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UniProtKB - P43034 (LIS1_HUMAN)

Protein

Platelet-activating factor acetylhydrolase IB subunit alpha

Gene

PAFAH1B1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for proper activation of Rho GTPases and actin polymerization at the leading edge of locomoting cerebellar neurons and postmigratory hippocampal neurons in response to calcium influx triggered via NMDA receptors. Non-catalytic subunit of an acetylhydrolase complex which inactivates platelet-activating factor (PAF) by removing the acetyl group at the SN-2 position (By similarity). Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ventricular/subventricular zone toward the cortical plate. Neuronal migration involves a process called nucleokinesis, whereby migrating cells extend an anterior process into which the nucleus subsequently translocates. During nucleokinesis dynein at the nuclear surface may translocate the nucleus towards the centrosome by exerting force on centrosomal microtubules. May also play a role in other forms of cell locomotion including the migration of fibroblasts during wound healing. Required for dynein recruitment to microtubule plus ends and BICD2-bound cargos (PubMed:22956769).By similarity2 Publications

GO - Molecular functioni

  • dynactin binding Source: BHF-UCL
  • dynein complex binding Source: UniProtKB
  • dynein intermediate chain binding Source: Ensembl
  • heparin binding Source: BHF-UCL
  • microtubule binding Source: BHF-UCL
  • microtubule plus-end binding Source: GO_Central
  • phospholipase A2 activity Source: Reactome
  • phospholipase binding Source: BHF-UCL
  • phosphoprotein binding Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionDevelopmental protein
Biological processCell cycle, Cell division, Differentiation, Lipid degradation, Lipid metabolism, Mitosis, Neurogenesis, Transport

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-8854518 AURKA Activation by TPX2
SignaLinkiP43034
SIGNORiP43034

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-activating factor acetylhydrolase IB subunit alphaUniRule annotation
Alternative name(s):
Lissencephaly-1 proteinUniRule annotation
Short name:
LIS-1UniRule annotation
PAF acetylhydrolase 45 kDa subunitUniRule annotation
Short name:
PAF-AH 45 kDa subunitUniRule annotation
PAF-AH alphaUniRule annotation
Short name:
PAFAH alphaUniRule annotation
Gene namesi
Name:PAFAH1B1UniRule annotation
Synonyms:LIS1UniRule annotation, MDCR, MDS, PAFAHA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000007168.12
HGNCiHGNC:8574 PAFAH1B1
MIMi601545 gene
neXtProtiNX_P43034

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus

Pathology & Biotechi

Involvement in diseasei

Lissencephaly 1 (LIS1)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA classical lissencephaly. It is characterized by agyria or pachygyria and disorganization of the clear neuronal lamination of normal six-layered cortex. The cortex is abnormally thick and poorly organized with 4 primitive layers. Associated with enlarged and dysmorphic ventricles and often hypoplasia of the corpus callosum.
See also OMIM:607432
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01539831F → S in LIS1. 1 PublicationCorresponds to variant dbSNP:rs121434486EnsemblClinVar.1
Natural variantiVAR_007724149H → R in LIS1; abrogates interaction with NDE1 and reduces neuronal migration in vitro. 3 PublicationsCorresponds to variant dbSNP:rs121434482EnsemblClinVar.1
Natural variantiVAR_015399162G → S in LIS1. 1 PublicationCorresponds to variant dbSNP:rs121434487EnsemblClinVar.1
Natural variantiVAR_037301277H → P in LIS1. 1 PublicationCorresponds to variant dbSNP:rs121434490EnsemblClinVar.1
Natural variantiVAR_015400317D → H in LIS1; reduces neuronal migration in vitro. 2 PublicationsCorresponds to variant dbSNP:rs121434485EnsemblClinVar.1
Subcortical band heterotopia (SBH)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionSBH is a mild brain malformation of the lissencephaly spectrum. It is characterized by bilateral and symmetric plates or bands of gray matter found in the central white matter between the cortex and cerebral ventricles, cerebral convolutions usually appearing normal.
See also OMIM:607432
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010203169S → P in SBH; abrogates interaction with NDE1 and reduces neuronal migration in vitro. 3 PublicationsCorresponds to variant dbSNP:rs121434484EnsemblClinVar.1
Natural variantiVAR_037300241R → P in SBH; somatic mosaicism in 18% of lymphocytes and 21% of hair root cells. 1 PublicationCorresponds to variant dbSNP:rs121434488EnsemblClinVar.1
Miller-Dieker lissencephaly syndrome (MDLS)
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA contiguous gene deletion syndrome of chromosome 17p13.3, characterized by classical lissencephaly and distinct facial features. Additional congenital malformations can be part of the condition.
See also OMIM:247200

Keywords - Diseasei

Disease mutation, Lissencephaly

Organism-specific databases

DisGeNETi5048
GeneReviewsiPAFAH1B1
MalaCardsiPAFAH1B1
MIMi247200 phenotype
607432 phenotype
OpenTargetsiENSG00000007168
Orphaneti217385 17p13.3 microduplication syndrome
95232 Lissencephaly due to LIS1 mutation
531 Miller-Dieker syndrome
99796 Subcortical band heterotopia
PharmGKBiPA32905

Polymorphism and mutation databases

BioMutaiPAFAH1B1
DMDMi1170794

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000510611 – 410Platelet-activating factor acetylhydrolase IB subunit alphaAdd BLAST410

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei53N6-acetyllysineCombined sources1
Modified residuei109PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP43034
MaxQBiP43034
PaxDbiP43034
PeptideAtlasiP43034
PRIDEiP43034
ProteomicsDBi55575
55576 [P43034-2]

PTM databases

iPTMnetiP43034
PhosphoSitePlusiP43034

Expressioni

Tissue specificityi

Fairly ubiquitous expression in both the frontal and occipital areas of the brain.

Gene expression databases

BgeeiENSG00000007168 Expressed in 235 organ(s), highest expression level in testis
CleanExiHS_PAFAH1B1
ExpressionAtlasiP43034 baseline and differential
GenevisibleiP43034 HS

Organism-specific databases

HPAiCAB004489
HPA020036

Interactioni

Subunit structurei

Component of cytosolic PAF-AH IB, which is composed of PAFAH1B1 (alpha), PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Trimer formation is not essential for the catalytic activity of the enzyme which is contributed solely by the PAFAH1B2 (beta) and PAFAH1B3 (gamma) subunits. Interacts with IQGAP1, KATNB1 and NUDC. Interacts with DAB1 when DAB1 is phosphorylated in response to RELN/reelin signaling (By similarity). Can self-associate. Interacts with DCX, dynein, dynactin, NDE1, NDEL1 and RSN. Interacts with DISC1, and this interaction is enhanced by NDEL1. Interacts with ASUN. Interacts with DCDC5 (PubMed:22159412).By similarity8 Publications

Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridi111085, 105 interactors
DIPiDIP-35691N
IntActiP43034, 34 interactors
MINTiP43034
STRINGi9606.ENSP00000380378

Structurei

3D structure databases

ProteinModelPortaliP43034
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 39LisHUniRule annotationAdd BLAST33
Repeati106 – 147WD 1Add BLAST42
Repeati148 – 187WD 2Add BLAST40
Repeati190 – 229WD 3Add BLAST40
Repeati232 – 271WD 4Add BLAST40
Repeati274 – 333WD 5Add BLAST60
Repeati336 – 377WD 6Add BLAST42
Repeati378 – 410WD 7Add BLAST33

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 102Interaction with NDEL1UniRule annotationAdd BLAST102
Regioni1 – 66Interaction with NDE1UniRule annotationAdd BLAST66
Regioni1 – 38Required for self-association and interaction with PAFAH1B2 and PAFAH1B3UniRule annotationAdd BLAST38
Regioni83 – 410Interaction with dynein and dynactinAdd BLAST328
Regioni367 – 409Interaction with DCX1 PublicationAdd BLAST43
Regioni388 – 410Interaction with NDEL1UniRule annotationAdd BLAST23

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili56 – 82UniRule annotationAdd BLAST27

Domaini

Dimerization mediated by the LisH domain may be required to activate dynein.UniRule annotation

Sequence similaritiesi

Belongs to the WD repeat LIS1/nudF family.UniRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0295 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00810000125363
HOGENOMiHOG000184015
HOVERGENiHBG006271
InParanoidiP43034
KOiK16794
OMAiNWVRALV
OrthoDBiEOG091G07Q1
PhylomeDBiP43034
TreeFamiTF105741

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03141 lis1, 1 hit
InterProiView protein in InterPro
IPR017252 Dynein_regulator_LIS1
IPR020472 G-protein_beta_WD-40_rep
IPR037190 LIS1_N
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08513 LisH, 1 hit
PF00400 WD40, 7 hits
PIRSFiPIRSF037647 Dynein_regulator_Lis1, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF109925 SSF109925, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43034-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVLSQRQRDE LNRAIADYLR SNGYEEAYSV FKKEAELDVN EELDKKYAGL 
        60         70         80         90        100
LEKKWTSVIR LQKKVMELES KLNEAKEEFT SGGPLGQKRD PKEWIPRPPE 
       110        120        130        140        150
KYALSGHRSP VTRVIFHPVF SVMVSASEDA TIKVWDYETG DFERTLKGHT 
       160        170        180        190        200
DSVQDISFDH SGKLLASCSA DMTIKLWDFQ GFECIRTMHG HDHNVSSVAI 
       210        220        230        240        250
MPNGDHIVSA SRDKTIKMWE VQTGYCVKTF TGHREWVRMV RPNQDGTLIA 
       260        270        280        290        300
SCSNDQTVRV WVVATKECKA ELREHEHVVE CISWAPESSY SSISEATGSE 
       310        320        330        340        350
TKKSGKPGPF LLSGSRDKTI KMWDVSTGMC LMTLVGHDNW VRGVLFHSGG 
       360        370        380        390        400
KFILSCADDK TLRVWDYKNK RCMKTLNAHE HFVTSLDFHK TAPYVVTGSV 
       410
DQTVKVWECR
Length:410
Mass (Da):46,638
Last modified:January 23, 2007 - v2
Checksum:i3AB68D2641BA31C9
GO
Isoform 2 (identifier: P43034-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     12-64: Missing.
     134-170: Missing.
     237-237: V → I
     238-410: Missing.

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,869
Checksum:iB594509D159C7657
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L3N5I3L3N5_HUMAN
Platelet-activating factor acetylhy...
PAFAH1B1
208Annotation score:
I3L495I3L495_HUMAN
Platelet-activating factor acetylhy...
PAFAH1B1
82Annotation score:
I3L384I3L384_HUMAN
Platelet-activating factor acetylhy...
PAFAH1B1
14Annotation score:

Sequence cautioni

The sequence AAA02882 differs from that shown. Chimeric cDNA.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21S → P in AAL34972 (Ref. 3) Curated1
Sequence conflicti21S → P in AAL34973 (Ref. 3) Curated1
Sequence conflicti93E → G in AAL34973 (Ref. 3) Curated1
Sequence conflicti177W → R in AAL34973 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01539831F → S in LIS1. 1 PublicationCorresponds to variant dbSNP:rs121434486EnsemblClinVar.1
Natural variantiVAR_007724149H → R in LIS1; abrogates interaction with NDE1 and reduces neuronal migration in vitro. 3 PublicationsCorresponds to variant dbSNP:rs121434482EnsemblClinVar.1
Natural variantiVAR_015399162G → S in LIS1. 1 PublicationCorresponds to variant dbSNP:rs121434487EnsemblClinVar.1
Natural variantiVAR_010203169S → P in SBH; abrogates interaction with NDE1 and reduces neuronal migration in vitro. 3 PublicationsCorresponds to variant dbSNP:rs121434484EnsemblClinVar.1
Natural variantiVAR_037300241R → P in SBH; somatic mosaicism in 18% of lymphocytes and 21% of hair root cells. 1 PublicationCorresponds to variant dbSNP:rs121434488EnsemblClinVar.1
Natural variantiVAR_037301277H → P in LIS1. 1 PublicationCorresponds to variant dbSNP:rs121434490EnsemblClinVar.1
Natural variantiVAR_015400317D → H in LIS1; reduces neuronal migration in vitro. 2 PublicationsCorresponds to variant dbSNP:rs121434485EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01937612 – 64Missing in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_019377134 – 170Missing in isoform 2. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_019378237V → I in isoform 2. 1 Publication1
Alternative sequenceiVSP_019379238 – 410Missing in isoform 2. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13385 mRNA Translation: AAA02880.1
L13386 mRNA Translation: AAA02881.1
L13387 mRNA Translation: AAA02882.1 Sequence problems.
U72342
, U72334, U72335, U72336, U72337, U72338, U72339, U72340, U72341 Genomic DNA Translation: AAC51111.1
AF208837 mRNA Translation: AAL34972.1
AF208838 mRNA Translation: AAL34973.1
AF400434 mRNA Translation: AAK92483.1
AK313078 mRNA Translation: BAG35904.1
BX538346 mRNA Translation: CAD98141.1
CH471108 Genomic DNA Translation: EAW90536.1
BC064638 mRNA Translation: AAH64638.1
CCDSiCCDS32528.1 [P43034-1]
PIRiS36113
RefSeqiNP_000421.1, NM_000430.3 [P43034-1]
XP_016880188.1, XM_017024699.1
XP_016880189.1, XM_017024700.1
XP_016880190.1, XM_017024701.1 [P43034-1]
UniGeneiHs.77318

Genome annotation databases

EnsembliENST00000397195; ENSP00000380378; ENSG00000007168 [P43034-1]
GeneIDi5048
KEGGihsa:5048
UCSCiuc002fuw.5 human [P43034-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L13385 mRNA Translation: AAA02880.1
L13386 mRNA Translation: AAA02881.1
L13387 mRNA Translation: AAA02882.1 Sequence problems.
U72342
, U72334, U72335, U72336, U72337, U72338, U72339, U72340, U72341 Genomic DNA Translation: AAC51111.1
AF208837 mRNA Translation: AAL34972.1
AF208838 mRNA Translation: AAL34973.1
AF400434 mRNA Translation: AAK92483.1
AK313078 mRNA Translation: BAG35904.1
BX538346 mRNA Translation: CAD98141.1
CH471108 Genomic DNA Translation: EAW90536.1
BC064638 mRNA Translation: AAH64638.1
CCDSiCCDS32528.1 [P43034-1]
PIRiS36113
RefSeqiNP_000421.1, NM_000430.3 [P43034-1]
XP_016880188.1, XM_017024699.1
XP_016880189.1, XM_017024700.1
XP_016880190.1, XM_017024701.1 [P43034-1]
UniGeneiHs.77318

3D structure databases

ProteinModelPortaliP43034
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111085, 105 interactors
DIPiDIP-35691N
IntActiP43034, 34 interactors
MINTiP43034
STRINGi9606.ENSP00000380378

PTM databases

iPTMnetiP43034
PhosphoSitePlusiP43034

Polymorphism and mutation databases

BioMutaiPAFAH1B1
DMDMi1170794

Proteomic databases

EPDiP43034
MaxQBiP43034
PaxDbiP43034
PeptideAtlasiP43034
PRIDEiP43034
ProteomicsDBi55575
55576 [P43034-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397195; ENSP00000380378; ENSG00000007168 [P43034-1]
GeneIDi5048
KEGGihsa:5048
UCSCiuc002fuw.5 human [P43034-1]

Organism-specific databases

CTDi5048
DisGeNETi5048
EuPathDBiHostDB:ENSG00000007168.12
GeneCardsiPAFAH1B1
GeneReviewsiPAFAH1B1
HGNCiHGNC:8574 PAFAH1B1
HPAiCAB004489
HPA020036
MalaCardsiPAFAH1B1
MIMi247200 phenotype
601545 gene
607432 phenotype
neXtProtiNX_P43034
OpenTargetsiENSG00000007168
Orphaneti217385 17p13.3 microduplication syndrome
95232 Lissencephaly due to LIS1 mutation
531 Miller-Dieker syndrome
99796 Subcortical band heterotopia
PharmGKBiPA32905
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0295 Eukaryota
ENOG410XP3K LUCA
GeneTreeiENSGT00810000125363
HOGENOMiHOG000184015
HOVERGENiHBG006271
InParanoidiP43034
KOiK16794
OMAiNWVRALV
OrthoDBiEOG091G07Q1
PhylomeDBiP43034
TreeFamiTF105741

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-HSA-68877 Mitotic Prometaphase
R-HSA-8854518 AURKA Activation by TPX2
SignaLinkiP43034
SIGNORiP43034

Miscellaneous databases

ChiTaRSiPAFAH1B1 human
GeneWikiiPAFAH1B1
GenomeRNAii5048
PROiPR:P43034
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000007168 Expressed in 235 organ(s), highest expression level in testis
CleanExiHS_PAFAH1B1
ExpressionAtlasiP43034 baseline and differential
GenevisibleiP43034 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_03141 lis1, 1 hit
InterProiView protein in InterPro
IPR017252 Dynein_regulator_LIS1
IPR020472 G-protein_beta_WD-40_rep
IPR037190 LIS1_N
IPR006594 LisH
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF08513 LisH, 1 hit
PF00400 WD40, 7 hits
PIRSFiPIRSF037647 Dynein_regulator_Lis1, 1 hit
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00667 LisH, 1 hit
SM00320 WD40, 7 hits
SUPFAMiSSF109925 SSF109925, 1 hit
SSF50978 SSF50978, 1 hit
PROSITEiView protein in PROSITE
PS50896 LISH, 1 hit
PS00678 WD_REPEATS_1, 4 hits
PS50082 WD_REPEATS_2, 7 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIS1_HUMAN
AccessioniPrimary (citable) accession number: P43034
Secondary accession number(s): B2R7Q7, Q8WZ88, Q8WZ89
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 195 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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