] CCDS686.1 [P43088-1] |
PIRi | A49973 |
RefSeqi | NP_000950.1, NM_000959.3 [P43088-1] NP_001034674.1, NM_001039585.1 [P43088-2] XP_016857362.1, XM_017001873.1 [P43088-4] |
Genome annotation databases
Ensembli | ENST00000370756; ENSP00000359792; ENSG00000122420 [P43088-2] ENST00000370757; ENSP00000359793; ENSG00000122420 [P43088-1] ENST00000370758; ENSP00000359794; ENSG00000122420 [P43088-1] |
GeneIDi | 5737 |
KEGGi | hsa:5737 |
UCSCi | uc001dim.4, human [P43088-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L24470 mRNA Translation: AAA17684.1 AF004021 mRNA Translation: AAB63152.1 AY337000 mRNA Translation: AAQ76788.1 AY485530 mRNA Translation: AAR84381.1 AK292845 mRNA Translation: BAF85534.1 AC096531 Genomic DNA No translation available. AL158841 Genomic DNA No translation available. AL136324 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06351.1 BC112965 mRNA Translation: AAI12966.1 AB041713 Genomic DNA Translation: BAA94756.1 |
CCDSi | CCDS30759.1 [P43088-2] CCDS686.1 [P43088-1] |
PIRi | A49973 |
RefSeqi | NP_000950.1, NM_000959.3 [P43088-1] NP_001034674.1, NM_001039585.1 [P43088-2] XP_016857362.1, XM_017001873.1 [P43088-4] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 111709, 14 interactors |
IntActi | P43088, 9 interactors |
STRINGi | 9606.ENSP00000359793 |
Chemistry databases
BindingDBi | P43088 |
ChEMBLi | CHEMBL1987 |
DrugBanki | DB00905, Bimatoprost DB01160, Dinoprost tromethamine DB00654, Latanoprost DB11660, Latanoprostene bunod DB08819, Tafluprost DB00287, Travoprost |
DrugCentrali | P43088 |
GuidetoPHARMACOLOGYi | 344 |
SwissLipidsi | SLP:000001573 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P43088, 2 sites |
iPTMneti | P43088 |
PhosphoSitePlusi | P43088 |
Genetic variation databases
BioMutai | PTGFR |
DMDMi | 1172442 |
Proteomic databases
PaxDbi | P43088 |
PeptideAtlasi | P43088 |
PRIDEi | P43088 |
ProteomicsDBi | 55578 [P43088-1] 55579 [P43088-2] |
Protocols and materials databases
Antibodypediai | 19743, 176 antibodies |
DNASUi | 5737 |
Genome annotation databases
Ensembli | ENST00000370756; ENSP00000359792; ENSG00000122420 [P43088-2] ENST00000370757; ENSP00000359793; ENSG00000122420 [P43088-1] ENST00000370758; ENSP00000359794; ENSG00000122420 [P43088-1] |
GeneIDi | 5737 |
KEGGi | hsa:5737 |
UCSCi | uc001dim.4, human [P43088-1] |
Organism-specific databases
CTDi | 5737 |
DisGeNETi | 5737 |
GeneCardsi | PTGFR |
HGNCi | HGNC:9600, PTGFR |
HPAi | ENSG00000122420, Low tissue specificity |
MIMi | 600563, gene |
neXtProti | NX_P43088 |
OpenTargetsi | ENSG00000122420 |
PharmGKBi | PA290 |
VEuPathDBi | HostDB:ENSG00000122420.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214583 |
HOGENOMi | CLU_045991_3_0_1 |
InParanoidi | P43088 |
OMAi | CFYKTEH |
OrthoDBi | 972015at2759 |
PhylomeDBi | P43088 |
TreeFami | TF324982 |
Enzyme and pathway databases
PathwayCommonsi | P43088 |
Reactomei | R-HSA-391908, Prostanoid ligand receptors R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P43088 |
Miscellaneous databases
BioGRID-ORCSi | 5737, 4 hits in 873 CRISPR screens |
ChiTaRSi | PTGFR, human |
GeneWikii | Prostaglandin_F_receptor |
GenomeRNAii | 5737 |
Pharosi | P43088, Tclin |
PROi | PR:P43088 |
RNActi | P43088, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000122420, Expressed in calcaneal tendon and 156 other tissues |
ExpressionAtlasi | P43088, baseline and differential |
Genevisiblei | P43088, HS |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR000141, PglndnF_rcpt IPR008365, Prostanoid_rcpt |
PANTHERi | PTHR11866, PTHR11866, 1 hit PTHR11866:SF4, PTHR11866:SF4, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01788, PROSTANOIDR PR00855, PRSTNOIDFPR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PF2R_HUMAN | |
Accessioni | P43088Primary (citable) accession number: P43088 Secondary accession number(s): A8K9Y0 Q9P1X4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 10, 2021 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM