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Entry version 174 (18 Sep 2019)
Sequence version 1 (01 Nov 1995)
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Protein

Neutral amino acid transporter A

Gene

SLC1A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-352230 Amino acid transport across the plasma membrane

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.23.3.1 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Neutral amino acid transporter A
Alternative name(s):
Alanine/serine/cysteine/threonine transporter 1
Short name:
ASCT-1
SATT
Solute carrier family 1 member 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC1A4
Synonyms:ASCT1, SATT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10942 SLC1A4

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600229 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43007

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei42 – 62HelicalSequence analysisAdd BLAST21
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 216ExtracellularSequence analysisAdd BLAST77
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Transmembranei298 – 318HelicalSequence analysisAdd BLAST21
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Transmembranei418 – 438HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA neurodevelopmental disorder characterized by thin corpus callosum, severe progressive microcephaly, severe intellectual disability, seizures, spasticity, and global developmental delay. Most patients are unable to achieve independent walking or speech.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075085256E → K in SPATCCM; does not affect localization at the cell surface; decreased uptake of L-serine and L-alanine; Vmax is decreased by at least 50% for both substrates; 3-fold increase of affinity for L-serine; 2-fold increase of affinity for L-alanine. 3 PublicationsCorresponds to variant dbSNP:rs201278558EnsemblClinVar.1
Natural variantiVAR_075086457R → W in SPATCCM; does not affect localization at the cell surface; loss of uptake of L-serine and L-alanine. 1 PublicationCorresponds to variant dbSNP:rs761533681EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6509

MalaCards human disease database

More...
MalaCardsi
SLC1A4
MIMi616657 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000115902

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
447997 Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35829

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2315

Drug and drug target database

More...
DrugBanki
DB00160 L-Alanine

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC1A4

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1173365

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002020791 – 532Neutral amino acid transporter AAdd BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi201N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi206N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei507PhosphoserineCombined sources1
Modified residuei527PhosphoserineBy similarity1
Modified residuei530PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P43007

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P43007

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P43007

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P43007

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43007

PeptideAtlas

More...
PeptideAtlasi
P43007

PRoteomics IDEntifications database

More...
PRIDEi
P43007

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55572 [P43007-1]
55573 [P43007-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43007

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43007

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P43007

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P43007

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000115902 Expressed in 228 organ(s), highest expression level in tendon of biceps brachii

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P43007 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA034963
HPA034964

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112400, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P43007, 5 interactors

Molecular INTeraction database

More...
MINTi
P43007

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000234256

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P43007

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3787 Eukaryota
COG1301 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157081

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000208776

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P43007

KEGG Orthology (KO)

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KOi
K05615

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMNLAPY

Database of Orthologous Groups

More...
OrthoDBi
1184392at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P43007

TreeFam database of animal gene trees

More...
TreeFami
TF315206

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00375 SDF, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF118215 SSF118215, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P43007-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEKSNETNGY LDSAQAGPAA GPGAPGTAAG RARRCAGFLR RQALVLLTVS
60 70 80 90 100
GVLAGAGLGA ALRGLSLSRT QVTYLAFPGE MLLRMLRMII LPLVVCSLVS
110 120 130 140 150
GAASLDASCL GRLGGIAVAY FGLTTLSASA LAVALAFIIK PGSGAQTLQS
160 170 180 190 200
SDLGLEDSGP PPVPKETVDS FLDLARNLFP SNLVVAAFRT YATDYKVVTQ
210 220 230 240 250
NSSSGNVTHE KIPIGTEIEG MNILGLVLFA LVLGVALKKL GSEGEDLIRF
260 270 280 290 300
FNSLNEATMV LVSWIMWYVP VGIMFLVGSK IVEMKDIIVL VTSLGKYIFA
310 320 330 340 350
SILGHVIHGG IVLPLIYFVF TRKNPFRFLL GLLAPFATAF ATCSSSATLP
360 370 380 390 400
SMMKCIEENN GVDKRISRFI LPIGATVNMD GAAIFQCVAA VFIAQLNNVE
410 420 430 440 450
LNAGQIFTIL VTATASSVGA AGVPAGGVLT IAIILEAIGL PTHDLPLILA
460 470 480 490 500
VDWIVDRTTT VVNVEGDALG AGILHHLNQK ATKKGEQELA EVKVEAIPNC
510 520 530
KSEEETSPLV THQNPAGPVA SAPELESKES VL
Length:532
Mass (Da):55,723
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i57925860042FCEB6
GO
Isoform 2 (identifier: P43007-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-220: Missing.
     267-345: WYVPVGIMFL...FATAFATCSS → C

Note: No experimental confirmation available.
Show »
Length:234
Mass (Da):24,620
Checksum:i4478DAA139931DAB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti117A → R in AAA02761 (PubMed:8101838).Curated1
Sequence conflicti127S → T in AAA19438 (PubMed:8340364).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01187837G → R. Corresponds to variant dbSNP:rs1064512Ensembl.1
Natural variantiVAR_075085256E → K in SPATCCM; does not affect localization at the cell surface; decreased uptake of L-serine and L-alanine; Vmax is decreased by at least 50% for both substrates; 3-fold increase of affinity for L-serine; 2-fold increase of affinity for L-alanine. 3 PublicationsCorresponds to variant dbSNP:rs201278558EnsemblClinVar.1
Natural variantiVAR_011879399V → I. Corresponds to variant dbSNP:rs759458Ensembl.1
Natural variantiVAR_075086457R → W in SPATCCM; does not affect localization at the cell surface; loss of uptake of L-serine and L-alanine. 1 PublicationCorresponds to variant dbSNP:rs761533681EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0428801 – 220Missing in isoform 2. 1 PublicationAdd BLAST220
Alternative sequenceiVSP_042881267 – 345WYVPV…ATCSS → C in isoform 2. 1 PublicationAdd BLAST79

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L14595 mRNA Translation: AAA02761.1
L19444 mRNA Translation: AAA19438.1
U05235
, U05229, U05230, U05231, U05232, U05233, U05234 Genomic DNA Translation: AAC51349.1
AK295687 mRNA Translation: BAH12156.1
AC007386 Genomic DNA Translation: AAF03519.1
CH471053 Genomic DNA Translation: EAW99932.1
CH471053 Genomic DNA Translation: EAW99933.1
BC026216 mRNA Translation: AAH26216.1
BC072423 mRNA Translation: AAH72423.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS1879.1 [P43007-1]
CCDS54362.1 [P43007-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
I37188
I55389

NCBI Reference Sequences

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RefSeqi
NP_001180422.1, NM_001193493.1 [P43007-2]
NP_003029.2, NM_003038.4 [P43007-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000234256; ENSP00000234256; ENSG00000115902 [P43007-1]
ENST00000531327; ENSP00000431942; ENSG00000115902 [P43007-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6509

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6509

UCSC genome browser

More...
UCSCi
uc010ypz.3 human [P43007-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14595 mRNA Translation: AAA02761.1
L19444 mRNA Translation: AAA19438.1
U05235
, U05229, U05230, U05231, U05232, U05233, U05234 Genomic DNA Translation: AAC51349.1
AK295687 mRNA Translation: BAH12156.1
AC007386 Genomic DNA Translation: AAF03519.1
CH471053 Genomic DNA Translation: EAW99932.1
CH471053 Genomic DNA Translation: EAW99933.1
BC026216 mRNA Translation: AAH26216.1
BC072423 mRNA Translation: AAH72423.1
CCDSiCCDS1879.1 [P43007-1]
CCDS54362.1 [P43007-2]
PIRiI37188
I55389
RefSeqiNP_001180422.1, NM_001193493.1 [P43007-2]
NP_003029.2, NM_003038.4 [P43007-1]

3D structure databases

SMRiP43007
ModBaseiSearch...

Protein-protein interaction databases

BioGridi112400, 8 interactors
IntActiP43007, 5 interactors
MINTiP43007
STRINGi9606.ENSP00000234256

Chemistry databases

ChEMBLiCHEMBL2315
DrugBankiDB00160 L-Alanine

Protein family/group databases

TCDBi2.A.23.3.1 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

PTM databases

iPTMnetiP43007
PhosphoSitePlusiP43007
SwissPalmiP43007

Polymorphism and mutation databases

BioMutaiSLC1A4
DMDMi1173365

Proteomic databases

EPDiP43007
jPOSTiP43007
MassIVEiP43007
MaxQBiP43007
PaxDbiP43007
PeptideAtlasiP43007
PRIDEiP43007
ProteomicsDBi55572 [P43007-1]
55573 [P43007-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6509
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000234256; ENSP00000234256; ENSG00000115902 [P43007-1]
ENST00000531327; ENSP00000431942; ENSG00000115902 [P43007-2]
GeneIDi6509
KEGGihsa:6509
UCSCiuc010ypz.3 human [P43007-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6509
DisGeNETi6509

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC1A4
HGNCiHGNC:10942 SLC1A4
HPAiHPA034963
HPA034964
MalaCardsiSLC1A4
MIMi600229 gene
616657 phenotype
neXtProtiNX_P43007
OpenTargetsiENSG00000115902
Orphaneti447997 Spastic tetraplegia-thin corpus callosum-progressive postnatal microcephaly syndrome
PharmGKBiPA35829

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3787 Eukaryota
COG1301 LUCA
GeneTreeiENSGT00940000157081
HOGENOMiHOG000208776
InParanoidiP43007
KOiK05615
OMAiIMNLAPY
OrthoDBi1184392at2759
PhylomeDBiP43007
TreeFamiTF315206

Enzyme and pathway databases

ReactomeiR-HSA-352230 Amino acid transport across the plasma membrane

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC1A4 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
SLC1A4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6509

Pharos

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Pharosi
P43007
PMAP-CutDBiP43007

Protein Ontology

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PROi
PR:P43007

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000115902 Expressed in 228 organ(s), highest expression level in tendon of biceps brachii
GenevisibleiP43007 HS

Family and domain databases

InterProiView protein in InterPro
IPR001991 Na-dicarboxylate_symporter
IPR018107 Na-dicarboxylate_symporter_CS
IPR036458 Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375 SDF, 1 hit
SUPFAMiSSF118215 SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSATT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43007
Secondary accession number(s): B7Z3C0, D6W5F0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 18, 2019
This is version 174 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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