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Protein

Huntingtin

Gene

Htt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in microtubule-mediated transport or vesicle function.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Huntingtin
Alternative name(s):
Huntington disease protein homolog
Short name:
HD protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Htt
Synonyms:Hd, Hdh
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96067 Htt

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1250362

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000839431 – 3119HuntingtinAdd BLAST3119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei9N6-acetyllysineBy similarity1
Modified residuei155N6-acetyllysineBy similarity1
Modified residuei213N6-acetyllysineBy similarity1
Modified residuei322N6-acetyllysineBy similarity1
Modified residuei396PhosphoserineCombined sources1
Modified residuei398PhosphoserineCombined sources1
Modified residuei411PhosphoserineCombined sources1
Modified residuei421N6-acetyllysineBy similarity1
Modified residuei620PhosphoserineBy similarity1
Modified residuei623PhosphoserineBy similarity1
Modified residuei1159Phosphoserine; by CDK5By similarity1
Modified residuei1179Phosphoserine; by CDK5By similarity1
Modified residuei1853PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation at Ser-1159 and Ser-1179 by CDK5 in response to DNA damage in nuclei of neurons protects neurons against polyglutamine expansion as well as DNA damage mediated toxicity.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P42859

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P42859

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P42859

PeptideAtlas

More...
PeptideAtlasi
P42859

PRoteomics IDEntifications database

More...
PRIDEi
P42859

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P42859

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P42859

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P42859

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

The highest level is seen throughout the brain, but it is also found in the stomach, heart, testis, adipose tissue, muscle, spleen, liver, and kidney.

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Predominant expression in neuronal tissues at all developmental stages. In 14.5 day old embryos, it is also detected in non-neuronal tissues. This expression is down-regulated in later stages of development.

Gene expression databases

CleanEx database of gene expression profiles

More...
CleanExi
MM_HTT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with PFN1 (By similarity). Interacts through its N-terminus with PRPF40A (By similarity). Interacts with PQBP1 (By similarity). Interacts with SETD2 (By similarity). Interacts with SH3GLB1 (PubMed:12456676). Interacts with SYVN (By similarity). Interacts with TPR; the interaction is inhibited by forms of Huntingtin with expanded polyglutamine stretch (By similarity). Interacts with ZDHHC13 (via ANK repeats) (PubMed:26198635). Interacts with ZDHHC17 (via ANK repeats) (PubMed:26198635). Interacts with F8A1/F8A2/F8A3 (By similarity).By similarity2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
P42859

Database of interacting proteins

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DIPi
DIP-41430N

Protein interaction database and analysis system

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IntActi
P42859, 22 interactors

Molecular INTeraction database

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MINTi
P42859

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000078945

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P42859

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P42859

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati183 – 220HEAT 1Add BLAST38
Repeati225 – 262HEAT 2Add BLAST38
Repeati782 – 819HEAT 3Add BLAST38
Repeati882 – 920HEAT 4Add BLAST39
Repeati1404 – 1441HEAT 5Add BLAST38

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni470 – 481Interaction with ZDHHC17By similarityAdd BLAST12

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi2372 – 2381Nuclear export signalBy similarity10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi18 – 24Poly-Gln7
Compositional biasi25 – 45Poly-ProAdd BLAST21
Compositional biasi49 – 59Poly-ProAdd BLAST11
Compositional biasi1417 – 1420Poly-Thr4
Compositional biasi1696 – 1699Poly-Gly4
Compositional biasi2615 – 2620Poly-Glu6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The N-terminal Gln-rich and Pro-rich domain has great conformational flexibility and is likely to exist in a fluctuating equilibrium of alpha-helical, random coil, and extended conformations.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the huntingtin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IDZV Eukaryota
ENOG410XSEC LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000082472

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG005953

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P42859

Database for complete collections of gene phylogenies

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PhylomeDBi
P42859

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat

The PANTHER Classification System

More...
PANTHERi
PTHR10170 PTHR10170, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF12372 DUF3652, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00375 HUNTINGTIN

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform Long (identifier: P42859-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MATLEKLMKA FESLKSFQQQ QQQQPPPQAP PPPPPPPPQP PQPPPQGQPP
60 70 80 90 100
PPPPPLPGPA EEPLHRPKKE LSATKKDRVN HCLTICENIV AQSLRNSPEF
110 120 130 140 150
QKLLGIAMEL FLLCSNDAES DVRMVADECL NKVIKALMDS NLPRLQLELY
160 170 180 190 200
KEIKKNGAPR SLRAALWRFA ELAHLVRPQK CRPYLVNLLP CLTRTSKRPE
210 220 230 240 250
ESVQETLAAA VPKIMASFGN FANDNEIKVL LKAFIANLKS SSPTVRRTAA
260 270 280 290 300
GSAVSICQHS RRTQYFYNWL LNVLLGLLVP MEEEHSTLLI LGVLLTLRCL
310 320 330 340 350
VPLLQQQVKD TSLKGSFGVT RKEMEVSPST EQLVQVYELT LHHTQHQDHN
360 370 380 390 400
VVTGALELLQ QLFRTPPPEL LQALTTPGGL GQLTLVQEEA RGRGRSGSIV
410 420 430 440 450
ELLAGGGSSC SPVLSRKQKG KVLLGEEEAL EDDSESRSDV SSSAFAASVK
460 470 480 490 500
SEIGGELAAS SGVSTPGSVG HDIITEQPRS QHTLQADSVD LSGCDLTSAA
510 520 530 540 550
TDGDEEDILS HSSSQFSAVP SDPAMDLNDG TQASSPISDS SQTTTEGPDS
560 570 580 590 600
AVTPSDSSEI VLDGADSQYL GMQIGQPQED DEEGAAGVLS GEVSDVFRNS
610 620 630 640 650
SLALQQAHLL ERMGHSRQPS DSSIDKYVTR DEVAEASDPE SKPCRIKGDI
660 670 680 690 700
GQPNDDDSAP LVHCVRLLSA SFLLTGEKKA LVPDRDVRVS VKALALSCIG
710 720 730 740 750
AAVALHPESF FSRLYKVPLN TTESTEEQYV SDILNYIDHG DPQVRGATAI
760 770 780 790 800
LCGTLVYSIL SRSRLRVGDW LGNIRTLTGN TFSLVDCIPL LQKTLKDESS
810 820 830 840 850
VTCKLACTAV RHCVLSLCSS SYSDLGLQLL IDMLPLKNSS YWLVRTELLD
860 870 880 890 900
TLAEIDFRLV SFLEAKAESL HRGAHHYTGF LKLQERVLNN VVIYLLGDED
910 920 930 940 950
PRVRHVAATS LTRLVPKLFY KCDQGQADPV VAVARDQSSV YLKLLMHETQ
960 970 980 990 1000
PPSHFSVSTI TRIYRGYSLL PSITDVTMEN NLSRVVAAVS HELITSTTRA
1010 1020 1030 1040 1050
LTFGCCEALC LLSAAFPVCT WSLGWHCGVP PLSASDESRK SCTVGMASMI
1060 1070 1080 1090 1100
LTLLSSAWFP LDLSAHQDAL ILAGNLLAAS APKSLRSSWT SEEEANSAAT
1110 1120 1130 1140 1150
RQEEIWPALG DRTLVPLVEQ LFSHLLKVIN ICAHVLDDVT PGPAIKAALP
1160 1170 1180 1190 1200
SLTNPPSLSP IRRKGKEKEP GEQASTPMSP KKVGEASAAS RQSDTSGPVT
1210 1220 1230 1240 1250
ASKSSSLGSF YHLPSYLKLH DVLKATHANY KVTLDLQNST EKFGGFLRSA
1260 1270 1280 1290 1300
LDVLSQILEL ATLQDIGKCV EEVLGYLKSC FSREPMMATV CVQQLLKTLF
1310 1320 1330 1340 1350
GTNLASQFDG LSSNPSKSQC RAQRLGSSSV RPGLYHYCFM APYTHFTQAL
1360 1370 1380 1390 1400
ADASLRNMVQ AEQERDASGW FDVLQKVSAQ LKTNLTSVTK NRADKNAIHN
1410 1420 1430 1440 1450
HIRLFEPLVI KALKQYTTTT SVQLQKQVLD LLAQLVQLRV NYCLLDSDQV
1460 1470 1480 1490 1500
FIGFVLKQFE YIEVGQFRES EAIIPNIFFF LVLLSYERYH SKQIIGIPKI
1510 1520 1530 1540 1550
IQLCDGIMAS GRKAVTHAIP ALQPIVHDLF VLRGTNKADA GKELETQKEV
1560 1570 1580 1590 1600
VVSMLLRLIQ YHQVLEMFIL VLQQCHKENE DKWKRLSRQV ADIILPMLAK
1610 1620 1630 1640 1650
QQMHIDSHEA LGVLNTLFEI LAPSSLRPVD MLLRSMFITP STMASVSTVQ
1660 1670 1680 1690 1700
LWISGILAIL RVLISQSTED IVLCRIQELS FSPHLLSCPV INRLRGGGGN
1710 1720 1730 1740 1750
VTLGECSEGK QKSLPEDTFS RFLLQLVGIL LEDIVTKQLK VDMSEQQHTF
1760 1770 1780 1790 1800
YCQELGTLLM CLIHIFKSGM FRRITAAATR LFTSDGCEGS FYTLESLNAR
1810 1820 1830 1840 1850
VRSMVPTHPA LVLLWCQILL LINHTDHRWW AEVQQTPKRH SLSCTKSLNP
1860 1870 1880 1890 1900
QKSGEEEDSG SAAQLGMCNR EIVRRGALIL FCDYVCQNLH DSEHLTWLIV
1910 1920 1930 1940 1950
NHIQDLISLS HEPPVQDFIS AIHRNSAASG LFIQAIQSRC ENLSTPTTLK
1960 1970 1980 1990 2000
KTLQCLEGIH LSQSGAVLTL YVDRLLGTPF RALARMVDTL ACRRVEMLLA
2010 2020 2030 2040 2050
ANLQSSMAQL PEEELNRIQE HLQNSGLAQR HQRLYSLLDR FRLSTVQDSL
2060 2070 2080 2090 2100
SPLPPVTSHP LDGDGHTSLE TVSPDKDWYL QLVRSQCWTR SDSALLEGAE
2110 2120 2130 2140 2150
LVNRIPAEDM NDFMMSSEFN LSLLAPCLSL GMSEIANGQK SPLFEAARGV
2160 2170 2180 2190 2200
ILNRVTSVVQ QLPAVHQVFQ PFLPIEPTAY WNKLNDLLGD TTSYQSLTIL
2210 2220 2230 2240 2250
ARALAQYLVV LSKVPAHLHL PPEKEGDTVK FVVMTVEALS WHLIHEQIPL
2260 2270 2280 2290 2300
SLDLQAGLDC CCLALQVPGL WGVLSSPEYV THACSLIHCV RFILEAIAVQ
2310 2320 2330 2340 2350
PGDQLLGPES RSHTPRAVRK EEVDSDIQNL SHVTSACEMV ADMVESLQSV
2360 2370 2380 2390 2400
LALGHKRNST LPSFLTAVLK NIVISLARLP LVNSYTRVPP LVWKLGWSPK
2410 2420 2430 2440 2450
PGGDFGTVFP EIPVEFLQEK EILKEFIYRI NTLGWTNRTQ FEETWATLLG
2460 2470 2480 2490 2500
VLVTQPLVME QEESPPEEDT ERTQIHVLAV QAITSLVLSA MTVPVAGNPA
2510 2520 2530 2540 2550
VSCLEQQPRN KPLKALDTRF GRKLSMIRGI VEQEIQEMVS QRENTATHHS
2560 2570 2580 2590 2600
HQAWDPVPSL LPATTGALIS HDKLLLQINP EREPGNMSYK LGQVSIHSVW
2610 2620 2630 2640 2650
LGNNITPLRE EEWDEEEEEE SDVPAPTSPP VSPVNSRKHR AGVDIHSCSQ
2660 2670 2680 2690 2700
FLLELYSRWI LPSSAARRTP VILISEVVRS LLVVSDLFTE RTQFEMMYLT
2710 2720 2730 2740 2750
LTELRRVHPS EDEILIQYLV PATCKAAAVL GMDKTVAEPV SRLLESTLRS
2760 2770 2780 2790 2800
SHLPSQIGAL HGILYVLECD LLDDTAKQLI PVVSDYLLSN LKGIAHCVNI
2810 2820 2830 2840 2850
HSQQHVLVMC ATAFYLMENY PLDVGPEFSA SVIQMCGVML SGSEESTPSI
2860 2870 2880 2890 2900
IYHCALRGLE RLLLSEQLSR LDTESLVKLS VDRVNVQSPH RAMAALGLML
2910 2920 2930 2940 2950
TCMYTGKEKA SPGRASDPSP ATPDSESVIV AMERVSVLFD RIRKGFPCEA
2960 2970 2980 2990 3000
RVVARILPQF LDDFFPPQDV MNKVIGEFLS NQQPYPQFMA TVVYKVFQTL
3010 3020 3030 3040 3050
HSAGQSSMVR DWVMLSLSNF TQRTPVAMAM WSLSCFLVSA STSPWVSAIL
3060 3070 3080 3090 3100
PHVISRMGKL EQVDVNLFCL VATDFYRHQI EEEFDRRAFQ SVFEVVAAPG
3110
SPYHRLLACL QNVHKVTTC
Length:3,119
Mass (Da):344,690
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iECA42B5916F50F4F
GO
Isoform Short (identifier: P42859-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1522-2001: Missing.

Note: Cannot be explained by a simple splicing event.
Show »
Length:2,639
Mass (Da):290,701
Checksum:i1D09B89A8EBE0A71
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9H5G3X9H5_MOUSE
Huntingtin
Htt Hdh, mCG_2547
3,120Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti2A → G in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti2A → G in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti2A → G in AAA91085 (PubMed:7759106).Curated1
Sequence conflicti29A → P in AAA89100 (PubMed:8009370).Curated1
Sequence conflicti116N → D in AAA89100 (PubMed:8009370).Curated1
Sequence conflicti116N → D in AAA91085 (PubMed:7759106).Curated1
Sequence conflicti138M → L in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti138M → L in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti521S → P in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti521S → P in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti524A → P in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti524A → P in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti533A → P in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti533A → P in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti607A → T in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti607A → T in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti769D → E in AAA89100 (PubMed:8009370).Curated1
Sequence conflicti972S → R in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti972S → R in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti1106W → C in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti1106W → C in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti1240T → N in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti1240T → N in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti1384N → T in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti1384N → T in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti1827H → Y in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti1979 – 1980PF → SS in AAA37799 (PubMed:8162057).Curated2
Sequence conflicti2062D → G in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti2062D → G in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti2570S → N in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti2570S → N in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti2866E → V in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti2866E → V in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti2877V → G in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti2877V → G in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti2882D → G in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti2882D → G in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti2887Q → H in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti2887Q → H in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti2915A → T in AAA37799 (PubMed:8162057).Curated1
Sequence conflicti2915A → T in AAA37800 (PubMed:8162057).Curated1
Sequence conflicti3025P → S in AAC52218 (PubMed:7647777).Curated1
Sequence conflicti3062 – 3063QV → LM in AAA37799 (PubMed:8162057).Curated2
Sequence conflicti3062 – 3063QV → LM in AAA37800 (PubMed:8162057).Curated2
Sequence conflicti3095 – 3096VV → EE in AAA37799 (PubMed:8162057).Curated2
Sequence conflicti3095 – 3096VV → EE in AAA37800 (PubMed:8162057).Curated2

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

The poly-Gln region does not appear to be polymorphic, explaining the absence of a murine HD-like disorder (PubMed:8009370).1 Publication

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0042821522 – 2001Missing in isoform Short. 1 PublicationAdd BLAST480

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L23312 mRNA Translation: AAA37799.1
L23313 mRNA Translation: AAA37800.1
L28827 mRNA Translation: AAA89100.1 Sequence problems.
U24233 mRNA Translation: AAC52218.1
AH003368 Genomic DNA Translation: AAA91085.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I49729

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.209071

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23312 mRNA Translation: AAA37799.1
L23313 mRNA Translation: AAA37800.1
L28827 mRNA Translation: AAA89100.1 Sequence problems.
U24233 mRNA Translation: AAC52218.1
AH003368 Genomic DNA Translation: AAA91085.1
PIRiI49729
UniGeneiMm.209071

3D structure databases

ProteinModelPortaliP42859
SMRiP42859
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiP42859
DIPiDIP-41430N
IntActiP42859, 22 interactors
MINTiP42859
STRINGi10090.ENSMUSP00000078945

Chemistry databases

ChEMBLiCHEMBL1250362

PTM databases

iPTMnetiP42859
PhosphoSitePlusiP42859
SwissPalmiP42859

Proteomic databases

EPDiP42859
MaxQBiP42859
PaxDbiP42859
PeptideAtlasiP42859
PRIDEiP42859

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:96067 Htt

Phylogenomic databases

eggNOGiENOG410IDZV Eukaryota
ENOG410XSEC LUCA
HOGENOMiHOG000082472
HOVERGENiHBG005953
InParanoidiP42859
PhylomeDBiP42859

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Htt mouse

Protein Ontology

More...
PROi
PR:P42859

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

CleanExiMM_HTT

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000091 Huntingtin
IPR028426 Huntingtin_fam
IPR024613 Huntingtin_middle-repeat
PANTHERiPTHR10170 PTHR10170, 1 hit
PfamiView protein in Pfam
PF12372 DUF3652, 1 hit
PRINTSiPR00375 HUNTINGTIN
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHD_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P42859
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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