Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

T-complex protein 1 subunit theta

Gene

Cct8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit theta
Short name:
TCP-1-theta
Alternative name(s):
CCT-theta
Gene namesi
Name:Cct8
Synonyms:Cctq
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:107183 Cct8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cilium, Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001283742 – 548T-complex protein 1 subunit thetaAdd BLAST547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei23PhosphoserineCombined sources1
Modified residuei30PhosphotyrosineBy similarity1
Modified residuei162PhosphoserineBy similarity1
Cross-linki224Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki254Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki260Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei269PhosphoserineBy similarity1
Modified residuei317PhosphoserineBy similarity1
Modified residuei318N6-acetyllysineBy similarity1
Modified residuei400N6-acetyllysineCombined sources1
Cross-linki459Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity
Modified residuei466N6-acetyllysineBy similarity1
Modified residuei505PhosphotyrosineBy similarity1
Cross-linki534Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei537PhosphoserineBy similarity1
Cross-linki539Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP42932
PaxDbiP42932
PeptideAtlasiP42932
PRIDEiP42932

2D gel databases

REPRODUCTION-2DPAGEiP42932

PTM databases

iPTMnetiP42932
PhosphoSitePlusiP42932
SwissPalmiP42932

Expressioni

Gene expression databases

BgeeiENSMUSG00000025613 Expressed in 309 organ(s), highest expression level in ear
CleanExiMM_CCT8
ExpressionAtlasiP42932 baseline and differential
GenevisibleiP42932 MM

Interactioni

Subunit structurei

Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG (By similarity). Interacts with DNAAF4 (PubMed:23872636).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198572, 41 interactors
CORUMiP42932
IntActiP42932, 42 interactors
MINTiP42932
STRINGi10090.ENSMUSP00000026704

Structurei

3D structure databases

ProteinModelPortaliP42932
SMRiP42932
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0362 Eukaryota
ENOG410XPXR LUCA
GeneTreeiENSGT00550000074783
HOVERGENiHBG103107
InParanoidiP42932
KOiK09500
OMAiWGLKYAV
OrthoDBiEOG091G05WZ
PhylomeDBiP42932
TreeFamiTF105699

Family and domain databases

CDDicd03341 TCP1_theta, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012721 Chap_CCT_theta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02346 chap_CCT_theta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

P42932-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALHVPKAPG FAQMLKDGAK HFSGLEEAVY RNIQACKELA QTTRTAYGPN
60 70 80 90 100
GMNKMVINRL EKLFVTNDAA TILRELEVQH PAAKMIVMAS HMQEQEVGDG
110 120 130 140 150
TNFVLVFAGA LLELAEELLR IGLSVSEVIS GYEIACKKAH EILPELVCCS
160 170 180 190 200
AKNLRDVDEV SSLLRTSIMS KQYGSETFLA KLIAQACVSI FPDSGNFNVD
210 220 230 240 250
NIRVCKILGS GIYSSSVLHG MVFKKETEGD VTSVKDAKIA VYSCPFDGMI
260 270 280 290 300
TETKGTVLIK TAEELMNFSK GEENLMDAQV KAIAGTGANV IVTGGKVADI
310 320 330 340 350
ALHYANKYNI MLVRLNSKWD LRRLCKTVGA TALPKLTPPV QEEMGHCDSV
360 370 380 390 400
YLSEVGDTQV VVFKHEKEDG AISTIVLRGS TDNLMDDIER AVDDGVNTFK
410 420 430 440 450
VLTRDKRLVP GGGATEIELA KQITSYGETC PGLEQYAIKK FAEAFEAIPR
460 470 480 490 500
ALAENSGVKA NEVISKLYSV HQEGNKNVGL DIEAEVPAVK DMLEASILDT
510 520 530 540
YLGKYWAIKL ATNAAVTVLR VDQIIMAKPA GGPKPPSGKK DWDDDQND
Length:548
Mass (Da):59,555
Last modified:January 23, 2007 - v3
Checksum:i4B5265250CFF1FE2
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BL49H3BL49_MOUSE
T-complex protein 1 subunit theta
Cct8
489Annotation score:
H3BKG2H3BKG2_MOUSE
T-complex protein 1 subunit theta
Cct8
158Annotation score:
H3BLL1H3BLL1_MOUSE
T-complex protein 1 subunit theta
Cct8
132Annotation score:
H3BJB6H3BJB6_MOUSE
T-complex protein 1 subunit theta
Cct8
239Annotation score:
H3BKR8H3BKR8_MOUSE
T-complex protein 1 subunit theta
Cct8
71Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37164 mRNA Translation: CAA85521.1
BC009007 mRNA Translation: AAH09007.1
CCDSiCCDS37384.1
PIRiJC4073
RefSeqiNP_033970.3, NM_009840.3
UniGeneiMm.328673

Genome annotation databases

EnsembliENSMUST00000026704; ENSMUSP00000026704; ENSMUSG00000025613
GeneIDi12469
KEGGimmu:12469
UCSCiuc007zul.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z37164 mRNA Translation: CAA85521.1
BC009007 mRNA Translation: AAH09007.1
CCDSiCCDS37384.1
PIRiJC4073
RefSeqiNP_033970.3, NM_009840.3
UniGeneiMm.328673

3D structure databases

ProteinModelPortaliP42932
SMRiP42932
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198572, 41 interactors
CORUMiP42932
IntActiP42932, 42 interactors
MINTiP42932
STRINGi10090.ENSMUSP00000026704

PTM databases

iPTMnetiP42932
PhosphoSitePlusiP42932
SwissPalmiP42932

2D gel databases

REPRODUCTION-2DPAGEiP42932

Proteomic databases

EPDiP42932
PaxDbiP42932
PeptideAtlasiP42932
PRIDEiP42932

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000026704; ENSMUSP00000026704; ENSMUSG00000025613
GeneIDi12469
KEGGimmu:12469
UCSCiuc007zul.1 mouse

Organism-specific databases

CTDi10694
MGIiMGI:107183 Cct8

Phylogenomic databases

eggNOGiKOG0362 Eukaryota
ENOG410XPXR LUCA
GeneTreeiENSGT00550000074783
HOVERGENiHBG103107
InParanoidiP42932
KOiK09500
OMAiWGLKYAV
OrthoDBiEOG091G05WZ
PhylomeDBiP42932
TreeFamiTF105699

Enzyme and pathway databases

ReactomeiR-MMU-390471 Association of TriC/CCT with target proteins during biosynthesis
R-MMU-6798695 Neutrophil degranulation
R-MMU-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Miscellaneous databases

ChiTaRSiCct8 mouse
PROiPR:P42932
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025613 Expressed in 309 organ(s), highest expression level in ear
CleanExiMM_CCT8
ExpressionAtlasiP42932 baseline and differential
GenevisibleiP42932 MM

Family and domain databases

CDDicd03341 TCP1_theta, 1 hit
Gene3Di1.10.560.10, 1 hit
3.30.260.10, 1 hit
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012721 Chap_CCT_theta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 1 hit
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 1 hit
TIGRFAMsiTIGR02346 chap_CCT_theta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCPQ_MOUSE
AccessioniPrimary (citable) accession number: P42932
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again