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Protein

Nodal

Gene

Nodal

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Essential for mesoderm formation and axial patterning during embryonic development.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Developmental protein, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal
Gene namesi
Name:Nodal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:97359 Nodal

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000003400027 – 244Sequence analysisAdd BLAST218
ChainiPRO_0000034001245 – 354NodalAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi254 ↔ 320By similarity
Disulfide bondi283 ↔ 351By similarity
Disulfide bondi287 ↔ 353By similarity
Disulfide bondi319InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43021
PRIDEiP43021

Expressioni

Developmental stagei

Expressed in the node during gastrulation. Expression is first detected in primitive streak-stage embryos at about the time of mesoderm formation. It then becomes highly localized in the node at the anterior of the primitive streak.1 Publication

Gene expression databases

BgeeiENSMUSG00000037171 Expressed in 208 organ(s), highest expression level in primitive knot
CleanExiMM_NODAL
GenevisibleiP43021 MM

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi201801, 2 interactors
STRINGi10090.ENSMUSP00000039653

Structurei

3D structure databases

ProteinModelPortaliP43021
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900 Eukaryota
ENOG410XT8Z LUCA
GeneTreeiENSGT00910000143982
HOGENOMiHOG000113815
HOVERGENiHBG108195
InParanoidiP43021
KOiK04666
OMAiHRVPSTC
OrthoDBiEOG091G0AB9
TreeFamiTF316134

Family and domain databases

Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR001839 TGF-b_C
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS
PANTHERiPTHR11848 PTHR11848, 1 hit
PfamiView protein in Pfam
PF00019 TGF_beta, 1 hit
SMARTiView protein in SMART
SM00204 TGFB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00250 TGF_BETA_1, 1 hit
PS51362 TGF_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43021-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAHSLRILL LQACWALLHP RAPTAAALPL WTRGQPSSPS PLAYMLSLYR
60 70 80 90 100
DPLPRADIIR SLQAQDVDVT GQNWTFTFDF SFLSQEEDLV WAELRLQLPG
110 120 130 140 150
PMDIPTEGPL TIDIFHQAKG DPERDPADCL ERIWMETFTV IPSQVTFASG
160 170 180 190 200
STVLEVTKPL SKWLKDPRAL EKQVSSRAEK CWHQPYTPPV PVASTNVLML
210 220 230 240 250
YSNRPQEQRQ LGGATLLWEA ESSWRAQEGQ LSVERGGWGR RQRRHHLPDR
260 270 280 290 300
SQLCRRVKFQ VDFNLIGWGS WIIYPKQYNA YRCEGECPNP VGEEFHPTNH
310 320 330 340 350
AYIQSLLKRY QPHRVPSTCC APVKTKPLSM LYVDNGRVLL EHHKDMIVEE

CGCL
Length:354
Mass (Da):40,476
Last modified:July 27, 2011 - v2
Checksum:i40ECFC6785BB5826
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93 – 94EL → DV in CAA49914 (PubMed:8429908).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70514 mRNA Translation: CAA49914.1
AK049290 mRNA Translation: BAC33661.1
AK082823 mRNA Translation: BAC38637.1
CH466553 Genomic DNA Translation: EDL32144.1
CCDSiCCDS23878.1
PIRiS29718
RefSeqiNP_038639.2, NM_013611.5
UniGeneiMm.57195

Genome annotation databases

EnsembliENSMUST00000049339; ENSMUSP00000039653; ENSMUSG00000037171
GeneIDi18119
KEGGimmu:18119
UCSCiuc007ffy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiNODAL_MOUSE
AccessioniPrimary (citable) accession number: P43021
Secondary accession number(s): Q8BH87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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