SLC1A1

Functionⁱ

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na⁺ ions and one proton, in parallel with the counter-transport of one K⁺ ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl^- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na⁺ symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Negatively regulated by ARL6IP5 (By similarity).By similarity5 Publications

Kineticsⁱ

K_M=
268 µM for L-glutamate
1 Publication
Manual assertion based on experiment inⁱ
- Ref.10
  "Caveolin-1 Sensitivity of Excitatory Amino Acid Transporters EAAT1, EAAT2, EAAT3, and EAAT4."
  Abousaab A., Warsi J., Elvira B., Lang F.
  J. Membr. Biol. 249:239-249(2016) [PubMed] [Europe PMC] [Abstract]
  Cited for: FUNCTION, SUBCELLULAR LOCATION, BIOPHYSICOCHEMICAL PROPERTIES.

Sites

Feature key	Position(s)	DescriptionActions	Length
Metal bindingⁱ	362	Sodium 1; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	364	Sodium 2; via carbonyl oxygenBy similarity	1
Metal bindingⁱ	366	Sodium 1By similarity	1
Binding siteⁱ	370	AspartateBy similarity	1
Binding siteⁱ	444	AspartateBy similarity	1
Metal bindingⁱ	451	Sodium 1; via carbonyl oxygenBy similarity	1
Binding siteⁱ	451	AspartateBy similarity	1
Metal bindingⁱ	455	Sodium 1By similarity	1

GO - Molecular functionⁱ

amino acid transmembrane transporter activity Source: Reactome
chloride transmembrane transporter activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8857541
cysteine transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21123949
glutamate:sodium symporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 8857541
glutamate binding Source: Ensembl
high-affinity glutamate transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26690923
- 8857541
L-glutamate transmembrane transporter activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21123949
metal ion binding Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 7521911
chloride transmembrane transport
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8857541
cysteine transport
Source: UniProtKB
Inferred from direct assayⁱ
- 21123949
D-aspartate import across plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 7521911
glutamate secretion Source: Reactome
ion transport Source: Reactome
L-aspartate import across plasma membrane
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 8857541
L-glutamate import
Source: UniProtKB
Inferred from direct assayⁱ
- 7521911
L-glutamate import across plasma membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 26690923
L-glutamate transmembrane transport
Source: UniProtKB
Inferred from direct assayⁱ
- 21123949
- 26690923
positive regulation of heart rate Source: Ensembl
protein homooligomerization Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Amino-acid transport, Symport, Transport
Ligand	Chloride, Metal-binding, Potassium, Sodium

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210500 Glutamate Neurotransmitter Release Cycle R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides R-HSA-5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)

Reactomeⁱ

R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)

Protein family/group databases

TCDBⁱ	2.A.23.2.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

TCDBⁱ

2.A.23.2.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Excitatory amino acid transporter 3 Alternative name(s): Excitatory amino-acid carrier 1 Neuronal and epithelial glutamate transporter Sodium-dependent glutamate/aspartate transporter 3 Solute carrier family 1 member 1
Gene namesⁱ	Name:SLC1A1 Synonyms:EAAC1, EAAT3
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000106688.11
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:10939 SLC1A1
MIMⁱ	133550 gene
neXtProtⁱ	NX_P43005

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 18	CytoplasmicCuratedAdd BLAST	18
Transmembraneⁱ	19 – 38	HelicalSequence analysisAdd BLAST	20
Topological domainⁱ	39 – 61	ExtracellularCuratedAdd BLAST	23
Transmembraneⁱ	62 – 82	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	83 – 93	CytoplasmicCuratedAdd BLAST	11
Transmembraneⁱ	94 – 114	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	115 – 205	ExtracellularCuratedAdd BLAST	91
Transmembraneⁱ	206 – 229	Helical; Name=4By similarityAdd BLAST	24
Topological domainⁱ	230 – 238	CytoplasmicCurated	9
Transmembraneⁱ	239 – 266	Helical; Name=5By similarityAdd BLAST	28
Topological domainⁱ	267 – 286	ExtracellularCuratedAdd BLAST	20
Transmembraneⁱ	287 – 308	Helical; Name=6By similarityAdd BLAST	22
Topological domainⁱ	309 – 313	CytoplasmicCurated	5
Intramembraneⁱ	314 – 344	Discontinuously helicalBy similarityAdd BLAST	31
Topological domainⁱ	345 – 353	CytoplasmicCurated	9
Transmembraneⁱ	354 – 380	Helical; Name=7By similarityAdd BLAST	27
Topological domainⁱ	381 – 393	ExtracellularCuratedAdd BLAST	13
Intramembraneⁱ	394 – 427	Discontinuously helicalBy similarityAdd BLAST	34
Topological domainⁱ	428 – 440	ExtracellularCuratedAdd BLAST	13
Transmembraneⁱ	441 – 462	Helical; Name=8By similarityAdd BLAST	22
Topological domainⁱ	463 – 524	CytoplasmicCuratedAdd BLAST	62

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Dicarboxylic aminoaciduria (DCBXA)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by abnormal excretion of urinary glutamate and aspartate, resulting from the incomplete reabsorption of anionic amino acids from the glomerular filtrate in the kidney. It can be associated with mental retardation.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_071953	395	Missing in DCBXA; inhibits L-glutamate and L-cysteine transport activities. 1 Publication		1
Natural variantⁱVAR_071954	445	R → W in DCBXA; reduces L-glutamate and L-cysteine transport activities; reduces cell membrane expression. 1 PublicationCorresponds to variant dbSNP:rs587777696EnsemblClinVar.		1

Schizophrenia 18 (SCZD18)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed:21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed:23341099).2 Publications

Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

Keywords - Diseaseⁱ

Disease mutation, Schizophrenia

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6505
MalaCards human disease database More...MalaCardsⁱ	SLC1A1
MIMⁱ	222730 phenotype 615232 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000106688
Orphanetⁱ	2195 Dicarboxylic aminoaciduria 166412 Hot water reflex epilepsy
PharmGKBⁱ	PA35826

Chemistry databases

ChEMBLⁱ	CHEMBL2721
Drug and drug target database More...DrugBankⁱ	DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB00230 Pregabalin
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	870

Polymorphism and mutation databases

BioMutaⁱ	SLC1A1
DMDMⁱ	1352332

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000202065	1 – 524	Excitatory amino acid transporter 3Add BLAST		524

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	43	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	178	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	195	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	517	PhosphoserineBy similarity	1
Modified residueⁱ	522	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Glycosylated.

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

EPDⁱ	P43005
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P43005
PaxDbⁱ	P43005
PeptideAtlas More...PeptideAtlasⁱ	P43005
PRIDEⁱ	P43005
ProteomicsDBⁱ	55571

PTM databases

iPTMnetⁱ	P43005
PhosphoSitePlusⁱ	P43005

Expressionⁱ

Tissue specificityⁱ

Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).3 Publications

Gene expression databases

Bgeeⁱ	ENSG00000106688 Expressed in 193 organ(s), highest expression level in caput epididymis
CleanExⁱ	HS_SLC1A1
ExpressionAtlasⁱ	P43005 baseline and differential
Genevisibleⁱ	P43005 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB015466 HPA020086

HPAⁱ

CAB015466
HPA020086

Interactionⁱ

Subunit structureⁱ

Homotrimer (Probable). Interacts with ARL6IP5 (By similarity).By similarityCurated

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LDLRAD1	Q5T700	3	EBI-745376,EBI-10173166
RNF5	Q99942	5	EBI-745376,EBI-348482

Protein-protein interaction databases

BioGridⁱ	112396, 42 interactors
IntActⁱ	P43005, 9 interactors
STRINGⁱ	9606.ENSP00000262352

Chemistry databases

BindingDBⁱ

P43005

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P43005
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	331 – 333	Aspartate bindingBy similarity		3
Regionⁱ	411 – 415	Aspartate bindingBy similarity		5

Domainⁱ

Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.By similarity

Sequence similaritiesⁱ

Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily. [View classification]Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3787 Eukaryota COG1301 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119117
HOGENOMⁱ	HOG000208776
HOVERGENⁱ	HBG000080
InParanoidⁱ	P43005
KEGG Orthology (KO) More...KOⁱ	K05612
OMAⁱ	YLYIAVI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0UCE
PhylomeDBⁱ	P43005
TreeFamⁱ	TF315206

Family and domain databases

Gene3Dⁱ	1.10.3860.10, 2 hits
InterProⁱ	View protein in InterPro IPR001991 Na-dicarboxylate_symporter IPR018107 Na-dicarboxylate_symporter_CS IPR036458 Na:dicarbo_symporter_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00375 SDF, 1 hit
SUPFAMⁱ	SSF118215 SSF118215, 1 hit
PROSITEⁱ	View protein in PROSITE PS00713 NA_DICARBOXYL_SYMP_1, 1 hit PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P43005-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MGKPARKGCE WKRFLKNNWV LLSTVAAVVL GITTGVLVRE HSNLSTLEKF 
        60         70         80         90        100
YFAFPGEILM RMLKLIILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFC 
       110        120        130        140        150
TTLIAVILGI VLVVSIKPGV TQKVGEIART GSTPEVSTVD AMLDLIRNMF 
       160        170        180        190        200
PENLVQACFQ QYKTKREEVK PPSDPEMNMT EESFTAVMTT AISKNKTKEY 
       210        220        230        240        250
KIVGMYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF NALSDATMKI 
       260        270        280        290        300
VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMATVL TGLAIHSIVI 
       310        320        330        340        350
LPLIYFIVVR KNPFRFAMGM AQALLTALMI SSSSATLPVT FRCAEENNQV 
       360        370        380        390        400
DKRITRFVLP VGATINMDGT ALYEAVAAVF IAQLNDLDLG IGQIITISIT 
       410        420        430        440        450
ATSASIGAAG VPQAGLVTMV IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV 
       460        470        480        490        500
NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN IVNPFALEST ILDNEDSDTK 
       510        520 
KSYVNGGFAV DKSDTISFTQ TSQF

Length:524

Mass (Da):57,100

Last modified:February 1, 1996 - v2

Checksum:ⁱFC6244ADC9EA228F

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0Y7R2	H0Y7R2_HUMAN		Amino acid transporter Amino acid transporter	SLC1A1	242	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	10	E → PS in AAA50430 (PubMed:7521911).Curated	1
Sequence conflictⁱ	92	L → V in AAH33040 (PubMed:15489334).Curated	1
Sequence conflictⁱ	94	A → V in AAA68628 (PubMed:7859077).Curated	1
Sequence conflictⁱ	94	A → V in AAC27511 (PubMed:11317217).Curated	1
Sequence conflictⁱ	96	V → L in AAA53215 (PubMed:7914198).Curated	1
Sequence conflictⁱ	170	K → N in AAA53215 (PubMed:7914198).Curated	1
Sequence conflictⁱ	172	P → A in AAA53215 (PubMed:7914198).Curated	1
Sequence conflictⁱ	260	L → H in AAA53215 (PubMed:7914198).Curated	1
Sequence conflictⁱ	280	R → A in AAA68628 (PubMed:7859077).Curated	1
Sequence conflictⁱ	376	V → G in AAC25029 (Ref. 8) Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_023309	27	A → G. Corresponds to variant dbSNP:rs2229885Ensembl.	1
Natural variantⁱVAR_023308	50	F → Y. Corresponds to variant dbSNP:rs2228621EnsemblClinVar.	1
Natural variantⁱVAR_071953	395	Missing in DCBXA; inhibits L-glutamate and L-cysteine transport activities. 1 Publication	1
Natural variantⁱVAR_071954	445	R → W in DCBXA; reduces L-glutamate and L-cysteine transport activities; reduces cell membrane expression. 1 PublicationCorresponds to variant dbSNP:rs587777696EnsemblClinVar.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U08989 mRNA Translation: AAA68628.1 U06469 mRNA Translation: AAA53215.1 U03506 mRNA Translation: AAA50430.1 AF074911 AF074910 Genomic DNA Translation: AAC27511.3 AB008536 mRNA Translation: BAB83767.1 AL162587 Genomic DNA No translation available. AL136231 Genomic DNA No translation available. BC033040 mRNA Translation: AAH33040.1 AF037982 mRNA Translation: AAC25029.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6452.1
PIRⁱ	A54856 I38433 I38560
NCBI Reference Sequences More...RefSeqⁱ	NP_004161.4, NM_004170.5
UniGeneⁱ	Hs.444915

Genome annotation databases

Ensemblⁱ	ENST00000262352; ENSP00000262352; ENSG00000106688
GeneIDⁱ	6505
KEGGⁱ	hsa:6505
UCSC genome browser More...UCSCⁱ	uc003zij.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P43005	Amino acid transporter		TARSY		526	UniRef90_P43005
Amino acid transporter		HUMAN		524
Excitatory amino acid transporter 3		CALJA		524
Amino acid transporter		RHIRO		524
Amino acid transporter		RHIBE		524
+29

Protein	Similar proteins		Species	Score	Length	Source
P43005	Excitatory amino acid transporter 1		MOUSE		543	UniRef50_P56564
Excitatory amino acid transporter 1		RAT		543
Excitatory amino acid transporter 1	)	HUMAN		542
Excitatory amino acid transporter 1		BOVIN		542
Excitatory amino acid transporter 4		CANLF		564
+742

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U08989 mRNA Translation: AAA68628.1 U06469 mRNA Translation: AAA53215.1 U03506 mRNA Translation: AAA50430.1 AF074911 AF074910 Genomic DNA Translation: AAC27511.3 AB008536 mRNA Translation: BAB83767.1 AL162587 Genomic DNA No translation available. AL136231 Genomic DNA No translation available. BC033040 mRNA Translation: AAH33040.1 AF037982 mRNA Translation: AAC25029.1
CCDSⁱ	CCDS6452.1
PIRⁱ	A54856 I38433 I38560
RefSeqⁱ	NP_004161.4, NM_004170.5
UniGeneⁱ	Hs.444915

3D structure databases

ProteinModelPortalⁱ	P43005
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112396, 42 interactors
IntActⁱ	P43005, 9 interactors
STRINGⁱ	9606.ENSP00000262352

Chemistry databases

BindingDBⁱ	P43005
ChEMBLⁱ	CHEMBL2721
DrugBankⁱ	DB00128 L-Aspartic Acid DB00142 L-Glutamic Acid DB00230 Pregabalin
GuidetoPHARMACOLOGYⁱ	870

Protein family/group databases

TCDBⁱ	2.A.23.2.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

TCDBⁱ

2.A.23.2.3 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

PTM databases

iPTMnetⁱ	P43005
PhosphoSitePlusⁱ	P43005

Polymorphism and mutation databases

BioMutaⁱ	SLC1A1
DMDMⁱ	1352332

Proteomic databases

EPDⁱ	P43005
MaxQBⁱ	P43005
PaxDbⁱ	P43005
PeptideAtlasⁱ	P43005
PRIDEⁱ	P43005
ProteomicsDBⁱ	55571

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6505
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000262352; ENSP00000262352; ENSG00000106688
GeneIDⁱ	6505
KEGGⁱ	hsa:6505
UCSCⁱ	uc003zij.3 human

Organism-specific databases

CTDⁱ	6505
DisGeNETⁱ	6505
EuPathDBⁱ	HostDB:ENSG00000106688.11
GeneCardsⁱ	SLC1A1
HGNCⁱ	HGNC:10939 SLC1A1
HPAⁱ	CAB015466 HPA020086
MalaCardsⁱ	SLC1A1
MIMⁱ	133550 gene 222730 phenotype 615232 phenotype
neXtProtⁱ	NX_P43005
OpenTargetsⁱ	ENSG00000106688
Orphanetⁱ	2195 Dicarboxylic aminoaciduria 166412 Hot water reflex epilepsy
PharmGKBⁱ	PA35826
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3787 Eukaryota COG1301 LUCA
GeneTreeⁱ	ENSGT00760000119117
HOGENOMⁱ	HOG000208776
HOVERGENⁱ	HBG000080
InParanoidⁱ	P43005
KOⁱ	K05612
OMAⁱ	YLYIAVI
OrthoDBⁱ	EOG091G0UCE
PhylomeDBⁱ	P43005
TreeFamⁱ	TF315206

Enzyme and pathway databases

Reactomeⁱ	R-HSA-210500 Glutamate Neurotransmitter Release Cycle R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides R-HSA-5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)

Reactomeⁱ

R-HSA-210500 Glutamate Neurotransmitter Release Cycle
R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-5619067 Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA)

Miscellaneous databases

ChiTaRSⁱ	SLC1A1 human
GeneWikiⁱ	SLC1A1
GenomeRNAiⁱ	6505
Protein Ontology More...PROⁱ	PR:P43005
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000106688 Expressed in 193 organ(s), highest expression level in caput epididymis
CleanExⁱ	HS_SLC1A1
ExpressionAtlasⁱ	P43005 baseline and differential
Genevisibleⁱ	P43005 HS

Family and domain databases

Gene3Dⁱ	1.10.3860.10, 2 hits
InterProⁱ	View protein in InterPro IPR001991 Na-dicarboxylate_symporter IPR018107 Na-dicarboxylate_symporter_CS IPR036458 Na:dicarbo_symporter_sf
Pfamⁱ	View protein in Pfam PF00375 SDF, 1 hit
SUPFAMⁱ	SSF118215 SSF118215, 1 hit
PROSITEⁱ	View protein in PROSITE PS00713 NA_DICARBOXYL_SYMP_1, 1 hit PS00714 NA_DICARBOXYL_SYMP_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EAA3_HUMAN
Accessionⁱ	P43005Primary (citable) accession number: P43005 Secondary accession number(s): O75587 , Q5VZ24, Q8N199, Q9UEW2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 169 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM

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UniParc

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Supporting data

UniProtKB - P43005 (EAA3_HUMAN)

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Excitatory amino acid transporter 3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

Kineticsⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ