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Protein

Enolase

Gene
N/A
Organism
Ricinus communis (Castor bean)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2-phospho-D-glycerate = phosphoenolpyruvate + H2O.

Cofactori

Mg2+By similarityNote: Mg2+ is required for catalysis and for stabilizing the dimer.By similarity

Pathwayi: glycolysis

This protein is involved in step 4 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. 2,3-bisphosphoglycerate-independent phosphoglycerate mutase
  4. Enolase
  5. Pyruvate kinase isozyme A, chloroplastic, Pyruvate kinase isozyme G, chloroplastic, Pyruvate kinase (RCOM_1122030), Pyruvate kinase (RCOM_1382790), Pyruvate kinase (RCOM_1382780), Pyruvate kinase (RCOM_0840740), Pyruvate kinase (RCOM_0342830), Pyruvate kinase (RCOM_0910580), Pyruvate kinase (RCOM_0865230), Pyruvate kinase (RCOM_1454580), Pyruvate kinase (RCOM_1581420), Pyruvate kinase (RCOM_0248610)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei164SubstrateBy similarity1
Binding sitei173SubstrateBy similarity1
Active sitei216Proton donorBy similarity1
Metal bindingi251MagnesiumBy similarity1
Metal bindingi301MagnesiumBy similarity1
Binding sitei301SubstrateBy similarity1
Metal bindingi328MagnesiumBy similarity1
Binding sitei328SubstrateBy similarity1
Active sitei353Proton acceptorBy similarity1
Binding sitei404SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processGlycolysis
LigandMagnesium, Metal-binding

Enzyme and pathway databases

SABIO-RKiP42896
UniPathwayi
UPA00109;UER00187

Names & Taxonomyi

Protein namesi
Recommended name:
Enolase (EC:4.2.1.11)
Alternative name(s):
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
OrganismiRicinus communis (Castor bean)
Taxonomic identifieri3988 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsMalpighialesEuphorbiaceaeAcalyphoideaeAcalypheaeRicinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001340781 – 445EnolaseAdd BLAST445

Proteomic databases

PRIDEiP42896

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP42896
SMRiP42896
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni380 – 383Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the enolase family.Curated

Phylogenomic databases

KOiK01689

Family and domain databases

CDDicd03313 enolase, 1 hit
Gene3Di3.20.20.120, 1 hit
3.30.390.10, 1 hit
HAMAPiMF_00318 Enolase, 1 hit
InterProiView protein in InterPro
IPR000941 Enolase
IPR036849 Enolase-like_C_sf
IPR029017 Enolase-like_N
IPR034390 Enolase-like_superfamily
IPR020810 Enolase_C
IPR020809 Enolase_CS
IPR020811 Enolase_N
PANTHERiPTHR11902 PTHR11902, 1 hit
PfamiView protein in Pfam
PF00113 Enolase_C, 1 hit
PF03952 Enolase_N, 1 hit
PIRSFiPIRSF001400 Enolase, 1 hit
PRINTSiPR00148 ENOLASE
SFLDiSFLDG00178 enolase, 1 hit
SFLDS00001 Enolase, 1 hit
SMARTiView protein in SMART
SM01192 Enolase_C, 1 hit
SM01193 Enolase_N, 1 hit
SUPFAMiSSF51604 SSF51604, 1 hit
TIGRFAMsiTIGR01060 eno, 1 hit
PROSITEiView protein in PROSITE
PS00164 ENOLASE, 1 hit

Sequencei

Sequence statusi: Complete.

P42896-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAITIVSVRA RQIFDSRGNP TVEADIKLSD GHLARAAVPS GASTGIYEAL
60 70 80 90 100
ELRDGGSDYL GKGVSKAVEN VNSIIGPALI GKDPTEQTAL DNFMVQELDG
110 120 130 140 150
TVNEWGWCKQ KLGANAILAV SLALCKAGAH VKGIPLYKHI ANLAGNKNLV
160 170 180 190 200
LPVPAFNVIN GGSHAGNKLA MQEFMILPVG ASSFKEAMKM GAEVYHHLKS
210 220 230 240 250
VIKKKYGQDA TNVGDEGGFA PNIQENKEGL ELLKTAIAKA GYTGKVVIGM
260 270 280 290 300
DVAASEFYGS DKTYDLNFKE ENNDGSQKIS GEALKDLYKS FASEYPIVSI
310 320 330 340 350
EDPFDQDDWE HYSKLTSEIG EKVQIVGDDL LVTNPKRVEK AIQEKACNAL
360 370 380 390 400
LLKVNQIGSV TESIEAVRMS KRAGWGVMAS HRSGETEDTF IADLSVGLAT
410 420 430 440
GQIKTGAPCR SERLAKYNQL LRIEEELGAE AVYAGAKFRT PVEPY
Length:445
Mass (Da):47,912
Last modified:November 1, 1995 - v1
Checksum:iA88EFE3A90CAE572
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28386 mRNA Translation: CAA82232.1
PIRiS39203
RefSeqiNP_001310701.1, NM_001323772.1

Genome annotation databases

GeneIDi8288376
KEGGircu:8288376

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28386 mRNA Translation: CAA82232.1
PIRiS39203
RefSeqiNP_001310701.1, NM_001323772.1

3D structure databases

ProteinModelPortaliP42896
SMRiP42896
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP42896

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi8288376
KEGGircu:8288376

Phylogenomic databases

KOiK01689

Enzyme and pathway databases

UniPathwayi
UPA00109;UER00187

SABIO-RKiP42896

Family and domain databases

CDDicd03313 enolase, 1 hit
Gene3Di3.20.20.120, 1 hit
3.30.390.10, 1 hit
HAMAPiMF_00318 Enolase, 1 hit
InterProiView protein in InterPro
IPR000941 Enolase
IPR036849 Enolase-like_C_sf
IPR029017 Enolase-like_N
IPR034390 Enolase-like_superfamily
IPR020810 Enolase_C
IPR020809 Enolase_CS
IPR020811 Enolase_N
PANTHERiPTHR11902 PTHR11902, 1 hit
PfamiView protein in Pfam
PF00113 Enolase_C, 1 hit
PF03952 Enolase_N, 1 hit
PIRSFiPIRSF001400 Enolase, 1 hit
PRINTSiPR00148 ENOLASE
SFLDiSFLDG00178 enolase, 1 hit
SFLDS00001 Enolase, 1 hit
SMARTiView protein in SMART
SM01192 Enolase_C, 1 hit
SM01193 Enolase_N, 1 hit
SUPFAMiSSF51604 SSF51604, 1 hit
TIGRFAMsiTIGR01060 eno, 1 hit
PROSITEiView protein in PROSITE
PS00164 ENOLASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiENO_RICCO
AccessioniPrimary (citable) accession number: P42896
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 28, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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Main funding by: National Institutes of Health

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