Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 100 (02 Jun 2021)
Sequence version 1 (01 Nov 1995)
Previous versions | rss
Add a publicationFeedback
Protein

Multidrug resistance protein CDR1

Gene

CDR1

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transporter, whose physiological function is not yet established. Confers resistance to the chemical cycloheximide.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi895 – 902ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntibiotic resistance, Cycloheximide resistance, Transport
LigandATP-binding, Nucleotide-binding

Protein family/group databases

Transport Classification Database

More...
TCDBi
3.A.1.205.4, the atp-binding cassette (abc) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance protein CDR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CDR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCandida albicans (Yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri5476 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 513CytoplasmicSequence analysisAdd BLAST513
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei514 – 534HelicalSequence analysisAdd BLAST21
Transmembranei549 – 569HelicalSequence analysisAdd BLAST21
Transmembranei598 – 618HelicalSequence analysisAdd BLAST21
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Transmembranei655 – 675HelicalSequence analysisAdd BLAST21
Transmembranei765 – 785HelicalSequence analysisAdd BLAST21
Topological domaini786 – 1195CytoplasmicSequence analysisAdd BLAST410
Transmembranei1196 – 1216HelicalSequence analysisAdd BLAST21
Transmembranei1230 – 1250HelicalSequence analysisAdd BLAST21
Transmembranei1281 – 1301HelicalSequence analysisAdd BLAST21
Transmembranei1315 – 1335HelicalSequence analysisAdd BLAST21
Transmembranei1356 – 1376HelicalSequence analysisAdd BLAST21
Transmembranei1467 – 1487HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1163109

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000934351 – 1501Multidrug resistance protein CDR1Add BLAST1501

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi535N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi724N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P43071

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43071

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini150 – 404ABC transporter 1PROSITE-ProRule annotationAdd BLAST255
Domaini859 – 1103ABC transporter 2PROSITE-ProRule annotationAdd BLAST245

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 30DisorderedSequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20Basic and acidic residuesSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR005285, Drug-R_PDR/CDR
IPR027417, P-loop_NTPase
IPR010929, PDR_CDR_ABC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF06422, PDR_CDR, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382, AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00956, 3a01205, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P43071-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDSKMSSQD ESKLEKAISQ DSSSENHSIN EYHGFDAHTS ENIQNLARTF
60 70 80 90 100
THDSFKDDSS AGLLKYLTHM SEVPGVNPYE HEEINNDQLN PDSENFNAKF
110 120 130 140 150
WVKNLRKLFE SDPEYYKPSK LGIGYRNLRA YGVANDSDYQ PTVTNALWKL
160 170 180 190 200
ATEGFRHFQK DDDSRYFDIL KSMDAIMRPG ELTVVLGRPG AGCSTLLKTI
210 220 230 240 250
AVNTYGFHIG KESQITYDGL SPHDIERHYR GDVIYSAETD VHFPHLSVGD
260 270 280 290 300
TLEFAARLRT PQNRGEGIDR ETYAKHMASV YMATYGLSHT RNTNVGNDFV
310 320 330 340 350
RGVSGGERKR VSIAEASLSG ANIQCWDNAT RGLDSATALE FIRALKTSAV
360 370 380 390 400
ILDTTPLIAI YQCSQDAYDL FDKVVVLYEG YQIFFGKATK AKEYFEKMGW
410 420 430 440 450
KCPQRQTTAD FLTSLTNPAE REPLPGYEDK VPRTAQEFET YWKNSPEYAE
460 470 480 490 500
LTKEIDEYFV ECERSNTRET YRESHVAKQS NNTRPASPYT VSFFMQVRYG
510 520 530 540 550
VARNFLRMKG DPSIPIFSVF GQLVMGLILS SVFYNLSQTT GSFYYRGAAM
560 570 580 590 600
FFAVLFNAFS SLLEIMSLFE ARPIVEKHKK YALYRPSADA LASIISELPV
610 620 630 640 650
KLAMSMSFNF VFYFMVNFRR NPGRFFFYWL MCIWCTFVMS HLFRSIGAVS
660 670 680 690 700
TSISGAMTPA TVLLLAMVIY TGFVIPTPSM LGWSRWINYI NPVGYVFESL
710 720 730 740 750
MVNEFHGREF QCAQYVPSGP GYENISRSNQ VCTAVGSVPG NEMVSGTNYL
760 770 780 790 800
AGAYQYYNSH KWRNLGITIG FAVFFLAIYI ALTEFNKGAM QKGEIVLFLK
810 820 830 840 850
GSLKKHKRKT AASNKGDIEA GPVAGKLDYQ DEAEAVNNEK FTEKGSTGSV
860 870 880 890 900
DFPENREIFF WRDLTYQVKI KKEDRVILDH VDGWVKPGQI TALMGASGAG
910 920 930 940 950
KTTLLNCLSE RVTTGIITDG ERLVNGHALD SSFQRSIGYV QQQDVHLPTS
960 970 980 990 1000
TVREALQFSA YLRQSNKISK KEKDDYVDYV IDLLEMTDYA DALVGVAGEG
1010 1020 1030 1040 1050
LNVEQRKRLT IGVELVAKPK LLLFLDEPTS GLDSQTAWSI CKLMRKLADH
1060 1070 1080 1090 1100
GQAILCTIHQ PSALIMAEFD RLLFLQKGGR TAYFGELGEN CQTMINYFEK
1110 1120 1130 1140 1150
YGADPCPKEA NPAEWMLQVV GAAPGSHAKQ DYFEVWRNSS EYQAVREEIN
1160 1170 1180 1190 1200
RMEAELSKLP RDNDPEALLK YAAPLWKQYL LVSWRTIVQD WRSPGYIYSK
1210 1220 1230 1240 1250
IFLVVSAALF NGFSFFKAKN NMQGLQNQMF SVFMFFIPFN TLVQQMLPYF
1260 1270 1280 1290 1300
VKQRDVYEVR EAPSRTFSWF AFIAGQITSE IPYQVAVGTI AFFCWYYPLG
1310 1320 1330 1340 1350
LYNNATPTDS VNPRGVLMWM LVTAFYVYTA TMGQLCMSFS ELADNAANLA
1360 1370 1380 1390 1400
TLLFTMCLNF CGVLAGPDVL PGFWIFMYRC NPFTYLVQAM LSTGLANTFV
1410 1420 1430 1440 1450
KCAEREYVSV KPPNGESCST YLDPYIKFAG GYFETRNDGS CAFCQMSSTN
1460 1470 1480 1490 1500
TFLKSVNSLY SERWRNFGIF IAFIAINIIL TVIFYWLARV PKGNREKKNK

K
Length:1,501
Mass (Da):169,938
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBB144A0BAD7ED233
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X77589 Genomic DNA Translation: CAA54692.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S57198

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X77589 Genomic DNA Translation: CAA54692.1
PIRiS57198

3D structure databases

SMRiP43071
ModBaseiSearch...

Chemistry databases

BindingDBiP43071
ChEMBLiCHEMBL1163109

Protein family/group databases

TCDBi3.A.1.205.4, the atp-binding cassette (abc) superfamily

Family and domain databases

CDDicd03233, ABCG_PDR_domain1, 1 hit
cd03232, ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593, AAA+_ATPase
IPR013525, ABC_2_trans
IPR029481, ABC_trans_N
IPR003439, ABC_transporter-like
IPR017871, ABC_transporter_CS
IPR034001, ABCG_PDR_1
IPR034003, ABCG_PDR_2
IPR005285, Drug-R_PDR/CDR
IPR027417, P-loop_NTPase
IPR010929, PDR_CDR_ABC
PfamiView protein in Pfam
PF01061, ABC2_membrane, 2 hits
PF00005, ABC_tran, 2 hits
PF14510, ABC_trans_N, 1 hit
PF06422, PDR_CDR, 1 hit
SMARTiView protein in SMART
SM00382, AAA, 2 hits
SUPFAMiSSF52540, SSF52540, 2 hits
TIGRFAMsiTIGR00956, 3a01205, 1 hit
PROSITEiView protein in PROSITE
PS00211, ABC_TRANSPORTER_1, 1 hit
PS50893, ABC_TRANSPORTER_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCDR1_CANAX
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43071
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 2, 2021
This is version 100 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again