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Protein

Phosphatidylinositol 4-kinase LSB6

Gene

LSB6

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in endocytic and/or exocytic pathways.1 Publication

Miscellaneous

Present with 56 molecules/cell in log phase SD medium.1 Publication

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate.2 Publications

Cofactori

Mg2+1 Publication, Mn2+1 Publication

GO - Molecular functioni

  • 1-phosphatidylinositol 4-kinase activity Source: SGD
  • ATP binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:MONOMER3O-352
ReactomeiR-SCE-1483248 Synthesis of PIPs at the ER membrane
R-SCE-1660499 Synthesis of PIPs at the plasma membrane
R-SCE-1660514 Synthesis of PIPs at the Golgi membrane
R-SCE-1660516 Synthesis of PIPs at the early endosome membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-kinase LSB6 (EC:2.7.1.67)
Short name:
PI4-kinase
Short name:
PtdIns-4-kinase
Alternative name(s):
LAS seventeen-binding protein 6
Short name:
LAS17-binding protein 6
Gene namesi
Name:LSB6
Ordered Locus Names:YJL100W
ORF Names:J0834
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL100W
SGDiS000003636 LSB6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000888501 – 607Phosphatidylinositol 4-kinase LSB6Add BLAST607

Proteomic databases

MaxQBiP42951
PaxDbiP42951
PRIDEiP42951

PTM databases

SwissPalmiP42951

Interactioni

Subunit structurei

Interacts with LAS17.1 Publication

Protein-protein interaction databases

BioGridi33657, 18 interactors
DIPiDIP-4035N
IntActiP42951, 8 interactors
MINTiP42951
STRINGi4932.YJL100W

Structurei

3D structure databases

ProteinModelPortaliP42951
SMRiP42951
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini170 – 507PI3K/PI4KAdd BLAST338

Sequence similaritiesi

Belongs to the PI3/PI4-kinase family.Curated

Phylogenomic databases

GeneTreeiENSGT00390000010434
HOGENOMiHOG000165420
InParanoidiP42951
KOiK13711
OMAiIILDYIM
OrthoDBiEOG092C1LL2

Family and domain databases

InterProiView protein in InterPro
IPR000403 PI3/4_kinase_cat_dom
IPR018936 PI3/4_kinase_CS
PfamiView protein in Pfam
PF00454 PI3_PI4_kinase, 1 hit
PROSITEiView protein in PROSITE
PS00916 PI3_4_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42951-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNEAYQHDH TVNPHQKIVV NSYDWLQFRD EQDHCKSKNP ITHASPGVGS
60 70 80 90 100
NAQNSDIAEA PQVFHPSYQS LVNVPSESPR PDQTSGSNPA VGLLHNAEDK
110 120 130 140 150
ASGQEEEGSQ YEIQYSVFRP LHAYPTKGLA YEQLRRKEEQ EQRENFNHLV
160 170 180 190 200
SDCIEAVETF GRELERIQTG SSGSYFVYGT RADESVPVGV FKPKDEEPYG
210 220 230 240 250
PFSPKWTKWA HRTFFPCLFG RSCLIPNLGY ICESAASLLD RRLETHLVPY
260 270 280 290 300
TDTASIESFN FYDNRKKWVL GYNLQKKKQK KLGSFQLFLK EYINADEFFH
310 320 330 340 350
KYPLPGMYSD VKHSFHRKSS GEDINHKPET TRNLTDETEP SKQINSSPIS
360 370 380 390 400
TESEENSKFE WTESSLSQFR LELEKLIILD YIMRNTDRGL DNWMVKLIKL
410 420 430 440 450
SNNKWRLKLA AIDNGLSFPW KHPDEWRLYP YGWLYLPLQL LAKPFSEQMR
460 470 480 490 500
SHFLPILTST NWWEESYQEF LALFSRDQDF NVRMWKKQWA VLKGQAFNVV
510 520 530 540 550
ETLKDPRQGP LELVRRTRCQ VIDEKMQVPC CPPPVSIFKN AIDEPIGSYS
560 570 580 590 600
TSPMVLPSTP STIPFHAHNQ SNSNPVYYDS TLHPFANKTV IAERLQIVNS

TPVFTWC
Length:607
Mass (Da):70,217
Last modified:November 1, 1995 - v1
Checksum:i9969EC2488A72456
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA Translation: CAA59394.1
Z49375 Genomic DNA Translation: CAA89395.1
BK006943 Genomic DNA Translation: DAA08700.1
PIRiS53387
RefSeqiNP_012435.1, NM_001181533.1

Genome annotation databases

EnsemblFungiiYJL100W; YJL100W; YJL100W
GeneIDi853345
KEGGisce:YJL100W

Similar proteinsi

Entry informationi

Entry nameiLSB6_YEAST
AccessioniPrimary (citable) accession number: P42951
Secondary accession number(s): D6VW84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: July 18, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names

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