Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Colipase

Gene

CLPS

Organism
Myocastor coypus (Coypu) (Nutria)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.
Enterostatin has a biological activity as a satiety signal.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDigestion, Lipid degradation, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Colipase
Gene namesi
Name:CLPS
OrganismiMyocastor coypus (Coypu) (Nutria)
Taxonomic identifieri10157 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaMyocastoridaeMyocastor

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 171 PublicationAdd BLAST17
PropeptideiPRO_000000570018 – 22Enterostatin, activation peptideSequence analysis5
ChainiPRO_000000570123 – 111ColipaseAdd BLAST89

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 45PROSITE-ProRule annotation
Disulfide bondi40 ↔ 56PROSITE-ProRule annotation
Disulfide bondi44 ↔ 78PROSITE-ProRule annotation
Disulfide bondi66 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 104PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the pancreas.

Interactioni

Subunit structurei

Forms a 1:1 stoichiometric complex with pancreatic lipase.PROSITE-ProRule annotation

Structurei

3D structure databases

ProteinModelPortaliP42889
SMRiP42889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the colipase family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG005373

Family and domain databases

CDDicd00039 COLIPASE, 1 hit
InterProiView protein in InterPro
IPR001981 Colipase
IPR017914 Colipase_C
IPR017915 Colipase_CS
IPR017913 Colipase_N
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF01114 Colipase, 1 hit
PF02740 Colipase_C, 1 hit
PRINTSiPR00128 COLIPASE
SMARTiView protein in SMART
SM00023 COLIPASE, 1 hit
PROSITEiView protein in PROSITE
PS00121 COLIPASE_1, 1 hit
PS51342 COLIPASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P42889-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEKVLALVLL TLAVAYAAPD PRGLIINLDN GELCLNSAQC KSQCCQHDSP
60 70 80 90 100
LGLARCADKA RENSGCSPQT IYGIYYLCPC ERGLTCDGDK SIIGAITNTN
110
YGICQDPQSK K
Length:111
Mass (Da):11,899
Last modified:November 1, 1995 - v1
Checksum:i7FF37DE7C169616B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82998 mRNA Translation: CAA58119.1
PIRiI48204

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82998 mRNA Translation: CAA58119.1
PIRiI48204

3D structure databases

ProteinModelPortaliP42889
SMRiP42889
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005373

Family and domain databases

CDDicd00039 COLIPASE, 1 hit
InterProiView protein in InterPro
IPR001981 Colipase
IPR017914 Colipase_C
IPR017915 Colipase_CS
IPR017913 Colipase_N
PANTHERiPTHR10041 PTHR10041, 1 hit
PfamiView protein in Pfam
PF01114 Colipase, 1 hit
PF02740 Colipase_C, 1 hit
PRINTSiPR00128 COLIPASE
SMARTiView protein in SMART
SM00023 COLIPASE, 1 hit
PROSITEiView protein in PROSITE
PS00121 COLIPASE_1, 1 hit
PS51342 COLIPASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOL_MYOCO
AccessioniPrimary (citable) accession number: P42889
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again