UniProtKB - P43027 (GDF5_MOUSE)
Growth/differentiation factor 5
Gdf5
Functioni
GO - Molecular functioni
- BMP binding Source: MGI
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: MGI
- signaling receptor binding Source: MGI
GO - Biological processi
- BMP signaling pathway Source: GO_Central
- chondroblast differentiation Source: MGI
- embryonic limb morphogenesis Source: MGI
- forelimb morphogenesis Source: MGI
- hindlimb morphogenesis Source: MGI
- negative regulation of chondrocyte differentiation Source: MGI
- negative regulation of epithelial cell proliferation Source: MGI
- negative regulation of mesenchymal cell apoptotic process Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- ossification involved in bone remodeling Source: Ensembl
- positive regulation of BMP signaling pathway Source: MGI
- positive regulation of chondrocyte differentiation Source: MGI
- positive regulation of neuron differentiation Source: MGI
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: GO_Central
- regulation of multicellular organism growth Source: MGI
- regulation of SMAD protein signal transduction Source: MGI
- response to mechanical stimulus Source: Ensembl
- SMAD protein signal transduction Source: MGI
- transmembrane receptor protein serine/threonine kinase signaling pathway Source: MGI
Keywordsi
Molecular function | Cytokine, Growth factor |
Biological process | Chondrogenesis |
Enzyme and pathway databases
Reactomei | R-MMU-2129379, Molecules associated with elastic fibres |
Names & Taxonomyi
Protein namesi | Recommended name: Growth/differentiation factor 5Short name: GDF-5 Alternative name(s): Bone morphogenetic protein 14 Short name: BMP-14 |
Gene namesi | Name:Gdf5 Synonyms:Bmp14, Bp, Gdf-5 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95688, Gdf5 |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: GO_Central
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPathology & Biotechi
Involvement in diseasei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
PropeptideiPRO_0000033914 | 28 – 375 | Sequence analysisAdd BLAST | 348 | |
ChainiPRO_0000033915 | 376 – 495 | Growth/differentiation factor 5Add BLAST | 120 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 183 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 394 ↔ 460 | By similarity | ||
Disulfide bondi | 423 ↔ 492 | By similarity | ||
Disulfide bondi | 427 ↔ 494 | By similarity | ||
Disulfide bondi | 459 | InterchainBy similarity |
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P43027 |
PRIDEi | P43027 |
PTM databases
GlyGeni | P43027, 1 site |
iPTMneti | P43027 |
PhosphoSitePlusi | P43027 |
Expressioni
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000038259, Expressed in limb bud and 148 other tissues |
Genevisiblei | P43027, MM |
Interactioni
Subunit structurei
Homodimer; disulfide-linked (By similarity).
Interacts with serine proteases, HTRA1 and HTRA3 (PubMed:15206957, PubMed:14973287). Following LPS binding, may form a complex with CXCR4, HSP90AA1 and HSPA8 (By similarity).
Interacts with high affinity with NOG; inhibits chondrogenesis (By similarity).
Interacts with high affinity with BMPR1B and lower affinity with BMPR1A; positively regulates chondrocyte differentiation and induces SMAD-dependent signaling.
Interacts with FBN1 (via N-terminal domain) and FBN2 (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- BMP binding Source: MGI
- cytokine activity Source: GO_Central
- growth factor activity Source: UniProtKB-KW
- identical protein binding Source: MGI
- signaling receptor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 199888, 2 interactors |
STRINGi | 10090.ENSMUSP00000048079 |
Miscellaneous databases
RNActi | P43027, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000160455 |
HOGENOMi | CLU_020515_0_0_1 |
InParanoidi | P43027 |
OMAi | PKARCSR |
OrthoDBi | 749511at2759 |
TreeFami | TF316134 |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MRLPKLLTLL LWHLAWLDLE LICTVLGAPD LGQRTPGAKP GLTKAEAKER
60 70 80 90 100
PPLARNVFRP GGHIYGVGAT NARAKGSSGQ TQAKKDEPRK MPPRSGGPET
110 120 130 140 150
KPGPSSQTRQ AAARTVTPKG QLPGGKASSK AGSAPSSFLL KKTREPGTPR
160 170 180 190 200
EPKEPFRPPP ITPHEYMLSL YRTLSDADRK GGNSSVKLEA GLANTITSFI
210 220 230 240 250
DKGQDDRGPA VRKQRYVFDI SALEKDGLLG AELRILRKKP LDVAKPAVPS
260 270 280 290 300
SGRVAQLKLS SCPSGRQPAA LLDVRSVPGL DGSGWEVFDI WKLFRNFKNS
310 320 330 340 350
AQLCLELEAW ERGRAVDLRG LGFERTARQV HEKALFLVFG RTKKRDLFFN
360 370 380 390 400
EIKARSGQDD KTVYEYLFSQ RRKRRAPLAN RQGKRPSKNL KARCSRKALH
410 420 430 440 450
VNFKDMGWDD WIIAPLEYEA FHCEGLCEFP LRSHLEPTNH AVIQTLMNSM
460 470 480 490
DPESTPPTCC VPTRLSPISI LFIDSANNVV YKQYEDMVVE SCGCR
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 98 | P → S2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08337 mRNA Translation: AAA18778.1 AL845445 Genomic DNA No translation available. CH466551 Genomic DNA Translation: EDL06156.1 BC034546 mRNA Translation: AAH34546.1 |
CCDSi | CCDS16958.1 |
PIRi | S43294 |
RefSeqi | NP_032135.2, NM_008109.3 |
Genome annotation databases
Ensembli | ENSMUST00000040162; ENSMUSP00000048079; ENSMUSG00000038259 |
GeneIDi | 14563 |
KEGGi | mmu:14563 |
UCSCi | uc012chg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08337 mRNA Translation: AAA18778.1 AL845445 Genomic DNA No translation available. CH466551 Genomic DNA Translation: EDL06156.1 BC034546 mRNA Translation: AAH34546.1 |
CCDSi | CCDS16958.1 |
PIRi | S43294 |
RefSeqi | NP_032135.2, NM_008109.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 199888, 2 interactors |
STRINGi | 10090.ENSMUSP00000048079 |
PTM databases
GlyGeni | P43027, 1 site |
iPTMneti | P43027 |
PhosphoSitePlusi | P43027 |
Proteomic databases
PaxDbi | P43027 |
PRIDEi | P43027 |
Protocols and materials databases
Antibodypediai | 2854, 399 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000040162; ENSMUSP00000048079; ENSMUSG00000038259 |
GeneIDi | 14563 |
KEGGi | mmu:14563 |
UCSCi | uc012chg.1, mouse |
Organism-specific databases
CTDi | 8200 |
MGIi | MGI:95688, Gdf5 |
Phylogenomic databases
eggNOGi | KOG3900, Eukaryota |
GeneTreei | ENSGT00940000160455 |
HOGENOMi | CLU_020515_0_0_1 |
InParanoidi | P43027 |
OMAi | PKARCSR |
OrthoDBi | 749511at2759 |
TreeFami | TF316134 |
Enzyme and pathway databases
Reactomei | R-MMU-2129379, Molecules associated with elastic fibres |
Miscellaneous databases
BioGRID-ORCSi | 14563, 1 hit in 17 CRISPR screens |
PROi | PR:P43027 |
RNActi | P43027, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038259, Expressed in limb bud and 148 other tissues |
Genevisiblei | P43027, MM |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR001839, TGF-b_C IPR001111, TGF-b_propeptide IPR015615, TGF-beta-rel IPR017948, TGFb_CS |
PANTHERi | PTHR11848, PTHR11848, 1 hit |
Pfami | View protein in Pfam PF00019, TGF_beta, 1 hit PF00688, TGFb_propeptide, 1 hit |
SMARTi | View protein in SMART SM00204, TGFB, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00250, TGF_BETA_1, 1 hit PS51362, TGF_BETA_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GDF5_MOUSE | |
Accessioni | P43027Primary (citable) accession number: P43027 Secondary accession number(s): A2ARK2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 10, 2021 | |
This is version 175 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families