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UniProtKB - P42938 (TDA10_YEAST)
Protein
Probable ATP-dependent kinase TDA10
Gene
TDA10
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
ATP-dependent kinase whose specificity is not yet known.
Miscellaneous
Present with 4280 molecules/cell in log phase SD medium.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 38 – 45 | ATPSequence analysis | 8 |
GO - Molecular functioni
- ATP binding Source: SGD
- glycerate kinase activity Source: GO_Central
Keywordsi
Molecular function | Kinase, Transferase |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.1.31, 984 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ATP-dependent kinase TDA10 (EC:2.7.-.-)Alternative name(s): Topoisomerase I damage affected protein 10 |
Gene namesi | Name:TDA10 Ordered Locus Names:YGR205W ORF Names:G7737 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000003437, TDA10 |
VEuPathDBi | FungiDB:YGR205W |
Pathology & Biotechi
Disruption phenotypei
Leads to cell death when overexpressing the camptothecin mimetic TOP1-T(722)A mutant.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000214076 | 1 – 290 | Probable ATP-dependent kinase TDA10Add BLAST | 290 |
Proteomic databases
MaxQBi | P42938 |
PaxDbi | P42938 |
PRIDEi | P42938 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 33458, 20 interactors |
DIPi | DIP-3866N |
IntActi | P42938, 5 interactors |
MINTi | P42938 |
STRINGi | 4932.YGR205W |
Miscellaneous databases
RNActi | P42938, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P42938 |
SMRi | P42938 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P42938 |
Family & Domainsi
Sequence similaritiesi
Belongs to the GLYK kinase family.Curated
Phylogenomic databases
eggNOGi | KOG2878, Eukaryota |
GeneTreei | ENSGT01020000230412 |
HOGENOMi | CLU_056986_0_0_1 |
InParanoidi | P42938 |
OMAi | KSTWTDA |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase |
SUPFAMi | SSF52540, SSF52540, 1 hit |
i Sequence
Sequence statusi: Complete.
P42938-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCDKSKTVLD YTIEFLDKYI PEWFETGNKC PLFIFFSGPQ GSGKSFTSIQ
60 70 80 90 100
IYNHLMEKYG GEKSIGYASI DDFYLTHEDQ LKLNEQFKNN KLLQGRGLPG
110 120 130 140 150
THDMKLLQEV LNTIFNNNEH PDQDTVVLPK YDKSQFKGEG DRCPTGQKIK
160 170 180 190 200
LPVDIFILEG WFLGFNPILQ GIENNDLLTG DMVDVNAKLF FYSDLLWRNP
210 220 230 240 250
EIKSLGIVFT TDNINNVYGW RLQQEHELIS KVGKGMTDEQ VHAFVDRYMP
260 270 280 290
SYKLYLNDFV RSESLGSIAT LTLGIDSNRN VYSTKTRCIE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12878 Genomic DNA Translation: AAA66317.1 Z49133 Genomic DNA Translation: CAA88998.1 Z72990 Genomic DNA Translation: CAA97232.1 AY558273 Genomic DNA Translation: AAS56599.1 BK006941 Genomic DNA Translation: DAA08299.1 |
PIRi | B29550 |
RefSeqi | NP_011721.3, NM_001181334.3 |
Genome annotation databases
EnsemblFungii | YGR205W_mRNA; YGR205W; YGR205W |
GeneIDi | 853119 |
KEGGi | sce:YGR205W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M12878 Genomic DNA Translation: AAA66317.1 Z49133 Genomic DNA Translation: CAA88998.1 Z72990 Genomic DNA Translation: CAA97232.1 AY558273 Genomic DNA Translation: AAS56599.1 BK006941 Genomic DNA Translation: DAA08299.1 |
PIRi | B29550 |
RefSeqi | NP_011721.3, NM_001181334.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1ODF | X-ray | 2.25 | A | 1-290 | [»] | |
AlphaFoldDBi | P42938 | |||||
SMRi | P42938 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 33458, 20 interactors |
DIPi | DIP-3866N |
IntActi | P42938, 5 interactors |
MINTi | P42938 |
STRINGi | 4932.YGR205W |
Proteomic databases
MaxQBi | P42938 |
PaxDbi | P42938 |
PRIDEi | P42938 |
Genome annotation databases
EnsemblFungii | YGR205W_mRNA; YGR205W; YGR205W |
GeneIDi | 853119 |
KEGGi | sce:YGR205W |
Organism-specific databases
SGDi | S000003437, TDA10 |
VEuPathDBi | FungiDB:YGR205W |
Phylogenomic databases
eggNOGi | KOG2878, Eukaryota |
GeneTreei | ENSGT01020000230412 |
HOGENOMi | CLU_056986_0_0_1 |
InParanoidi | P42938 |
OMAi | KSTWTDA |
Enzyme and pathway databases
BRENDAi | 2.7.1.31, 984 |
Miscellaneous databases
EvolutionaryTracei | P42938 |
PROi | PR:P42938 |
RNActi | P42938, protein |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase |
SUPFAMi | SSF52540, SSF52540, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TDA10_YEAST | |
Accessioni | P42938Primary (citable) accession number: P42938 Secondary accession number(s): D6VUY8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | May 25, 2022 | |
This is version 162 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome VII
Yeast (Saccharomyces cerevisiae) chromosome VII: entries and gene names - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families