UniProtKB - P42910 (PTPC1_ECOLI)
Protein
N-acetylgalactosamine permease IIC component 1
Gene
agaC
Organism
Escherichia coli (strain K12)
Status
Functioni
The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system is involved in N-acetylgalactosamine transport.
GO - Biological processi
- phosphoenolpyruvate-dependent sugar phosphotransferase system Source: GO_Central
Keywordsi
Biological process | Phosphotransferase system, Sugar transport, Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:AGAC-MONOMER ECOL316407:JW3108-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: N-acetylgalactosamine permease IIC component 1Alternative name(s): EIIC-Aga PTS system N-acetylgalactosamine-specific EIIC component 1 |
Gene namesi | Name:agaC Synonyms:yraE Ordered Locus Names:b3139, JW3108 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 10 | PeriplasmicSequence analysis | 10 | |
Transmembranei | 11 – 31 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 32 – 33 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 34 – 54 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 55 – 66 | PeriplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 67 – 87 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 88 – 94 | CytoplasmicSequence analysis | 7 | |
Transmembranei | 95 – 115 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 116 – 141 | PeriplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 142 – 162 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 163 – 177 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 178 – 198 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 199 – 209 | PeriplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 210 – 230 | HelicalPROSITE-ProRule annotationAdd BLAST | 21 | |
Topological domaini | 231 – 267 | CytoplasmicSequence analysisAdd BLAST | 37 |
GO - Cellular componenti
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: EcoCyc
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000186660 | 1 – 267 | N-acetylgalactosamine permease IIC component 1Add BLAST | 267 |
Proteomic databases
PaxDbi | P42910 |
PRIDEi | P42910 |
Interactioni
Protein-protein interaction databases
BioGridi | 4262422, 14 interactors |
STRINGi | 511145.b3139 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 237 | PTS EIIC type-4PROSITE-ProRule annotationAdd BLAST | 237 |
Domaini
The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG4105ETZ Bacteria COG3715 LUCA |
HOGENOMi | HOG000097553 |
KOi | K10985 |
PhylomeDBi | P42910 |
Family and domain databases
InterProi | View protein in InterPro IPR004700 PTS_IIC_man |
Pfami | View protein in Pfam PF03609 EII-Sor, 1 hit |
TIGRFAMsi | TIGR00822 EII-Sor, 1 hit |
PROSITEi | View protein in PROSITE PS51106 PTS_EIIC_TYPE_4, 1 hit |
i Sequence
Sequence statusi: Complete.
P42910-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHEITLLQGL SLAALVFVLG IDFWLEALFL FRPIIVCTLT GAILGDIQTG
60 70 80 90 100
LITGGLTELA FAGLTPAGGV QPPNPIMAGL MTTVIAWSTG VDAKTAIGLG
110 120 130 140 150
LPFSLLMQYV ILFFYSAFSL FMTKADKCAK EADTAAFSRL NWTTMLIVAS
160 170 180 190 200
AYAVIAFLCT YLAQGAMQAL VKAMPAWLTH GFEVAGGILP AVGFGLLLRV
210 220 230 240 250
MFKAQYIPYL IAGFLFVCYI QVSNLLPVAV LGAGFAVYEF FNAKSRQQAQ
260
PQPVASKNEE EDYSNGI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57942.1 U00096 Genomic DNA Translation: AAC76173.1 AP009048 Genomic DNA Translation: BAE77185.1 |
PIRi | G65103 |
RefSeqi | NP_417608.1, NC_000913.3 WP_000544489.1, NZ_STEB01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC76173; AAC76173; b3139 BAE77185; BAE77185; BAE77185 |
GeneIDi | 947652 |
KEGGi | ecj:JW3108 eco:b3139 |
PATRICi | fig|1411691.4.peg.3591 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U18997 Genomic DNA Translation: AAA57942.1 U00096 Genomic DNA Translation: AAC76173.1 AP009048 Genomic DNA Translation: BAE77185.1 |
PIRi | G65103 |
RefSeqi | NP_417608.1, NC_000913.3 WP_000544489.1, NZ_STEB01000001.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGridi | 4262422, 14 interactors |
STRINGi | 511145.b3139 |
Proteomic databases
PaxDbi | P42910 |
PRIDEi | P42910 |
Genome annotation databases
EnsemblBacteriai | AAC76173; AAC76173; b3139 BAE77185; BAE77185; BAE77185 |
GeneIDi | 947652 |
KEGGi | ecj:JW3108 eco:b3139 |
PATRICi | fig|1411691.4.peg.3591 |
Organism-specific databases
EchoBASEi | EB2623 |
Phylogenomic databases
eggNOGi | ENOG4105ETZ Bacteria COG3715 LUCA |
HOGENOMi | HOG000097553 |
KOi | K10985 |
PhylomeDBi | P42910 |
Enzyme and pathway databases
BioCyci | EcoCyc:AGAC-MONOMER ECOL316407:JW3108-MONOMER |
Miscellaneous databases
PROi | PR:P42910 |
Family and domain databases
InterProi | View protein in InterPro IPR004700 PTS_IIC_man |
Pfami | View protein in Pfam PF03609 EII-Sor, 1 hit |
TIGRFAMsi | TIGR00822 EII-Sor, 1 hit |
PROSITEi | View protein in PROSITE PS51106 PTS_EIIC_TYPE_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTPC1_ECOLI | |
Accessioni | P42910Primary (citable) accession number: P42910 Secondary accession number(s): Q2M971 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1995 |
Last sequence update: | November 1, 1995 | |
Last modified: | November 13, 2019 | |
This is version 127 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- Escherichia coli
Escherichia coli (strain K12): entries and cross-references to EcoGene