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Protein

Growth/differentiation factor 7

Gene

Gdf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • cytokine activity Source: GO_Central
  • growth factor activity Source: UniProtKB-KW
  • protein homodimerization activity Source: MGI
  • transforming growth factor beta receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 7
Short name:
GDF-7
Gene namesi
Name:Gdf7
Synonyms:Gdf-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:95690 Gdf7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000003392420 – 315Sequence analysisAdd BLAST296
ChainiPRO_0000033925316 – 461Growth/differentiation factor 7Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi79N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi360 ↔ 426By similarity
Disulfide bondi389 ↔ 458By similarity
Disulfide bondi393 ↔ 460By similarity
Disulfide bondi425InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43029
PeptideAtlasiP43029
PRIDEiP43029

PTM databases

PhosphoSitePlusiP43029

Expressioni

Gene expression databases

BgeeiENSMUSG00000037660 Expressed in 16 organ(s), highest expression level in shoulder
CleanExiMM_GDF7

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231945, 1 interactor
IntActiP43029, 3 interactors
MINTiP43029
STRINGi10090.ENSMUSP00000038301

Structurei

3D structure databases

ProteinModelPortaliP43029
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi311 – 315Poly-Arg5
Compositional biasi326 – 351Poly-GlyAdd BLAST26

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000231514
HOVERGENiHBG107938
InParanoidiP43029
KOiK20013
OMAiLVGQRWE
OrthoDBiEOG091G09KP
PhylomeDBiP43029
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P43029-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPAWSP GGGGGGRTLA
60 70 80 90 100
RAPGPSALQA AAVPGPRAVR RAAGSGFRNG SVVPHHFMMS LYRSLAGRAP
110 120 130 140 150
VAAASGHGRV DTITGFTDQA TQDETAAAEP GQSFLFDVSS LSEADEVVNA
160 170 180 190 200
ELRVLRRRSP EPDRDSATLL PRLLLSTCPD EAGTAHLLHS RAAEPLGGAR
210 220 230 240 250
WEAFDVTDAV QSHRRWPRAS RKFCLVLRAV TASESSPLAL RRLGFGWPGG
260 270 280 290 300
GDGGGTAAEE RALLVISSRT QRKESLFREI RAQARALRAA AEPPPDPGPG
310 320 330 340 350
AGSRKANLGG RRRRRTALAG TRGAQGSGGG GGGGGGGGGG GGGGGGGAGR
360 370 380 390 400
GHGRRGRSRC SRKSLHVDFK ELGWDDWIIA PLDYEAYHCE GVCDFPLRSH
410 420 430 440 450
LEPTNHAIIQ TLLNSMAPDA APASCCVPAR LSPISILYID AANNVVYKQY
460
EDMVVEACGC R
Length:461
Mass (Da):47,891
Last modified:July 19, 2004 - v2
Checksum:i92C2511C86EDE478
GO
Isoform 2 (identifier: P43029-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-130: Missing.

Show »
Length:453
Mass (Da):47,106
Checksum:iCB9D5A45E7D22648
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_010764123 – 130Missing in isoform 2. 1 Publication8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525752 mRNA Translation: AAP97721.1
AH010605 Genomic DNA Translation: AAK30843.1
U08339 Unassigned DNA Translation: AAA18780.1
CCDSiCCDS83954.1 [P43029-1]
PIRiS43296
RefSeqiNP_001299805.1, NM_001312876.1 [P43029-1]
NP_038555.1, NM_013527.1 [P43029-2]
UniGeneiMm.271308

Genome annotation databases

EnsembliENSMUST00000037313; ENSMUSP00000038301; ENSMUSG00000037660 [P43029-1]
ENSMUST00000220073; ENSMUSP00000151234; ENSMUSG00000037660 [P43029-2]
GeneIDi238057
KEGGimmu:238057
UCSCiuc007mzl.1 mouse [P43029-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525752 mRNA Translation: AAP97721.1
AH010605 Genomic DNA Translation: AAK30843.1
U08339 Unassigned DNA Translation: AAA18780.1
CCDSiCCDS83954.1 [P43029-1]
PIRiS43296
RefSeqiNP_001299805.1, NM_001312876.1 [P43029-1]
NP_038555.1, NM_013527.1 [P43029-2]
UniGeneiMm.271308

3D structure databases

ProteinModelPortaliP43029
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231945, 1 interactor
IntActiP43029, 3 interactors
MINTiP43029
STRINGi10090.ENSMUSP00000038301

PTM databases

PhosphoSitePlusiP43029

Proteomic databases

PaxDbiP43029
PeptideAtlasiP43029
PRIDEiP43029

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037313; ENSMUSP00000038301; ENSMUSG00000037660 [P43029-1]
ENSMUST00000220073; ENSMUSP00000151234; ENSMUSG00000037660 [P43029-2]
GeneIDi238057
KEGGimmu:238057
UCSCiuc007mzl.1 mouse [P43029-2]

Organism-specific databases

CTDi151449
MGIiMGI:95690 Gdf7

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00760000118883
HOGENOMiHOG000231514
HOVERGENiHBG107938
InParanoidiP43029
KOiK20013
OMAiLVGQRWE
OrthoDBiEOG091G09KP
PhylomeDBiP43029
TreeFamiTF316134

Miscellaneous databases

PROiPR:P43029
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037660 Expressed in 16 organ(s), highest expression level in shoulder
CleanExiMM_GDF7

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
PF00688 TGFb_propeptide, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGDF7_MOUSE
AccessioniPrimary (citable) accession number: P43029
Secondary accession number(s): Q7TNX4, Q99MY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 19, 2004
Last modified: November 7, 2018
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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