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UniProtKB - P42920 (RL3_BACSU)
Protein
50S ribosomal protein L3
Gene
rplC
Organism
Bacillus subtilis (strain 168)
Status
Functioni
One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity).
Strongly stimulates 23S rRNA precursor processing by mini-ribonuclease 3 (MrnC); 20-30% DMSO can replace L3, suggesting the protein may alter rRNA conformation.
UniRule annotation1 PublicationGO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: GO_Central
GO - Biological processi
- positive regulation of rRNA processing Source: UniProtKB
- rRNA processing Source: UniProtKB-KW
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Biological process | rRNA processing |
Enzyme and pathway databases
BioCyci | BSUB:BSU01160-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L3UniRule annotationShort name: BL3 |
Gene namesi | Name:rplCUniRule annotation Ordered Locus Names:BSU01160 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000077066 | 1 – 209 | 50S ribosomal protein L3Add BLAST | 209 |
Proteomic databases
jPOSTi | P42920 |
PaxDbi | P42920 |
PRIDEi | P42920 |
Interactioni
Subunit structurei
Protein-protein interaction databases
IntActi | P42920, 2 interactors |
STRINGi | 224308.BSU01160 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P42920 |
SMRi | P42920 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 122 – 152 | DisorderedSequence analysisAdd BLAST | 31 |
Sequence similaritiesi
Belongs to the universal ribosomal protein uL3 family.UniRule annotation
Phylogenomic databases
eggNOGi | COG0087, Bacteria |
InParanoidi | P42920 |
OMAi | KRMAGRY |
PhylomeDBi | P42920 |
Family and domain databases
HAMAPi | MF_01325_B, Ribosomal_L3_B, 1 hit |
InterProi | View protein in InterPro IPR000597, Ribosomal_L3 IPR019927, Ribosomal_L3_bac/org-type IPR019926, Ribosomal_L3_CS IPR009000, Transl_B-barrel_sf |
PANTHERi | PTHR11229, PTHR11229, 1 hit |
Pfami | View protein in Pfam PF00297, Ribosomal_L3, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
TIGRFAMsi | TIGR03625, L3_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00474, RIBOSOMAL_L3, 1 hit |
i Sequence
Sequence statusi: Complete.
P42920-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTKGILGRKI GMTQVFAENG DLIPVTVIEA APNVVLQKKT AENDGYEAIQ
60 70 80 90 100
LGFDDKREKL SNKPEKGHVA KAETAPKRFV KELRGVEMDA YEVGQEVKVE
110 120 130 140 150
IFSAGEIVDV TGVSKGKGFQ GAIKRHGQSR GPMSHGSRYH RRPGSMGPVD
160 170 180 190 200
PNRVFKGKLL PGRMGGEQIT VQNLEIVKVD AERNLLLIKG NVPGAKKSLI
TVKSAVKSK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43929 Genomic DNA Translation: AAC45956.1 D50302 Genomic DNA Translation: BAA08831.1 AL009126 Genomic DNA Translation: CAB11892.1 D64127 Genomic DNA Translation: BAA11007.1 |
PIRi | G69694 |
RefSeqi | NP_387997.1, NC_000964.3 WP_004399671.1, NZ_JNCM01000029.1 |
Genome annotation databases
EnsemblBacteriai | CAB11892; CAB11892; BSU_01160 |
GeneIDi | 936239 |
KEGGi | bsu:BSU01160 |
PATRICi | fig|224308.179.peg.119 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U43929 Genomic DNA Translation: AAC45956.1 D50302 Genomic DNA Translation: BAA08831.1 AL009126 Genomic DNA Translation: CAB11892.1 D64127 Genomic DNA Translation: BAA11007.1 |
PIRi | G69694 |
RefSeqi | NP_387997.1, NC_000964.3 WP_004399671.1, NZ_JNCM01000029.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3J3V | electron microscopy | 13.30 | D | 1-209 | [»] | |
3J3W | electron microscopy | 10.70 | D | 1-209 | [»] | |
3J9W | electron microscopy | 3.90 | BE | 1-209 | [»] | |
5NJT | electron microscopy | 3.80 | X | 2-208 | [»] | |
6HA1 | electron microscopy | 3.10 | D | 1-209 | [»] | |
6HA8 | electron microscopy | 3.50 | D | 1-209 | [»] | |
6HTQ | electron microscopy | 4.50 | D | 2-207 | [»] | |
6PPF | electron microscopy | 3.40 | D | 1-209 | [»] | |
6PPK | electron microscopy | 4.40 | D | 1-209 | [»] | |
6PVK | electron microscopy | 3.40 | D | 1-209 | [»] | |
6TNN | electron microscopy | 3.07 | X | 1-209 | [»] | |
6TPQ | electron microscopy | 3.07 | X | 1-209 | [»] | |
7AQC | electron microscopy | 2.99 | D | 1-209 | [»] | |
7AQD | electron microscopy | 3.10 | D | 1-209 | [»] | |
7AS8 | electron microscopy | 2.90 | F | 1-209 | [»] | |
7AS9 | electron microscopy | 3.50 | F | 1-209 | [»] | |
7OPE | electron microscopy | 3.20 | F | 1-209 | [»] | |
AlphaFoldDBi | P42920 | |||||
SMRi | P42920 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
IntActi | P42920, 2 interactors |
STRINGi | 224308.BSU01160 |
Proteomic databases
jPOSTi | P42920 |
PaxDbi | P42920 |
PRIDEi | P42920 |
Genome annotation databases
EnsemblBacteriai | CAB11892; CAB11892; BSU_01160 |
GeneIDi | 936239 |
KEGGi | bsu:BSU01160 |
PATRICi | fig|224308.179.peg.119 |
Phylogenomic databases
eggNOGi | COG0087, Bacteria |
InParanoidi | P42920 |
OMAi | KRMAGRY |
PhylomeDBi | P42920 |
Enzyme and pathway databases
BioCyci | BSUB:BSU01160-MONOMER |
Family and domain databases
HAMAPi | MF_01325_B, Ribosomal_L3_B, 1 hit |
InterProi | View protein in InterPro IPR000597, Ribosomal_L3 IPR019927, Ribosomal_L3_bac/org-type IPR019926, Ribosomal_L3_CS IPR009000, Transl_B-barrel_sf |
PANTHERi | PTHR11229, PTHR11229, 1 hit |
Pfami | View protein in Pfam PF00297, Ribosomal_L3, 1 hit |
SUPFAMi | SSF50447, SSF50447, 1 hit |
TIGRFAMsi | TIGR03625, L3_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00474, RIBOSOMAL_L3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RL3_BACSU | |
Accessioni | P42920Primary (citable) accession number: P42920 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families