UniProtKB - P43005 (EAA3_HUMAN)
Protein
Excitatory amino acid transporter 3
Gene
SLC1A1
Organism
Homo sapiens (Human)
Status
Functioni
Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7914198, PubMed:7521911, PubMed:8857541, PubMed:26690923, PubMed:21123949). Can also transport L-cysteine (PubMed:21123949). Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion (PubMed:7521911, PubMed:8857541, PubMed:26690923). Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (PubMed:8857541, PubMed:26690923). Plays an important role in L-glutamate and L-aspartate reabsorption in renal tubuli (PubMed:21123949). Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity). Contributes to glutathione biosynthesis and protection against oxidative stress via its role in L-glutamate and L-cysteine transport (By similarity). Negatively regulated by ARL6IP5 (By similarity).By similarity5 Publications
Kineticsi
- KM=268 µM for L-glutamate1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 362 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 364 | Sodium 2; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 366 | Sodium 1By similarity | 1 | |
Binding sitei | 370 | AspartateBy similarity | 1 | |
Binding sitei | 444 | AspartateBy similarity | 1 | |
Metal bindingi | 451 | Sodium 1; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 451 | AspartateBy similarity | 1 | |
Metal bindingi | 455 | Sodium 1By similarity | 1 |
GO - Molecular functioni
- chloride transmembrane transporter activity Source: UniProtKB
- cysteine transmembrane transporter activity Source: UniProtKB
- D-aspartate transmembrane transporter activity Source: ARUK-UCL
- glutamate:sodium symporter activity Source: UniProtKB
- glutamate binding Source: Ensembl
- high-affinity glutamate transmembrane transporter activity Source: UniProtKB
- identical protein binding Source: Ensembl
- L-aspartate transmembrane transporter activity Source: ARUK-UCL
- L-glutamate transmembrane transporter activity Source: UniProtKB
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- blood vessel morphogenesis Source: ARUK-UCL
- chemical synaptic transmission Source: ProtInc
- chloride transmembrane transport Source: UniProtKB
- cysteine transport Source: UniProtKB
- D-aspartate import across plasma membrane Source: UniProtKB
- D-aspartate transport Source: ARUK-UCL
- glutamate secretion Source: Reactome
- ion transport Source: Reactome
- L-aspartate import across plasma membrane Source: UniProtKB
- L-aspartate transmembrane transport Source: ARUK-UCL
- L-glutamate import Source: UniProtKB
- L-glutamate import across plasma membrane Source: UniProtKB
- L-glutamate transmembrane transport Source: UniProtKB
- maintenance of blood-brain barrier Source: ARUK-UCL
- neuron death in response to oxidative stress Source: ARUK-UCL
- positive regulation of heart rate Source: Ensembl
- transepithelial transport Source: ARUK-UCL
- transport across blood-brain barrier Source: ARUK-UCL
Keywordsi
Biological process | Amino-acid transport, Symport, Transport |
Ligand | Chloride, Metal-binding, Potassium, Sodium |
Enzyme and pathway databases
PathwayCommonsi | P43005 |
Reactomei | R-HSA-210500, Glutamate Neurotransmitter Release Cycle R-HSA-425393, Transport of inorganic cations/anions and amino acids/oligopeptides R-HSA-5619067, Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) |
Protein family/group databases
TCDBi | 2.A.23.2.3, the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family |
Names & Taxonomyi
Protein namesi | Recommended name: Excitatory amino acid transporter 3Alternative name(s): Excitatory amino-acid carrier 1 Neuronal and epithelial glutamate transporter Sodium-dependent glutamate/aspartate transporter 3 Solute carrier family 1 member 1 |
Gene namesi | Name:SLC1A1 Synonyms:EAAC1, EAAT3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000106688.11 |
HGNCi | HGNC:10939, SLC1A1 |
MIMi | 133550, gene |
neXtProti | NX_P43005 |
Subcellular locationi
Endosome
- Early endosome membrane By similarity
- Late endosome membrane By similarity
- Recycling endosome membrane By similarity
Plasma membrane
- Cell membrane 5 Publications; Multi-pass membrane protein By similarity
- Apical cell membrane 1 Publication; Multi-pass membrane protein By similarity
Other locations
- synaptosome By similarity
Endosome
- early endosome membrane Source: UniProtKB-SubCell
- late endosome membrane Source: UniProtKB-SubCell
- recycling endosome membrane Source: UniProtKB-SubCell
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- perisynaptic space Source: ARUK-UCL
- synaptic cleft Source: ARUK-UCL
Plasma Membrane
- apical plasma membrane Source: UniProtKB
- integral component of plasma membrane Source: UniProtKB
- plasma membrane Source: UniProtKB
Other locations
- apical dendrite Source: ARUK-UCL
- asymmetric synapse Source: ARUK-UCL
- axon Source: ARUK-UCL
- axon terminus Source: ARUK-UCL
- cell periphery Source: ARUK-UCL
- dendrite Source: ARUK-UCL
- dendritic shaft Source: ARUK-UCL
- dendritic spine Source: ARUK-UCL
- distal dendrite Source: ARUK-UCL
- glial cell projection Source: ARUK-UCL
- integral component of membrane Source: ARUK-UCL
- membrane Source: ARUK-UCL
- neuronal cell body Source: ARUK-UCL
- perikaryon Source: ARUK-UCL
- presynapse Source: ARUK-UCL
- proximal dendrite Source: ARUK-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 18 | CytoplasmicCuratedAdd BLAST | 18 | |
Transmembranei | 19 – 38 | HelicalSequence analysisAdd BLAST | 20 | |
Topological domaini | 39 – 61 | ExtracellularCuratedAdd BLAST | 23 | |
Transmembranei | 62 – 82 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 83 – 93 | CytoplasmicCuratedAdd BLAST | 11 | |
Transmembranei | 94 – 114 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 115 – 205 | ExtracellularCuratedAdd BLAST | 91 | |
Transmembranei | 206 – 229 | Helical; Name=4By similarityAdd BLAST | 24 | |
Topological domaini | 230 – 238 | CytoplasmicCurated | 9 | |
Transmembranei | 239 – 266 | Helical; Name=5By similarityAdd BLAST | 28 | |
Topological domaini | 267 – 286 | ExtracellularCuratedAdd BLAST | 20 | |
Transmembranei | 287 – 308 | Helical; Name=6By similarityAdd BLAST | 22 | |
Topological domaini | 309 – 313 | CytoplasmicCurated | 5 | |
Intramembranei | 314 – 344 | Discontinuously helicalBy similarityAdd BLAST | 31 | |
Topological domaini | 345 – 353 | CytoplasmicCurated | 9 | |
Transmembranei | 354 – 380 | Helical; Name=7By similarityAdd BLAST | 27 | |
Topological domaini | 381 – 393 | ExtracellularCuratedAdd BLAST | 13 | |
Intramembranei | 394 – 427 | Discontinuously helicalBy similarityAdd BLAST | 34 | |
Topological domaini | 428 – 440 | ExtracellularCuratedAdd BLAST | 13 | |
Transmembranei | 441 – 462 | Helical; Name=8By similarityAdd BLAST | 22 | |
Topological domaini | 463 – 524 | CytoplasmicCuratedAdd BLAST | 62 |
Keywords - Cellular componenti
Cell junction, Cell membrane, Endosome, Membrane, Synapse, SynaptosomePathology & Biotechi
Involvement in diseasei
Dicarboxylic aminoaciduria (DCBXA)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive disorder characterized by abnormal excretion of urinary glutamate and aspartate, resulting from the incomplete reabsorption of anionic amino acids from the glomerular filtrate in the kidney. It can be associated with mental retardation.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071953 | 395 | Missing in DCBXA; inhibits L-glutamate and L-cysteine transport activities. 1 Publication | 1 | |
Natural variantiVAR_071954 | 445 | R → W in DCBXA; reduces L-glutamate and L-cysteine transport activities; reduces cell membrane expression. 1 PublicationCorresponds to variant dbSNP:rs587777696EnsemblClinVar. | 1 |
Schizophrenia 18 (SCZD18)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed:21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed:23341099).2 Publications
Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.
Related information in OMIMKeywords - Diseasei
Disease mutation, SchizophreniaOrganism-specific databases
DisGeNETi | 6505 |
MalaCardsi | SLC1A1 |
MIMi | 222730, phenotype 615232, phenotype |
OpenTargetsi | ENSG00000106688 |
Orphaneti | 2195, Dicarboxylic aminoaciduria 166412, Hot water reflex epilepsy |
PharmGKBi | PA35826 |
Miscellaneous databases
Pharosi | P43005, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2721 |
DrugBanki | DB00128, Aspartic acid DB00142, Glutamic acid DB00230, Pregabalin |
DrugCentrali | P43005 |
GuidetoPHARMACOLOGYi | 870 |
Polymorphism and mutation databases
BioMutai | SLC1A1 |
DMDMi | 1352332 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000202065 | 1 – 524 | Excitatory amino acid transporter 3Add BLAST | 524 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 43 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 178 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 517 | PhosphoserineBy similarity | 1 | |
Modified residuei | 522 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Glycosylated.
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
EPDi | P43005 |
jPOSTi | P43005 |
MassIVEi | P43005 |
MaxQBi | P43005 |
PaxDbi | P43005 |
PeptideAtlasi | P43005 |
PRIDEi | P43005 |
ProteomicsDBi | 55571 |
PTM databases
GlyGeni | P43005, 4 sites, 1 O-linked glycan (1 site) |
iPTMneti | P43005 |
PhosphoSitePlusi | P43005 |
Expressioni
Tissue specificityi
Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).3 Publications
Gene expression databases
Bgeei | ENSG00000106688, Expressed in caput epididymis and 202 other tissues |
ExpressionAtlasi | P43005, baseline and differential |
Genevisiblei | P43005, HS |
Organism-specific databases
HPAi | ENSG00000106688, Tissue enhanced (intestine, kidney) |
Interactioni
Subunit structurei
Homotrimer (Probable).
Interacts with ARL6IP5.
Interacts with SORCS2; this interaction is important for normal expression at the cell membrane (By similarity).
By similarityCuratedBinary interactionsi
Hide detailsP43005
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112396, 51 interactors |
IntActi | P43005, 37 interactors |
STRINGi | 9606.ENSP00000262352 |
Chemistry databases
BindingDBi | P43005 |
Miscellaneous databases
RNActi | P43005, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P43005 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 331 – 333 | Aspartate bindingBy similarity | 3 | |
Regioni | 411 – 415 | Aspartate bindingBy similarity | 5 |
Domaini
Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.By similarity
Sequence similaritiesi
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A1 subfamily. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3787, Eukaryota |
GeneTreei | ENSGT00940000155397 |
HOGENOMi | CLU_019375_3_2_1 |
InParanoidi | P43005 |
OMAi | YLYIAVI |
OrthoDBi | 1184392at2759 |
PhylomeDBi | P43005 |
TreeFami | TF315206 |
Family and domain databases
Gene3Di | 1.10.3860.10, 2 hits |
InterProi | View protein in InterPro IPR001991, Na-dicarboxylate_symporter IPR018107, Na-dicarboxylate_symporter_CS IPR036458, Na:dicarbo_symporter_sf |
Pfami | View protein in Pfam PF00375, SDF, 1 hit |
SUPFAMi | SSF118215, SSF118215, 1 hit |
PROSITEi | View protein in PROSITE PS00713, NA_DICARBOXYL_SYMP_1, 1 hit PS00714, NA_DICARBOXYL_SYMP_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P43005-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKPARKGCE WKRFLKNNWV LLSTVAAVVL GITTGVLVRE HSNLSTLEKF
60 70 80 90 100
YFAFPGEILM RMLKLIILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFC
110 120 130 140 150
TTLIAVILGI VLVVSIKPGV TQKVGEIART GSTPEVSTVD AMLDLIRNMF
160 170 180 190 200
PENLVQACFQ QYKTKREEVK PPSDPEMNMT EESFTAVMTT AISKNKTKEY
210 220 230 240 250
KIVGMYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF NALSDATMKI
260 270 280 290 300
VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMATVL TGLAIHSIVI
310 320 330 340 350
LPLIYFIVVR KNPFRFAMGM AQALLTALMI SSSSATLPVT FRCAEENNQV
360 370 380 390 400
DKRITRFVLP VGATINMDGT ALYEAVAAVF IAQLNDLDLG IGQIITISIT
410 420 430 440 450
ATSASIGAAG VPQAGLVTMV IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV
460 470 480 490 500
NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN IVNPFALEST ILDNEDSDTK
510 520
KSYVNGGFAV DKSDTISFTQ TSQF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0Y7R2 | H0Y7R2_HUMAN | Amino acid transporter | SLC1A1 | 242 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 | E → PS in AAA50430 (PubMed:7521911).Curated | 1 | |
Sequence conflicti | 92 | L → V in AAH33040 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 94 | A → V in AAA68628 (PubMed:7859077).Curated | 1 | |
Sequence conflicti | 94 | A → V in AAC27511 (PubMed:11317217).Curated | 1 | |
Sequence conflicti | 96 | V → L in AAA53215 (PubMed:7914198).Curated | 1 | |
Sequence conflicti | 170 | K → N in AAA53215 (PubMed:7914198).Curated | 1 | |
Sequence conflicti | 172 | P → A in AAA53215 (PubMed:7914198).Curated | 1 | |
Sequence conflicti | 260 | L → H in AAA53215 (PubMed:7914198).Curated | 1 | |
Sequence conflicti | 280 | R → A in AAA68628 (PubMed:7859077).Curated | 1 | |
Sequence conflicti | 376 | V → G in AAC25029 (Ref. 8) Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_023309 | 27 | A → G. Corresponds to variant dbSNP:rs2229885Ensembl. | 1 | |
Natural variantiVAR_023308 | 50 | F → Y. Corresponds to variant dbSNP:rs2228621EnsemblClinVar. | 1 | |
Natural variantiVAR_071953 | 395 | Missing in DCBXA; inhibits L-glutamate and L-cysteine transport activities. 1 Publication | 1 | |
Natural variantiVAR_071954 | 445 | R → W in DCBXA; reduces L-glutamate and L-cysteine transport activities; reduces cell membrane expression. 1 PublicationCorresponds to variant dbSNP:rs587777696EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08989 mRNA Translation: AAA68628.1 U06469 mRNA Translation: AAA53215.1 U03506 mRNA Translation: AAA50430.1 AF074911 , AF143773, AF074903, AF074904, AF074905, AF074906, AF074907, AF074908, AF074909, AF074910 Genomic DNA Translation: AAC27511.3 AB008536 mRNA Translation: BAB83767.1 AL162587 Genomic DNA No translation available. AL136231 Genomic DNA No translation available. BC033040 mRNA Translation: AAH33040.1 AF037982 mRNA Translation: AAC25029.1 |
CCDSi | CCDS6452.1 |
PIRi | A54856 I38433 I38560 |
RefSeqi | NP_004161.4, NM_004170.5 |
Genome annotation databases
Ensembli | ENST00000262352; ENSP00000262352; ENSG00000106688 |
GeneIDi | 6505 |
KEGGi | hsa:6505 |
UCSCi | uc003zij.3, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08989 mRNA Translation: AAA68628.1 U06469 mRNA Translation: AAA53215.1 U03506 mRNA Translation: AAA50430.1 AF074911 , AF143773, AF074903, AF074904, AF074905, AF074906, AF074907, AF074908, AF074909, AF074910 Genomic DNA Translation: AAC27511.3 AB008536 mRNA Translation: BAB83767.1 AL162587 Genomic DNA No translation available. AL136231 Genomic DNA No translation available. BC033040 mRNA Translation: AAH33040.1 AF037982 mRNA Translation: AAC25029.1 |
CCDSi | CCDS6452.1 |
PIRi | A54856 I38433 I38560 |
RefSeqi | NP_004161.4, NM_004170.5 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6S3Q | electron microscopy | 3.34 | A/B/C | 1-480 | [»] | |
SMRi | P43005 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112396, 51 interactors |
IntActi | P43005, 37 interactors |
STRINGi | 9606.ENSP00000262352 |
Chemistry databases
BindingDBi | P43005 |
ChEMBLi | CHEMBL2721 |
DrugBanki | DB00128, Aspartic acid DB00142, Glutamic acid DB00230, Pregabalin |
DrugCentrali | P43005 |
GuidetoPHARMACOLOGYi | 870 |
Protein family/group databases
TCDBi | 2.A.23.2.3, the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family |
PTM databases
GlyGeni | P43005, 4 sites, 1 O-linked glycan (1 site) |
iPTMneti | P43005 |
PhosphoSitePlusi | P43005 |
Polymorphism and mutation databases
BioMutai | SLC1A1 |
DMDMi | 1352332 |
Proteomic databases
EPDi | P43005 |
jPOSTi | P43005 |
MassIVEi | P43005 |
MaxQBi | P43005 |
PaxDbi | P43005 |
PeptideAtlasi | P43005 |
PRIDEi | P43005 |
ProteomicsDBi | 55571 |
Protocols and materials databases
ABCDi | P43005, 1 sequenced antibody |
Antibodypediai | 3650, 346 antibodies |
DNASUi | 6505 |
Genome annotation databases
Ensembli | ENST00000262352; ENSP00000262352; ENSG00000106688 |
GeneIDi | 6505 |
KEGGi | hsa:6505 |
UCSCi | uc003zij.3, human |
Organism-specific databases
CTDi | 6505 |
DisGeNETi | 6505 |
EuPathDBi | HostDB:ENSG00000106688.11 |
GeneCardsi | SLC1A1 |
HGNCi | HGNC:10939, SLC1A1 |
HPAi | ENSG00000106688, Tissue enhanced (intestine, kidney) |
MalaCardsi | SLC1A1 |
MIMi | 133550, gene 222730, phenotype 615232, phenotype |
neXtProti | NX_P43005 |
OpenTargetsi | ENSG00000106688 |
Orphaneti | 2195, Dicarboxylic aminoaciduria 166412, Hot water reflex epilepsy |
PharmGKBi | PA35826 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3787, Eukaryota |
GeneTreei | ENSGT00940000155397 |
HOGENOMi | CLU_019375_3_2_1 |
InParanoidi | P43005 |
OMAi | YLYIAVI |
OrthoDBi | 1184392at2759 |
PhylomeDBi | P43005 |
TreeFami | TF315206 |
Enzyme and pathway databases
PathwayCommonsi | P43005 |
Reactomei | R-HSA-210500, Glutamate Neurotransmitter Release Cycle R-HSA-425393, Transport of inorganic cations/anions and amino acids/oligopeptides R-HSA-5619067, Defective SLC1A1 is implicated in schizophrenia 18 (SCZD18) and dicarboxylic aminoaciduria (DCBXA) |
Miscellaneous databases
BioGRID-ORCSi | 6505, 5 hits in 842 CRISPR screens |
ChiTaRSi | SLC1A1, human |
GeneWikii | SLC1A1 |
GenomeRNAii | 6505 |
Pharosi | P43005, Tchem |
PROi | PR:P43005 |
RNActi | P43005, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000106688, Expressed in caput epididymis and 202 other tissues |
ExpressionAtlasi | P43005, baseline and differential |
Genevisiblei | P43005, HS |
Family and domain databases
Gene3Di | 1.10.3860.10, 2 hits |
InterProi | View protein in InterPro IPR001991, Na-dicarboxylate_symporter IPR018107, Na-dicarboxylate_symporter_CS IPR036458, Na:dicarbo_symporter_sf |
Pfami | View protein in Pfam PF00375, SDF, 1 hit |
SUPFAMi | SSF118215, SSF118215, 1 hit |
PROSITEi | View protein in PROSITE PS00713, NA_DICARBOXYL_SYMP_1, 1 hit PS00714, NA_DICARBOXYL_SYMP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EAA3_HUMAN | |
Accessioni | P43005Primary (citable) accession number: P43005 Secondary accession number(s): O75587 Q9UEW2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 184 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations