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Protein

Tetranectin

Gene

Clec3b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis (By similarity).By similarity

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • carbohydrate binding Source: MGI
  • heparin binding Source: UniProtKB
  • kringle domain binding Source: MGI

GO - Biological processi

  • bone mineralization Source: UniProtKB
  • ossification Source: UniProtKB
  • positive regulation of plasminogen activation Source: UniProtKB
  • skeletal system development Source: MGI

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Tetranectin
Short name:
TN
Alternative name(s):
C-type lectin domain family 3 member B
Plasminogen kringle 4-binding protein
Gene namesi
Name:Clec3b
Synonyms:Tna
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:104540 Clec3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001747222 – 202TetranectinAdd BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 81PROSITE-ProRule annotation
Disulfide bondi98 ↔ 197PROSITE-ProRule annotation
Disulfide bondi173 ↔ 189PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP43025
PaxDbiP43025
PeptideAtlasiP43025
PRIDEiP43025

Expressioni

Tissue specificityi

Highest expression in lung and skeletal muscle.

Gene expression databases

CleanExiMM_CLEC3B

Interactioni

Subunit structurei

Homotrimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026890

Structurei

3D structure databases

ProteinModelPortaliP43025
SMRiP43025
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 198C-type lectinPROSITE-ProRule annotationAdd BLAST122

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000060248
HOVERGENiHBG108270
InParanoidiP43025
PhylomeDBiP43025

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P43025-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFWGTYLLF CLFSFLSQLT AESPTPKAKK AANAKKDLVS SKMFEELKNR
60 70 80 90 100
MDVLAQEVAL LKEKQALQTV CLKGTKVNLK CLLAFTQPKT FHEASEDCIS
110 120 130 140 150
QGGTLGTPQS ELENEALFEY ARHSVGNDAN IWLGLNDMAA EGAWVDMTGG
160 170 180 190 200
LLAYKNWETE ITTQPDGGKA ENCAALSGAA NGKWFDKRCR DQLPYICQFA

IV
Length:202
Mass (Da):22,257
Last modified:February 1, 1996 - v2
Checksum:i639E7334D58EB04E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8CFZ6Q8CFZ6_MOUSE
C-type lectin domain family 3, memb...
Clec3b Tna
202Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti19 – 20LT → VI in AAA96811 (PubMed:8563165).Curated2
Sequence conflicti84A → T in AAA96811 (PubMed:8563165).Curated1
Sequence conflicti180A → R in AAA96811 (PubMed:8563165).Curated1
Sequence conflicti188R → Q in AAA96811 (PubMed:8563165).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79199 mRNA Translation: CAA55791.1
U08595 mRNA Translation: AAA96811.1
X98122 Genomic DNA Translation: CAA66804.1
CCDSiCCDS23656.1
PIRiJC4031
UniGeneiMm.34588

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79199 mRNA Translation: CAA55791.1
U08595 mRNA Translation: AAA96811.1
X98122 Genomic DNA Translation: CAA66804.1
CCDSiCCDS23656.1
PIRiJC4031
UniGeneiMm.34588

3D structure databases

ProteinModelPortaliP43025
SMRiP43025
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000026890

Proteomic databases

MaxQBiP43025
PaxDbiP43025
PeptideAtlasiP43025
PRIDEiP43025

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:104540 Clec3b

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000060248
HOVERGENiHBG108270
InParanoidiP43025
PhylomeDBiP43025

Miscellaneous databases

ChiTaRSiClec3b mouse
PROiPR:P43025
SOURCEiSearch...

Gene expression databases

CleanExiMM_CLEC3B

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTETN_MOUSE
AccessioniPrimary (citable) accession number: P43025
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: July 18, 2018
This is version 120 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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