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Entry version 196 (23 Feb 2022)
Sequence version 1 (01 Nov 1995)
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Protein

Excitatory amino acid transporter 1

Gene

SLC1A3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium-dependent, high-affinity amino acid transporter that mediates the uptake of L-glutamate and also L-aspartate and D-aspartate (PubMed:7521911, PubMed:8123008, PubMed:20477940, PubMed:26690923, PubMed:28032905, PubMed:28424515).

Functions as a symporter that transports one amino acid molecule together with two or three Na+ ions and one proton, in parallel with the counter-transport of one K+ ion (PubMed:20477940).

Mediates Cl- flux that is not coupled to amino acid transport; this avoids the accumulation of negative charges due to aspartate and Na+ symport (PubMed:20477940).

Plays a redundant role in the rapid removal of released glutamate from the synaptic cleft, which is essential for terminating the postsynaptic action of glutamate (By similarity).

By similarity6 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=525 µM for L-glutamate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi394Sodium 1; via carbonyl oxygenBy similarity1
Metal bindingi396Sodium 2; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi398Sodium 1By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei402AspartateCombined sources1 Publication1
Binding sitei476AspartateCombined sources1 Publication1
Metal bindingi483Sodium 1; via carbonyl oxygenBy similarity1
Binding sitei483AspartateCombined sources1 Publication1
Metal bindingi487Sodium 1By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Symport, Transport
LigandChloride, Metal-binding, Potassium, Sodium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
P43003

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-210455, Astrocytic Glutamate-Glutamine Uptake And Metabolism
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-425393, Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-5619062, Defective SLC1A3 causes episodic ataxia 6 (EA6)

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P43003

SIGNOR Signaling Network Open Resource

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SIGNORi
P43003

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.23.2.6, the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Excitatory amino acid transporter 12 Publications
Alternative name(s):
Sodium-dependent glutamate/aspartate transporter 11 Publication
Short name:
GLAST-11 Publication
Solute carrier family 1 member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC1A3
Synonyms:EAAT12 Publications, GLAST, GLAST11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:10941, SLC1A3

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600111, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P43003

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000079215

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 47Cytoplasmic1 PublicationAdd BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei48 – 68Helical; Name=11 PublicationAdd BLAST21
Topological domaini69 – 86Extracellular1 PublicationAdd BLAST18
Transmembranei87 – 108Helical; Name=21 PublicationAdd BLAST22
Topological domaini109 – 122Cytoplasmic1 PublicationAdd BLAST14
Transmembranei123 – 145Helical; Name=31 PublicationAdd BLAST23
Topological domaini146 – 236Extracellular1 PublicationAdd BLAST91
Transmembranei237 – 260Helical; Name=41 PublicationAdd BLAST24
Topological domaini261 – 269Cytoplasmic1 Publication9
Transmembranei270 – 297Helical; Name=51 PublicationAdd BLAST28
Topological domaini298 – 318Extracellular1 PublicationAdd BLAST21
Transmembranei319 – 340Helical; Name=61 PublicationAdd BLAST22
Topological domaini341 – 345Cytoplasmic1 Publication5
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a region that is buried within a membrane, but does not cross it.<p><a href='/help/intramem' target='_top'>More...</a></p>Intramembranei346 – 376Discontinuously helical1 PublicationAdd BLAST31
Topological domaini377 – 385Cytoplasmic1 Publication9
Transmembranei386 – 412Helical; Name=71 PublicationAdd BLAST27
Topological domaini413 – 425Extracellular1 PublicationAdd BLAST13
Intramembranei426 – 459Discontinuously helical1 PublicationAdd BLAST34
Topological domaini460 – 472Extracellular1 PublicationAdd BLAST13
Transmembranei473 – 494Helical; Name=81 PublicationAdd BLAST22
Topological domaini495 – 542Cytoplasmic1 PublicationAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Episodic ataxia 6 (EA6)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder characterized by episodic ataxia, seizures, migraine and alternating hemiplegia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_031733290P → R in EA6. 1 PublicationCorresponds to variant dbSNP:rs137852619EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi363S → R: Loss of electrogenic glutamate transport. Strongly decreased L-aspartate and L-glutamate uptake combined with strongly increased permeability ot other ions; when associated with M-477. 1 Publication1
Mutagenesisi477R → M: Strongly decreased L-aspartate and L-glutamate uptake combined with strongly increased permeability ot other ions; when associated with R-363. 1 Publication1
Mutagenesisi523Y → F: No effect on activity. 1 Publication1

Keywords - Diseasei

Disease variant

Organism-specific databases

DisGeNET

More...
DisGeNETi
6507

MalaCards human disease database

More...
MalaCardsi
SLC1A3
MIMi612656, phenotype

Open Targets

More...
OpenTargetsi
ENSG00000079215

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
2131, Alternating hemiplegia of childhood
209967, Episodic ataxia type 6

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35828

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P43003, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3085

Drug and drug target database

More...
DrugBanki
DB08868, Fingolimod
DB00142, Glutamic acid

DrugCentral

More...
DrugCentrali
P43003

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
868

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
SLC1A3

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1169458

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002020571 – 542Excitatory amino acid transporter 1Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei512PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P43003

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P43003

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P43003

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P43003

PeptideAtlas

More...
PeptideAtlasi
P43003

PRoteomics IDEntifications database

More...
PRIDEi
P43003

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
55567 [P43003-1]
55568 [P43003-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P43003

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P43003

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P43003

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Detected in brain (PubMed:8218410, PubMed:7521911, PubMed:8123008). Detected at very much lower levels in heart, lung, placenta and skeletal muscle (PubMed:7521911, PubMed:8123008). Highly expressed in cerebellum, but also found in frontal cortex, hippocampus and basal ganglia (PubMed:7521911).3 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000079215, Expressed in cerebellum and 223 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P43003, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P43003, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000079215, Group enriched (brain, choroid plexus, retina)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:28424515).

Interacts with isoform 2 of BSG (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
112398, 52 interactors

Protein interaction database and analysis system

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IntActi
P43003, 17 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000265113

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P43003

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P43003, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1542
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P43003

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni363 – 365Aspartate bindingCombined sources1 Publication3
Regioni443 – 447Aspartate bindingCombined sources1 Publication5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Contains eight transmembrane regions plus two helical hairpins that dip into the membrane. These helical hairpin structures play an important role in the transport process. The first enters the membrane from the cytoplasmic side, the second one from the extracellular side. During the transport cycle, the regions involved in amino acid transport, and especially the helical hairpins, move vertically by about 15-18 Angstroms, alternating between exposure to the aqueous phase and reinsertion in the lipid bilayer. In contrast, the regions involved in trimerization do not move.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3787, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000155464

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P43003

Identification of Orthologs from Complete Genome Data

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OMAi
SFSKRVF

Database of Orthologous Groups

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OrthoDBi
540689at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P43003

TreeFam database of animal gene trees

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TreeFami
TF315206

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3860.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001991, Na-dicarboxylate_symporter
IPR018107, Na-dicarboxylate_symporter_CS
IPR036458, Na:dicarbo_symporter_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00375, SDF, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF118215, SSF118215, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00713, NA_DICARBOXYL_SYMP_1, 1 hit
PS00714, NA_DICARBOXYL_SYMP_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 24 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P43003-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTKSNGEEPK MGGRMERFQQ GVRKRTLLAK KKVQNITKED VKSYLFRNAF
60 70 80 90 100
VLLTVTAVIV GTILGFTLRP YRMSYREVKY FSFPGELLMR MLQMLVLPLI
110 120 130 140 150
ISSLVTGMAA LDSKASGKMG MRAVVYYMTT TIIAVVIGII IVIIIHPGKG
160 170 180 190 200
TKENMHREGK IVRVTAADAF LDLIRNMFPP NLVEACFKQF KTNYEKRSFK
210 220 230 240 250
VPIQANETLV GAVINNVSEA METLTRITEE LVPVPGSVNG VNALGLVVFS
260 270 280 290 300
MCFGFVIGNM KEQGQALREF FDSLNEAIMR LVAVIMWYAP VGILFLIAGK
310 320 330 340 350
IVEMEDMGVI GGQLAMYTVT VIVGLLIHAV IVLPLLYFLV TRKNPWVFIG
360 370 380 390 400
GLLQALITAL GTSSSSATLP ITFKCLEENN GVDKRVTRFV LPVGATINMD
410 420 430 440 450
GTALYEALAA IFIAQVNNFE LNFGQIITIS ITATAASIGA AGIPQAGLVT
460 470 480 490 500
MVIVLTSVGL PTDDITLIIA VDWFLDRLRT TTNVLGDSLG AGIVEHLSRH
510 520 530 540
ELKNRDVEMG NSVIEENEMK KPYQLIAQDN ETEKPIDSET KM
Length:542
Mass (Da):59,572
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6E9F62D35A3A5A29
GO
Isoform 2 (identifier: P43003-2) [UniParc]FASTAAdd to basket
Also known as: EAAT1ex9skip

The sequence of this isoform differs from the canonical sequence as follows:
     430-475: SITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFL → R

Note: Expressed throughout the CNS, both in gray matter and axonal tracts, at levels ranging between 10% and 20% of isoform 1. Localizes to ER, has no functional glutamate uptake activity, and exerts a dominant negative effect isoform 1.Curated
Show »
Length:497
Mass (Da):55,149
Checksum:i7C21EC2B467E1C11
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 24 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E7EUS7E7EUS7_HUMAN
Amino acid transporter
SLC1A3
101Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUV6E7EUV6_HUMAN
Amino acid transporter
SLC1A3
106Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0U3A0A087X0U3_HUMAN
Amino acid transporter
SLC1A3
430Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087WT87A0A087WT87_HUMAN
Amino acid transporter
SLC1A3
496Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8P5A0A7P0T8P5_HUMAN
Amino acid transporter
SLC1A3
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9A4A0A7P0T9A4_HUMAN
Amino acid transporter
SLC1A3
162Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T807A0A7P0T807_HUMAN
Amino acid transporter
SLC1A3
148Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T8Q1A0A7P0T8Q1_HUMAN
Amino acid transporter
SLC1A3
133Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0TB50A0A7P0TB50_HUMAN
Amino acid transporter
SLC1A3
129Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A7P0T9Z4A0A7P0T9Z4_HUMAN
Amino acid transporter
SLC1A3
123Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti366S → CT (PubMed:8218410).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011877219E → D. Corresponds to variant dbSNP:rs2032892EnsemblClinVar.1
Natural variantiVAR_031733290P → R in EA6. 1 PublicationCorresponds to variant dbSNP:rs137852619EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_043913430 – 475SITAT…VDWFL → R in isoform 2. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L19158 mRNA No translation available.
U03504 mRNA Translation: AAA50428.1
D26443 mRNA Translation: BAA05462.1
Z31713 Z31710 Genomic DNA Translation: CAA83507.1
AY954110 mRNA Translation: AAY28724.1
AK312304 mRNA Translation: BAG35230.1
AC008957 Genomic DNA No translation available.
AC010631 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55945.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3919.1 [P43003-1]
CCDS54844.1 [P43003-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
S38353

NCBI Reference Sequences

More...
RefSeqi
NP_001160167.1, NM_001166695.2 [P43003-2]
NP_001276869.1, NM_001289940.1
NP_004163.3, NM_004172.4 [P43003-1]
XP_005248399.1, XM_005248342.2 [P43003-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000265113; ENSP00000265113; ENSG00000079215
ENST00000381918; ENSP00000371343; ENSG00000079215
ENST00000679983; ENSP00000505238; ENSG00000079215
ENST00000679992; ENSP00000506585; ENSG00000079215
ENST00000680125; ENSP00000506424; ENSG00000079215 [P43003-2]
ENST00000680318; ENSP00000505057; ENSG00000079215
ENST00000681926; ENSP00000505850; ENSG00000079215 [P43003-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6507

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6507

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...
MANE-Selecti
ENST00000265113.9; ENSP00000265113.4; NM_004172.5; NP_004163.3

UCSC genome browser

More...
UCSCi
uc003jkj.4, human [P43003-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19158 mRNA No translation available.
U03504 mRNA Translation: AAA50428.1
D26443 mRNA Translation: BAA05462.1
Z31713 Z31710 Genomic DNA Translation: CAA83507.1
AY954110 mRNA Translation: AAY28724.1
AK312304 mRNA Translation: BAG35230.1
AC008957 Genomic DNA No translation available.
AC010631 Genomic DNA No translation available.
CH471119 Genomic DNA Translation: EAW55945.1
CCDSiCCDS3919.1 [P43003-1]
CCDS54844.1 [P43003-2]
PIRiS38353
RefSeqiNP_001160167.1, NM_001166695.2 [P43003-2]
NP_001276869.1, NM_001289940.1
NP_004163.3, NM_004172.4 [P43003-1]
XP_005248399.1, XM_005248342.2 [P43003-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LLMX-ray3.25A1-148[»]
A243-542[»]
5LLUX-ray3.32A1-148[»]
A243-542[»]
5LM4X-ray3.10A1-148[»]
A243-542[»]
5MJUX-ray3.71A1-148[»]
A243-542[»]
7NPWelectron microscopy3.99A/B/C29-497[»]
SMRiP43003
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112398, 52 interactors
IntActiP43003, 17 interactors
STRINGi9606.ENSP00000265113

Chemistry databases

BindingDBiP43003
ChEMBLiCHEMBL3085
DrugBankiDB08868, Fingolimod
DB00142, Glutamic acid
DrugCentraliP43003
GuidetoPHARMACOLOGYi868

Protein family/group databases

TCDBi2.A.23.2.6, the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family

PTM databases

iPTMnetiP43003
PhosphoSitePlusiP43003
SwissPalmiP43003

Genetic variation databases

BioMutaiSLC1A3
DMDMi1169458

Proteomic databases

jPOSTiP43003
MassIVEiP43003
MaxQBiP43003
PaxDbiP43003
PeptideAtlasiP43003
PRIDEiP43003
ProteomicsDBi55567 [P43003-1]
55568 [P43003-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22936, 403 antibodies from 39 providers

The DNASU plasmid repository

More...
DNASUi
6507

Genome annotation databases

EnsembliENST00000265113; ENSP00000265113; ENSG00000079215
ENST00000381918; ENSP00000371343; ENSG00000079215
ENST00000679983; ENSP00000505238; ENSG00000079215
ENST00000679992; ENSP00000506585; ENSG00000079215
ENST00000680125; ENSP00000506424; ENSG00000079215 [P43003-2]
ENST00000680318; ENSP00000505057; ENSG00000079215
ENST00000681926; ENSP00000505850; ENSG00000079215 [P43003-2]
GeneIDi6507
KEGGihsa:6507
MANE-SelectiENST00000265113.9; ENSP00000265113.4; NM_004172.5; NP_004163.3
UCSCiuc003jkj.4, human [P43003-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6507
DisGeNETi6507

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SLC1A3
HGNCiHGNC:10941, SLC1A3
HPAiENSG00000079215, Group enriched (brain, choroid plexus, retina)
MalaCardsiSLC1A3
MIMi600111, gene
612656, phenotype
neXtProtiNX_P43003
OpenTargetsiENSG00000079215
Orphaneti2131, Alternating hemiplegia of childhood
209967, Episodic ataxia type 6
PharmGKBiPA35828
VEuPathDBiHostDB:ENSG00000079215

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3787, Eukaryota
GeneTreeiENSGT00940000155464
InParanoidiP43003
OMAiSFSKRVF
OrthoDBi540689at2759
PhylomeDBiP43003
TreeFamiTF315206

Enzyme and pathway databases

PathwayCommonsiP43003
ReactomeiR-HSA-210455, Astrocytic Glutamate-Glutamine Uptake And Metabolism
R-HSA-210500, Glutamate Neurotransmitter Release Cycle
R-HSA-425393, Transport of inorganic cations/anions and amino acids/oligopeptides
R-HSA-5619062, Defective SLC1A3 causes episodic ataxia 6 (EA6)
SignaLinkiP43003
SIGNORiP43003

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
6507, 6 hits in 1039 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SLC1A3, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Glutamate_aspartate_transporter

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6507
PharosiP43003, Tchem

Protein Ontology

More...
PROi
PR:P43003
RNActiP43003, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000079215, Expressed in cerebellum and 223 other tissues
ExpressionAtlasiP43003, baseline and differential
GenevisibleiP43003, HS

Family and domain databases

Gene3Di1.10.3860.10, 1 hit
InterProiView protein in InterPro
IPR001991, Na-dicarboxylate_symporter
IPR018107, Na-dicarboxylate_symporter_CS
IPR036458, Na:dicarbo_symporter_sf
PfamiView protein in Pfam
PF00375, SDF, 1 hit
SUPFAMiSSF118215, SSF118215, 1 hit
PROSITEiView protein in PROSITE
PS00713, NA_DICARBOXYL_SYMP_1, 1 hit
PS00714, NA_DICARBOXYL_SYMP_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEAA1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P43003
Secondary accession number(s): B2R5T3, Q4JCQ8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 23, 2022
This is version 196 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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