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Entry version 146 (07 Oct 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Hevein-like preproprotein

Gene

HEL

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fungal growth inhibitors. Neither CB-HEL nor CD-HEL have chitinase activity, but both have antimicrobial activities. CD-HEL has RNase, but no DNase activity.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • chitin binding Source: TAIR
  • ribonuclease activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAntimicrobial, Fungicide, Hydrolase, Nuclease, Pathogenesis-related protein
Biological processPlant defense
LigandChitin-binding

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
CBM18, Carbohydrate-Binding Module Family 18

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hevein-like preproprotein
Cleaved into the following 2 chains:
CD-HEL (EC:3.1.-.-)
Alternative name(s):
RNase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HEL
Ordered Locus Names:At3g04720
ORF Names:F7O18.21
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT3G04720

The Arabidopsis Information Resource

More...
TAIRi
locus:2084918, AT3G04720

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000528422 – 212Hevein-like preproproteinAdd BLAST191
ChainiPRO_000042156822 – ?CB-HEL
ChainiPRO_0000421569? – 212CD-HEL

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi24 ↔ 391 Publication
Disulfide bondi33 ↔ 451 Publication
Disulfide bondi38 ↔ 521 Publication
Disulfide bondi58 ↔ 621 Publication
Disulfide bondi100 ↔ 132PROSITE-ProRule annotation
Disulfide bondi121 ↔ 155PROSITE-ProRule annotation
Disulfide bondi135 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43082

PRoteomics IDEntifications database

More...
PRIDEi
P43082

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
230128

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by ethylene, methyl jasmonate, wounding and virus infection. Weakly induced by salicylic acid and 2,6-dichlorisonicotinic acid.2 Publications

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P43082, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43082, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

CB-HEL interacts strongly with a fungal fruiting body lectin.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4967, 1 interactor

Protein interaction database and analysis system

More...
IntActi
P43082, 1 interactor

STRING: functional protein association networks

More...
STRINGi
3702.AT3G04720.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43082

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini22 – 64Chitin-binding type-1PROSITE-ProRule annotationAdd BLAST43
Domaini72 – 193BarwinPROSITE-ProRule annotationAdd BLAST122

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The C-terminal vacuolar sorting signal (VSS) (194-212) is required for vacuolar localization.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4742, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1328439_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43082

Identification of Orthologs from Complete Genome Data

More...
OMAi
CPGNICC

Database of Orthologous Groups

More...
OrthoDBi
1332779at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43082

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.40.10, 1 hit
3.30.60.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018226, Barwin_CS
IPR001153, Barwin_dom
IPR001002, Chitin-bd_1
IPR018371, Chitin-binding_1_CS
IPR036861, Endochitinase-like_sf
IPR036908, RlpA-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00967, Barwin, 1 hit
PF00187, Chitin_bind_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00602, BARWIN
PR00451, CHITINBINDNG

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00270, ChtBD1, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50685, SSF50685, 1 hit
SSF57016, SSF57016, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00771, BARWIN_1, 1 hit
PS00772, BARWIN_2, 1 hit
PS51174, BARWIN_3, 1 hit
PS00026, CHIT_BIND_I_1, 1 hit
PS50941, CHIT_BIND_I_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P43082-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKIRLSITII LLSYTVATVA GQQCGRQGGG RTCPGNICCS QYGYCGTTAD
60 70 80 90 100
YCSPTNNCQS NCWGSGPSGP GESASNVRAT YHFYNPAQNN WDLRAVSAYC
110 120 130 140 150
STWDADKPYA WRSKYGWTAF CGPAGPRGQA SCGKCLRVKN TRTNAAVTVR
160 170 180 190 200
IVDQCSNGGL DLDVAMFNQI DTDGFGYQQG HLIVDYQFVD CGNELIGQPD
210
SRNMLVSAID RV
Length:212
Mass (Da):22,937
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1EDAD140A21AA692
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U01880 mRNA Translation: AAA20642.1
AC011437 Genomic DNA Translation: AAF04912.1
CP002686 Genomic DNA Translation: AEE74125.1
AF370536 mRNA Translation: AAK48963.1
BT000046 mRNA Translation: AAN15365.1
AY088644 mRNA Translation: AAM66966.1

NCBI Reference Sequences

More...
RefSeqi
NP_187123.1, NM_111344.6

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT3G04720.1; AT3G04720.1; AT3G04720

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
819632

Gramene; a comparative resource for plants

More...
Gramenei
AT3G04720.1; AT3G04720.1; AT3G04720

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT3G04720

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01880 mRNA Translation: AAA20642.1
AC011437 Genomic DNA Translation: AAF04912.1
CP002686 Genomic DNA Translation: AEE74125.1
AF370536 mRNA Translation: AAK48963.1
BT000046 mRNA Translation: AAN15365.1
AY088644 mRNA Translation: AAM66966.1
RefSeqiNP_187123.1, NM_111344.6

3D structure databases

SMRiP43082
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4967, 1 interactor
IntActiP43082, 1 interactor
STRINGi3702.AT3G04720.1

Protein family/group databases

CAZyiCBM18, Carbohydrate-Binding Module Family 18

Proteomic databases

PaxDbiP43082
PRIDEiP43082
ProteomicsDBi230128

Genome annotation databases

EnsemblPlantsiAT3G04720.1; AT3G04720.1; AT3G04720
GeneIDi819632
GrameneiAT3G04720.1; AT3G04720.1; AT3G04720
KEGGiath:AT3G04720

Organism-specific databases

AraportiAT3G04720
TAIRilocus:2084918, AT3G04720

Phylogenomic databases

eggNOGiKOG4742, Eukaryota
HOGENOMiCLU_1328439_0_0_1
InParanoidiP43082
OMAiCPGNICC
OrthoDBi1332779at2759
PhylomeDBiP43082

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P43082

Gene expression databases

ExpressionAtlasiP43082, baseline and differential
GenevisibleiP43082, AT

Family and domain databases

Gene3Di2.40.40.10, 1 hit
3.30.60.10, 1 hit
InterProiView protein in InterPro
IPR018226, Barwin_CS
IPR001153, Barwin_dom
IPR001002, Chitin-bd_1
IPR018371, Chitin-binding_1_CS
IPR036861, Endochitinase-like_sf
IPR036908, RlpA-like_sf
PfamiView protein in Pfam
PF00967, Barwin, 1 hit
PF00187, Chitin_bind_1, 1 hit
PRINTSiPR00602, BARWIN
PR00451, CHITINBINDNG
SMARTiView protein in SMART
SM00270, ChtBD1, 1 hit
SUPFAMiSSF50685, SSF50685, 1 hit
SSF57016, SSF57016, 1 hit
PROSITEiView protein in PROSITE
PS00771, BARWIN_1, 1 hit
PS00772, BARWIN_2, 1 hit
PS51174, BARWIN_3, 1 hit
PS00026, CHIT_BIND_I_1, 1 hit
PS50941, CHIT_BIND_I_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHEVL_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43082
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 7, 2020
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
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