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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi156Zinc 1; catalyticBy similarity1
Binding sitei204NADBy similarity1
Binding sitei209NADBy similarity1
Binding sitei343NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 186NADBy similarity7
Nucleotide bindingi271 – 273NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Protein family/group databases

MoonDBiP43067 Curated
MoonProtiP43067

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
40 kDa allergen
Allergen Can a 1
Allergen Can a I
Allergen: Cand a 1
Gene namesi
Name:ADH1
Synonyms:CAD
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei177 Cand a 1
3173 Cand a 1.0101

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607171 – 350Alcohol dehydrogenase 1Add BLAST350

Proteomic databases

PRIDEiP43067

2D gel databases

COMPLUYEAST-2DPAGEiP43067

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43067
SMRiP43067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit

Sequencei

Sequence statusi: Complete.

P43067-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEQIPKTQK AVVFDTNGGQ LVYKDYPVPT PKPNELLIHV KYSGVCHTDL
60 70 80 90 100
HARKGDWPLA TKLPLVGGHE GAGVVVGMGE NVKGWKIGDF AGIKWLNGSC
110 120 130 140 150
MSCEFCQQGA EPNCGEADLS GYTHDGSFEQ YATADAVQAA KIPAGTDLAN
160 170 180 190 200
VAPILCAGVT VYKALKTADL AAGQWVAISG AGGGLGSLAV QYARAMGLRV
210 220 230 240 250
VAIDGGDEKG EFVKSLGAEA YVDFTKDKDI VEAVKKATDG GPHGAINVSV
260 270 280 290 300
SEKAIDQSVE YVRPLGKVVL VGLPAHAKVT APVFDAVVKS IEIKGSYVGN
310 320 330 340 350
RKDTAEAIDF FSRGLIKCPI KIVGLSDLPE VFKLMEEGKI LGRYVLDTSK
Length:350
Mass (Da):36,879
Last modified:November 1, 1995 - v1
Checksum:iC3DFE2E70F42D634
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39H → N in AAA53300 (Ref. 2) Curated1
Sequence conflicti53R → W in AAA53300 (Ref. 2) Curated1
Sequence conflicti140A → T no nucleotide entry (PubMed:1777830).Curated1
Sequence conflicti212F → L in AAA53300 (Ref. 2) Curated1
Sequence conflicti227D → A no nucleotide entry (PubMed:1777830).Curated1
Sequence conflicti313R → S no nucleotide entry (PubMed:1777830).Curated1
Sequence conflicti327D → E in AAA53300 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81694 Genomic DNA Translation: CAA57342.1
U15924 mRNA Translation: AAA53300.1
PIRiS63781 S52153

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81694 Genomic DNA Translation: CAA57342.1
U15924 mRNA Translation: AAA53300.1
PIRiS63781 S52153

3D structure databases

ProteinModelPortaliP43067
SMRiP43067
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei177 Cand a 1
3173 Cand a 1.0101
MoonDBiP43067 Curated
MoonProtiP43067

2D gel databases

COMPLUYEAST-2DPAGEiP43067

Proteomic databases

PRIDEiP43067

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR002328 ADH_Zn_CS
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00059 ADH_ZINC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_CANAX
AccessioniPrimary (citable) accession number: P43067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 20, 2018
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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