Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Cytochrome c oxidase subunit 6A1, mitochondrial

Gene

Cox6a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A1, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-liver
Gene namesi
Name:Cox6a1
Synonyms:Cox6al
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:103099 Cox6a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Mice have walking difficulties. Histologic examination shows thinned sciatic nerves and neurogenic muscular changes, including small angular fibers and small group atrophy. Electrophysiologic studies show delayed motor nerve conduction velocities compared to controls. COX activity and ATP contents in liver cells are decreased.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 26MitochondrionBy similarityAdd BLAST26
ChainiPRO_000000612027 – 111Cytochrome c oxidase subunit 6A1, mitochondrialAdd BLAST85

Proteomic databases

EPDiP43024
MaxQBiP43024
PaxDbiP43024
PeptideAtlasiP43024
PRIDEiP43024
TopDownProteomicsiP43024

2D gel databases

SWISS-2DPAGEiP43024

PTM databases

PhosphoSitePlusiP43024

Expressioni

Gene expression databases

CleanExiMM_COX6A1

Interactioni

Protein-protein interaction databases

BioGridi198843, 1 interactor
CORUMiP43024
IntActiP43024, 1 interactor
STRINGi10090.ENSMUSP00000047661

Structurei

3D structure databases

ProteinModelPortaliP43024
SMRiP43024
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3469 Eukaryota
ENOG411253X LUCA
HOVERGENiHBG060482
InParanoidiP43024
KOiK02266
OMAiHEEHERP

Family and domain databases

CDDicd00925 Cyt_c_Oxidase_VIa, 1 hit
Gene3Di4.10.95.10, 1 hit
InterProiView protein in InterPro
IPR001349 Cyt_c_oxidase_su6a
IPR018507 Cyt_c_oxidase_su6a_CS
IPR036418 Cyt_c_oxidase_su6a_sf
PANTHERiPTHR11504 PTHR11504, 1 hit
PfamiView protein in Pfam
PF02046 COX6A, 1 hit
PIRSFiPIRSF000277 COX6A1, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD006036 Cyt_c_oxidase_su6a, 1 hit
SUPFAMiSSF81411 SSF81411, 1 hit
PROSITEiView protein in PROSITE
PS01329 COX6A, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

P43024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAVLSASR VSRPLGRALP GLRRPMSSGA HGEEGSARMW KALTYFVALP
60 70 80 90 100
GVGVSMLNVF LKSRHEEHER PPFVAYPHLR IRTKPFPWGD GNHTLFHNPH
110
VNPLPTGYED E
Length:111
Mass (Da):12,352
Last modified:February 1, 1996 - v2
Checksum:i76D5EDA5F79EC5E7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9DCW5Q9DCW5_MOUSE
Cytochrome c oxidase subunit 6A, mi...
Cox6a1 mCG_19235
112Annotation score:

Sequence cautioni

The sequence AAA17836 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence AAA53066 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L06465 mRNA Translation: AAA53066.1 Different initiation.
U08440 mRNA Translation: AAA17836.1 Different initiation.
RefSeqiNP_031774.1, NM_007748.3
UniGeneiMm.43415

Genome annotation databases

GeneIDi12861
KEGGimmu:12861

Similar proteinsi

Entry informationi

Entry nameiCX6A1_MOUSE
AccessioniPrimary (citable) accession number: P43024
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: May 23, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again