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Protein

T-complex protein 1 subunit eta

Gene

CCT7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. In yeast may play a role in mitotic spindle formation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-31565-MONOMER
ReactomeiR-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta
Short name:
TCP-1-eta
Alternative name(s):
CCT-eta
Gene namesi
Name:CCT7
Ordered Locus Names:YJL111W
ORF Names:J0804
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome X

Organism-specific databases

EuPathDBiFungiDB:YJL111W
SGDiS000003647 CCT7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283721 – 550T-complex protein 1 subunit etaAdd BLAST550

Proteomic databases

MaxQBiP42943
PaxDbiP42943
PRIDEiP42943

PTM databases

iPTMnetiP42943

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi33645, 128 interactors
ComplexPortaliCPX-2156 Chaperonin-containing T-complex
DIPiDIP-6758N
IntActiP42943, 44 interactors
MINTiP42943
STRINGi4932.YJL111W

Structurei

3D structure databases

ProteinModelPortaliP42943
SMRiP42943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

GeneTreeiENSGT00550000074832
HOGENOMiHOG000226730
InParanoidiP42943
KOiK09499
OMAiQGCPNAK
OrthoDBiEOG092C1WYZ

Family and domain databases

CDDicd03340 TCP1_eta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02345 chap_CCT_eta, 1 hit
PROSITEiView protein in PROSITE
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequencei

Sequence statusi: Complete.

P42943-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNFGSQTPTI VVLKEGTDAS QGKGQIISNI NACVAVQEAL KPTLGPLGSD
60 70 80 90 100
ILIVTSNQKT TISNDGATIL KLLDVVHPAA KTLVDISRAQ DAEVGDGTTS
110 120 130 140 150
VTILAGELMK EAKPFLEEGI SSHLIMKGYR KAVSLAVEKI NELAVDITSE
160 170 180 190 200
KSSGRELLER CARTAMSSKL IHNNADFFVK MCVDAVLSLD RNDLDDKLIG
210 220 230 240 250
IKKIPGGAME ESLFINGVAF KKTFSYAGFE QQPKKFNNPK ILSLNVELEL
260 270 280 290 300
KAEKDNAEVR VEHVEDYQAI VDAEWQLIFE KLRQVEETGA NIVLSKLPIG
310 320 330 340 350
DLATQFFADR NIFCAGRVSA DDMNRVIQAV GGSIQSTTSD IKPEHLGTCA
360 370 380 390 400
LFEEMQIGSE RYNLFQGCPQ AKTCTLLLRG GAEQVIAEVE RSLHDAIMIV
410 420 430 440 450
KRALQNKLIV AGGGATEMEV SKCLRDYSKT IAGKQQMIIN AFAKALEVIP
460 470 480 490 500
RQLCENAGFD AIEILNKLRL AHSKGEKWYG VVFETENIGD NFAKFVWEPA
510 520 530 540 550
LVKINALNSA TEATNLILSV DETITNKGSE SANAGMMPPQ GAGRGRGMPM
Length:550
Mass (Da):59,736
Last modified:November 1, 1995 - v1
Checksum:iA428FEC2ACD54B4B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA Translation: CAA59383.1
Z49386 Genomic DNA Translation: CAA89406.1
BK006943 Genomic DNA Translation: DAA08689.1
PIRiS53376
RefSeqiNP_012424.1, NM_001181544.1

Genome annotation databases

EnsemblFungiiYJL111W; YJL111W; YJL111W
GeneIDi853333
KEGGisce:YJL111W

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85021 Genomic DNA Translation: CAA59383.1
Z49386 Genomic DNA Translation: CAA89406.1
BK006943 Genomic DNA Translation: DAA08689.1
PIRiS53376
RefSeqiNP_012424.1, NM_001181544.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V81X-ray3.80G/O/g/o1-550[»]
4V8RX-ray3.80AH/Ah/BH/Bh1-550[»]
4V94X-ray3.80G/O/g/o1-550[»]
5GW4electron microscopy4.70H/h1-550[»]
5GW5electron microscopy4.60H/h1-550[»]
ProteinModelPortaliP42943
SMRiP42943
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi33645, 128 interactors
ComplexPortaliCPX-2156 Chaperonin-containing T-complex
DIPiDIP-6758N
IntActiP42943, 44 interactors
MINTiP42943
STRINGi4932.YJL111W

PTM databases

iPTMnetiP42943

Proteomic databases

MaxQBiP42943
PaxDbiP42943
PRIDEiP42943

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYJL111W; YJL111W; YJL111W
GeneIDi853333
KEGGisce:YJL111W

Organism-specific databases

EuPathDBiFungiDB:YJL111W
SGDiS000003647 CCT7

Phylogenomic databases

GeneTreeiENSGT00550000074832
HOGENOMiHOG000226730
InParanoidiP42943
KOiK09499
OMAiQGCPNAK
OrthoDBiEOG092C1WYZ

Enzyme and pathway databases

BioCyciYEAST:G3O-31565-MONOMER
ReactomeiR-SCE-390471 Association of TriC/CCT with target proteins during biosynthesis
R-SCE-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

PROiPR:P42943

Family and domain databases

CDDicd03340 TCP1_eta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02345 chap_CCT_eta, 1 hit
PROSITEiView protein in PROSITE
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCPH_YEAST
AccessioniPrimary (citable) accession number: P42943
Secondary accession number(s): D6VW73
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 10, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome X
    Yeast (Saccharomyces cerevisiae) chromosome X: entries and gene names
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Main funding by: National Institutes of Health

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