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Protein

50S ribosomal protein L2

Gene

rplB

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

BioCyciBSUB:BSU01190-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L2UniRule annotation
Short name:
BL2
Gene namesi
Name:rplBUniRule annotation
Ordered Locus Names:BSU01190
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001295292 – 27750S ribosomal protein L2Add BLAST276

Proteomic databases

PaxDbiP42919
PRIDEiP42919

Interactioni

Subunit structurei

Forms a bridge to the 30S subunit in the 70S ribosome (By similarity). Part of the 50S ribosomal subunit.By similarity1 Publication

Protein-protein interaction databases

IntActiP42919, 1 interactor
MINTiP42919
STRINGi224308.Bsubs1_010100000615

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J3Velectron microscopy13.30C1-277[»]
3J3Welectron microscopy10.70C1-277[»]
3J9Welectron microscopy3.90BD1-277[»]
5NJTelectron microscopy3.80W2-276[»]
ProteinModelPortaliP42919
SMRiP42919
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the universal ribosomal protein uL2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CFD Bacteria
COG0090 LUCA
HOGENOMiHOG000232982
InParanoidiP42919
KOiK02886
OMAiHGYIKGV
PhylomeDBiP42919

Family and domain databases

Gene3Di2.30.30.30, 1 hit
4.10.950.10, 1 hit
HAMAPiMF_01320_B Ribosomal_L2_B, 1 hit
InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR022666 Rbsml_prot_L2_RNA-bd_dom
IPR014722 Rib_L2_dom2
IPR002171 Ribosomal_L2
IPR005880 Ribosomal_L2_bac/org-type
IPR022669 Ribosomal_L2_C
IPR022671 Ribosomal_L2_CS
IPR014726 Ribosomal_L2_dom3
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR13691 PTHR13691, 1 hit
PfamiView protein in Pfam
PF00181 Ribosomal_L2, 1 hit
PF03947 Ribosomal_L2_C, 1 hit
PIRSFiPIRSF002158 Ribosomal_L2, 1 hit
SMARTiView protein in SMART
SM01383 Ribosomal_L2, 1 hit
SM01382 Ribosomal_L2_C, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
SSF50249 SSF50249, 1 hit
TIGRFAMsiTIGR01171 rplB_bact, 1 hit
PROSITEiView protein in PROSITE
PS00467 RIBOSOMAL_L2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42919-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIKKYKPTS NGRRGMTTSD FAEITTDKPE KSLLAPLHKK GGRNNQGKLT
60 70 80 90 100
VRHQGGGHKR QYRVIDFKRD KDGIPGRVAT VEYDPNRSAN IALINYADGE
110 120 130 140 150
KRYILAPKGI QVGTEIMSGP EADIKVGNAL PLINIPVGTV VHNIELKPGK
160 170 180 190 200
GGQLVRSAGT SAQVLGKEGK YVLVRLNSGE VRMILSACRA SIGQVGNEQH
210 220 230 240 250
ELINIGKAGR SRWKGIRPTV RGSVMNPNDH PHGGGEGRAP IGRKSPMSPW
260 270
GKPTLGFKTR KKKNKSDKFI VRRRKNK
Length:277
Mass (Da):30,274
Last modified:June 16, 2009 - v3
Checksum:iE126BCA251035A96
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9T → S in AAC45959 (PubMed:9371452).Curated1
Sequence conflicti9T → S in BAA08834 (PubMed:8969501).Curated1
Sequence conflicti116I → V in AAC45959 (PubMed:9371452).Curated1
Sequence conflicti256G → E in BAA08834 (PubMed:8969501).Curated1
Sequence conflicti262K → Q in BAA08834 (PubMed:8969501).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U43929 Genomic DNA Translation: AAC45959.1
D50302 Genomic DNA Translation: BAA08834.1
AL009126 Genomic DNA Translation: CAB11895.2
PIRiF69694
RefSeqiNP_388000.2, NC_000964.3
WP_003225795.1, NZ_JNCM01000029.1

Genome annotation databases

EnsemblBacteriaiCAB11895; CAB11895; BSU01190
GeneIDi936817
KEGGibsu:BSU01190
PATRICifig|224308.179.peg.122

Similar proteinsi

Entry informationi

Entry nameiRL2_BACSU
AccessioniPrimary (citable) accession number: P42919
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: June 16, 2009
Last modified: February 28, 2018
This is version 129 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

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