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Entry version 178 (16 Oct 2019)
Sequence version 2 (15 Jul 1998)
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Protein

Excitatory amino acid transporter 2

Gene

SLC1A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:14506254, PubMed:15265858, PubMed:26690923). Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion (PubMed:14506254). Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (PubMed:14506254). Essential for the rapid removal of released glutamate from the synaptic cleft, and for terminating the postsynaptic action of glutamate (By similarity).By similarity3 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=391 µM for L-glutamate1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi393Sodium 1; via carbonyl oxygenBy similarity1
    Metal bindingi395Sodium 2; via carbonyl oxygenBy similarity1
    Metal bindingi397Sodium 1By similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei401AspartateBy similarity1
    Binding sitei475AspartateBy similarity1
    Metal bindingi482Sodium 1; via carbonyl oxygenBy similarity1
    Binding sitei482AspartateBy similarity1
    Metal bindingi486Sodium 1By similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Biological processAmino-acid transport, Symport, Transport
    LigandChloride, Metal-binding, Potassium, Sodium

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
    R-HSA-210500 Glutamate Neurotransmitter Release Cycle
    R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

    Protein family/group databases

    Transport Classification Database

    More...
    TCDBi
    2.A.23.2.7 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Excitatory amino acid transporter 2
    Alternative name(s):
    Glutamate/aspartate transporter II
    Sodium-dependent glutamate/aspartate transporter 2
    Solute carrier family 1 member 2
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:SLC1A2
    Synonyms:EAAT2, GLT1
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

    Organism-specific databases

    Human Gene Nomenclature Database

    More...
    HGNCi
    HGNC:10940 SLC1A2

    Online Mendelian Inheritance in Man (OMIM)

    More...
    MIMi
    600300 gene

    neXtProt; the human protein knowledge platform

    More...
    neXtProti
    NX_P43004

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

    Topology

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 44CytoplasmicCuratedAdd BLAST44
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei45 – 64HelicalSequence analysisAdd BLAST20
    Topological domaini65 – 87ExtracellularCuratedAdd BLAST23
    Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
    Topological domaini109 – 120CytoplasmicCuratedAdd BLAST12
    Transmembranei121 – 142HelicalSequence analysisAdd BLAST22
    Topological domaini143 – 235ExtracellularCuratedAdd BLAST93
    Transmembranei236 – 259Helical; Name=4By similarityAdd BLAST24
    Topological domaini260 – 268CytoplasmicCurated9
    Transmembranei269 – 296Helical; Name=5By similarityAdd BLAST28
    Topological domaini297 – 317ExtracellularCuratedAdd BLAST21
    Transmembranei318 – 339Helical; Name=6By similarityAdd BLAST22
    Topological domaini340 – 344CytoplasmicCurated5
    <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei345 – 375Discontinuously helicalBy similarityAdd BLAST31
    Topological domaini376 – 384CytoplasmicCurated9
    Transmembranei385 – 411Helical; Name=7By similarityAdd BLAST27
    Topological domaini412 – 424ExtracellularCuratedAdd BLAST13
    Intramembranei425 – 458Discontinuously helicalBy similarityAdd BLAST34
    Topological domaini459 – 471ExtracellularCuratedAdd BLAST13
    Transmembranei472 – 493Helical; Name=8By similarityAdd BLAST22
    Topological domaini494 – 574CytoplasmicCuratedAdd BLAST81

    Keywords - Cellular componenti

    Cell membrane, Membrane

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    <p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

    Epileptic encephalopathy, early infantile, 41 (EIEE41)2 Publications
    The disease is caused by mutations affecting the gene represented in this entry.
    Disease descriptionA form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. EIEE41 inheritance is autosomal dominant.
    Related information in OMIM
    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07708382G → R in EIEE41. 2 PublicationsCorresponds to variant dbSNP:rs886037942EnsemblClinVar.1
    Natural variantiVAR_07708485L → P in EIEE41. 1 PublicationCorresponds to variant dbSNP:rs886037943EnsemblClinVar.1
    Natural variantiVAR_080229289P → R in EIEE41. 1 Publication1

    Keywords - Diseasei

    Disease mutation, Epilepsy

    Organism-specific databases

    DisGeNET

    More...
    DisGeNETi
    6506

    MalaCards human disease database

    More...
    MalaCardsi
    SLC1A2
    MIMi617105 phenotype

    Open Targets

    More...
    OpenTargetsi
    ENSG00000110436

    Orphanet; a database dedicated to information on rare diseases and orphan drugs

    More...
    Orphaneti
    442835 Undetermined early-onset epileptic encephalopathy

    The Pharmacogenetics and Pharmacogenomics Knowledge Base

    More...
    PharmGKBi
    PA35827

    Miscellaneous databases

    Pharos NIH Druggable Genome Knowledgebase

    More...
    Pharosi
    P43004

    Chemistry databases

    ChEMBL database of bioactive drug-like small molecules

    More...
    ChEMBLi
    CHEMBL4973

    Drug and drug target database

    More...
    DrugBanki
    DB00142 Glutamic Acid

    DrugCentral

    More...
    DrugCentrali
    P43004

    IUPHAR/BPS Guide to PHARMACOLOGY

    More...
    GuidetoPHARMACOLOGYi
    869

    Polymorphism and mutation databases

    BioMuta curated single-nucleotide variation and disease association database

    More...
    BioMutai
    SLC1A2

    Domain mapping of disease mutations (DMDM)

    More...
    DMDMi
    3041668

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002020611 – 574Excitatory amino acid transporter 2Add BLAST574

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei3PhosphoserineBy similarity1
    Modified residuei21PhosphoserineBy similarity1
    Modified residuei25PhosphoserineBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi38S-palmitoyl cysteineBy similarity1
    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi206N-linked (GlcNAc...) asparagineSequence analysis1
    Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
    Modified residuei506PhosphoserineBy similarity1
    Modified residuei521PhosphoserineBy similarity1
    Modified residuei532PhosphoserineBy similarity1
    Modified residuei534PhosphoserineBy similarity1
    Modified residuei539PhosphotyrosineBy similarity1
    Modified residuei544PhosphoserineBy similarity1
    Modified residuei560PhosphoserineBy similarity1
    Modified residuei564PhosphoserineBy similarity1

    <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

    Glycosylated.1 Publication
    Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.By similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    MassIVE - Mass Spectrometry Interactive Virtual Environment

    More...
    MassIVEi
    P43004

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    P43004

    PeptideAtlas

    More...
    PeptideAtlasi
    P43004

    PRoteomics IDEntifications database

    More...
    PRIDEi
    P43004

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    55569 [P43004-1]
    55570 [P43004-2]

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    P43004

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    P43004

    SwissPalm database of S-palmitoylation events

    More...
    SwissPalmi
    P43004

    Miscellaneous databases

    CutDB - Proteolytic event database

    More...
    PMAP-CutDBi
    P43004

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSG00000110436 Expressed in 163 organ(s), highest expression level in occipital lobe

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    P43004 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    P43004 HS

    Organism-specific databases

    Human Protein Atlas

    More...
    HPAi
    CAB002574
    HPA009172

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Homotrimer (PubMed:15265858, PubMed:15483603, PubMed:26483543). Isoform 3 can oligomerize with isoform 1 (PubMed:20688910).

    Interacts with AJUBA (By similarity).

    By similarity4 Publications

    <p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

    WithEntry#Exp.IntActNotes
    P106364EBI-3440986,EBI-366182

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGrid)

    More...
    BioGridi
    112397, 10 interactors

    CORUM comprehensive resource of mammalian protein complexes

    More...
    CORUMi
    P43004

    Protein interaction database and analysis system

    More...
    IntActi
    P43004, 3 interactors

    Molecular INTeraction database

    More...
    MINTi
    P43004

    STRING: functional protein association networks

    More...
    STRINGi
    9606.ENSP00000278379

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni362 – 364Aspartate bindingBy similarity3
    Regioni442 – 446Aspartate bindingBy similarity5

    <p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.By similarity

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG3787 Eukaryota
    COG1301 LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000155379

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    P43004

    KEGG Orthology (KO)

    More...
    KOi
    K05613

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    ICSFVVP

    Database of Orthologous Groups

    More...
    OrthoDBi
    1184392at2759

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    P43004

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF315206

    Family and domain databases

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    1.10.3860.10, 2 hits

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR001991 Na-dicarboxylate_symporter
    IPR018107 Na-dicarboxylate_symporter_CS
    IPR036458 Na:dicarbo_symporter_sf

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00375 SDF, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF118215 SSF118215, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
    PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

    This entry has 3 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All

    Isoform 1 (identifier: P43004-1) [UniParc]FASTAAdd to basket

    This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide
            10         20         30         40         50
    MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT
    60 70 80 90 100
    VFGVILGAVC GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS
    110 120 130 140 150
    LITGLSGLDA KASGRLGTRA MVYYMSTTII AAVLGVILVL AIHPGNPKLK
    160 170 180 190 200
    KQLGPGKKND EVSSLDAFLD LIRNLFPENL VQACFQQIQT VTKKVLVAPP
    210 220 230 240 250
    PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM NVLGLIGFFI
    260 270 280 290 300
    AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI
    310 320 330 340 350
    IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG
    360 370 380 390 400
    IFQAWITALG TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG
    410 420 430 440 450
    TALYEAVAAI FIAQMNGVVL DGGQIVTVSL TATLASVGAA SIPSAGLVTM
    460 470 480 490 500
    LLILTAVGLP TEDISLLVAV DWLLDRMRTS VNVVGDSFGA GIVYHLSKSE
    510 520 530 540 550
    LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA AHNSVIVDEC
    560 570
    KVTLAANGKS ADCSVEEEPW KREK
    Length:574
    Mass (Da):62,104
    Last modified:July 15, 1998 - v2
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC8104E6727979435
    GO
    Isoform 2 (identifier: P43004-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Show »
    Length:565
    Mass (Da):61,228
    Checksum:iA7286207F550252F
    GO
    Isoform 3 (identifier: P43004-3) [UniParc]FASTAAdd to basket
    Also known as: EEAT2b

    The sequence of this isoform differs from the canonical sequence as follows:
         553-574: TLAANGKSADCSVEEEPWKREK → HFPFMDIETCI

    Show »
    Length:563
    Mass (Da):61,008
    Checksum:iC13903644ADD1802
    GO

    <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

    There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
    EntryEntry nameProtein names
    Gene namesLengthAnnotation
    A0A2R8Y642A0A2R8Y642_HUMAN
    Amino acid transporter
    SLC1A2
    435Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    C9J9N5C9J9N5_HUMAN
    Amino acid transporter
    SLC1A2
    409Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    H0YEK4H0YEK4_HUMAN
    Amino acid transporter
    SLC1A2
    574Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8Y4W1A0A2R8Y4W1_HUMAN
    Amino acid transporter
    SLC1A2
    571Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8Y860A0A2R8Y860_HUMAN
    Amino acid transporter
    SLC1A2
    579Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8YFE3A0A2R8YFE3_HUMAN
    Amino acid transporter
    SLC1A2
    496Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2U3TZS7A0A2U3TZS7_HUMAN
    Amino acid transporter
    SLC1A2
    570Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A163QEF0A0A163QEF0_HUMAN
    Amino acid transporter
    SLC1A2
    566Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8Y4D1A0A2R8Y4D1_HUMAN
    Amino acid transporter
    SLC1A2
    397Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    A0A2R8Y4N0A0A2R8Y4N0_HUMAN
    Amino acid transporter
    SLC1A2
    330Annotation score:

    Annotation score:2 out of 5

    <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
    There are more potential isoformsShow all

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti7A → T in BAG60911 (PubMed:14702039).Curated1
    Sequence conflicti19H → P in AAA50429 (PubMed:7521911).Curated1
    Sequence conflicti27E → G in CAA83532 (PubMed:7522567).Curated1
    Sequence conflicti50T → Q in AAA18900 (PubMed:8172925).Curated1
    Sequence conflicti58A → S in AAA18900 (PubMed:8172925).Curated1
    Sequence conflicti141A → G in CAA83532 (PubMed:7522567).Curated1
    Sequence conflicti155P → A in CAA83532 (PubMed:7522567).Curated1
    Sequence conflicti211V → E in AAA50429 (PubMed:7521911).Curated1
    Sequence conflicti253 – 255GIA → AIP in CAA83532 (PubMed:7522567).Curated3
    Sequence conflicti263 – 289AKLMV…MWYSP → GQADGGFLQHFERDCNEVSD HDHVVLS in CAA83532 (PubMed:7522567).CuratedAdd BLAST27
    Sequence conflicti347F → L in AAA50429 (PubMed:7521911).Curated1
    Sequence conflicti539Y → F in CAA83532 (PubMed:7522567).Curated1
    Sequence conflicti556A → G in CAA83532 (PubMed:7522567).Curated1
    Sequence conflicti563 – 565CSV → RVL in CAA83532 (PubMed:7522567).Curated3
    Sequence conflicti570W → G in CAA83532 (PubMed:7522567).Curated1

    Natural variant

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Natural variantiVAR_07708382G → R in EIEE41. 2 PublicationsCorresponds to variant dbSNP:rs886037942EnsemblClinVar.1
    Natural variantiVAR_07708485L → P in EIEE41. 1 PublicationCorresponds to variant dbSNP:rs886037943EnsemblClinVar.1
    Natural variantiVAR_080229289P → R in EIEE41. 1 Publication1

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0371521 – 9Missing in isoform 2. 1 Publication9
    Alternative sequenceiVSP_054934553 – 574TLAAN…WKREK → HFPFMDIETCI in isoform 3. 1 PublicationAdd BLAST22

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    U03505 mRNA Translation: AAA50429.1
    U01824 mRNA Translation: AAA18900.1
    Z32517 mRNA Translation: CAA83532.1
    D85884 mRNA Translation: BAA28706.1
    AY066021 mRNA Translation: AAL57716.1
    AK298769 mRNA Translation: BAG60911.1
    AC090625 Genomic DNA No translation available.
    AL133330 Genomic DNA No translation available.
    CH471064 Genomic DNA Translation: EAW68143.1
    BC132768 mRNA Translation: AAI32769.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS31459.1 [P43004-1]
    CCDS55756.1 [P43004-2]

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    I37426
    I38432

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001182657.1, NM_001195728.2 [P43004-2]
    NP_001239581.1, NM_001252652.1 [P43004-2]
    NP_004162.2, NM_004171.3 [P43004-1]

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENST00000278379; ENSP00000278379; ENSG00000110436 [P43004-1]
    ENST00000395753; ENSP00000379102; ENSG00000110436 [P43004-2]
    ENST00000643000; ENSP00000495164; ENSG00000110436 [P43004-2]
    ENST00000643305; ENSP00000494828; ENSG00000110436 [P43004-3]
    ENST00000644050; ENSP00000496123; ENSG00000110436 [P43004-2]
    ENST00000644299; ENSP00000494669; ENSG00000110436 [P43004-2]
    ENST00000645194; ENSP00000496093; ENSG00000110436 [P43004-2]
    ENST00000645634; ENSP00000493945; ENSG00000110436 [P43004-2]
    ENST00000647104; ENSP00000494025; ENSG00000110436 [P43004-2]

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    6506

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    hsa:6506

    UCSC genome browser

    More...
    UCSCi
    uc001mwd.4 human [P43004-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U03505 mRNA Translation: AAA50429.1
    U01824 mRNA Translation: AAA18900.1
    Z32517 mRNA Translation: CAA83532.1
    D85884 mRNA Translation: BAA28706.1
    AY066021 mRNA Translation: AAL57716.1
    AK298769 mRNA Translation: BAG60911.1
    AC090625 Genomic DNA No translation available.
    AL133330 Genomic DNA No translation available.
    CH471064 Genomic DNA Translation: EAW68143.1
    BC132768 mRNA Translation: AAI32769.1
    CCDSiCCDS31459.1 [P43004-1]
    CCDS55756.1 [P43004-2]
    PIRiI37426
    I38432
    RefSeqiNP_001182657.1, NM_001195728.2 [P43004-2]
    NP_001239581.1, NM_001252652.1 [P43004-2]
    NP_004162.2, NM_004171.3 [P43004-1]

    3D structure databases

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    SWISS-MODEL Interactive Workspace

    More...
    SWISS-MODEL-Workspacei
    Submit a new modelling project...

    Protein-protein interaction databases

    BioGridi112397, 10 interactors
    CORUMiP43004
    IntActiP43004, 3 interactors
    MINTiP43004
    STRINGi9606.ENSP00000278379

    Chemistry databases

    ChEMBLiCHEMBL4973
    DrugBankiDB00142 Glutamic Acid
    DrugCentraliP43004
    GuidetoPHARMACOLOGYi869

    Protein family/group databases

    TCDBi2.A.23.2.7 the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

    PTM databases

    iPTMnetiP43004
    PhosphoSitePlusiP43004
    SwissPalmiP43004

    Polymorphism and mutation databases

    BioMutaiSLC1A2
    DMDMi3041668

    Proteomic databases

    MassIVEiP43004
    PaxDbiP43004
    PeptideAtlasiP43004
    PRIDEiP43004
    ProteomicsDBi55569 [P43004-1]
    55570 [P43004-2]

    Genome annotation databases

    EnsembliENST00000278379; ENSP00000278379; ENSG00000110436 [P43004-1]
    ENST00000395753; ENSP00000379102; ENSG00000110436 [P43004-2]
    ENST00000643000; ENSP00000495164; ENSG00000110436 [P43004-2]
    ENST00000643305; ENSP00000494828; ENSG00000110436 [P43004-3]
    ENST00000644050; ENSP00000496123; ENSG00000110436 [P43004-2]
    ENST00000644299; ENSP00000494669; ENSG00000110436 [P43004-2]
    ENST00000645194; ENSP00000496093; ENSG00000110436 [P43004-2]
    ENST00000645634; ENSP00000493945; ENSG00000110436 [P43004-2]
    ENST00000647104; ENSP00000494025; ENSG00000110436 [P43004-2]
    GeneIDi6506
    KEGGihsa:6506
    UCSCiuc001mwd.4 human [P43004-1]

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    6506
    DisGeNETi6506

    GeneCards: human genes, protein and diseases

    More...
    GeneCardsi
    SLC1A2
    HGNCiHGNC:10940 SLC1A2
    HPAiCAB002574
    HPA009172
    MalaCardsiSLC1A2
    MIMi600300 gene
    617105 phenotype
    neXtProtiNX_P43004
    OpenTargetsiENSG00000110436
    Orphaneti442835 Undetermined early-onset epileptic encephalopathy
    PharmGKBiPA35827

    GenAtlas: human gene database

    More...
    GenAtlasi
    Search...

    Phylogenomic databases

    eggNOGiKOG3787 Eukaryota
    COG1301 LUCA
    GeneTreeiENSGT00940000155379
    InParanoidiP43004
    KOiK05613
    OMAiICSFVVP
    OrthoDBi1184392at2759
    PhylomeDBiP43004
    TreeFamiTF315206

    Enzyme and pathway databases

    ReactomeiR-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism
    R-HSA-210500 Glutamate Neurotransmitter Release Cycle
    R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides

    Miscellaneous databases

    ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

    More...
    ChiTaRSi
    SLC1A2 human

    The Gene Wiki collection of pages on human genes and proteins

    More...
    GeneWikii
    SLC1A2

    Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

    More...
    GenomeRNAii
    6506
    PharosiP43004
    PMAP-CutDBiP43004

    Protein Ontology

    More...
    PROi
    PR:P43004

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSG00000110436 Expressed in 163 organ(s), highest expression level in occipital lobe
    ExpressionAtlasiP43004 baseline and differential
    GenevisibleiP43004 HS

    Family and domain databases

    Gene3Di1.10.3860.10, 2 hits
    InterProiView protein in InterPro
    IPR001991 Na-dicarboxylate_symporter
    IPR018107 Na-dicarboxylate_symporter_CS
    IPR036458 Na:dicarbo_symporter_sf
    PfamiView protein in Pfam
    PF00375 SDF, 1 hit
    SUPFAMiSSF118215 SSF118215, 1 hit
    PROSITEiView protein in PROSITE
    PS00713 NA_DICARBOXYL_SYMP_1, 1 hit
    PS00714 NA_DICARBOXYL_SYMP_2, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEAA2_HUMAN
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43004
    Secondary accession number(s): B4DQE9
    , Q14417, Q541G6, U3KQQ4
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 15, 1998
    Last modified: October 16, 2019
    This is version 178 of the entry and version 2 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. SIMILARITY comments
      Index of protein domains and families
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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