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Protein

Pheromone-regulated membrane protein 10

Gene

PRM10

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

This is a truncated version of an UPF0442 family protein. Strain S288c has a frameshift in position 382, which disrupts the gene coding for this protein and produces two ORFs YJL107C and YJL108C. A contiguous sequence for a S.cerevisiae UPF0442 family protein can be found in strain YJM789 (AC A6ZQL9).Curated

Enzyme and pathway databases

BioCyciYEAST:G3O-31562-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Pheromone-regulated membrane protein 10
Gene namesi
Name:PRM10
Ordered Locus Names:YJL108C
ORF Names:J0811
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

SGDiS000003644 PRM10

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 65CytoplasmicSequence analysisAdd BLAST65
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87ExtracellularSequence analysis1
Transmembranei88 – 108HelicalSequence analysisAdd BLAST21
Topological domaini109 – 117CytoplasmicSequence analysis9
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Topological domaini139 – 141ExtracellularSequence analysis3
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 180CytoplasmicSequence analysisAdd BLAST18
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 216ExtracellularSequence analysisAdd BLAST15
Transmembranei217 – 237HelicalSequence analysisAdd BLAST21
Topological domaini238 – 241CytoplasmicSequence analysis4
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 271ExtracellularSequence analysis9
Transmembranei272 – 292HelicalSequence analysisAdd BLAST21
Topological domaini293CytoplasmicSequence analysis1
Transmembranei294 – 314HelicalSequence analysisAdd BLAST21
Topological domaini315 – 352ExtracellularSequence analysisAdd BLAST38
Transmembranei353 – 373HelicalSequence analysisAdd BLAST21
Topological domaini374 – 383CytoplasmicSequence analysis10

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002030451 – 383Pheromone-regulated membrane protein 10Add BLAST383

Proteomic databases

PaxDbiP42946
PRIDEiP42946

Interactioni

Protein-protein interaction databases

BioGridi33648, 56 interactors
DIPiDIP-7510N
IntActiP42946, 2 interactors
MINTiP42946
STRINGi4932.YJL108C

Structurei

3D structure databases

ProteinModelPortaliP42946
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UPF0442 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000066081
InParanoidiP42946
OMAiMPMTVIM
OrthoDBiEOG092C35Y4

Family and domain databases

InterProiView protein in InterPro
IPR010619 ThrE
IPR024528 ThrE_2
PfamiView protein in Pfam
PF06738 ThrE, 1 hit
PF12821 ThrE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P42946-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIVSFGDATT RTSEVQLVRC TQGLNLWKLH QVHAVYKRVV HDTLGADEGN
60 70 80 90 100
ALLDQILADT NLYPPWMCVL LYAFCSAMVT PYAFGGDWVN LAISFFMGLC
110 120 130 140 150
VGSLQFILSQ KSYMYSNVFE ISASIVVSFC GRAFGSIPRS HICFGAVTQG
160 170 180 190 200
SLALILPGYI ILCGALELQS RSLVAGAVRM FYAIIYSLFL GFGITLGSAL
210 220 230 240 250
FGWMYHNATN EISCPQLISP WFRFLFVPAF TISISLLNQA HISQLPVMVF
260 270 280 290 300
ISCTGYVVTY WAGKHFANST EFTAALAAFV IGVLGNLYSR IWKGLAVSAM
310 320 330 340 350
LPAIFVQVPS GIASQNSLLS GLQSANTIVN ANETITTSTS DPSSSMSFGM
360 370 380
TMIQVCVGIS VGLFASSLFV YPFGKKKTGL FSL
Length:383
Mass (Da):41,488
Last modified:November 1, 1995 - v1
Checksum:i2030F73D1823CE04
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129F → S in AAS56210 (PubMed:17322287).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA Translation: CAA59386.1
Z49383 Genomic DNA Translation: CAA89402.1
AY557884 Genomic DNA Translation: AAS56210.1
AY227895 Genomic DNA Translation: AAQ17204.1
BK006943 Genomic DNA Translation: DAA08692.1
PIRiS53379
RefSeqiNP_012427.1, NM_001181541.1

Genome annotation databases

EnsemblFungiiYJL108C; YJL108C; YJL108C
GeneIDi853336
KEGGisce:YJL108C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA Translation: CAA59386.1
Z49383 Genomic DNA Translation: CAA89402.1
AY557884 Genomic DNA Translation: AAS56210.1
AY227895 Genomic DNA Translation: AAQ17204.1
BK006943 Genomic DNA Translation: DAA08692.1
PIRiS53379
RefSeqiNP_012427.1, NM_001181541.1

3D structure databases

ProteinModelPortaliP42946
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33648, 56 interactors
DIPiDIP-7510N
IntActiP42946, 2 interactors
MINTiP42946
STRINGi4932.YJL108C

Proteomic databases

PaxDbiP42946
PRIDEiP42946

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL108C; YJL108C; YJL108C
GeneIDi853336
KEGGisce:YJL108C

Organism-specific databases

SGDiS000003644 PRM10

Phylogenomic databases

HOGENOMiHOG000066081
InParanoidiP42946
OMAiMPMTVIM
OrthoDBiEOG092C35Y4

Enzyme and pathway databases

BioCyciYEAST:G3O-31562-MONOMER

Miscellaneous databases

PROiPR:P42946

Family and domain databases

InterProiView protein in InterPro
IPR010619 ThrE
IPR024528 ThrE_2
PfamiView protein in Pfam
PF06738 ThrE, 1 hit
PF12821 ThrE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPRM10_YEAST
AccessioniPrimary (citable) accession number: P42946
Secondary accession number(s): D6VW76, E9P8R0, E9P8T9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 7, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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Main funding by: National Institutes of Health

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